Articles tagged with Drug Studies
The new strategy combines design of a chemical library, virtual screening, automated synthesis, and in vitro study of biological activity. This approach accelerates and automates the process of prototype molecule optimization, increasing chances of finding potential medicinal molecules.
A recent study found that initiating potentially inappropriate medication is associated with a higher risk of fracture-specific hospitalizations and mortality. The study also revealed higher hospital costs, highlighting the importance of monitoring and managing medication use in older adults.
A new study found that substandard and falsified medicines are a serious problem in much of the world. In low- and middle-income countries, over 13% of essential medicines are substandard or falsified, with antimalarials and antibiotics being the most commonly affected.
Research suggests that increasing alcohol taxes is the most cost-effective method of reducing alcohol-related harms. A 50% hike in alcohol excise taxes could add up to 500 healthy years of life for every 1 million people. Restrictions on advertising and hours of sale are also recommended.
A Johns Hopkins study found that fewer than half of Baltimore caregivers for preschool children with asthma can manage their child's chronic condition. The researchers evaluated caregiver preparedness through medication availability, identification, and dosing instructions.
Researchers developed an AI algorithm that analyzes brain scans to classify illness and predict medication response in patients with complex mood disorders. The algorithm correctly classified MDD and bipolar I diagnoses with 92.4% accuracy, predicting the correct medication response for 11 out of 12 patients.
A clinical trial called GutHeart Trial examines the relationship between gut bacteria and heart failure, testing antibiotic, probiotic yeast, or no treatment on patients with heart failure. The study aims to develop new treatment strategies and better understand how gut leakage affects inflammatory processes and heart failure.
A network meta-analysis and systematic review found methylphenidate to be the most effective and safe ADHD drug for short-term treatment in children, with amphetamines being the preferred choice for adults. However, more research is needed to confirm long-term effects of ADHD medications.
Extended-release naltrexone helps HIV-positive individuals reduce their number of heavy drinking days and improve antiretroviral therapy adherence. The study found significant decreases in heavy drinking days among participants receiving naltrexone, but no effect on antiretroviral adherence.
Researchers found that states expanding Medicaid eligibility in 2014-2015 saw a significant increase in diabetes medication prescriptions, with a 30% rise per 1,000 people. This growth was particularly notable for newer, more advanced forms of insulin and other medications, suggesting improved treatment outcomes.
Five low- and middle-income countries lack trained health workers and essential medicines, hindering readiness for noncommunicable diseases. Policymakers can engage private sector in addressing NCD burden through partnerships, medicine procurement, and service financing.
A clinical trial using stem cell transplants aims to grow a new immune system for people with untreated Crohn's disease. This innovative approach may help reduce gut inflammation and improve quality of life for patients suffering from the condition.
A new study by the University of Exeter found that considering patient characteristics such as sex and BMI can significantly improve treatment outcomes in type 2 diabetes. The research suggests that obese females are more likely to have good blood glucose control on thiazolidinediones, while non-obese males benefit from sulfonylureas.
A UCLA-led study found that many people with heart failure do not receive recommended medications, and when prescribed, they are often at lower-than-recommended doses. The research highlights the need for new strategies to improve medication dosing and outcomes for people with heart failure.
A new study published in Molecular Genetics and Metabolism identified the drug nitisinone as a treatment for alkaptonuria, also known as black bone disease. The treatment significantly reduces the accumulation of homogentisic acid, stopping disease progression and partially reversing ochronosis.
Recent research found a significant correlation between conspiracy mentality and preference for alternative medical treatments in Germany and the USA. Individuals with a strong proclivity to believe in conspiracy theories tend to display a positive attitude towards alternative concepts and reject conventional medical treatments.
A breakthrough swallowable sensor has been found to be 3,000 times more accurate than current technology for diagnosing gut disorders. The gas-sensing capsule provides real-time detection and measurement of hydrogen, carbon dioxide, and oxygen in the gut.
Researchers have developed a new method called matching-adjusted indirect comparison (MAIC) to compare the effectiveness of drugs with limited data, enabling more accurate reimbursement decisions. By analyzing patient characteristics, MAIC provides unbiased estimates of treatment effects, helping to optimize resource allocation.
BACE inhibitors may fail Alzheimer's trials due to impaired differentiation of newborn cells, according to a study published in eNeuro. The research suggests that partial BACE inhibition could represent an alternative strategy for reducing AD pathology while maintaining adult neurogenesis.
A study found that women and older people are significantly underrepresented in clinical trials for heart disease, with women making up only 29% of participants. This lack of representation could have adverse consequences on care for these patient groups, as their bodies respond differently to treatments.
Research on cannabidiol (CBD) has shown promising results in treating rare seizure disorders, with clinical trials halving the number of seizures in 40% of children and young adults. However, more studies are needed to determine its efficacy for other ailments, as some patients experienced side effects.
The review found that sexual transmission of Zika virus is more common from men to women than from women to men. The median serial interval and duration of ZIKV RNA persistence in semen were also longer than in the female genital tract.
The RIVER study tested a 'kick and kill' approach to target HIV reservoirs, forcing the virus out of hiding and killing it. Despite initial findings that the therapy didn't add up to a potential cure, researchers say the trial paves the way for testing different combinations to tackle persistent HIV in patients on antiretroviral treatm...
A two-day intermittent calorie restriction diet was found to be effective for glycemic control in patients with type 2 diabetes, comparable to a daily calorie restriction diet. The study suggests that this approach may be more sustainable than traditional daily calorie restriction diets.
A drug currently in clinical trials for treating Parkinson's disease shows promising effects on strengthening heart contractions in dogs and rabbits. The new compound works differently than current drugs, suggesting its use may be a safer way to increase heart contraction strength without the risk of dangerous complications.
A retrospective study of 179 patients with chronic hepatitis C found that original and generic direct acting antivirals achieved sustained virologic response in over 90% of patients. The original medicines group showed slight superiority, but the generic medicines group still demonstrated high efficacy.
A study by University of Rhode Island and Brown University researchers found that ADHD medications did not improve cognition in healthy college students, but instead impaired working memory. The medication did show attention and focus improvements, but these effects failed to translate to better performance on neurocognitive tasks.
A clinical trial found that adrenaline increases the survival rate of patients with cardiac arrests by less than 1%, but almost doubles the risk of severe brain damage for survivors. The study raises questions about the future use of adrenaline in such cases and its impact on patient outcomes.
Research found trials supporting drugs granted 'breakthrough' status often lacked randomization and control groups, enrolling small patient numbers. This suggests a lack of robust evidence to support the use of these therapies for serious or life-threatening conditions.
A study by Rutgers Brain Health Institute discovered that the hypothalamus' 'orexin' neurons play a key role in controlling food motivation. Orexin blockers have shown promise in reducing binge-like eating episodes, providing new hope for treatment options.
Researchers have developed a new ALS therapy that extends survival and reverses signs of neuromuscular damage in mice and rats with SOD1 mutations. The investigational drug, an antisense oligonucleotide, has shown impressive effects in preclinical trials.
A pre-clinical pilot study found that a combination therapy of CBD and an NMDA antagonist improved cognitive functions and showed no adverse effects in animals. Researchers believe this treatment could reduce symptoms associated with concussion, traumatic brain injury, and post-injury brain cell inflammation.
Recent studies suggest a potential relationship between air pollution and infertility, menstrual irregularity, uterine fibroids, and endometriosis. Researchers emphasize the need for further exploration of these findings to support policy guidelines on air pollution and human health.
A new study by the Institute for Health Metrics and Evaluation identifies communities at risk of dying from snakebites. The analysis reveals regions and nations with limited access to treatment and healthcare, highlighting the need for greater measures to support countries in implementing snakebite prevention and treatment programs.
A major new study published in Science Translational Medicine found that a hepatitis C vaccine would significantly reduce transmission among injecting drug users, even if it doesn't provide complete sterilizing immunity. The study estimated that the risk of transmission could decrease to between 1 and 25 percent with vaccination.
Research shows patients are more likely to fill prescriptions when they pay less for high-value medications, which can prevent costly health issues. This approach, called value-based insurance design, also leads to decreased spending elsewhere in the healthcare system.
Researchers are testing whether drastically cutting calories twice a week can change MS symptoms. A study found that intermittent fasting reduced MS-like symptoms in mice, with changes in immune cells and gut microbiome.
Researchers have found that injection of adalimumab into Dupuytren's disease nodules reduces the development of myofibroblasts, the cell type causing Dupuytren's disease. The study shows promising results, bringing new hope to patients with this disabling condition.
A recent study published in the Journal of Head Trauma Rehabilitation found that obesity and overweight are associated with chronic disease risks for survivors of moderate to severe traumatic brain injury. The study included 7,287 adults with TBI who underwent inpatient acute rehabilitation.
A study published in The BMJ found that direct oral anticoagulants (DOACs) are associated with reduced risks of major bleeding compared to warfarin. Apixaban was shown to have the lowest numbers needed to treat over six months to avoid one extra major bleed.
A large randomized placebo-controlled study found no evidence that rhG-CSF improves outcomes in women with a history of unexplained recurrent pregnancy losses. The study involved 150 women and showed similar clinical pregnancy rates between the treatment and placebo groups.
A recent study published in CMAJ found anticonvulsants to be ineffective for chronic low back pain and lumbar radicular pain, with a higher risk of adverse events.
A recent study published in Nature Medicine found that Zika virus infection increased the risk of miscarriage or stillbirth by 26% in pregnant monkeys. Researchers also discovered damage to the placenta and cell death, which can lead to poor pregnancy outcomes. The true rate of human miscarriage may be higher than previously reported.
A Vanderbilt University Medical Center study found that deep brain stimulation (DBS) therapy can slow the progression of tremor in early-stage Parkinson's disease patients. DBS applied in early-stage Parkinson's disease may slow the progression of tremor, a finding that suggests potential for new treatment options.
A randomized controlled trial found that higher daily doses of rifampin killed more TB bacteria in sputum cultures without increasing adverse effects. The study also showed that higher doses resulted in increased elimination rates of TB bacteria from sputum.
A new clinical trial tests a medication blocking ghrelin levels in patients with alcohol use disorder. Researchers found a statistically significant reduction in craving and food cravings in 12 patient volunteers. The study aims to further assess the drug's efficacy in a larger placebo-controlled trial.
Researchers at CU Anschutz Medical Campus found little association between suicide and hypoxia, contradicting longstanding theories. Social isolation and access to firearms were identified as significant contributors to high-altitude suicide rates.
A new study finds that enzalutamide significantly lowers the risk of metastasis or death in men with non-metastatic castrate-resistant prostate cancer, delaying cancer re-appearance by almost two years. The drug also shows a 71% lower risk of metastasis or death compared to placebo.
PharmaMar and Chugai agree on an early termination of their license agreement for Zepsyre in Japan, allowing PharmaMar to regain rights to the compound. PharmaMar will receive €3,000,000 from Chugai and can now pursue new partnerships for the drug.
A major study found that medications used to treat diabetes in adults are not effective on youth. The disease is progressing rapidly in young people due to the growing obesity epidemic.
A NIH-funded study of 91 youth ages 10-19 found that neither initial treatment with long-acting insulin followed by metformin, nor metformin alone preserved the body's ability to make insulin. Metformin did show modest improvement in blood glucose levels.
Women are largely underrepresented in clinical trials of heart failure medications, with limited evidence on their efficacy. Precision medicine may lead to more effective medications by incorporating sex-aware randomized clinical trials.
Allowing pharmacists to write prescriptions is associated with increased access to healthcare services, improved patient outcomes, and enhanced utilisation of their skills. Pharmacists' diagnosis skills were a primary concern among organisational issues.
Maureen Dubreuil, a BU researcher, has been recognized for her outstanding contributions to the field of spondyloarthritis. Her work focuses on comorbidities and pharmacoepidemiology of spondyloarthritis, with a particular emphasis on heart disease and patient preferences for treatments.
A recent clinical trial has shown that tamsulosin is not effective in promoting the passage of ureteral stones, contradicting previous small studies. The study's findings suggest that the medication may be beneficial for specific subgroups of patients with larger or distal stones.
Researchers found significant reductions in all-cause and opioid-related mortality among overdose survivors taking methadone or buprenorphine. However, only three out of ten overdose survivors receive these medications.
Investigational medicines became available to terminally ill patients through expanded access programs, allowing for the assessment of drug timing and duration. The study aimed to better understand this process and its implications for patient care.
A new study published in Research in Social and Administrative Pharmacy demonstrates that pharmacist-delivered home medication management review services effectively resolve treatment-related problems for patients with chronic health conditions. The intervention service resulted in a significant reduction of treatment-related problems,...
Researchers at FAU have successfully developed proteins that function like a shuttle to release medication directly in the body where it's needed. This breakthrough could enable targeted and tissue-specific administration of medication in future, potentially lowering doses and reducing side effects.
A novel medication, BYL719, demonstrates efficacy in treating CLOVES Syndrome by reducing vascular masses and improving quality of life. Patients show significant symptom reduction, growth stabilization, and improved overall health.