Articles tagged with Drug Studies
The National Institute on Alcohol Abuse and Alcoholism has awarded $3.1 million to the Medical University of South Carolina to continue testing medications that could help individuals with alcohol use disorder. The goal is to reduce vulnerability to relapse and improve treatment options for those affected by alcohol misuse.
Chronic kidney disease affects 37 million Americans, but primary care physicians lack sufficient knowledge and resources to effectively identify and manage patients. A focus group study found that PCPs need more training, resources, and clinical support tools to address the growing epidemic of CKD.
The NLMT trial tests eight targeted therapies tailored to specific molecular changes in cancer cells. Researchers found promising responses with single-agent targeted therapy, particularly in oncogene-addicted NSCLC, and identified potential biomarkers for further research.
Researchers found a 14.5% increase in appropriate use of preventive medicine and a 41% reduction in blood pressure among patients using SMARTHealth. The program, developed by the George Institute, empowers local women with training on blood sample collection and data analysis to provide cardiovascular care.
Researchers tested immunotherapy in young and old mice with triple negative breast cancer, finding that age affects the efficacy of ICB therapy. The study found significant reduction in tumor growth and better overall survival rates in young mice compared to aged mice.
A recent review found that individuals with good medication adherence have a lower risk of needing hospitalisation due to any cause (17% reduction) and long-term mortality risk (21% reduction). Medication non-adherence is associated with increased risks of adverse health outcomes in older populations.
A study of 691 patients found that starting statins late did not increase mortality risk, but rather reducing dosage did. Patients who took high-dose statins throughout the study had the lowest mortality rate, while those with reduced dosages had the highest death rate.
Researchers found men living alone have lower anticoagulation control with warfarin, with median TTR of 57%, compared to cohabiting men. Women living alone also had lower TTR, but the difference was small and non-significant.
A community-based intervention involving non-physician health workers and personal supporters significantly reduced cardiovascular risk in patients with hypertension. The study found a 40% reduction in cardiovascular risk, improved blood pressure control, and enhancements in medication adherence, physical activity, and diet.
A new study published in the New England Journal of Medicine shows that opening all clogged arteries after a serious heart attack leads to a 26% reduction in patient risk of dying or having a recurrent heart attack. This approach also shows no major downside to additional procedures.
A new study suggests that a diabetes medication called empagliflozin can protect against heart disease by regulating circulating progenitor cells and reducing inflammation. The findings from the EMPA-HEART CardioLink-6 Trial may provide the basis for new therapies for patients with heart disease complicated by diabetes.
A new medication that boosts endocannabinoids in the brain shows promise to treat post-traumatic stress disorder (PTSD) by enhancing fear extinction learning. The study found that participants who received the FAAH inhibitor remembered fear extinction memory better, offering hope for a new treatment.
A new study published in The BMJ found that SGLT2 inhibitors, commonly used for type 2 diabetes, reduce the risk of heart failure by 34% compared to another type of diabetes drug. The study also showed a 20% lower risk of death among patients taking SGLT2 inhibitors.
A proof-of-concept trial found ecopipam significantly reduced stuttering symptoms, including increased speech fluency and faster reading completion. The medication was well-tolerated, with no serious adverse effects or signals of weight gain or abnormal movement disorders.
A novel targeting strategy using a click reaction-assisted immune cell targeting (CRAIT) method enables deep tumor penetration of drug-loaded nanoparticles. This approach has shown promising results in reducing tumor burden in aggressive breast cancer models, offering new hope for cancer treatment.
A new study identified a transcriptional signature in B cells that correlates with protection from SIV or HIV infection in five independent trials of HIV-1 vaccine candidates. The gene expression signature was found to be associated with the only human HIV vaccine trial that previously showed modest efficacy, RV144.
New research reveals that 36% of post-market studies for pre-approved prescription drugs were not completed, with 50% taking an average of 5 years to begin. The study suggests that manufacturers lack incentive to complete these studies due to lax enforcement and high costs.
A study by UMass Amherst researcher Elizabeth Evans found that individuals who perceived buprenorphine as unacceptable were least likely to use the medication during follow-up. The study also identified common reasons people disliking buprenorphine, such as negative physical reactions and side effects.
Researchers found that frequent interruptions to sitting time with simple resistance activities lowered postprandial insulin responses and insulin:glucose in adults with overweight or obesity. An agent-based model also showed community diffusion strategies as key drivers of pediatric programs for childhood obesity prevention.
Researchers identify various disease mechanisms underlying progressive MS, highlighting the need for precise therapy approaches targeting different pathomechanisms. Financial obstacles, including patent expirations, also hinder the development of new drugs.
Researchers at Boston University School of Public Health found that patients who start long-term buprenorphine treatment before discharge from a short-term inpatient program are less likely to relapse and more likely to keep up treatment. This approach reduces the risk of overdose and improves outcomes for opioid users.
The CIRM grant will enable pre-investigational new drug studies for neural stem cells as a potential treatment for perinatal hypoxic-ischemic brain injury, which can cause cerebral palsy and other neurological disorders. The project aims to protect at-risk brain cells and potentially restore balance to the injured region.
Stories undermine strong facts by disrupting people's ability to process information in an elaborated manner. When facts are weak, stories embedded within them lead to greater persuasion than facts alone, but when facts are strong, the opposite effect occurs.
The FDA approved a new minimally invasive open-heart surgery approach for low-surgical-risk patients with aortic stenosis. Baylor Scott & White has performed over 3,600 TAVRs and is a top-five provider nationally. This marks a significant shift towards catheter-based treatment options.
Children with mild asthma can effectively manage their condition by using inhalers when symptoms occur, reducing steroid medication use by almost 75%.
Research in flies reveals potential drug targets for gout, metabolic syndrome, diabetes, and kidney stones by manipulating insulin-like signaling pathway. Elevated uric acid levels increase risk of these diseases, emphasizing the importance of routine screenings in humans.
A recent study found that fewer than eight per cent of cancer drug trials included participation from all four major races in the US between 2008 and 2018. Black and Hispanic patients were particularly underrepresented, with rates of 22 per cent and 44 per cent respectively.
Researchers have identified a combination of treatments that may be more powerful than current therapy alone for children with Ewing sarcoma. The new approach combines FAK inhibitors with aurora kinase B targets to kill cancer cells and inhibit tumor progression.
Researchers at USF's Global Center for Hearing and Speech Research have developed a novel treatment for age-related hearing loss, combining aldosterone supplements with anti-inflammatory medications. The treatment has shown promising results in pre-clinical trials on mice, slowing down or preventing age-linked hearing impairment.
The study examined 3,368 medical aid in dying prescriptions from Oregon (1998-2017) and Washington (2009-2017), finding that most patients were insured, non-Hispanic white individuals with cancer. The primary reasons for pursuing medical aid in dying were loss of autonomy, impaired quality of life, and loss of dignity.
A new study demonstrates that antiviral drugs for hepatitis C reduce liver-related deaths by nearly 50% in patients with a history of liver cancer. The finding reverses prior misconceptions about the relationship between hepatitis C and liver cancer recurrence.
Researchers have invented an affordable solution to measure tremor in mice using a smartphone, potentially leading to new treatments. The method uses a cage with rubber bands and a mounted smartphone to detect vibrations, producing comparable results to expensive equipment.
Researchers found tens of thousands of new protein families, likely involved in intercellular communication and warfare, among others. These small proteins may serve as new antibiotics or drugs for human use.
A study of 8,183 TRICARE patients found no significant differences in quality-of-care metrics between African American and white patients following coronary artery bypass grafting. The results suggest that universal insurance and equal-access healthcare systems may be eradicating racial disparities in care.
A review of clinical trials published in top psychology and psychiatry journals found that more than half of the abstracts contained 'spin' - exaggerating the clinical significance of a particular treatment without statistics to back it up. This practice raises concerns about its impact on doctors' treatment decisions.
Researchers have developed an artificial human eye replica, the blinking eye-on-a-chip, to model dry eye disease (DED). The device mimics the complex pathophysiology of DED, allowing scientists and drug developers to test experimental treatments.
Autopsies reveal that meth users have increased deposits of collagen in the heart muscle, leading to irreversible damage and an enlarged heart. The study suggests that monitoring heart function is crucial for early detection and prevention of further deterioration.
A new study has found that ursodeoxycholic acid, the current recommended treatment for intrahepatic cholestasis of pregnancy, is ineffective in preventing preterm birth and stillbirth. The trial of 605 pregnant women with ICP found no meaningful improvement in outcomes with the drug.
The OUtMATCH study will test the ability of omalizumab to increase tolerance to peanut and other food allergens in children and adults. The trial aims to enroll 225 participants with a history of multiple food allergies, assessing whether biweekly or monthly injections of omalizumab can prevent allergic reactions.
A new vaccine candidate, DS-Cav1, has shown promising results in a Phase 1 human clinical trial, eliciting large increases in RSV-neutralizing antibodies that were sustained for several months. The vaccine's structure-based design approach aims to overcome the challenges of traditional methods in creating an RSV vaccine.
A study led by Harvard T.H. Chan School of Public Health found that children and adolescents born with HIV are less likely to adhere to their medications as they age. The prevalence of detectable viral load, a factor associated with nonadherence, also increases with age.
Participants in low-income areas had a higher chance of dying from any cause, hospitalization and death related to heart failure, and developing end-stage kidney disease. The study found that socioeconomic context impacts cardiovascular outcomes.
Researchers found that a soybean antioxidant compound blocked damage to blood vessels in laboratory tests, potentially preventing cardiovascular side effects of recreational and medical marijuana use. The study suggests JW-1 could be a new way to protect blood vessels without psychiatric side effects.
A groundbreaking trial has started to test the safety and effectiveness of a novel, off-the-shelf device designed to treat complex aortic aneurysms. The investigational GORE EXCLUDER Thoracoabdominal Branch Endoprosthesis (TAMBE) allows for minimally invasive endovascular repair, avoiding traditional open surgical approaches.
Daily intake of Montmorency tart cherry juice improved memory scores among adults aged 65-73, with notable reductions in movement time and errors during visual and spatial working memory tasks. Compliance was high, but larger studies are warranted to confirm findings.
A Phase 1 clinical trial found a MERS-CoV vaccine candidate to be well-tolerated and induce robust immune responses in healthy adult volunteers. Over 85% of participants exhibited detectable immune responses after just two vaccinations, with the response persisting throughout the study.
The FDA has approved erdafitinib as a targeted therapy for patients with advanced bladder cancer who have specific gene mutations in the FGFR3 gene. The drug achieved a 40% overall response rate and was well-tolerated, offering an alternative to existing treatments.
The HOPE study found that most women accepted the dapivirine ring and used it consistently throughout the year. The study showed a significant reduction in HIV incidence among participants, with an estimated 39% decrease in risk compared to those not offered the ring.
In a large 24-week study, rheumatoid arthritis patients saw substantial improvement from daily use of an experimental compound. Filgotinib, a selective JAK-1 inhibitor, showed significant benefits in reducing joint swelling and improving disease activity compared to placebo.
Early treatment with stimulant medication has strong protective effects against mood disorders, conduct disorders, substance use disorders, driving impairments, and academic failure in children and young adults with ADHD. The study found that three participants needed to be treated to prevent one from developing serious outcomes.
A study of 427 young African women found that 95% initiated PrEP but use fell after three months, with only 9% maintaining high adherence. Tailored support strategies are needed to maintain PrEP use and optimize protection against HIV acquisition.
A vaginal ring that releases an antiviral drug has been shown to reduce the risk of HIV by 39% in a study of over 1,400 women in southern and eastern Africa. The study found that participants used the ring more consistently than in previous trials, with higher adherence rates.
A recent study by Yale researchers has identified middle-aged adults as a vulnerable population to serious falls due to medication use. Polypharmacy and the simultaneous use of benzodiazepines, muscle relaxants, and prescription opioids increase fall risk.
A US study found that engaging disenfranchised men who have sex with men living with HIV in the US is possible, but achieving and maintaining viral suppression remains a challenge. Despite some progress, many participants still face personal, practical, and structural barriers to achieving success.
Researchers found music to be as effective as midazolam in lowering anxiety before anesthetic procedures. The study used Marconi Union's 'Weightless' song and noise-canceling headphones to reduce anxiety levels.
A recent study published in the British Journal of Anaesthesia found that people with diabetes taking gliflozin medications are at risk of ketoacidosis during surgery. Euglycaemic ketoacidosis can be deceiving, presenting with normal blood sugar levels, and may be missed easily by clinicians.
A recent review explores how artificial intelligence can improve the success of clinical trials. AI-based models can help with trial design, patient recruitment, and monitoring adherence, potentially boosting success rates by up to 30%.
A recent study found that nearly 11% of high school seniors reported misusing prescription drugs in the past year, with 44% relying on multiple sources. This increases the risk of substance use disorders and other issues.
A systematic review of menstrual cups suggests they are a safe option for menstruation management. The review found similar leakage levels to disposable pads or tampons, with some studies showing significant less leakage. Practice, peer support, and training are key to initiation and adoption.
A clinical trial is underway to treat acid attack victims with a revolutionary new approach using collagenase enzyme. The treatment aims to restore sight by softening the underlying tissue and allowing stem cells to repair damage.