Articles tagged with Drug Studies
New studies show that catheter ablation is not more effective than drug therapy in preventing strokes and deaths from atrial fibrillation. However, patients who undergo the procedure experience significant improvements in quality of life and symptoms, including reduced hospitalizations and recurrences of the condition.
A two-week treatment course for adult patients with chronic Chagas disease was shown to be as effective as an eight-week standard treatment in improving sustained parasitological response at six months. The new regimen also significantly reduced side effects, encouraging wider adoption by the medical community.
A two-week treatment course showed similar efficacy and fewer side effects than the standard eight-week treatment in adult patients with chronic Chagas disease. The results bring new hope for people living with this silent disease and could change access to treatment in endemic countries.
A Danish study of over half a million people found that cholesterol-lowering statin medications lower the risk of brain haemorrhages by 22-35% compared to non-users. The study rebuffs suspicions that statins increase the risk of brain haemorrhages.
A randomized trial of ivermectin mass administration in children aged five or younger shows a 20% reduction in malaria episodes without adverse events. The study suggests ivermectin could be a useful tool in disease reduction to combat residual transmission.
A study from MIT and Brigham and Women's Hospital found that nearly all pills and capsules contain ingredients that can cause allergic reactions or irritations in certain patients. The researchers aim to raise awareness of this issue and stimulate reforms to protect patients.
Researchers found that the medication amphotericin helps lung cells function, making it easier for patients to fight chronic bacterial infections. The finding holds special promise for a subset of patients who do not respond to current treatments.
A recent analysis found that giving the steroid betamethasone to pregnant women at risk of late-preterm delivery results in lower hospital stays for infants. The study estimated costs for over 1,400 mother-infant pairs and found that the average cost for those who received the drug was $4,681, compared to $5,379 for those who did not.
A new study published in Wilderness & Environmental Medicine found that a lower dose of acetazolamide (62.5 mg twice daily) was as effective in preventing acute mountain sickness symptoms as the standard prophylactic dose (125 mg twice daily). However, this reduced dose showed similar side effects with both doses.
Tenapanor, a novel agent blocking intestinal phosphate absorption, significantly reduces serum phosphate levels in patients with kidney failure on hemodialysis. The study found tenapanor showed significant benefits over placebo during the withdrawal period.
A study led by Mount Sinai researchers found that aspiration is equally effective as traditional stent retriever approach for clot removal, with significant cost savings. The study showed comparable clinical results between the two approaches, including similar functional outcomes and revascularization rates.
A new study found that losing Medicare coverage before the three-year post-transplant mark significantly increases the risk of kidney failure and decreases medication adherence. This has significant policy implications, highlighting the need for healthcare safety nets and access to immunosuppressive medications.
Nonmedical prescription drug use leads to 360,000 ED visits in US, mostly benzodiazepines and opioids; young adults under 35 most affected. The study proposes expanding naloxone distribution and implementing screening for polysubstance use.
A recent study published at the American Heart Association's Epidemiology and Prevention | Lifestyle and Cardiometabolic Health Scientific Sessions 2019 reveals that young women in the US tend to worry more about stress and mood disorders than their heart health. The research, which surveyed 331 young women ages 15-24, found that only ...
Researchers found that using antibiotic soap and nasal ointment reduces infections in non-ICU patients with medical devices. The study showed a 30% decrease in bloodstream infections and nearly 40% decrease in antibiotic-resistant bacteria infections.
The ABATE Infection Trial found that daily antiseptic bathing with nasal ointment reduced hospital-acquired bloodstream infections by 30% in patients with central venous catheters, a high-risk group. This intervention also decreased antibiotic-resistant organisms, including MRSA and vancomycin-resistant enterococcus, in this patient po...
Recent clinical trials conducted by the Regenstrief Institute found that traditional drug-focused approaches are ineffective in managing delirium in ICU patients. Implementing deprescribing strategies and exploring alternative methods, such as waking and mobilization, may be more effective in reducing delirium severity and duration.
Researchers found that high flavonoid cocoa powder improved fatigue in people with multiple sclerosis by reducing mental and physical fatigue. Participants who drank the high flavonoid version showed a moderate effect on fatigability and improvements in pain symptoms, while those drinking low flavonoid cocoa saw no significant benefits.
Researchers at Clemson University developed a targeted nano therapy that destroyed calcium buildup in arteries without causing side effects. The therapy mimics a human's chronic kidney disease and has the potential to benefit thousands of patients.
A new study suggests that moderate alcohol consumption has health benefits, particularly for older adults. Researchers found that younger people are more likely to die from alcohol-related causes than they are to benefit from drinking, while older individuals tend to experience the health benefits often mentioned in news stories.
Researchers at Lobachevsky University studied the thermodynamic and structural properties of hevein, a protein with antimicrobial activity. The study revealed a phase transition at 222.8 K, which may lead to the development of new resistant crops and medicines.
Researchers tested an experimental treatment boosting Glial Cell Line Derived Neurotrophic Factor (GDNF) to regenerate dopamine brain cells in patients with Parkinson's. After nine months, the group receiving GDNF showed a 100% improvement in affected brain areas, offering hope for a potential reversal of the condition.
A pioneering clinical trial has shown promising effects on restoring brain cells damaged in Parkinson's. While the treatment did not significantly impact symptoms, it demonstrated significant improvements in brain scans, suggesting long-term beneficial effects may be possible.
A genetic discovery identifies a gene mutation allowing clinicians to tailor alternative treatments to patients at risk of thiopurine-induced bone marrow suppression. The test could reduce risks and costs associated with IBD treatment.
A student-led rheumatology interest group at George Washington University significantly increased student engagement with the field of rheumatology. The group's establishment led to a rise in publications by rheumatology students and enrollment in the rheumatology elective.
Professor Marjan van den Akker is appointed as endowed chair for polypharmacy and health services research, focusing on frequent disease combinations and their medical treatment. She aims to improve care for patients with multimorbidity by developing and evaluating interventions.
Researchers at Brigham and Women's Hospital have developed an intelligent-injector for tissue-targeting (i2T2) that detects changes in resistance to deliver medication safely and effectively. The device was tested on animal models and found to precisely deliver medication without overshoot injuries.
A new study published in eNeuro found that Ritalin had no impact on neuronal activity in the prefrontal cortex of monkeys. The researchers observed improved performance in attention tasks at higher doses, but not in brain activity.
A survey of Colorado home health care clinicians found that 60% lacked adequate information from hospitals to guide patient treatment. The study highlights major gaps in communication between hospital and home health staff, which can result in medication errors and other serious consequences.
Researchers at Penn Medicine have successfully cured nine patients of Hepatitis C after receiving heart transplants from deceased donors who were infected with the disease. The study suggests that using HCV-infected organs may be a viable option for patients awaiting a heart transplant.
Researchers found that a single dose of PD-1 inhibitor before surgery can lead to complete remission and cancer-free follow-up for more than two years. Immune responses from this therapy can peak within seven days, allowing for earlier guidance on the most effective treatment approach.
A new study by the University of Texas at Austin found that medication abortion use increased to 33% after the FDA label change, despite ongoing restrictions. The study reveals that Texas providers can now offer medication abortion consistent with medical evidence, increasing options for women.
The proportion of early-stage drug trials tackling rare cancer types has increased sharply, with the analysis highlighting a changing treatment landscape. New molecularly-targeted anticancer drugs and immunotherapy are being evaluated for less common tumour types.
UCSF researchers created a blockchain-based system to ensure the integrity of clinical trials data, creating an immutable audit trail that makes tampering visible. The system allows for real-time reporting of adverse events and protects data from corruption.
A new oral medication targeting NF-κB, a key link between loss of dystrophin and disease progression, has been well-tolerated in boys with Duchenne muscular dystrophy. The Phase 1 clinical trial results indicate that the drug can reduce levels of NF-κB-regulated genes and serum proteins thought to originate from damaged muscles.
A new study published in JAMA Psychiatry found that combining antidepressants with antipsychotic drugs may have benefits for individuals with schizophrenia. The research suggests that antidepressant use can reduce the risk of hospitalization by 16% compared to antipsychotics and by 22% compared to benzodiazepines.
A small pilot clinical study suggests that nitisinone increases melanin production in some people with oculocutaneous albinism type 1B, a rare genetic disease. The drug may help protect against the sun's UV rays and promote normal vision development.
The CASSINI Trial found that while there was no significant reduction in venous thromboembolism or death over 180 days, cancer patients taking rivaroxaban had a lower incidence of these events while on the drug or during the treatment period.
A Kanazawa University study found that Xeno/endobiotic metabolism potencies differ significantly between rat strains and sexes. The study quantified the absolute mRNA expression of Ugt isoforms in rats' livers and small intestines, revealing variations in metabolism between strains and sexes.
Researchers found patients taking proton pump inhibitors (PPIs) were 28.4 times more likely to develop chronic kidney disease compared to those taking histamine-2 receptor antagonists. PPIs were also linked to higher rates of acute kidney injury, end-stage renal disease, and unspecified kidney impairment.
Research at Fred Hutchinson Cancer Center found that patients face structural and clinical barriers to participating in clinical trials, with nearly 22% deemed ineligible. The team calls for policy changes such as expanding trial locations and proactively discussing options with patients to increase access and participation.
For patients with stable ischemic heart disease, aggressive risk factor modification and optimized medical management are crucial. Novel agents like ivabradine improve treatment options for symptom control in patients unresponsive to current treatments.
A new study published in The Lancet found that one brief exposure to general anesthesia does not result in measurable neurodevelopmental or behavioral problems up to the age of 5 years. However, more research is needed to confirm the findings in girls and children with multiple and prolonged exposure to anesthesia.
A recent study published by The Endocrine Society found that oral complications are rare in women taking medications for postmenopausal osteoporosis. Despite concerns among dentists and patients, the rate of osteonecrosis of the jaw (ONJ) was low, with only 5.2 cases per 10,000 patient-years reported.
Researchers have found GS-441524 to be highly effective in treating FIP, with 26 out of 31 cats showing significant improvement in appetite and weight gain. The treatment has also been shown to be safe for cats of all ages and stages of the disease.
A new study published in the Annals of the American Thoracic Society found that Puerto Rican children were more than five times as likely as Mexican American children to have poor adherence to asthma control medications. Girls of both ethnic groups were also more likely to have poor or decreasing use of the medications.
A new analysis of over 11.5 million medical papers found that almost three-quarters do not report outcomes for men and women. Female authors are more likely to report on sex-differences, highlighting the importance of diversity in research and the scientific workforce.
A clinical trial, REACH, is examining the safety and use of oral pre-exposure prophylaxis (PrEP) and a vaginal ring in adolescent girls and young women in southern Africa. The study aims to expand HIV prevention choices for this disproportionately affected population.
A new study found that removing at least 70% of the intracerebral clot is crucial for patients to make a meaningful recovery after a brain hemorrhage. The research, known as MISTIE III, involved 506 patients and showed that ideal outcomes were achieved when no more than 15 milliliters of clotted blood remained at the site of injury.
A new drug candidate, givosiran, has shown promising results in treating acute porphyria by preventing attacks and reducing hemin need by up to 83%, according to a recent clinical trial. The study's lead author notes that the treatment can effectively prevent acute attacks in seriously afflicted patients with limited options.
A study tested minimally-invasive surgery for brain bleeds and found it didn't improve functional recovery compared to medical therapy. However, the procedure was associated with fewer deaths and improved outcomes in patients with smaller blood clots.
A recent study found that over 30% of healthcare reviews fail to fully report potential side effects of medical interventions, highlighting the need for more accurate reporting and proactive approaches to prompt reviewers to include these critical details.
Patrick D. Lyden, MD, is recognized for his contributions to stroke treatment and management through the development of tPA and refinement of the National Institutes of Health Stroke Scale. He continues to advance stroke care through clinical trials and research on neuroprotection.
Researchers at the University of Seville have characterized the normal electrical activity in PC-3 prostate cancer cells, showing a low-frequency pattern between 0.1 and 10 Hz. This study aims to explore the relationship between electrical patterns and cell proliferation, with potential applications for medicine delivery.
Research at UT Southwestern Medical Center found exercise reduces visceral fat more significantly than medication per pound of body weight lost. Exercise can melt visceral fat, lowering risk of heart disease and diabetes.
A comprehensive analysis of medications prescribed for children and adolescents with anxiety disorders found SSRIs to be the most effective and best-tolerated treatment. The study examined over a dozen medications from 22 randomized controlled trials, providing guidance for clinicians in selecting evidence-based medication treatments.
Matthew D. Disney's laboratory has proven that RNA can be a small-molecule drug target, offering new ways to tackle incurable diseases. His work has already provided lead medicines for genetic diseases and difficult-to-treat cancers.
A new prenatal genetic testing approach has been shown to improve the diagnosis of fetal anomalies, identifying a significant cause in nearly half of affected pregnancies. The technique, known as whole exome sequencing, offers a valuable addition to standard prenatal tests, providing clear diagnoses and easing parental fears.
The Lung Cancer Master Protocol (Lung-MAP) is expanding to include patients with all types of advanced stage non-small cell lung cancers. This will allow thousands of new patients to enroll in the trial and benefit from investigational drugs, addressing a significant need for new treatments.
Researchers in Canada identified seven core principles to improve substance use treatment systems, emphasizing the need for collaboration between sectors and a population-level approach. These principles aim to identify strengths, gaps, and required enhancements in system design.