Articles tagged with Drug Studies
A global clinical trial has shown that chimeric antigen receptor (CAR) T cell therapy can lead to long-lasting remissions in patients with relapsed/refractory diffuse large B-cell lymphoma. The treatment, known as Kymriah, modified patients' own immune T cells to target cancer cells and achieved high remission rates.
Researchers have developed an effective monoclonal antibody treatment, lanadelumab, that can reduce the frequency of life-threatening swelling attacks in patients with hereditary angioedema. The treatment has shown a 90% reduction in attack rate and can be self-administered every two weeks.
A new combination treatment of venetoclax and azacitidine has shown a 91 percent response rate in older adults with newly diagnosed acute myeloid leukemia (AML). The treatment has been associated with no more side effects than the use of azacitidine alone, and patients with IDH mutations have experienced long-lasting responses.
A randomized, controlled trial is enrolling patients with confirmed Ebola virus disease in the Democratic Republic of Congo to compare mortality among those receiving three investigational drugs with a control group. The trial aims to establish the safety and efficacy of these treatments in a comprehensive response to combat Ebola.
A Phase 3 clinical trial shows that lanadelumab injections significantly reduce the number of hereditary angioedema attacks, with improvements in quality of life. The treatment also outperforms placebo in reducing attack frequency and severity.
A new study by McGill University researchers suggests that clinical trials may promote the use of ineffective and costly treatments, particularly with blockbuster pain drug pregabalin. The researchers found that despite strong evidence supporting pregabalin's effectiveness for certain conditions, many studies failed to conduct rigorous...
A neuroimaging study reveals that the medial prefrontal cortex (mPFC) shows increased activity when patients are shown drug cues, indicating a potential target for addiction treatment. The study aims to develop a novel non-invasive therapy using transcranial magnetic stimulation (TMS) to modulate neural networks.
Researchers developed a new oral immunotherapy drug, AR101, derived from peanut protein, to build tolerance in peanut allergy sufferers. The study found that more than two-thirds of participants taking the active drug could tolerate a dose of peanut protein equivalent to about two peanut kernels.
A clinical trial found that aspirin reduced the number of polyps overall, including on the right side, while EPA reduced polyps on the left side. Both compounds had preventative effects by reducing specific types of polyps.
A new study found that only about a third of mandatory pediatric post-marketing drug studies were completed within seven years, leading to a lack of child-specific information on medication labels. This perpetuates off-label prescribing that may be unsafe or ineffective for children.
A Kansas State University researcher is studying the impact of sex hormones on trauma survival in both men and women. She aims to identify differences in response to medication and surgery after traumatic events and develop more effective treatments.
A new study finds that CP201, a nerve-cell-protecting snippet of ADNP protein, normalizes disrupted neural connectivity and improves vocal communication in ADNP-deficient mice. The research paves the way for a clinical trial to treat social, motor, and vocal communication impediments in ADNP syndrome patients.
A new study by RCSI found that older hospital patients are 72% more likely to receive inappropriate prescriptions, regardless of other factors. The research highlights the need for healthcare providers to consider the potential adverse effects of hospitalization on prescribing appropriate medication for older adults.
A new study found that social media users who view alcohol ads are more likely to 'Like' or 'Share' an ad when it has pro-drinking comments. The researchers suggest that the industry needs to improve its self-regulatory system to limit or ban comments on social media advertising.
Researchers at MD Anderson Cancer Center report high response rates of 90% among frontline-treated patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN). The study, led by Naveen Pemmaraju, presents a novel targeted therapy targeting CD-123, a cell surface receptor expressed in BPDCN and other hematologic malignancies.
Two studies found that fewer than 25% of California retail pharmacies dispense naloxone without a physician's prescription, and 69% of Texas chain pharmacies reported having the medication in stock. The studies aimed to assess naloxone accessibility after legislation allowed pharmacists to provide the antidote without a prescription.
The Infectious Diseases Society of America (IDSA) has released new guidelines for outpatient parenteral antimicrobial therapy (OPAT), emphasizing the importance of review by an infectious diseases specialist before starting treatment. Regular monitoring and blood tests are also recommended to ensure patient safety.
A study led by St. Michael's Hospital researchers found that empagliflozin significantly reduces left ventricular mass index, a key indicator of heart disease. The medication has profound cardiovascular benefits, including improved cardiac structure and reduced mortality rates in people with Type 2 diabetes and heart disease.
Researchers have found a new therapeutic target for pancreatic cancer, RIP1 Kinase, which can be used in combination with other immune-boosting therapies to increase survival rates. The study shows that the drug GSK547 helps to mount a more aggressive attack against tumor cells, doubling survival to 50 days in mice.
A study on UK dairy farm medicines storage practices found most farmers store medicines appropriately, but with room for improvement. Inappropriate use and disposal of expired medicines are common, highlighting the need for open conversations between veterinarians and farmers.
Researchers presented a phase 2 trial showing capivasertib's potential in treating various types of cancer with the AKT mutation. The treatment resulted in tumor shrinkage in 23% of patients and prolonged time without tumor growth for 52%.
A Yale-led research study found that a drug therapy used for chronic heart failure also improves markers of poor prognosis in individuals hospitalized with acute heart failure. The treatment reduced NT-proBNP levels more quickly than standard therapy, indicating substantial improvement in heart failure severity.
A new study of over 174,000 patients found that being treated with too much medication for hypothyroidism can lead to an increased risk of atrial fibrillation and stroke. The research suggests that the optimal healthy range of free thyroxine (fT4) levels may need to be reconsidered.
The REDUCE-IT trial found that icosapent ethyl reduced the risk of death due to cardiovascular causes, heart attack, and stroke by 25%, including a 20% reduction in death and 31% reduction in heart attack. This may set a new standard for patients with elevated triglycerides and increased cardiovascular risk despite statin therapy.
The Dapagliflozin Effect on CardiovascuLAR Events - Thrombolysis in Myocardial Infarction 58 trial found that dapagliflozin markedly reduced the risk of hospitalization for heart failure and progression of renal disease, with benefits seen across the study population.
A recent trial found that low-dose methotrexate did not lower cardiovascular event rates in patients at high risk for heart disease and stroke. The study, which included over 4,700 participants, showed no significant reduction in major adverse cardiovascular events compared to placebo.
A new study found that focused ultrasound thalamotomy improves quality of life in people with medication-resistant Parkinson's disease. The procedure showed significant and sustained benefits in functional disability and overall well-being.
A new anti-thrombosis drug based on magnetite nanoparticles has been developed by ITMO University researchers. The drug successfully passed preclinical testing, showing a 20 times shorter clot dissolution time and a lower minimum dose required to achieve the therapeutic effect compared to traditional medications.
A recent study from Massachusetts General Hospital found no association between urate manipulation and blood pressure, suggesting that treating neurodegenerative disorders with elevated urate levels may not increase the risk of hypertension. The study used phase 2 clinical trial results and animal model studies to support its findings.
Researchers at University of Tsukuba found that dopamine neurons are key to inhibiting preplanned actions in monkeys, suggesting a possible mechanism for treating diseases with impaired inhibition. The study used gaze fixation experiments to train monkeys to redirect their attention and measure neuronal activity.
A large international clinical trial found that alirocumab, a PCSK9 antibody, reduced the chance of additional heart problems or stroke in heart attack survivors. LDL cholesterol levels decreased by 50% with alirocumab treatment, leading to a 15% reduction in risk of death from coronary heart disease, another heart attack, or stroke.
A study of almost 2,400 patients in Michigan who underwent surgery found that more opioids were prescribed than used. Patients used about 27 percent of the opioids prescribed, with larger prescriptions associated with increased use.
A Phase 2 clinical trial found that zoliflodacin cured most cases of uncomplicated gonorrhea, with cure rates ranging from 98% to 100%, depending on the dose. The antibiotic also showed promise in treating rectal and throat infections, although performance varied between doses.
Research detects 69 pharmaceutical compounds in stream insects, which can pass to predators in water and on land, exposing them to therapeutically-relevant doses. The study highlights the chronic drug pollution concentrated in aquatic insects and its potential ecological consequences.
A study of 28 middle school and high school students found that they take on significant responsibilities in managing medications, often without formal education. The investigation also highlights the importance of recognizing and supporting youth caregivers to promote their well-being and contribute to patient care.
Researchers at Brown University have developed an electroencephalography-based test to measure pain levels, providing a more objective approach than the traditional visual analogue scale. The test uses brain activity oscillations to determine pain levels and has shown promise in evaluating medication efficacy in animal models.
A large-scale study found no strong associations between prenatal exposure to certain medications and increased autism spectrum disorder (ASD) risk. However, the risk was higher for children whose mothers had pre-existing conditions, suggesting a potential link between maternal health and ASD development.
The ANRS NAMSAL study has compared the efficacy of dolutegravir-based treatment with efavirenz 400 mg in over 600 participants living with HIV. The results show that dolutegravir-based treatment is not inferior to efavirenz, and it is considered a valid treatment option for first-line treatment in low and middle-income countries.
A new study finds that women receiving hormone-blocking injections during chemotherapy have a higher chance of becoming pregnant without negative side effects. The injections protect the ovaries from chemotherapy's effects, reducing the risk of early menopause and improving survival rates.
Scientists have discovered how the Seneca Valley Virus interacts with tumor receptors, allowing it to selectively target cancer cells while sparing healthy tissues. The study provides detailed images of the virus and its receptor, enabling researchers to design improved cancer therapies.
A combination of buprenorphine and samidorphan has shown significant symptom reduction in patients with major depression, with no evidence of dependence or withdrawal. The trials suggest a new class of antidepressants with a novel mechanism of action could have a significant impact for patients with persistent symptoms.
Researchers have developed an implantable delivery system that enables patients to go 15 months in between treatments, significantly improving the conventional regimen of nearly monthly eye injections. The study found that patients treated with the highest drug concentration were able to maintain their vision for a longer period.
Recent clinical trials have shown promising results in reducing progression of kidney disease and improving cardiovascular outcomes in patients with type 2 diabetes. These trials investigated the effects of linagliptin, a DPP inhibitor, on kidney outcomes, as well as high-dose versus low-dose intravenous iron therapy for hemodialysis p...
Research found that people have a tendency to dichotomize data distributions and ignore differences in the degree to which instances differ from an explicit or inferred midpoint. This binary bias influences how people interpret sequences of information across various contexts and graphical displays.
Scientists at NTU Singapore have engineered an antiviral peptide that exploits the Zika virus' viral membrane, reducing disease symptoms and deaths in infected mice. The peptide can cross the blood-brain barrier to tackle viral infection in mouse brains, a critical feature since Zika targets the brain and central nervous system.
The dapivirine-levonorgestrel ring provided protection against HIV infection and unintended pregnancy for 90 days, with plasma concentrations of levonorgestrel consistent with those required for contraception. The ring was well-tolerated and showed promising results in its first clinical study.
A new study published in the Journal of Bone and Joint Surgery found that home care with physical therapy significantly improves recovery rates for knee replacement surgery patients. The study analyzed Medicare claims data and found that patients receiving six to nine home-care visits by a physical therapist had better outcomes.
The combination of avelumab and axitinib improved progression-free survival (PFS) by 6.6 months in previously untreated patients with advanced renal cell carcinoma, with confirmed objective response rates of 55.2% and 25.5%. The study's findings support the potential of this new treatment approach for patients with advanced RCC.
A study highlights the existence of barriers to the inclusion of 12 to 25-year-olds in both adult and paediatric early phase clinical trials. The legal minimum age limit in Europe is 18 years, preventing young patients from participating in trials designed for their tumor type.
A multiyear clinical trial found that patients who chose their form of treatment, whether medication or therapy, improved more than those who were simply prescribed one or the other. Patients who received prolonged exposure therapy showed a significant reduction in PTSD symptoms and were more likely to lose their diagnosis over time.
A new treatment for lymphedema symptoms has been found to be effective in restoring skin health and reducing swelling. Ketoprofen, an anti-inflammatory drug, has shown promising results in two clinical trials, with participants experiencing significant improvements in skin thickness and appearance.
A trial revealed that nurse-led care significantly improves gout treatment outcomes, including higher ULT adoption and better patient adherence. Patients receiving nurse-led care had lower urate levels, reduced flare-ups, and improved quality of life.
A study from Australia found a rapid decline in new HIV infections after the implementation of pre-exposure prophylaxis (PrEP) for men who have sex with men. The study, which followed 3,700 participants, showed a significant reduction in HIV diagnoses by 25% within one year.
The 11th World Stroke Congress brought together leading international experts to discuss various aspects of stroke care. A Canadian study found that while access to stroke rehabilitation improved, provincial and regional differences persist, with bed capacity hindering prompt access. Another study analyzed gender differences in accessi...
Researchers at the University of Arizona are testing green light therapy for controlling HIV-related neuropathic pain, showing a 60% reduction in patient pain. The therapy may also have potential benefits for other types of pain and provide a safer alternative to opioids.
A study from University of California San Diego found that patients who recorded videos of themselves taking TB medications had better adherence to treatment than those observed in-person. VDOT (video directly observed therapy) was also cost-effective and preferred over traditional DOT.
A new study suggests that ultrasound measurements after surgery can predict the likelihood of arteriovenous fistula maturation in individual dialysis patients. At 6 weeks after AVF creation, ultrasound measurements of AVF blood flow, diameter, and depth predicted future AVF maturation with moderate accuracy.
Two new clinical trials are underway at Cummings Veterinary Medical Center at Tufts University to study deadly cancers in dogs. These studies focus on osteosarcoma and solid tumors, and may provide valuable information for human cancer treatments.
A study published in Molecular Psychiatry has identified two subanesthetic doses of ketamine as effective in reducing symptoms of treatment-resistant depression. The doses of 0.5 mg/kg and 1.0 mg/kg showed significant symptom improvement, while lower doses did not produce the same results.
Researchers developed a contact lens that changes color as drugs are released into the eye, enabling real-time monitoring of treatment efficacy. The molecularly imprinted contact lenses can indicate sustained release of many ophthalmic drugs, potentially reducing side effects.