Articles tagged with Drug Studies
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Introgen presents Phase I trial results on RPR/INGN 201, showing safety and expression in ovarian cancer, lung carcinoma, and glioblastoma patients. The therapy has demonstrated significant potential in treating these life-threatening conditions.
Familial adenomatous polyposis (FAP) patients treated with Aptosyn experienced a clinically significant reduction in precancerous colon polyp formation after six months of therapy. Over 18 months, patients showed an overall 75% reduction in polyps, highlighting the compound's potential as a treatment for FAP.
A new study found a combination therapy of Serzone and psychotherapy to be highly effective in treating chronic forms of major depression, with an 85-percent response rate. The treatment approach produced significant improvement in patients sooner than psychotherapy alone, and with fewer side effects.
A large clinical trial is underway at UCSF to study a combination drug therapy for osteoporosis, using recombinant human parathyroid hormone (1-84) and alendronate. The trial aims to combine agents that speed up bone formation and resorption with those that slow down resorption, resulting in a net gain of bone strength.
Two studies in Annals of Internal Medicine explore cost-effectiveness of statins on specific populations. Statin therapy was found to be reasonably cost-effective for patients aged 75-84 years old with a history of heart attack, increasing life expectancy by four months while costing $18,800 per quality-adjusted life year. Cost-effecti...
The METHRO II study found that H 376/95 was effective in preventing venous thrombo-embolism in patients undergoing total hip or total knee replacement surgery. The incidence of venous thrombo-embolism was significantly lower with the highest dosage of H 376/95 compared to dalteparin.
The American College of Physicians-American Society of Internal Medicine has released new guidelines for treating depression with antidepressant drugs. The guidelines highlight the effectiveness of both older and newer medications, as well as the potential risks associated with St. John's wort. Patients should consult their doctor to d...
Researchers found a new class of drugs called selective apoptotic anti-neoplastic drugs (SAANDs) that can safely slow tumor growth in men with advanced prostate cancer. The study showed significant results with minimal side effects.
Researchers found that TRAIL causes catastrophic damage to human liver cells, but not to liver cells from mice and nonhuman primates. The study's findings indicate that results of standard preclinical tests may mislead investigators about an agent's safety for use in humans.
Researchers found that modulating the cholinergic system significantly impacts schizophrenia symptoms, with potential therapeutic benefits for positive and negative symptoms. The study challenges decades-long dominance of the dopaminergic system in schizophrenia research.
Researchers at Northwestern University report a rare but potentially fatal blood disease known as thrombotic thrombocytopenic purpura (TTP) associated with clopidogrel use. The disorder causes mass destruction of blood platelets, anemia, and other severe symptoms.
New research reveals that menstrual function matures rapidly after the first period, accompanied by a surge in hormones, rather than gradually over four to six years as previously thought. This finding has significant implications for adolescent pregnancy prevention and contraception initiation.
A drug used to help people quit smoking may also reduce cocaine cravings in rats, with results showing a reduction of over 40% in self-administration. Mecamylamine blocks nicotinic receptors, which are involved in generating feelings of pleasure and can contribute to addiction.
Elias J. Corey has developed a new method for synthesizing ecteinascidin and phthalascidin, two drugs estimated to be at least 100 times more powerful than Taxol in inhibiting tumor cell growth. The findings have shown promising results in soft-tissue sarcoma treatment and could lead to faster availability of these life-saving drugs.
The NIH granted Vion Pharmaceuticals a two-year, $750,000 Small Business Innovation and Research (SBIR) grant to enhance the anti-tumor efficacy of its TAPET bacterial vector. The goal is to deliver potent anti-cancer agents directly at the tumor site, leveraging TAPET's preferential replication in tumors.
Researchers at USC found no significant change in average sperm count over three decades, contradicting previous studies. Sperm abnormalities were common, but did not impact overall fertility.
A study by Duke University psychologists found that specific drugs for treating AIDS, heart disease, and depression have foul or bitter tastes that can stop patients from taking their medication. This phenomenon affects not only nutrition but also mood and well-being.
A follow-up study of ENBREL (etanercept) treatment for chronic heart failure found sustained improvement in New York Heart Association (NYHA) class and no increase in adverse events. The study involved 12 patients treated with ENBREL for nine months, showing continued tolerability of the drug.
A clinical trial revealed that regular aspirin was as effective as sibrafiban in preventing blood clots, while high-dose sibrafiban showed increased risk of death and second heart attacks. Aspirin's minimal risks make it a hard-to-beat option.
Researchers at Yale and Alexion discovered harmful complement activation in patients with acute coronary syndrome, increasing the risk of cardiovascular disease. The study found that activated complement levels increased by up to 70% in ACS patients' hearts, compared to 16% in stable angina patients.
A large clinical trial, ALLHAT, has stopped part of its study due to Cardura being less effective at lowering blood pressure and preventing heart failure. The study compared Cardura with a diuretic, finding those taking Cardura had more serious hypertension complications
A study by UB neurosurgeons found that cigarette smoking is associated with larger brain aneurysms, which can lead to life-threatening complications. The research, published in the journal Neurosurgery, showed that smokers were more likely to develop large aneurysms than non-smokers.
Researchers at Duke University developed heat-triggered liposomes that can deliver anti-cancer drugs to tumors, delaying growth and eradicating human tumors in mice. The new technology uses specially engineered liposomes that release their cargo rapidly when heated to temperatures just above normal body temperature.
A study by Jeffrey Mogil, a professor of psychology and neuroscience at the University of Illinois, reveals that genetic differences play a significant role in pain response. The research found that involved genes are different in males and females, leading to varying responses to pain and analgesics.
A new anti-angiogenesis drug delivered as a nose drop has shown promising results in treating AIDS-related Kaposi's Sarcoma. The study found a major response rate of 36% among patients, with some experiencing complete remission and others experiencing stabilization or regression of their disease for several weeks after stopping treatment.
A new study published in the Archives of Internal Medicine found that treatment rates for patients with a history of heart disease were low, but women were disproportionately under-treated. Only 12% of women with high LDL levels achieved an acceptable level, compared to 31% of men.
Emergency room physicians demonstrate similar door-to-needle time and outcomes as neurologists in treating acute stroke patients. The study's results show that ER physicians can safely administer clot-busting treatments within minutes of a patient's arrival.
Researchers at Duke University Medical Center analyzed over 3,000 patients in triple-drug combination trials and found that those taking fewer pills had better treatment outcomes. Patients on simpler regimens with as few as four pills per day had significantly higher success rates compared to those on complex regimens.
A study published in the New England Journal of Medicine found that anti-IgE therapy significantly improved symptoms in patients with allergic asthma, with 33% and 43% completely eliminating oral corticosteroid use. This new approach may greatly improve treatment outcomes for those with allergic asthma.
Researchers at Fox Chase Cancer Center are conducting a clinical trial to investigate the efficacy of fenretinide, a vitamin A-related medicine, in preventing ovarian cancer. Women with high-risk factors for breast and ovarian cancer will take part in this study to examine the molecular effects of fenretinide on ovarian tissue.
A nationwide clinical trial showed that Vagus Nerve Stimulation (VNS) improved the condition of 40% of patients with severe treatment-resistant depression, enabling them to return to work and normal activities. The treatment has been compared to electroconvulsive therapy and may have potential as an alternative for some patients.
A novel combination of efavirenz and nelfinavir demonstrates strong, sustained results in controlling HIV infection in children. The treatment achieves undetectable virus levels in more than half of the children studied, with fewer side effects and a simplified daily regimen.
A study of 14 patients with refractory Crohn's disease found that all participants responded to thalidomide treatment, with significant improvements in disease activity and fistula closure. The median daily steroid dose fell by over 70%, indicating a potential steroid-sparing effect.
A new University at Buffalo study shows that a single dose of Adderall can effectively manage children's behavior and performance throughout an entire school day. The results suggest that 14 out of 16 kids who responded to medication could get by on once-a-day doses of Adderall, skipping the mid-day dose.
The University of California, San Francisco is part of a national study evaluating medications that duplicate glucosamine and chondroitin sulfate for treating knee osteoarthritis. The four-year trial aims to assess efficacy, safety, and side effects in over 1,000 patients.
Rheumatoid arthritis patients receiving a single dose of Alexion's 5G1.1 showed significant reduction in joint pain and symptoms compared to placebo-treated patients, with 50% achieving an ACR20 score. The company is currently enrolling up to 200 patients in a Phase II efficacy trial employing multiple doses of 5G1.1.
A study of 2,708 participants found that beta-blocker bucindolol did not reduce death from heart failure. The results contrast with other trials and raise questions about the use of beta-blockers in advanced heart failure.
A six-year randomized study of 5,059 U.S. veterans found that taking one aspirin a day after a heart attack is as effective as combining it with an anti-clotting drug in reducing post-heart attack risk. The study recommends solo aspirin use due to its cost-effectiveness and lack of need for monitoring.
A new study published in Neurology found that lamotrigine significantly reduces partial seizures and secondary generalized seizures in children. The medication has been proven safe and effective, allowing children to participate in daily activities without drowsiness.
A cholesterol-lowering drug, pravastatin, has been shown to reduce stroke risk by 20% in patients with heart disease or high cholesterol. The study pooled data from three clinical trials involving over 19,700 participants and found a significant reduction in stroke rate, particularly among those with coronary heart disease.
Researchers found that highly active antiretroviral therapy (HAART) helped patients with CMV retinitis stop taking standard anti-CMV medications without progression. HAART also partially restored the immune system, allowing it to fight other serious infections.
The University of North Carolina at Chapel Hill has been awarded a $42.1 million federal contract to study the effectiveness and safety of new anti-psychotic drugs for treating schizophrenia and Alzheimer's disease. The five-year study will enroll 1,000 patients with schizophrenia and 400-500 Alzheimer's patients.
A Phase I/II trial of NUVANCE, an investigational once-a-week inhaled asthma treatment, suggests the drug helped stabilize lung function for up to 12 weeks following discontinuation of inhaled corticosteroids. The treatment was generally well tolerated, with minimal decline in forced expiratory volume.
A clinical trial is underway at UCSF to test the effectiveness of traditional Tibetan medicine as a sole therapy for advanced breast cancer. The trial, led by Yeshi Dhonden and Dr. Debu Tripathy, aims to evaluate the impact of individualized herbal therapies on tumor size in women with stage IV breast cancer.
New data confirm Relenza's effectiveness in targeting viral replication and reducing complications in patients with influenza B. High concentrations of the drug in the lungs also reduce the risk of resistance development.
A study found that despite comprehensive treatment, four patients became infected with HIV at least six months after initial exposure due to ongoing contact with infected partners. Counseling strategies targeting misconceptions about transmission are crucial to preventing future infections.
A new clinical trial confirms zaleplon's safety and tolerability for the long-term treatment of insomnia, lasting up to 12 months. The medication showed no withdrawal symptoms upon discontinuation, making it a good option for chronic insomnia sufferers.
Researchers at the University of Washington have found that amiodarone can save lives in patients who do not respond to defibrillation, improving resuscitation rates by nearly 30% compared to standard treatments. The drug showed particular benefits for women and those treated late in the course of resuscitation.
A study published in the New England Journal of Medicine shows that adding spironolactone to standard treatment regimens for heart failure reduced mortality by 30 percent. The research confirms aldosterone's role in heart failure pathophysiology and opens the door to more effective treatment options.
Research published in Molecular Psychiatry found St. John's Wort to have a better antidepressant effect than placebo and comparable effects to standard antidepressants. The herb's favorable side effect profile may contribute to its advantages over other medications.
A study of heart attack patients in Latin America and North America found that those in Latin America received fewer diagnostic procedures and treatments, leading to higher mortality rates. The research highlights the need for further studies on practice patterns and outcomes in Latin America.
A new medication nalmefene has been found to reduce the risk of relapse in alcohol-dependent individuals. In a 12-week clinical trial, patients who received nalmefene were 2.4 times less likely to relapse than those who received a placebo.
Researchers at the University of Arkansas for Medical Sciences have developed a new long-acting treatment to block the psychoactive effects of phencyclidine (PCP) in drug addicts. The therapy uses monoclonal antibodies to prevent or slow PCP entry into the brain, providing immediate protection.
A landmark study published in Science found no evidence of Porcine Endogenous Retrovirus (PERV) infection in 160 patients who received living pig tissue transplants. The study, which tested the safety of xenotransplantation, showed that pig tissue can survive in the human body for long periods with no ill effects.
The Interstitial Cystitis Clinical Trials Group is conducting a clinical trial using pentosan polysulfate sodium (ElmironR) and hydroxyzine hydrochloride (AtaraxR) to treat IC. The trial aims to evaluate the effectiveness of these oral drugs in relieving symptoms in patients with IC.
A small pilot study found that nine of 13 patients reported long-term decreased binge eating episodes, with four ending uncontrolled consumption completely. Topiramate, approved for epilepsy, shows promise in treating binge eating disorder with minimal side effects.
A new study found that patients with higher levels of conscientiousness are less likely to die suddenly from cardiovascular disease. Patients who faithfully take their prescribed medication, such as amiodarone, are also more likely to engage in healthy behaviors like eating a heart-healthy diet and socializing.
A 5-year clinical trial led by Thomas Jefferson University aims to investigate the effects of GM1 ganglioside on improving Parkinson's disease symptoms, delaying disease progression, and restoring damaged brain cells. The study will compare the drug to standard treatments, using advanced imaging techniques to visualize dopamine termina...
Researchers observed a substantial reduction in mortality for heart failure patients who received the Aldactone medication regimen, reducing deaths by 30 percent. The study found that aldosterone blockade played an important role in this reduction and opens the door to developing more effective treatment options.
The study found that aggressively lowering 'bad' cholesterol with atorvastatin reduced ischemic events by 36% compared to balloon angioplasty, delaying cardiac events in patients with stable coronary artery disease. Researchers concluded that this therapy is a safe and effective initial strategy for reducing ischemic events.