Articles tagged with Drug Studies
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Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
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The CASSINI Trial found that while there was no significant reduction in venous thromboembolism or death over 180 days, cancer patients taking rivaroxaban had a lower incidence of these events while on the drug or during the treatment period.
A Kanazawa University study found that Xeno/endobiotic metabolism potencies differ significantly between rat strains and sexes. The study quantified the absolute mRNA expression of Ugt isoforms in rats' livers and small intestines, revealing variations in metabolism between strains and sexes.
Researchers found patients taking proton pump inhibitors (PPIs) were 28.4 times more likely to develop chronic kidney disease compared to those taking histamine-2 receptor antagonists. PPIs were also linked to higher rates of acute kidney injury, end-stage renal disease, and unspecified kidney impairment.
Research at Fred Hutchinson Cancer Center found that patients face structural and clinical barriers to participating in clinical trials, with nearly 22% deemed ineligible. The team calls for policy changes such as expanding trial locations and proactively discussing options with patients to increase access and participation.
For patients with stable ischemic heart disease, aggressive risk factor modification and optimized medical management are crucial. Novel agents like ivabradine improve treatment options for symptom control in patients unresponsive to current treatments.
A new study published in The Lancet found that one brief exposure to general anesthesia does not result in measurable neurodevelopmental or behavioral problems up to the age of 5 years. However, more research is needed to confirm the findings in girls and children with multiple and prolonged exposure to anesthesia.
A recent study published by The Endocrine Society found that oral complications are rare in women taking medications for postmenopausal osteoporosis. Despite concerns among dentists and patients, the rate of osteonecrosis of the jaw (ONJ) was low, with only 5.2 cases per 10,000 patient-years reported.
Researchers have found GS-441524 to be highly effective in treating FIP, with 26 out of 31 cats showing significant improvement in appetite and weight gain. The treatment has also been shown to be safe for cats of all ages and stages of the disease.
A new study published in the Annals of the American Thoracic Society found that Puerto Rican children were more than five times as likely as Mexican American children to have poor adherence to asthma control medications. Girls of both ethnic groups were also more likely to have poor or decreasing use of the medications.
A new analysis of over 11.5 million medical papers found that almost three-quarters do not report outcomes for men and women. Female authors are more likely to report on sex-differences, highlighting the importance of diversity in research and the scientific workforce.
A clinical trial, REACH, is examining the safety and use of oral pre-exposure prophylaxis (PrEP) and a vaginal ring in adolescent girls and young women in southern Africa. The study aims to expand HIV prevention choices for this disproportionately affected population.
A new study found that removing at least 70% of the intracerebral clot is crucial for patients to make a meaningful recovery after a brain hemorrhage. The research, known as MISTIE III, involved 506 patients and showed that ideal outcomes were achieved when no more than 15 milliliters of clotted blood remained at the site of injury.
A new drug candidate, givosiran, has shown promising results in treating acute porphyria by preventing attacks and reducing hemin need by up to 83%, according to a recent clinical trial. The study's lead author notes that the treatment can effectively prevent acute attacks in seriously afflicted patients with limited options.
A study tested minimally-invasive surgery for brain bleeds and found it didn't improve functional recovery compared to medical therapy. However, the procedure was associated with fewer deaths and improved outcomes in patients with smaller blood clots.
A recent study found that over 30% of healthcare reviews fail to fully report potential side effects of medical interventions, highlighting the need for more accurate reporting and proactive approaches to prompt reviewers to include these critical details.
Patrick D. Lyden, MD, is recognized for his contributions to stroke treatment and management through the development of tPA and refinement of the National Institutes of Health Stroke Scale. He continues to advance stroke care through clinical trials and research on neuroprotection.
Researchers at the University of Seville have characterized the normal electrical activity in PC-3 prostate cancer cells, showing a low-frequency pattern between 0.1 and 10 Hz. This study aims to explore the relationship between electrical patterns and cell proliferation, with potential applications for medicine delivery.
Research at UT Southwestern Medical Center found exercise reduces visceral fat more significantly than medication per pound of body weight lost. Exercise can melt visceral fat, lowering risk of heart disease and diabetes.
A comprehensive analysis of medications prescribed for children and adolescents with anxiety disorders found SSRIs to be the most effective and best-tolerated treatment. The study examined over a dozen medications from 22 randomized controlled trials, providing guidance for clinicians in selecting evidence-based medication treatments.
Matthew D. Disney's laboratory has proven that RNA can be a small-molecule drug target, offering new ways to tackle incurable diseases. His work has already provided lead medicines for genetic diseases and difficult-to-treat cancers.
A new prenatal genetic testing approach has been shown to improve the diagnosis of fetal anomalies, identifying a significant cause in nearly half of affected pregnancies. The technique, known as whole exome sequencing, offers a valuable addition to standard prenatal tests, providing clear diagnoses and easing parental fears.
The Lung Cancer Master Protocol (Lung-MAP) is expanding to include patients with all types of advanced stage non-small cell lung cancers. This will allow thousands of new patients to enroll in the trial and benefit from investigational drugs, addressing a significant need for new treatments.
Researchers in Canada identified seven core principles to improve substance use treatment systems, emphasizing the need for collaboration between sectors and a population-level approach. These principles aim to identify strengths, gaps, and required enhancements in system design.
Researchers have successfully produced high-quality human proteins in eggs from genetically modified hens, offering a promising alternative to expensive mammalian cell culture techniques. The study found that the proteins worked at least as well as those produced using existing methods, with no adverse effects on the chickens.
A study suggests that regular use of aspirin or other NSAIDs can improve the survival of patients with head and neck squamous cell carcinoma (HNSCC) who have mutations in the PIK3CA gene. This is due to the reduction of prostaglandin E2, an inflammatory molecule that promotes tumor growth.
For adolescents with obesity, weight loss medications may be an effective option that hasn't improved with lifestyle modification or surgery. Researchers recommend evidence-based guidance on medication use, emphasizing the importance of monitoring and further research.
A new study found that extending medication time for varenicline to 24 weeks combined with 24 weeks of counseling sessions improves quitting success rates and reduces relapse risk in cancer patients. For those taking the medication as directed, quit rates increased significantly.
A study found surgery to remove the thymus gland improves clinical outcomes and reduces immunosuppressive medications for up to five years. The procedure may also result in significant healthcare savings, with reduced hospitalizations and medication costs.
Researchers discovered that STAT5B facilitates leukemogenesis in B-cell acute lymphocytic leukemia. They found that the absence of STAT5B increases interferon response and suppresses transformation. This understanding may enable precision medicine strategies to treat disease.
Researchers have successfully constructed a three-dimensional human epidermis based on predictions made by their mathematical model of epidermal homeostasis. The epidermal equivalent exhibits excellent barrier functionality and thickness, providing a promising new tool for basic research and drug development.
A study analyzed combined results from 18 randomized clinical trials on morphine and other medications for treating neonatal abstinence syndrome in newborns exposed to opioids during pregnancy. Buprenorphine was associated with the shortest length of treatment, but further research is needed for wide-scale adoption.
A recent NYU study found that health literacy is associated with better adherence to blood pressure medications among Hispanic individuals. Despite this connection, the majority of patients in the study population lack adequate health literacy and exhibit poor medication adherence rates.
Researchers found that mavoglurant improves eye gaze behavior and alters reactivity to faces in patients with fragile X syndrome. The study shows significant improvements in eye contact and reduced pupil reactivity to emotional faces.
A new 90-day vaginal ring containing tenofovir is being tested for its safety in preventing HIV and herpes simplex virus type 2 (HSV-2) infections. The Phase I study aims to determine the safety of the ring for three months, with results expected mid-2020.
Researchers from UPV/EHU propose improvements to study cognitive function enhancers for patients with schizophrenia. The analysis of nine clinical trials reveals limitations and proposes methodological enhancements to guarantee effectiveness, safety, and tolerance.
A new clinical trial is enrolling patients to test the safety and efficacy of fecal microbiota transplantation (FMT) by enema for recurrent Clostridium difficile-associated disease (CDAD). The trial aims to provide critical data on the long-term safety of FMT in preventing CDAD recurrence.
Researchers developed new chromenone-based derivatives with potent AChE and BChE inhibitory activity. These dual inhibitors may be effective in treating neurodegenerative disorders like Alzheimer's disease.
A landmark study published in the New England Journal of Medicine has found that ibrutinib is significantly more effective than standard therapy in treating CLL, causing fewer side effects and requiring less frequent patient visits. Ibrutinib was shown to improve survival rates by 13% compared to standard treatment.
A new SWOG Cancer Research Network study found that cancer patients with comorbidities such as hypertension or asthma are less likely to participate in clinical trials. The study suggests that allowing patients with manageable comorbidities to join trials could increase treatment opportunities for thousands of patients.
A large cohort study found that exposure to statins, blood pressure medications, and diabetes treatments reduced rates of psychiatric hospitalization and self-harm in patients with serious mental illnesses. The study suggests that these commonly used drugs may have repurposed benefits for individuals with schizophrenia, bipolar disorde...
A review of published studies indicates that use of benzodiazepines and related drugs may increase the risk of pneumonia. The analysis found a 1.25-fold higher odds for developing pneumonia among current and recent BZRD users compared to non-users.
Researchers found pyronaridine-artesunate to be as effective as currently used artemisinin-based combination therapies for treating uncomplicated P. falciparum malaria. Mild liver injuries were observed in some patients but no severe damage was reported. The treatment holds promise for areas with rising artemisinin resistance.
Researchers conducted a first-in-human trial of senolytic drugs on patients with idiopathic pulmonary fibrosis (IPF), an age-related disease. The study showed significant improvements in participants' mobility, with an average increase of 21.5 meters in six-minute walk distance.
A study of over 913,000 Danish children found a significant association between prenatal exposure to valproate and an increased risk of attention-deficit/hyperactivity disorder (ADHD). The study also found no associations with other antiepileptic drugs.
A study published in Family Medicine and Community Health found that family support plays a significant role in motivating individuals with type 2 diabetes to improve their self-management behaviors and glycemic control. The research highlights the importance of motivation in managing chronic diseases like diabetes.
Researchers at MIT have developed an inhalable form of messenger RNA that can be delivered directly to the lungs, showing promise for treating various lung diseases. The aerosol-formulated mRNA was found to induce lung cells in mice to produce a target protein, paving the way for potential treatments.
A new study published in the journal Addiction found that allowing smokers to determine their own nicotine intake while quitting can lead to higher success rates. The results suggest that most smokers can tolerate doses four times higher than those normally recommended, making them more likely to stay smoke-free.
PCSK9 inhibitors significantly reduce Low-Density Lipoprotein Cholesterol (LDL-C) levels by more than 50-60% in patients with Familial Hypercholesterolemia (FH). The study also found that alirocumab reduces all-cause mortality compared to evolocumab, suggesting potential differences in cardiovascular outcomes.
The proposal calls for pharmaceutical companies to collect post-marketing data in all minority groups, classifying responsiveness based on ethnicity. Package labelling should include efficacy data from minority populations.
Several studies have shown that reducing LDL-C to levels lower than 50 mg/dl can provide cardiovascular benefits. However, data on the impact of lowering LDL-C below 25 mg/dl is limited, with some evidence suggesting no increased risk of cancer or hemorrhagic stroke.
Research reveals flavonoids as potent P-gp modulators with high binding affinity and low toxicity, offering a new generation of drug candidates to reverse multidrug resistance. Synthetic flavonoid dimer FD18 specifically targets the pseudodimeric structure of the drug transporter.
A new study analyzed combined results of 47 randomized clinical trials, lasting at least 12 months, involving 22,000 patients with knee osteoarthritis. The research found uncertainty around long-term effectiveness of medications in controlling pain, highlighting the need for large randomized clinical trials.
Case Western Reserve University researcher Sanjay Gupta has been awarded nearly $1 million to investigate drug resistance mechanisms in prostate cancer. He will test two promising medications, simvastatin and metformin, to overcome drug resistance and halt metastasis.
Chemical synthesis breakthrough offers hope in combating lethal drug-resistant infections; researchers develop efficient, scaleable antibiotics to fight Staphylococcus aureus and other bacterial species.
Researchers discovered two tri-terpenoids, ursolic acid and lupeol, with potential activity against Alzheimer's disease pathology. Lupeol showed better binding affinity than ursolic acid, suggesting its potential as a BACE1 inhibitor for AD therapy.
Aerobic exercise shows promise in improving cognitive function and reducing weight gain in schizophrenia patients. Researchers are enrolling over 200 participants to test the effects of aerobic exercise versus a control group.
A phase three clinical trial found that sorafenib stopped progression of desmoid tumors for two years in 80 percent of patients who completed treatment. This is a significant increase in progression-free survival compared to placebo, with researchers describing it as 'a truly remarkable outcome'.
A first-in-human clinical trial found sutimlimab to be effective in treating severe hemolytic anemia in cold agglutinin disease. The investigational drug rapidly halted red blood cell destruction, increased hemoglobin levels, and eliminated the need for blood transfusions.
A new study in the Journal of Neuromuscular Diseases describes the use of a child-compatible, hand-held device to assess pulmonary function in teens with DMD. The results show that weekly use of the device was well accepted by participants, with high adherence rates and reliable data compared to standard spirometry.
A daily dose of buprenorphine-naloxone is cost-effective compared to monthly injections of extended-release naltrexone, with similar effectiveness in quality of life and time abstaining from opioids. The researchers conclude that buprenorphine-naloxone should be preferred as the first-line treatment for opioid use disorder.