Articles tagged with Drug Studies
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The Alzheimer’s Disease Cooperative Study (ADCS) has received a five-year grant of $54 million to conduct clinical trials and research on new approaches to treating and preventing Alzheimer’s disease. Researchers aim to delay the onset of the disease and have already made significant progress in the past decade.
The ADCS has expanded its clinical trials to test new therapies for Alzheimer's disease, including a cholesterol-lowering statin drug, an antioxidant, and a high-dose vitamin regimen. The trials aim to slow the progression of cognitive decline in people with AD.
A study found that invasive management improves quality of life and reduces major adverse cardiac events in elderly patients with CAD. Patients aged 75 or older with chronic angina benefit from revascularisation procedures.
Research found that patients taking Reminyl experienced reduced time spent supervising and assisting daily activities, while caregivers reported a decrease in stress and an increase in independence. The medication may delay institutionalization and have a positive economic impact.
Researchers are enrolling patients in a clinical trial to investigate the safety and tolerability of early antiretroviral therapy for recently infected HIV patients. The study aims to determine whether early intervention can reduce disease progression, viral mutations, and immune system damage.
A study published in Obesity Research found that bupropion, an antidepressant approved for depression and smoking cessation, is effective for long-term weight loss in obese women. Women who took bupropion combined with a 1,600-calorie diet lost significantly more weight than those on placebo, with sustained effects for up to two years.
The Lancet highlights concerns about the increasing involvement of sponsors in medical research, exerting control over trial design, data access, and interpretation. The international committee of medical journal editors has strengthened guidelines to restrict publication of research with compromised objectivity.
A Phase Ib clinical trial led by Duke University Medical Center cardiologists has cleared its first hurdle for a potential new treatment that prevents the formation of blood clots earlier than other agents. The drug inhibits Factor Xa, a pivotal clotting factor involved in blood clot formation.
A new drug breaks down collagen bonds in blood vessels, reducing stiffness in older individuals. This could be a treatment for high blood pressure, heart failure, and diabetes complications.
Researchers at Texas A&M University have discovered a marine compound, pateamine A, with immunosuppressive properties. The study could lead to the development of new immunosuppressive drugs, and pharmaceutical companies are already inquiring about licensing the compound.
A recent international trial has shown that oxytocin is more effective than misoprostol in reducing maternal blood loss immediately after childbirth. The study found that 4% of women taking misoprostol experienced excessive bleeding compared to 3% on oxytocin.
A recent study published in Clinical Therapeutics found that reminder programs may not improve medication adherence among patients taking pravastatin. Patients who complied with their medication regimen were more likely to adopt other coronary risk-reducing behaviors, such as regular exercise and better eating habits.
A study of 347 patients found that CoQ10 slowed the decline of patients with Huntington's disease by an average of 15 percent, improving cognitive skills and daily responsibilities. However, the results are inconclusive due to limited patient numbers, and more research is needed before CoQ10 can be recommended as a treatment.
A large-scale clinical trial tested two investigational drugs, remacemide and Coenzyme Q10, to slow the progression of Huntington's disease. While Coenzyme Q10 seemed to improve the condition after one year, the overall results are inconclusive as to its effectiveness in slowing down the disease.
A Yale University study found that tracking unexplained illness and death can aid in identifying emerging infectious diseases. The research compared two surveillance methods, finding prospective surveillance to be 32% more sensitive than retrospective evaluation.
A new skin patch has shown effective treatment of Parkinson's disease in a large-scale study. Patients who received the medication improved their motor skills by an average of 20-30% compared to those who received a placebo.
A study reformulates a common anti-depressive medication of the nineteenth century, revealing that it would have delivered a daily dose of mercury exceeding current safety standards. Mercury poisoning may have explained Lincoln's neurological symptoms, including insomnia and rage attacks, but also contributed to his famous composure.
Researchers found that ACE inhibitors slowed kidney disease progression, especially for patients with proteinuria. The medications were beneficial for kidney patients and should be given to most patients with kidney disease.
A new report by the University of California, San Francisco, reveals that California's tobacco control program is 'stalled and adrift,' with a significant lack of funding. Despite initial optimism under Governor Gray Davis, the program has been slow to implement aggressive measures, leading to thousands of unnecessary deaths from smoking.
The study recommends that physicians specifically ask patients about herbal medication use before surgery, as many patients fail to disclose their use. Herbal medications can affect heart rate, blood clotting, and immune function, making it essential for patients to stop taking them before surgery.
Exanta, a novel oral anticoagulant, has demonstrated comparable efficacy to warfarin or low molecular weight heparin in preventing blood clots. The European phase III trial showed that Exanta is effective and well-tolerated for VTE prophylaxis in orthopaedic surgery.
A recent study found that problem drinkers with HIV are more likely to take their medications off schedule, highlighting the importance of screening for alcohol problems among persons with HIV infection. Nearly half of problem drinkers reported taking medication off schedule during the previous week.
A new study published in the Archives of Internal Medicine shows that patients with heart failure can tolerate higher doses of ACE inhibitors without severe side effects. The research found that nearly all patients experienced only slight decreases in blood pressure and kidney function, which can be managed by adjusting the dose.
A study found that the cholesterol-lowering drug pravastatin reduced stroke risk by 20% in patients with heart disease or high cholesterol. The medication also showed benefit when combined with aspirin and blood-pressure-lowering drugs, providing a new approach to preventing strokes.
The review analyzes all previous studies of St. John's wort as a treatment for major depressive disorder, finding it to be a promising drug but also raising cautionary notes about interactions with certain medications. Long-term effectiveness is still being determined through ongoing research.
A new study published in JAMA found that steroid hormone drug fludrocortisone does not alleviate symptoms of chronic fatigue syndrome (CFS), particularly neurally mediated hypotension (NMH). Researchers recommend further testing of other drugs or drug combinations to benefit CFS patients with NMH.
Venlafaxine has been shown to alleviate hot flashes in postmenopausal women, including those with breast cancer, by reducing symptoms by 61%. The study found that a daily dose of 37.5-75mg was optimal for effect, with mild improvements in quality of life and no significant impact on libido.
A new clinical trial will compare the effectiveness of aspirin, clopidogrel, and warfarin in preventing heart attacks, strokes, and deaths in patients with chronic heart failure. The study, funded by the VA, will enroll 4,500 patients and provide insights into which medication is most effective, safe, and cost-efficient.
A recent study found that newer anti-psychotic drugs like clozapine are more effective in treating first-time schizophrenia patients than traditional medications. The research also suggests a potential link between toxoplasmosis and poorer treatment outcomes.
Two pivotal trials of Zevalin radioimmunotherapy show overall response rates of 80% and 74%, with patients achieving complete responses to therapy. Toxicity was primarily hematologic, transient and reversible.
Researchers found that 82% of complications from angioplasty occurred within 18 hours, with most happening at the time of procedure. The study aimed to identify the temporal spectrum of ischemic complications, and their findings have implications for hospital length-of-stay policies.
A Yale study shows that combining newer antipsychotic drugs with a nicotine patch leads to nearly triple the success rate in quitting smoking for schizophrenic patients. The study found that this combination was particularly effective in reducing carbon monoxide levels, a by-product of cigarette smoke.
A new study found that enrolling patients with chest pain in clinical trials takes an average of 8+ minutes longer than treating them directly. Despite this delay, researchers believe the potential benefits of participation outweigh the time difference, and doctors should enroll more patients in trials.
A Duke University Medical Center study found that ACE inhibitors are prescribed in just over half the cases they should be, despite clear evidence of their benefits. The study's author suggests increasing physician education and implementing an oversight system to ensure patients receive the best treatments.
A Mediterranean-style diet rich in olive oil, fruit, and fish was associated with a lower risk of death after a heart attack. The study found that participants who consumed more fresh fruits and vegetables had a reduced risk of dying within 42 months after their heart attack.
A new study suggests that losartan, a type of hypertension medication, may improve sexual function in men with high blood pressure. After 12 weeks of treatment, 88% of hypertensive males with sexual dysfunction reported improvement in at least one area of sexuality. The drug also showed promise in improving overall quality of life.
A 52-week study found that patients treated with 6-12 mg of rivastigmine daily showed significantly better cognitive function than those on placebo or lower doses. The treatment reduced cognitive decline and improved outcomes in patients with mild to moderate Alzheimer's disease.
A controlled trial of a warfarin therapy control program demonstrated its effectiveness in reducing major bleeding and maintaining acceptable blood clotting levels in elderly patients. The study also found that immediate treatment for mild chronic hepatitis C virus (HCV) would increase survival and reduce costs.
Researchers will study blood samples from sepsis patients to confirm the link between free radicals and falling blood pressure. The goal is to understand why blood pressure continues to plummet despite using pharmacological agents that should increase and maintain vascular pressure.
A study has shown that two new medications, LAAM and buprenorphine, are effective in treating heroin addiction, with all three medications dramatically reducing heroin use. The research found that patients on these medications had a 90% drop in heroin use and were more likely to stay in treatment.
A large randomized trial evaluating a compound intended to boost the immune response of HIV patients showed no effect on slowing disease progression. The study, led by UCSF and Harvard researchers, defied the sponsor's attempt to block publication, affirming the University's right to publish unfavorable or neutral research findings.
GL701 significantly reduced lupus flares, with 18% of patients experiencing flares compared to 34% on placebo. The study also showed improved quality of life and reduced adverse events.
A systematic review of herbal medicines for asthma treatment found limited conclusive evidence, with most trials of poor quality and potential side effects. Researchers conclude that properly designed studies are urgently needed to assess the safety and treatment value of herbal medicines.
The AAPS Annual Meeting highlights the growing burden of non-communicable diseases, with new treatments offering hope for patients. The meeting showcases innovative therapies, including an inhalable flu vaccine and a new AIDS medication regimen.
A study by the Childhood Asthma Management Program Research Group found that inhaled steroids are a safe and effective treatment option for mild asthma, reducing hospitalizations and urgent care visits. The medication also showed no significant long-term adverse effects on growth or development.
European cancer specialists expect an overview of anti-oestrogen drug trials by 2005, allowing evaluation of long-term effects on breast cancer incidence and mortality. The US FDA has approved tamoxifen for high-risk women, but European experts are cautious due to differing trial results.
The phase III clinical trial demonstrated a significant reduction in S. aureus bacteremias during the first ten months, but not after one-year follow-up. The study found that StaphVAX-induced antibodies protected against bloodstream infections.
A clinical trial shows that a single dose of Zithromax is as effective as a 10-day course of Augmentin in treating acute otitis media in children. The study found high treatment success rates for both regimens.
A study published in JAMA found that patients taking Celebrex had two- to threefold fewer serious gastrointestinal complications compared to those receiving ibuprofen or diclofenac. The medication was also associated with lower incidence of stomach upset, abdominal pain, and nausea.
A new study published in the New England Journal of Medicine found that a testosterone patch improved sexual function and psychological well-being in surgically postmenopausal women. The study showed that treatment with higher doses of testosterone substantially improved outcomes, while lower doses had less effect.
Researchers found Sudafed to be relatively safe for divers, but Dramamine could have serious consequences on mental functioning and judgment. The studies used hyperbaric oxygen chambers to simulate pressures at different depths, revealing the effects of medications on scuba diving performance.
The COPERNICUS trial demonstrates a significant survival benefit of carvedilol in patients with advanced heart failure, reducing mortality rates by 35%. The study involved over 2,200 patients and showed that carvedilol decreased mortality rates compared to placebo.
A study of 27,743 patients found that long-acting calcium channel blockers increased the risk of heart attacks and congestive heart failure by 26% and 27%, respectively. The findings suggest that alternative antihypertensive drugs like diuretics, beta-blockers, and ACE inhibitors may be more effective in preventing cardiovascular events.
A new study shows that drug treatment interruptions can boost HIV-specific immune responses in chronically infected patients, with one patient controlling his viral infection without drugs for at least four months. This approach, known as structured treatment interruption, may provide a sustainable alternative to current treatments.
A new minimally invasive procedure called endoscopic pancreatic sphincterotomy (EPS) has shown promise in providing long-term pain relief for patients with chronic pancreatitis. According to a recent study by Johns Hopkins physicians, 62% of patients reported significant improvement in their pain levels after undergoing the procedure.
A preliminary study found that combining Agenerase with low-dose ritonavir increases amprenavir plasma levels, potentially improving treatment goals. The study, conducted on PI-experienced patients, showed a significant increase in amprenavir concentrations when ritonavir was added.
A new study published in Neurology demonstrates that oxcarbazepine is safe and effective enough to be used alone in patients with partial epilepsy who do not respond to other anti-epileptic drugs. The results show that 12% of patients were seizure-free during a four-month trial, offering new hope for those struggling with the condition.
Researchers discovered a new approach to treating schizophrenia by creating medications that only last intermittently in the brain, reducing prominent side effects. This breakthrough opens doors to significant changes in how schizophrenia is treated and could lead to more effective medications with better tolerability.
A study published in Neurology found that estrogen had no effect on improving memory and mental functions in postmenopausal women with mild to moderate Alzheimer's disease after a 12-week period. Researchers suggest further trials are needed to determine the effectiveness of estrogen in preventing or delaying the onset of Alzheimer's.
The NHLBI's IMPACT study will investigate whether patients with mild asthma require daily anti-inflammatory medication. The trial, which started recently, will compare the effectiveness of inhaled corticosteroids and leukotriene modifiers.