Articles tagged with Drug Studies
Researchers found that electronic inhaler monitoring, combined with a disease management program, reduced healthcare utilization in patients with COPD. The study showed a significant reduction in COPD-related hospitalizations and ER visits, from an average of 3.4 to 2.2 trips per year.
A team of UK scientists has identified the mechanism behind hardening of the arteries, which is associated with dementia, heart disease, high blood pressure, and stroke. They found that a generic medication normally used to treat acne could be an effective treatment for the condition.
A systematic review suggests that lithium's effects on breastfeeding are poorly understood due to sparse and poorly designed studies. Expert recommendations vary, and more research is necessary to inform patient decisions.
A clinical trial found that teplizumab, an immunotherapy drug, can delay the onset of type 1 diabetes in people at high risk. The study, published in the New England Journal of Medicine, showed a median delay of two years in children and adults.
Researchers review aspects of RA detection and intervention, highlighting potential for early screening and prevention. Studies discuss the development of effective preventive measures, which could significantly alter disease course and quality of life.
A randomized clinical trial found that patients taking IDegLira achieved and maintained lower blood glucose levels for longer periods compared to those taking insulin only. The study showed improved outcomes without the need for additional therapy, reducing side effects often associated with insulin-only treatment.
Researchers found that an immunotherapy treatment, teplizumab, effectively delayed the progression to clinical type 1 diabetes in high-risk individuals. Participants who received teplizumab took longer to develop clinical disease, with a median time of 48 months compared to just over 24 months for those in the control group.
A large international clinical trial found that dulaglutide reduced cardiovascular events by 12% and kidney disease by 15% in people with Type 2 diabetes. The study, REWIND, followed over 9,900 participants for five years.
A study of adults and youth with type 2 diabetes found that improvements in insulin release wane after treatment stops, highlighting the need for continued treatment. In contrast, youth experience more aggressive disease progression during and after treatment.
A large, multi-year randomized trial found no evidence to support claims that PPIs cause serious health issues such as pneumonia, chronic kidney disease, diabetes, and dementia. The study suggests that limiting prescriptions of PPI therapy is not appropriate due to the benefits outweighing the risks.
A new study found significant issues with non-medical use of alprazolam in the UK, particularly among younger adults. The estimated national prevalence of lifetime and recent use was 0.32% and 1.30%, respectively.
UC researchers present findings from the Belatacept Early Steroid Withdrawal Trial (BEST), showing that belatacept can safely and effectively treat kidney transplant patients. The study demonstrates reduced side effects and cardiovascular risk reduction compared to traditional immunosuppressive regimens.
A clinical trial found that galantamine reduced opioid positive urine samples and prolonged abstinence in participants. The medication's dual mechanism of action may offer new strategies for treating opioid use disorder.
The National Institutes of Health will fund clinical trials to assess genomic medicine interventions for managing diseases such as high blood pressure, depression, and chronic pain. The trials aim to improve treatment outcomes by tailoring drug prescriptions based on patients' genetic makeup.
A Phase II clinical trial conducted at MD Anderson Cancer Center revealed an 84.6% overall response rate and 38.5% complete response rate when combination targeted therapy was given prior to chemotherapy for newly diagnosed patients with a specific type of diffuse large B-cell lymphoma. The findings suggest that patients who respond to...
A new study has identified several potential approaches for improving medication adherence among Latinos with diabetes, including simple measures like pillboxes and family member education. The study also highlights specific challenges faced by underserved Latino communities, such as difficulty understanding medications and managing mu...
A study found that patients taking antihypertensive drugs had a decreased risk of developing dementia, with calcium channel blockers showing the most significant association. The study analyzed data from over 12,000 patients and suggested that these medications may help delay or reduce dementia onset.
The POLO trial shows that olaparib significantly reduces the risk of disease progression or death in metastatic pancreatic cancer patients with BRCA mutations. Progression-free survival was 7.4 months on the olaparib arm, compared to 3.8 months on the placebo arm.
Researchers at Fred Hutchinson Cancer Center have successfully treated cancer patients with HIV using immunotherapy drug pembrolizumab. The study found that the drug was safe and effective in patients with well-controlled HIV, offering hope for inclusivity in future clinical trials.
The NCI-MATCH trial found a combination of dabrafenib and trametinib to be effective in treating patients with BRAF mutations across 17 distinct tumor types, including several rare cancer types. The treatment showed promising activity outside of currently approved FDA indications.
A large study has demonstrated that enzalutamide improves outcomes for men with metastatic hormone-sensitive prostate cancer, with an overall survival rate of 80% after three years. This new treatment option is especially relevant for men who cannot tolerate chemotherapy and have a lower burden of disease.
Researchers developed COXEN, a predictive tool that analyzes gene expression to predict response to chemotherapy in bladder cancer patients. The trial showed COXEN's ability to predict response using Gemcitabine-Cisplatin (GC) biomarker.
Researchers suggest that cannabinoids may relieve symptoms of OCD and related disorders through targeting the endocannabinoid system. Animal study data and preliminary human clinical trial results support continued pharmaceutical development.
A virtual clinical trial using real-world data found entrectinib to be more effective than crizotinib in treating ROS1+ lung cancer. Patients on entrectinib stayed on treatment longer and had a 44% increased chance of cancer recurrence compared to those on crizotinib.
A study from Joslin Diabetes Center found that removing senescent beta-cells can recover their function and improve glucose metabolism in mice with insulin resistance. The researchers hope to develop a potential treatment using senolytics, which target aging cells contributing to disease dysfunction.
A new study presented at ASCO 2019 shows that brigatinib is effective in patients who have received another next-generation ALK inhibitor. The 40-50 percent response rate suggests that brigatinib may be a useful treatment option for these patients. Detailed molecular analyses will help determine the characteristics of patients sensitiv...
A recent study published in Psychopharmacology found that MDMA-assisted psychotherapy significantly improved PTSD symptoms, with 54% of participants no longer meeting criteria after two sessions. The therapy was compared to small doses or non-drug psychotherapy and showed promising results.
A new study suggests that 7-hydroxymitragynine, a kratom metabolite, is responsible for the treatment's therapeutic effects. The researchers found that most of the analgesic effect comes from this compound rather than mitragynine.
A national survey found hundreds of young carers struggling to keep up with studies due to unpredictable family responsibilities. Experts call for tailored programs to improve engagement and future outcomes.
Researchers aim to determine if stopping anticholinergic medications improves cognition and potentially delays or prevents dementia. The 'Reducing Risk of Dementia through Deprescribing' study will enroll 344 older adults and monitor the impact on cognitive function over 2 years.
A study of 20,000 patients found that reading their clinicians' visit notes significantly improves patient-reported behaviors and perceptions concerning benefits versus risks. Patients reported increased understanding of medications and felt more in control of their medications after reading their notes.
Patients with stable chronic heart failure can safely discontinue diuretics without increased dyspnoea or reuse of the medication. The ReBIC-1 trial found no significant differences in symptom relief between patients who stopped and those who continued taking furosemide.
A new nerve stimulation therapy may provide a new treatment option for the most common type of stroke. The study found that this active nerve cell cluster stimulation reduced patients' degree of disability three months after they suffered an acute cortical ischemic stroke.
A new study from the University of Cambridge suggests that virtual reality can spot navigation problems in early Alzheimer's disease, a condition affecting over 525,000 people in the UK. The research highlights the potential of new technologies to help diagnose and monitor conditions like Alzheimer's.
Researchers tracked outcomes from 537 people with brain haemorrhage while taking antiplatelet medicines, finding fewer recurrences compared to those who didn't take these treatments. The study suggests treatments may reduce rather than increase risk of further bleeding in the brain.
SWOG researchers present numerous high-impact trials at ASCO, focusing on symptom control, survivorship, and quality of care. Studies explore the effectiveness of text messaging for medication adherence in breast cancer patients and investigate gender disparities in severe adverse events among chemotherapy recipients.
A recent study found that children with cancer wait an average of 6.5 years longer than adults to access new drugs. Researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center are advocating for improved pediatric trial timelines. The delay can lead to a lack of effective treatments for life-threatening diseases.
Researchers at UC San Diego found that neonatal nicotine exposure changes the biochemistry of the reward circuitry in mice brains, increasing their preference for nicotine in later adulthood. This study suggests a potential mechanism for how early life exposure to nicotine may contribute to addiction later in life.
Researchers found that doctors were as accurate in estimating patients' adherence as patients were in reporting their medication habits. Developing a medication routine or habit can lessen the risk of forgetting medication. The study aims to provide insights for doctors to effectively identify and address barriers to medication adherence.
A recent study published in Journal of Thoracic Oncology found that about 3% of brigatinib patients experience shortness of breath within hours of starting the drug. However, with appropriate supportive care, most patients can rapidly build tolerance and continue on the drug without incident.
A study published in the American Journal of Psychiatry found that CBD significantly reduced craving and anxiety induced by drug cues in individuals with heroin use disorder. The study also revealed that CBD tended to reduce physiological measures of stress reactivity, such as increased heart rate and cortisol levels.
A new study found that IVUS-guided drug-eluting stent implantation significantly reduces target vessel failure and improves quality of life in chronic kidney disease patients. The treatment approach was compared to traditionally used angiography-guidance, showing better outcomes at the 12-month mark.
Patients with severe eosinophilic asthma continued to experience fewer exacerbations and improved pulmonary function with long-term benralizumab treatment. The BORA study found that the risk of infection did not increase over time, and long-term use was well-tolerated.
A new study by Intermountain Healthcare introduces the Summit Score, a computer-calculated system that predicts COPD patient outcomes with higher accuracy. The score takes into account various risk factors and can help doctors plan and administer better patient care.
In a Phase 2 trial, RTB101 reduced the incidence of respiratory tract infections by 68.9% in adults with asthma over 16 weeks. The therapy was well-tolerated and effective during winter cold and flu season.
Researchers used big data to identify four distinct subtypes of sepsis, each with unique clinical characteristics and treatment needs. These findings could lead to the development of precision medicine approaches for sepsis treatment, potentially improving patient outcomes.
Exposure to environmental pollutants alters brain development, affecting sexual development and fertility for multiple generations. Research suggests that current levels of endocrine-disrupting chemicals may already be causing long-lasting harm.
A National Institutes of Health-sponsored clinical trial found that light sedation and intermittent neuromuscular blockade is as effective as deep sedation and continuous paralysis in improving survival rates for ICU patients with acute respiratory distress syndrome (ARDS). The trial, which involved over 1,000 patients across North Ame...
Researchers developed a blood test that measures tumor DNA, allowing for early detection of treatment response in patients with stage III or IV melanoma. The study found that the test detected BRAF mutations in 93% of patients before treatment and showed improved survival rates for those whose tumors shrunk after targeted therapy.
A meta-analysis found that removing all tumor tissue reduces the risk of cancer recurrence in dogs by 60%. The study, published in Veterinary and Comparative Oncology, analyzed data from 10 studies involving 278 dogs with soft tissue sarcoma.
A meta-analysis found that inappropriate prescribing in primary care is associated with emergency room visits, adverse drug events, and functional decline. The study highlights the need for effective interventions to address this issue and its impact on older adults' quality of life.
Researchers found simvastatin helped delay disability worsening and slow brain atrophy in people with secondary progressive MS. The study suggests statins may have independent effects on the disease, beyond cholesterol lowering.
The LATITUDE study evaluates the effectiveness of a combination of two experimental injectable formulations of antiretroviral drugs in managing HIV infection. Volunteers will receive either conventional oral ART or long-acting injectable therapies, with the goal of achieving durable viral suppression and improved treatment adherence.
Researchers are conducting a multi-center study to determine which medication, azithromycin or roflumilast, is more effective in reducing the risk of death and hospitalization in people with COPD. The clinical trial will enroll over 3,000 patients at 30 centers across the US.
A study by Fertility Centers of Illinois found that children conceived through assisted reproductive technology (ART) achieve similar developmental milestones as those conceived naturally, with a slight advantage at 12 months. The study analyzed data from over 1,800 parents and showed no significant impact on childhood development.
A new study published in The Lancet has identified levetiracetam as a safe and effective alternative to phenytoin for treating convulsive status epilepticus (CSE) in children. The trial, conducted by the EcLiPSE Team, involved over 300 children and found that levetiracetam may be considered as an alternative treatment to phenytoin.
A QUT analysis of studies on attitudes towards medicinal cannabis found that health professionals are broadly supportive but concerned about psychiatric harm and misuse. They also lack knowledge across all aspects, including pharmacology and legislation.
A recent survey reveals that nearly half of the public incorrectly believes heart failure is a normal part of aging, highlighting low awareness among both patients and the general public. Exercise has been found to be beneficial for patients with heart failure, with over half recognizing its potential as a treatment option.
The PARTNER 3 Low-Risk TAVR Trial found that TAVR significantly reduces the incidence of adverse events and re-hospitalizations compared to SAVR in low-risk surgical patients. After one year, these benefits were maintained, with improved ICU and hospital stay lengths.
A meta-analysis of 46 trials found soy protein reduces LDL cholesterol, supporting its inclusion as a heart-healthy food option. Researchers hope their findings inform the FDA's evaluation of soy protein.