Articles tagged with Drug Studies
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
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Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
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A new computer-based model developed by Johns Hopkins researchers accurately predicts which patients with a rare heart condition will benefit from an implanted defibrillator. The model identifies patients most likely to benefit from the device while preventing unnecessary surgery, potentially saving thousands of lives annually.
Researchers at the University of Utah Health found that pairing music with pain medications improved analgesic outcomes by up to 90% in mouse models. The study showed significant reductions in inflammation and pain responses, suggesting a potential therapeutic strategy for managing pain.
A collaborative project between C-Path and Japan's PMDA aims to generate critical data for safety decisions in early-stage clinical trials. The study will compare biomarkers in healthy Japanese volunteers with similar Western subjects, informing regulatory submissions.
A study found that patients with type 2 diabetes who are untreated develop signs of Alzheimer's disease 1.6 times faster than those without diabetes. Medication for diabetes may be keeping Alzheimer's away.
A new clinical trial found that burosumab significantly improves rickets and related outcomes in children with X-linked hypophosphatemia compared to conventional therapy. The study, which included 61 children, showed substantial healing of rickets in 72% of participants who received burosumab.
A study found that patients who stayed on phentermine longer experienced greater weight loss than those who took the drug for three months or less. Longer-term use was not associated with increased risk of heart attack, stroke, or death.
A clinical trial assessing the safety of experimental compound ANS-6637 has begun in healthy adults at the National Institutes of Health Clinical Center. The trial will evaluate how the compound affects opioid use disorder and provide groundwork for future studies to develop effective treatments for cravings, a major barrier to sobriety.
A big data study has identified certain ADHD medications that increase the risk of psychosis in young people. The research found that patients taking amphetamines are more likely to develop psychosis than those taking methylphenidates.
A study published in Alimentary Pharmacology & Therapeutics found that older patients with Crohn's disease can be safely treated with combined immunosuppression. The research showed that remission rates were similar between older and younger patients, and there was no increase in side effects in older patients.
Researchers found that Asian subgroups have varying risks of death from heart disease and stroke, with women losing more years due to stroke. The study identified unique risks for each subgroup, including cerebrovascular disease affecting Vietnamese and Filipino men and women, resulting in lost life expectancy.
A new Australian drug trial has achieved a remarkable result, clearing the bone marrow of leukemia in almost 60% of patients. The combination therapy, combining venetoclax with LDAC, led to a 54% response rate and half the study population surviving longer than 10 months.
A new trial found TAVR to be equal to or better than open-heart surgery for patients with severe aortic stenosis who are considered low surgical risk. The study showed that TAVR was associated with lower rates of disabling stroke and death from any cause, as well as improved quality of life and hemodynamics.
A one-off operation targeting kidney nerves successfully maintains reduced blood pressure in hypertension patients, with fewer medication requirements. The procedure, known as renal denervation, was found to be effective in controlling blood pressure without long-term safety concerns.
Patients who stopped taking aspirin three months after receiving a stent had a significantly lower rate of bleeding and no higher rate of death from any cause, heart attack, or stroke compared to those following standard therapy. The study's results balance ischemic and bleeding risks in patients undergoing PCI.
Researchers found that ticagrelor has comparable efficacy to clopidogrel in patients treated with clot busters for a heart attack. The trial also showed that ticagrelor is safe for use in this patient population, with low rates of major bleeding.
A recent study found that both radial and femoral approaches for percutaneous coronary intervention (PCI) are equally effective in terms of survival rates at 30 days. The research, which enrolled nearly 2,300 patients, suggests that operators can achieve similar results with either approach if they have efficient systems and teams in p...
Patients who stopped taking aspirin and continued clopidogrel fared significantly better after one year, with a reduced risk of bleeding and no increase in clot-related events. The study suggests that stopping DAPT after one month may be a good option for patients after drug-eluting stent implantation.
A large randomized controlled trial found that two frontline two-drug combinations including amlodipine significantly reduced blood pressure levels more than a third combination without amlodipine. The study, conducted in sub-Saharan Africa, showed that nearly half of adults have high blood pressure, often receiving ineffective treatment.
Researchers at Kazan Federal University have developed a two-gene medication that recovers motor functions in rats after spinal cord injuries. The medication, which targets VEGF and FGF2 genes, stimulates axon growth and regeneration by increasing blood flow and neuron survivability.
Transcatheter aortic valve replacement (TAVR) significantly reduces the primary endpoint of death, stroke, and re-hospitalizations in patients with severe, symptomatic aortic stenosis at low surgical risk. TAVR also shows lower rates of mortality, stroke, and repeat hospitalizations compared to surgery.
Researchers found that systematic depression screening after a heart attack did not impact patients' quality of life. Depression was identified in about 7% of screened patients, and interventions such as medication, phone-based psychotherapy sessions, or a combination both were shown to be effective in reducing depressive symptoms.
A new study found that taking statins reduces the risk of a second major adverse cardiovascular event by almost 50% when patients adhere to their prescribed regimen. However, only about six percent of patients in an insured population follow their statin medication as directed.
A recent study using big data analysis has found that catheter ablation is associated with a lower risk of stroke, death, and major bleeding in patients with atrial fibrillation. The research, led by Mayo Clinic, used a large cohort of patients to replicate the results of a clinical trial and provide complementary evidence for clinicians.
New studies show that catheter ablation is not more effective than drug therapy in preventing strokes and deaths from atrial fibrillation. However, patients who undergo the procedure experience significant improvements in quality of life and symptoms, including reduced hospitalizations and recurrences of the condition.
A two-week treatment course for adult patients with chronic Chagas disease was shown to be as effective as an eight-week standard treatment in improving sustained parasitological response at six months. The new regimen also significantly reduced side effects, encouraging wider adoption by the medical community.
A two-week treatment course showed similar efficacy and fewer side effects than the standard eight-week treatment in adult patients with chronic Chagas disease. The results bring new hope for people living with this silent disease and could change access to treatment in endemic countries.
A Danish study of over half a million people found that cholesterol-lowering statin medications lower the risk of brain haemorrhages by 22-35% compared to non-users. The study rebuffs suspicions that statins increase the risk of brain haemorrhages.
A randomized trial of ivermectin mass administration in children aged five or younger shows a 20% reduction in malaria episodes without adverse events. The study suggests ivermectin could be a useful tool in disease reduction to combat residual transmission.
A study from MIT and Brigham and Women's Hospital found that nearly all pills and capsules contain ingredients that can cause allergic reactions or irritations in certain patients. The researchers aim to raise awareness of this issue and stimulate reforms to protect patients.
Researchers found that the medication amphotericin helps lung cells function, making it easier for patients to fight chronic bacterial infections. The finding holds special promise for a subset of patients who do not respond to current treatments.
A recent analysis found that giving the steroid betamethasone to pregnant women at risk of late-preterm delivery results in lower hospital stays for infants. The study estimated costs for over 1,400 mother-infant pairs and found that the average cost for those who received the drug was $4,681, compared to $5,379 for those who did not.
A new study published in Wilderness & Environmental Medicine found that a lower dose of acetazolamide (62.5 mg twice daily) was as effective in preventing acute mountain sickness symptoms as the standard prophylactic dose (125 mg twice daily). However, this reduced dose showed similar side effects with both doses.
Tenapanor, a novel agent blocking intestinal phosphate absorption, significantly reduces serum phosphate levels in patients with kidney failure on hemodialysis. The study found tenapanor showed significant benefits over placebo during the withdrawal period.
A study led by Mount Sinai researchers found that aspiration is equally effective as traditional stent retriever approach for clot removal, with significant cost savings. The study showed comparable clinical results between the two approaches, including similar functional outcomes and revascularization rates.
A new study found that losing Medicare coverage before the three-year post-transplant mark significantly increases the risk of kidney failure and decreases medication adherence. This has significant policy implications, highlighting the need for healthcare safety nets and access to immunosuppressive medications.
Nonmedical prescription drug use leads to 360,000 ED visits in US, mostly benzodiazepines and opioids; young adults under 35 most affected. The study proposes expanding naloxone distribution and implementing screening for polysubstance use.
A recent study published at the American Heart Association's Epidemiology and Prevention | Lifestyle and Cardiometabolic Health Scientific Sessions 2019 reveals that young women in the US tend to worry more about stress and mood disorders than their heart health. The research, which surveyed 331 young women ages 15-24, found that only ...
Researchers found that using antibiotic soap and nasal ointment reduces infections in non-ICU patients with medical devices. The study showed a 30% decrease in bloodstream infections and nearly 40% decrease in antibiotic-resistant bacteria infections.
The ABATE Infection Trial found that daily antiseptic bathing with nasal ointment reduced hospital-acquired bloodstream infections by 30% in patients with central venous catheters, a high-risk group. This intervention also decreased antibiotic-resistant organisms, including MRSA and vancomycin-resistant enterococcus, in this patient po...
Recent clinical trials conducted by the Regenstrief Institute found that traditional drug-focused approaches are ineffective in managing delirium in ICU patients. Implementing deprescribing strategies and exploring alternative methods, such as waking and mobilization, may be more effective in reducing delirium severity and duration.
Researchers found that high flavonoid cocoa powder improved fatigue in people with multiple sclerosis by reducing mental and physical fatigue. Participants who drank the high flavonoid version showed a moderate effect on fatigability and improvements in pain symptoms, while those drinking low flavonoid cocoa saw no significant benefits.
Researchers at Clemson University developed a targeted nano therapy that destroyed calcium buildup in arteries without causing side effects. The therapy mimics a human's chronic kidney disease and has the potential to benefit thousands of patients.
A new study suggests that moderate alcohol consumption has health benefits, particularly for older adults. Researchers found that younger people are more likely to die from alcohol-related causes than they are to benefit from drinking, while older individuals tend to experience the health benefits often mentioned in news stories.
Researchers at Lobachevsky University studied the thermodynamic and structural properties of hevein, a protein with antimicrobial activity. The study revealed a phase transition at 222.8 K, which may lead to the development of new resistant crops and medicines.
Researchers tested an experimental treatment boosting Glial Cell Line Derived Neurotrophic Factor (GDNF) to regenerate dopamine brain cells in patients with Parkinson's. After nine months, the group receiving GDNF showed a 100% improvement in affected brain areas, offering hope for a potential reversal of the condition.
A pioneering clinical trial has shown promising effects on restoring brain cells damaged in Parkinson's. While the treatment did not significantly impact symptoms, it demonstrated significant improvements in brain scans, suggesting long-term beneficial effects may be possible.
A genetic discovery identifies a gene mutation allowing clinicians to tailor alternative treatments to patients at risk of thiopurine-induced bone marrow suppression. The test could reduce risks and costs associated with IBD treatment.
A student-led rheumatology interest group at George Washington University significantly increased student engagement with the field of rheumatology. The group's establishment led to a rise in publications by rheumatology students and enrollment in the rheumatology elective.
Professor Marjan van den Akker is appointed as endowed chair for polypharmacy and health services research, focusing on frequent disease combinations and their medical treatment. She aims to improve care for patients with multimorbidity by developing and evaluating interventions.
Researchers at Brigham and Women's Hospital have developed an intelligent-injector for tissue-targeting (i2T2) that detects changes in resistance to deliver medication safely and effectively. The device was tested on animal models and found to precisely deliver medication without overshoot injuries.
A new study published in eNeuro found that Ritalin had no impact on neuronal activity in the prefrontal cortex of monkeys. The researchers observed improved performance in attention tasks at higher doses, but not in brain activity.
A survey of Colorado home health care clinicians found that 60% lacked adequate information from hospitals to guide patient treatment. The study highlights major gaps in communication between hospital and home health staff, which can result in medication errors and other serious consequences.
Researchers at Penn Medicine have successfully cured nine patients of Hepatitis C after receiving heart transplants from deceased donors who were infected with the disease. The study suggests that using HCV-infected organs may be a viable option for patients awaiting a heart transplant.
Researchers found that a single dose of PD-1 inhibitor before surgery can lead to complete remission and cancer-free follow-up for more than two years. Immune responses from this therapy can peak within seven days, allowing for earlier guidance on the most effective treatment approach.
A new study by the University of Texas at Austin found that medication abortion use increased to 33% after the FDA label change, despite ongoing restrictions. The study reveals that Texas providers can now offer medication abortion consistent with medical evidence, increasing options for women.
The proportion of early-stage drug trials tackling rare cancer types has increased sharply, with the analysis highlighting a changing treatment landscape. New molecularly-targeted anticancer drugs and immunotherapy are being evaluated for less common tumour types.
UCSF researchers created a blockchain-based system to ensure the integrity of clinical trials data, creating an immutable audit trail that makes tampering visible. The system allows for real-time reporting of adverse events and protects data from corruption.
A new oral medication targeting NF-κB, a key link between loss of dystrophin and disease progression, has been well-tolerated in boys with Duchenne muscular dystrophy. The Phase 1 clinical trial results indicate that the drug can reduce levels of NF-κB-regulated genes and serum proteins thought to originate from damaged muscles.
A new study published in JAMA Psychiatry found that combining antidepressants with antipsychotic drugs may have benefits for individuals with schizophrenia. The research suggests that antidepressant use can reduce the risk of hospitalization by 16% compared to antipsychotics and by 22% compared to benzodiazepines.
A small pilot clinical study suggests that nitisinone increases melanin production in some people with oculocutaneous albinism type 1B, a rare genetic disease. The drug may help protect against the sun's UV rays and promote normal vision development.