No need to treat "simple" febrile seizures in young children
A recent AAP recommendation suggests that young children with simple febrile seizures do not need anticonvulsant medication, instead aiming to prevent unnecessary testing and drug therapy.
Drug Studies
Articles tagged with Drug Studies
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Faculty research contributes to new cervical cancer treatment
Researchers at Case Western Reserve University found a new combination therapy, called chemoradiation, that increases survival rates by 50% for cervical cancer patients. The treatment combines radiation with platinum-based chemotherapy agents, leading to more effective cancer cell killing and lower side effects.
Immune system rebounds for some children with AIDS, finds UF study
A University of Florida study found that in two-thirds of the 44 children treated, T cell numbers increased to normal levels. Children under 6 showed the most pronounced improvement, with their immune systems recovering dramatically.
Full bone mass restored to most postmenopausal women with osteoporosis in two-year trial of new treatment
In a groundbreaking two-year study, nearly two-thirds of postmenopausal women with osteoporosis regained their original bone mass after receiving a new treatment. The synthetic parathyroid hormone treatment was three times more effective than current medications in reversing bone loss.
Angina sufferers find significant relief with noninvasive technique
A new study found that enhanced external counterpulsation (EECP) significantly reduces angina pain in patients. The treatment, which involves inflating cuffs on the legs during heartbeats, improves cardiac blood flow and pumping efficiency.
Randomized Contolled Study Shows Neostigmine Is An Effective Treatment For Acute Colonic Pseudo-Obstruction
A new study published in the New England Journal of Medicine confirms that intravenous neostigmine is an effective and safe treatment for acute colonic pseudo-obstruction. The study involved 21 patients with severe abdominal distention and dilated colon who had failed to improve after 24 hours of conservative treatment.
Oregon Health Sciences University, Portland, Oregon receives $6.5 million to fund studies on health of adolescents and firefighters
The university will fund studies to enhance firefighters' exercise and nutrition, prevent eating disorders and drug use among adolescent female athletes, and test random, unannounced drug testing for high school athletes. Principal investigators Linn Goldberg and Diane Elliot will lead the research.
DDW Studies Present Evidence That Thalomid (Thalidomide) Is Active In Treating Crohn's Disease
Researchers found that Thalomid significantly improved symptoms for two-thirds of patients with chronic, steroid-dependent or unresponsive Crohn's disease. Common side effects included drowsiness and peripheral neuropathy. The study suggests a Phase III trial using Thalomid to treat Crohn's disease should be conducted.
Essential 'Allergy Feedback Loop' Discovered By Hopkins
Scientists found a biochemical link between IgE antibody levels and immune cell receptor count, stanching allergic symptoms. When the drug reduced IgE, new receptors sprouted on immune cells, confirming this link.
UT Southwestern Study To Test Efficacy Of St. John's Wort For Treatment Of Depression
UT Southwestern Medical Center is conducting a three-month study to test the efficacy of St. John's Wort in treating major depression. Participants will be given either St. John's Wort, sertraline, or a placebo and monitored by physicians to understand its effectiveness.
New Three Year Follow-up Data Of Novantrone In Multiple Sclerosis
Patients with secondary progressive multiple sclerosis treated with Novantrone experienced a sustained reduction in their number of attacks and delay in disability progression compared to those treated with placebo. The treatment resulted in generally manageable side effects and a smaller number of relapses in the third year.
Advertising May Influence Physicians' Choice Of Blood Pressure Drugs
A study found a significant increase in advertising for calcium channel blockers and ACE inhibitors, paralleling a trend away from beta blockers and diuretics. The authors suggest that pharmaceutical marketing efforts may have contributed to this shift, despite scientific evidence favoring the older drugs.
First Trial Comparing Adderall To Ritalin For ADHD Shows It To Be Longer-Lasting, Equally As Effective
A new study has found that Adderall lasts longer than Ritalin in treating ADHD symptoms, and is at least as effective. The trial involved 25 children who took part in an eight-week program and showed significant improvements in social behavior and academic performance with both medications.
Emory Receives $14 Million Federal Grant To Coordinate 50-Site Brain Attack Prevention Trial
The Emory-led WASID study aims to compare the effectiveness of warfarin and aspirin in preventing stroke and vascular death in patients with intracranial stenosis. The five-year trial will evaluate 806 high-risk patients at 50 sites across North America.
Higher Doses Of Methadone May Do The Trick, New Study Says
Researchers found that high-dose methadone (80-100mg) resulted in a sharper reduction in illicit opioid use compared to moderate doses (40-50mg), with some patients requiring even higher doses for optimal benefit. The study, conducted at Johns Hopkins Medicine, underscores the need for more consistent treatment dosages nationwide.
NHLBI Clinical Trial Stopped Early: Successful Ventilator Strategy Found For Intensive Care Patients On Life Support
A large clinical trial of mechanical ventilator use for intensive care patients with Acute Respiratory Distress Syndrome (ARDS) has been stopped early due to the success of a smaller breath strategy. This approach was found to reduce deaths by approximately 25 percent, improving the care and saving thousands of lives each year.
At Last There's A Way To Fight The Dreaded E.coli
A new drug has been developed to target E.coli infections, reducing the risk of kidney damage by half in trials. The drug, developed by Synsorb Biotech, works by mimicking the receptors on gut cells to which the bacterium's deadly 'shiga' toxin binds, allowing it to mop up the toxin undigested.
Heart Valve Abnormalities Examined In Relation To Duration Of Diet Drug Use
A study by Duke University researchers found that the longer a person used the popular diet drug combination fen/phen, the greater the likelihood they had a heart valve abnormality. Mild or greater aortic regurgitation was detected in 8.8% of patients who used the drug for three months or more, compared to 3.6% of a control group.
When It Comes To Heart Attacks, Size Apparently Does Matter
Researchers at Duke University Medical Center found a new drug reduces the size of myocardial infarctions without necessarily reducing incidence. This challenges traditional trial methods that focus on reducing death and heart attacks.
Depression Kills In More Ways Than Suicide
A review of 57 studies found depression to be linked to increased risk of death from heart disease and other factors, with suicide accounting for less than 1% of deaths among depressed patients
Vanderbilt University Medical Center Forms Institute For Coffee Studies
The Institute for Coffee Studies will investigate the effects of coffee on the brain, depression, and alcohol dependency. Researchers aim to identify potential medicinal compounds in coffee that could benefit human health, with a focus on chlorogenic acids and their impact on neurotransmitter systems.
Smart Cards For Pregnant Women
A study is testing smart cards for pregnant women to access their medical records. The card contains a computer chip summarizing the patient's record, which can be updated with new information upon each visit. This system aims to improve healthcare efficiency and reduce redundant tests.
American Heart Association Comment: Results Of Cardiac Insufficiency Bisoprolol Study II (CIBIS-II)
The CIBIS-II trial found that beta-blockers significantly reduced deaths from all causes by 34 percent and sudden deaths by 44 percent among patients with mild or moderate heart failure. The results support the use of beta-blockers in treating stable patients with this condition.
Maxim Phase II Clinical Trial Highlights Substantial Increase In Leukemia-FreeSurvival For Acute Myelogenous Leukemia Patients
Clinical trials show substantial increase in leukemia-free survival among AML patients treated with Maxamine Therapy. The treatment has been shown to prevent relapse and prolong remission while maintaining a good quality of life.
Severe Pain Following Shingles Safely Relieved In Clinical Trial Of Anti-Convulsant Drug Gabapentin
A recent study found gabapentin to be at least as effective as tricyclic antidepressants in treating postherpetic neuralgia, with better-tolerated side effects. The eight-week clinical trial involved 229 patients and reported a significant drop in pain levels for those treated with gabapentin.
Differences In Brain Function Found For Attention Deficit Disorder
Researchers found a clear difference in brain activation between boys with ADD and those without, specifically in the striatal region involved in motor control. Ritalin improved impulse control in both groups but had different effects on brain activity in those with and without ADD.
Faster Relief From Influenza Symptoms For 'High Risk' And Otherwise Healthy Patients With Inhaled Zanamivir
A study found that inhaled zanamivir significantly reduces the time to recover from influenza symptoms by up to one-third and complications by 71% in high-risk patients. It also showed faster return to normal activities and better health status scores compared to placebo.
Pairing Two Drugs With Angioplasty May Offer Best Success In Treating Heart Attacks
Researchers found that combining abciximab with two low-dose boluses of reteplase provided complete blood flow to up to 35% more patients than using abciximab alone or in combination with a single dose of reteplase. This new strategy may represent an exciting new step in treating most heart attacks.
Medication Used To Stop Organ Rejection Found to Successfully Treat The Most Common, Chronic Skin Disease In Children
Researchers have found that tacrolimus can effectively treat moderate-to-severe atopic dermatitis in children, with a success rate of 67-70% and minimal systemic side effects. This treatment approach offers an alternative to corticosteroid ointments, which can cause skin thinning and other complications.
Physicians Slow To Adopt Newer Drugs For Atrial Fibrillation
A study found that physicians are slow to adopt newer medications for atrial fibrillation, with older drugs continuing to be used despite their limitations. The research team calls for better treatment guidelines and physician education to improve patient care.
Elderly Patients May Be Undertreated For High Cholesterol, Wake Forest Doctor Says
A recent study found that less than 20% of eligible elderly patients with high cholesterol received treatment, despite being at risk for death from coronary heart disease. The Cardiovascular Health Study suggests that older patients and their physicians may have preferred dietary therapy over pharmacological treatment.
MGH To Lead Major National Study Of Bipolar Disorder
The Massachusetts General Hospital is leading a five-year, $20 million research study to improve the diagnosis and treatment of bipolar disorder. The study aims to evaluate existing treatment protocols and test new medications for the condition.
BioNumerik Reports The Supercomputer Supported Discovery Of New, Non-Toxic Chemotherapy Protecting Agent
BioNumerik Pharmaceuticals has discovered a new non-toxic platinum protecting agent, BNP7787, which substantially reduces the toxicity of platinum-type anticancer drugs. Preclinical studies show that BNP7787 increases cisplatin's antitumor activity while protecting against kidney toxicity, vomiting, and bone marrow toxicities.
Penn Study Finds 52% Of Resident Physicians Self-Prescribe Medications
A study by researchers at the University of Pennsylvania found that 52% of resident physicians self-prescribe medications, with 42% obtained from hospital sample closets or pharmaceutical company representatives. The practice raises concerns about lost professional objectivity and potential conflicts-of-interest.
Patients are sought for a clinical study to determine
A clinical trial is underway to investigate whether estrogen can enhance the effects of drugs used to treat Parkinson's patients, who experience a 'roller coaster' effect from daily Levodopa use. The study aims to determine if hormone replacement therapy can improve the effectiveness and duration of Mirapex treatment.
Novel Therapy Significantly Reduces Spinal Fractures In Postmenopausal WomenWith Two Years Of Therapy
A two-year study by UCSF researchers found that raloxifene significantly reduced the risk of spinal fractures in osteoporotic postmenopausal women. Women taking raloxifene had a 52% lower risk of first-time spinal fractures, and those with previous spinal fractures had a 38% lower risk compared to placebo
Study Shows Calcitonin-Salmon Nasal Spray Helps Prevent New Spinal Fractures In Women With Existing Osteoporosis
A recent study shows that calcitonin-salmon nasal spray significantly reduces the incidence of new spinal fractures in postmenopausal women with existing osteoporosis. The treatment, which is currently indicated for women over 5 years past menopause and without estrogen replacement therapy options.
The HERS Study Results And Ongoing Studies Of Women And Heart Disease
The HERS study found that hormone replacement therapy did not prevent further heart attacks or death from coronary heart disease (CHD) in postmenopausal women with CHD, despite positive effects on lipoproteins. However, the treatment increased the risk of clots and lung embolism.
Remembering Your Medications: Older Are Wiser
A University of Michigan study found that busy individuals are more prone to medication errors, whereas older adults tend to exhibit better adherence rates. The researchers developed the 'Busy Life Style Questionnaire' to measure daily chaos and identified being too busy as the primary risk factor for mistakes.
Drug Reduces Heart Attack, Death Rates In Patients With Unstable Angina
The study found that Eptifibatide reduced heart attack and death by an overall 1.5 percent worldwide, with a significant effect even among patients already taking aspirin or heparin. The drug works by inhibiting the receptor that causes platelets to bind together and form a clot.
USC/Norris Study Finds No Benefit Of Finasteride In Preventing Prostate Cancer In Men At Elevated Risk
A new study by USC/Norris Cancer Center scientists raises questions about the potential use of finasteride to prevent prostate cancer. Finasteride, commonly used to treat benign prostate disease, may not be effective as a chemopreventive agent against prostate cancer in men with high PSA levels.
Epilepsy Drugs Useful To Treat Alzheimer's, Studies Find
Medicines commonly used to treat epilepsy appear effective in soothing agitation in people with Alzheimer's disease, a symptom affecting nearly all patients. The findings suggest these compounds may be as good as or better than current treatments for agitation, promising relief for families and caregivers.
Anti-Depressants: Miracle Drugs Or Placebos With A Buzz?
A meta-analysis of 19 drug studies involving 2,318 patients suggests that three-quarters of the beneficial effect of anti-depressant medications can be attributed to the placebo effect. The remaining 25 percent may be due to side effects of the medication.
Potential HIV Vaccine Trial Participants Tell Researchers: Be Open And HonestAnd Do No Harm
Research participants advocate for full disclosure of experimental vaccine details, physical and social harm reduction, and community collaboration. They also want assurance of compensation, confidentiality, and support in case of adverse reactions.
Former Head Of The American Public Health Association Worries That Some Public Health Programs May Infringe On Civil Liberties
A former head of the American Public Health Association raises concerns about public health programs infringing on civil liberties. Dr. Eugene Feingold questions whether these programs prioritize individual rights over public interest, highlighting the need for careful consideration.
OHSU Scientists Begin Human Trials Of A Drug Aimed At The Underlying Cause Of Chronic Myelogenous Leukemia
Oregon Health & Science University scientists begin human trials of a targeted drug therapy for chronic myelogenous leukemia, aiming to eliminate leukemia cells with a faulty gene. The investigational drug has shown success in destroying BCR-ABL cells in mice and animal trials.
Modafinil Improves The Quality Of Life Of Narcolepsy Patients
A study found that modafinil significantly improved the quality of life for patients with narcolepsy, reducing daytime sleepiness and increasing productivity. The medication provided sustained benefits over an extended period without debilitating side effects.
Jefferson Researchers Provide Leads To Potential Parkinson's Treatment
Researchers at Thomas Jefferson University found that a naturally occurring substance in the cell membrane, GM1 ganglioside, improved symptoms in Parkinson's disease patients and slowed progression. The study showed significant differences in motor abilities between those who received the drug and those who did not.
First Patients Enrolled In NIH Clinical Trial On Effects Of Marijuana In HIV Patients
A two-year study on the effects of marijuana in HIV patients is underway, examining its impact on the immune system, virus levels, and interactions with antiviral drugs. The trial, which began last week, will enroll 63 patients over 18 months to assess the safety of THC for HIV/AIDS treatment.
Widely Used Therapy May Not Be Effective In Treatment Of Acute Stroke
A large clinical trial found that widely used therapy with LMW heparinoids after a stroke has little effect on producing good outcomes or preventing second strokes. However, the therapy may be beneficial for patients with large artery atherosclerosis.
Anti-Clotting Drug May Cause Potentially Fatal Platelet Disorder
Researchers found TTP develops within four weeks of starting ticlopidine therapy, causing mass destruction of blood platelets and high mortality rates. Early detection and treatment with plasmapheresis significantly reduce death risk, but most neurologists and cardiologists are unaware of this side effect.
BioNumerik Reports Preclinical Antitumor Data On Two Novel Supercomputer Engineered Anticancer Agents At 89th Annual AACR Conference
BioNumerik's novel chemoprotecting agent BNP7787 appears to completely protect against major toxicities associated with widely used platinum anticancer drugs. The company's Karenitecins demonstrate potent oral antitumor activity and bypass common drug resistance mechanisms.
Diuretics And Beta-Blockers Are Best Drugs To Combat High Blood Pressure, Study Finds
A study of 6,100 veterans found that diuretics and diuretic plus beta-blocker regimens were the most effective in lowering blood pressure, producing average pressures of 140.1/81.9 mmHg. In contrast, calcium channel blockers had the highest average pressures of 149.0/86.5 mmHg.
Study Shows Weight Loss, Dietary Changes Achievable For Many Older People
A study of 975 older adults with hypertension found that about 40 percent maintained diet and exercise changes, enabling them to stop taking medication for high blood pressure. Participants who made moderate changes in body weight and salt intake showed impressive results, controlling blood pressure without medication.
TONE Study Results
The TONE study shows that weight loss and sodium reduction produce significant results in reducing the need for blood pressure medicine. Lifestyle interventions led to a 30% reduction in blood pressure medication use among participants.
Study Tracks Changes In Primary Care Of Children
Primary care physicians are spending more time with their young patients, providing increased preventive services and counseling. The study also found a rise in medication prescriptions, including antibiotics and the stimulant Ritalin, without clear evidence of their appropriateness.
Four-Year Study Shows Long-Term Effectiveness Of Proscar In Treating Enlarged Prostates
Researchers from 95 medical centers found that finasteride significantly reduced prostate surgery and urinary retention risk. Over four years, patients treated with Proscar experienced a 20% prostate size reduction and lower risks of complications.
New Heart-Attack Indicator Dramatically Improves Diagnostic Accuracy Of ER Doctors: TnT/Echocardiogram Combination Could Reduce Needless Admissions
A new clinical approach combining echocardiograms with troponin T levels significantly increases diagnostic accuracy for chest pain, predicting hospital admissions and cardiac events. This method has the potential to reduce unnecessary hospitalizations and improve patient outcomes.
Study Reviews Medication Use In Elderly Cardiac Patients After Discharge
A recent study at Penn State's Hershey Medical Center found that hospitalized cardiac patients experience significant fluctuations in adjusting to their medications. Researchers discovered that more than 50% of patients went home with at least 10 different medications, creating challenges for managing drug reactions and side effects.
Optimizing Working Memory: Effects Of Dopamine-Like Drug Enhances Short-Term Memory, Up To A Point
Researchers discover that dopamine levels can enhance or impair working memory, with a low dose of the drug bromocriptine improving scores in low-capacity subjects but worsening performance in high-capacity individuals. The study suggests an optimal level of dopamine for short-term memory to function properly.