Articles tagged with Drug Studies
Researchers have successfully produced high-quality human proteins in eggs from genetically modified hens, offering a promising alternative to expensive mammalian cell culture techniques. The study found that the proteins worked at least as well as those produced using existing methods, with no adverse effects on the chickens.
A study suggests that regular use of aspirin or other NSAIDs can improve the survival of patients with head and neck squamous cell carcinoma (HNSCC) who have mutations in the PIK3CA gene. This is due to the reduction of prostaglandin E2, an inflammatory molecule that promotes tumor growth.
For adolescents with obesity, weight loss medications may be an effective option that hasn't improved with lifestyle modification or surgery. Researchers recommend evidence-based guidance on medication use, emphasizing the importance of monitoring and further research.
A new study found that extending medication time for varenicline to 24 weeks combined with 24 weeks of counseling sessions improves quitting success rates and reduces relapse risk in cancer patients. For those taking the medication as directed, quit rates increased significantly.
A study found surgery to remove the thymus gland improves clinical outcomes and reduces immunosuppressive medications for up to five years. The procedure may also result in significant healthcare savings, with reduced hospitalizations and medication costs.
Researchers discovered that STAT5B facilitates leukemogenesis in B-cell acute lymphocytic leukemia. They found that the absence of STAT5B increases interferon response and suppresses transformation. This understanding may enable precision medicine strategies to treat disease.
Researchers have successfully constructed a three-dimensional human epidermis based on predictions made by their mathematical model of epidermal homeostasis. The epidermal equivalent exhibits excellent barrier functionality and thickness, providing a promising new tool for basic research and drug development.
A study analyzed combined results from 18 randomized clinical trials on morphine and other medications for treating neonatal abstinence syndrome in newborns exposed to opioids during pregnancy. Buprenorphine was associated with the shortest length of treatment, but further research is needed for wide-scale adoption.
A recent NYU study found that health literacy is associated with better adherence to blood pressure medications among Hispanic individuals. Despite this connection, the majority of patients in the study population lack adequate health literacy and exhibit poor medication adherence rates.
Researchers found that mavoglurant improves eye gaze behavior and alters reactivity to faces in patients with fragile X syndrome. The study shows significant improvements in eye contact and reduced pupil reactivity to emotional faces.
A new 90-day vaginal ring containing tenofovir is being tested for its safety in preventing HIV and herpes simplex virus type 2 (HSV-2) infections. The Phase I study aims to determine the safety of the ring for three months, with results expected mid-2020.
Researchers from UPV/EHU propose improvements to study cognitive function enhancers for patients with schizophrenia. The analysis of nine clinical trials reveals limitations and proposes methodological enhancements to guarantee effectiveness, safety, and tolerance.
A new clinical trial is enrolling patients to test the safety and efficacy of fecal microbiota transplantation (FMT) by enema for recurrent Clostridium difficile-associated disease (CDAD). The trial aims to provide critical data on the long-term safety of FMT in preventing CDAD recurrence.
Researchers developed new chromenone-based derivatives with potent AChE and BChE inhibitory activity. These dual inhibitors may be effective in treating neurodegenerative disorders like Alzheimer's disease.
A landmark study published in the New England Journal of Medicine has found that ibrutinib is significantly more effective than standard therapy in treating CLL, causing fewer side effects and requiring less frequent patient visits. Ibrutinib was shown to improve survival rates by 13% compared to standard treatment.
A new SWOG Cancer Research Network study found that cancer patients with comorbidities such as hypertension or asthma are less likely to participate in clinical trials. The study suggests that allowing patients with manageable comorbidities to join trials could increase treatment opportunities for thousands of patients.
A large cohort study found that exposure to statins, blood pressure medications, and diabetes treatments reduced rates of psychiatric hospitalization and self-harm in patients with serious mental illnesses. The study suggests that these commonly used drugs may have repurposed benefits for individuals with schizophrenia, bipolar disorde...
A review of published studies indicates that use of benzodiazepines and related drugs may increase the risk of pneumonia. The analysis found a 1.25-fold higher odds for developing pneumonia among current and recent BZRD users compared to non-users.
Researchers found pyronaridine-artesunate to be as effective as currently used artemisinin-based combination therapies for treating uncomplicated P. falciparum malaria. Mild liver injuries were observed in some patients but no severe damage was reported. The treatment holds promise for areas with rising artemisinin resistance.
Researchers conducted a first-in-human trial of senolytic drugs on patients with idiopathic pulmonary fibrosis (IPF), an age-related disease. The study showed significant improvements in participants' mobility, with an average increase of 21.5 meters in six-minute walk distance.
A study of over 913,000 Danish children found a significant association between prenatal exposure to valproate and an increased risk of attention-deficit/hyperactivity disorder (ADHD). The study also found no associations with other antiepileptic drugs.
A study published in Family Medicine and Community Health found that family support plays a significant role in motivating individuals with type 2 diabetes to improve their self-management behaviors and glycemic control. The research highlights the importance of motivation in managing chronic diseases like diabetes.
Researchers at MIT have developed an inhalable form of messenger RNA that can be delivered directly to the lungs, showing promise for treating various lung diseases. The aerosol-formulated mRNA was found to induce lung cells in mice to produce a target protein, paving the way for potential treatments.
A new study published in the journal Addiction found that allowing smokers to determine their own nicotine intake while quitting can lead to higher success rates. The results suggest that most smokers can tolerate doses four times higher than those normally recommended, making them more likely to stay smoke-free.
PCSK9 inhibitors significantly reduce Low-Density Lipoprotein Cholesterol (LDL-C) levels by more than 50-60% in patients with Familial Hypercholesterolemia (FH). The study also found that alirocumab reduces all-cause mortality compared to evolocumab, suggesting potential differences in cardiovascular outcomes.
The proposal calls for pharmaceutical companies to collect post-marketing data in all minority groups, classifying responsiveness based on ethnicity. Package labelling should include efficacy data from minority populations.
Several studies have shown that reducing LDL-C to levels lower than 50 mg/dl can provide cardiovascular benefits. However, data on the impact of lowering LDL-C below 25 mg/dl is limited, with some evidence suggesting no increased risk of cancer or hemorrhagic stroke.
Research reveals flavonoids as potent P-gp modulators with high binding affinity and low toxicity, offering a new generation of drug candidates to reverse multidrug resistance. Synthetic flavonoid dimer FD18 specifically targets the pseudodimeric structure of the drug transporter.
A new study analyzed combined results of 47 randomized clinical trials, lasting at least 12 months, involving 22,000 patients with knee osteoarthritis. The research found uncertainty around long-term effectiveness of medications in controlling pain, highlighting the need for large randomized clinical trials.
Case Western Reserve University researcher Sanjay Gupta has been awarded nearly $1 million to investigate drug resistance mechanisms in prostate cancer. He will test two promising medications, simvastatin and metformin, to overcome drug resistance and halt metastasis.
Chemical synthesis breakthrough offers hope in combating lethal drug-resistant infections; researchers develop efficient, scaleable antibiotics to fight Staphylococcus aureus and other bacterial species.
Researchers discovered two tri-terpenoids, ursolic acid and lupeol, with potential activity against Alzheimer's disease pathology. Lupeol showed better binding affinity than ursolic acid, suggesting its potential as a BACE1 inhibitor for AD therapy.
Aerobic exercise shows promise in improving cognitive function and reducing weight gain in schizophrenia patients. Researchers are enrolling over 200 participants to test the effects of aerobic exercise versus a control group.
A phase three clinical trial found that sorafenib stopped progression of desmoid tumors for two years in 80 percent of patients who completed treatment. This is a significant increase in progression-free survival compared to placebo, with researchers describing it as 'a truly remarkable outcome'.
A first-in-human clinical trial found sutimlimab to be effective in treating severe hemolytic anemia in cold agglutinin disease. The investigational drug rapidly halted red blood cell destruction, increased hemoglobin levels, and eliminated the need for blood transfusions.
A new study in the Journal of Neuromuscular Diseases describes the use of a child-compatible, hand-held device to assess pulmonary function in teens with DMD. The results show that weekly use of the device was well accepted by participants, with high adherence rates and reliable data compared to standard spirometry.
A daily dose of buprenorphine-naloxone is cost-effective compared to monthly injections of extended-release naltrexone, with similar effectiveness in quality of life and time abstaining from opioids. The researchers conclude that buprenorphine-naloxone should be preferred as the first-line treatment for opioid use disorder.
A phase 2 trial found that an oral spray containing THC-CBD reduced spasticity in adults with motor neuron disease, improving muscle tone and pain levels. The treatment was well-tolerated and showed promise as a potential option for managing symptoms.
A study of 100 patients found that linking medication reminders to electronic health records (EHRs) improved adherence among glaucoma patients. The reminders were delivered via text or voice message for three months and were reported useful by 74% of participants.
A study at Duke University Medical Center found that weekly whole-body massage improved symptoms of knee osteoarthritis, including pain and mobility, in patients. The treatment maintained its benefits over 52 weeks, suggesting a potential complement to existing treatments.
Researchers found that haloperidol did not benefit elective thoracic surgery ICU patients when given prophylactically, except in those who had undergone esophagectomy. The study suggests a need for a personalized approach to delirium prevention and treatment, focusing on high-risk patients.
A Vanderbilt University Medical Center study found that high-dose antipsychotic medications increase the risk of unexpected death in children and young adults. The study analyzed data from over 250,000 children and young people aged 5-24, revealing a 3.5-fold increased risk of unexpected death compared to those taking lower doses.
A study of 250,000 children aged 5-24 found that those taking higher doses of antipsychotics were at a higher risk of dying from unintentional overdose or cardiovascular causes. The findings highlight the need for careful prescribing and monitoring of these medications in young people.
Researchers compared the Nike Vaporfly 4% with traditional track spikes, finding that the shoe reduces oxygen update rates and improves performance by 4.2%. The study suggests that lighter running shoes like the NVF can propel athletes forward more efficiently.
Researchers aim to evaluate a low dose blood-thinning medication for people with advanced kidney disease, a condition affecting over 30.5 million globally. The five-year trial will also investigate the safety of this medication in reducing heart attacks, strokes and deaths.
Researchers at the University of Iowa used a multidisciplinary approach to identify 90 FDA-approved drugs that may have potential as anti-seizure treatments. Gene expression profiling and bioinformatics revealed that these drugs significantly reduced seizures in zebrafish models.
A new review of 28 scientific studies substantiates that changes in diet, prescription medications, and physical activity reduce food cravings. Losing weight and avoiding frequent eating of certain foods are proven strategies to manage cravings.
A large study found that taking metformin reduced weekly pregnancy weight gain, but did not improve other pregnancy outcomes. The research supports the need for pre-pregnancy dietary and lifestyle interventions to break the cycle of intergenerational obesity.
A phase 2 trial of 70 men with cannabis dependence or use disorder found that an experimental drug reduced cannabis use and withdrawal symptoms compared to placebo. The drug, PF-04457845, works by blocking an enzyme that breaks down a natural endocannabinoid chemical in the brain.
A recent study published in The Lancet found that fluoxetine, a common antidepressant, does not improve physical ability or reduce disability after stroke. However, researchers did note a small increase in bone fractures among those taking the medication.
A large Nordic study found liraglutide reduces the risk of myocardial infarction, stroke, or cardiovascular death among type 2 diabetes patients. The study also showed a lower risk of cardiovascular death and any cause of death with liraglutide treatment.
The combination of ibrutinib plus rituximab was superior to standard treatment in improving progression-free survival and overall survival for patients with chronic lymphocytic leukemia. The treatment also showed fewer serious side effects compared to the standard FCR regimen.
Medication administration errors are a significant concern, with omissions being the most common cause, particularly among elderly patients. The study highlights the need for vigilant attention to safe dosing practices, especially in older adults.
A study found that older adults with heart failure who take five or more medications are at higher risk for cognitive impairment and difficulty performing daily activities. The researchers suggest that healthcare providers should consider these limitations when prescribing medications, as they may unnecessarily expose patients to incre...
A randomized trial of over 3000 participants found that sharing personalized ultrasound scan images reduces cardiovascular disease risk. The study showed improved outcomes in smoking cessation, physical activity, statins, and antihypertensive medication.
A new combination therapy involving ipilimumab, nivolumab, and brentuximab vedotin safely reduces tumor size or spread in 95% of patients with recurrent Hodgkin lymphoma, achieving complete remission in 16 patients.
A new randomised trial found that sharing pictorial representations of personalised scans showing the extent of atherosclerosis reduced cardiovascular disease risk one year later. The study showed improvements in total and LDL cholesterol levels, with the strongest effect seen for those at highest risk.
A follow-up analysis of axi-cel-treated patients with diffuse large B-cell lymphoma (DLBCL) reported that 51% were still alive two years post-treatment. The study found that 83% achieved a reduction in cancer activity, and 39% had ongoing responses. CAR-T cell persistence and B-cell recovery were also observed in most patients.
Researchers at Dana-Farber Cancer Institute present positive results from clinical trials of CAR T-cell therapy and immunotherapy for patients with leukemia and lymphoma. The studies show that Yescarta provides durable benefit to lymphoma patients, while pembrolizumab achieves long-lasting responses in patients with an aggressive form ...
The phase-2 JULIET trial found that CAR-T cell therapy achieved a 52% favorable response rate in patients with relapsed or refractory diffuse large B-cell lymphoma, with 40% experiencing complete responses. Sixty-five percent of patients remained relapse-free after one year.