Articles tagged with Drug Studies
A review of clinical trials published in top psychology and psychiatry journals found that more than half of the abstracts contained 'spin' - exaggerating the clinical significance of a particular treatment without statistics to back it up. This practice raises concerns about its impact on doctors' treatment decisions.
Researchers have developed an artificial human eye replica, the blinking eye-on-a-chip, to model dry eye disease (DED). The device mimics the complex pathophysiology of DED, allowing scientists and drug developers to test experimental treatments.
Autopsies reveal that meth users have increased deposits of collagen in the heart muscle, leading to irreversible damage and an enlarged heart. The study suggests that monitoring heart function is crucial for early detection and prevention of further deterioration.
A new study has found that ursodeoxycholic acid, the current recommended treatment for intrahepatic cholestasis of pregnancy, is ineffective in preventing preterm birth and stillbirth. The trial of 605 pregnant women with ICP found no meaningful improvement in outcomes with the drug.
The OUtMATCH study will test the ability of omalizumab to increase tolerance to peanut and other food allergens in children and adults. The trial aims to enroll 225 participants with a history of multiple food allergies, assessing whether biweekly or monthly injections of omalizumab can prevent allergic reactions.
A new vaccine candidate, DS-Cav1, has shown promising results in a Phase 1 human clinical trial, eliciting large increases in RSV-neutralizing antibodies that were sustained for several months. The vaccine's structure-based design approach aims to overcome the challenges of traditional methods in creating an RSV vaccine.
A study led by Harvard T.H. Chan School of Public Health found that children and adolescents born with HIV are less likely to adhere to their medications as they age. The prevalence of detectable viral load, a factor associated with nonadherence, also increases with age.
Participants in low-income areas had a higher chance of dying from any cause, hospitalization and death related to heart failure, and developing end-stage kidney disease. The study found that socioeconomic context impacts cardiovascular outcomes.
Researchers found that a soybean antioxidant compound blocked damage to blood vessels in laboratory tests, potentially preventing cardiovascular side effects of recreational and medical marijuana use. The study suggests JW-1 could be a new way to protect blood vessels without psychiatric side effects.
A groundbreaking trial has started to test the safety and effectiveness of a novel, off-the-shelf device designed to treat complex aortic aneurysms. The investigational GORE EXCLUDER Thoracoabdominal Branch Endoprosthesis (TAMBE) allows for minimally invasive endovascular repair, avoiding traditional open surgical approaches.
Daily intake of Montmorency tart cherry juice improved memory scores among adults aged 65-73, with notable reductions in movement time and errors during visual and spatial working memory tasks. Compliance was high, but larger studies are warranted to confirm findings.
A Phase 1 clinical trial found a MERS-CoV vaccine candidate to be well-tolerated and induce robust immune responses in healthy adult volunteers. Over 85% of participants exhibited detectable immune responses after just two vaccinations, with the response persisting throughout the study.
The FDA has approved erdafitinib as a targeted therapy for patients with advanced bladder cancer who have specific gene mutations in the FGFR3 gene. The drug achieved a 40% overall response rate and was well-tolerated, offering an alternative to existing treatments.
The HOPE study found that most women accepted the dapivirine ring and used it consistently throughout the year. The study showed a significant reduction in HIV incidence among participants, with an estimated 39% decrease in risk compared to those not offered the ring.
In a large 24-week study, rheumatoid arthritis patients saw substantial improvement from daily use of an experimental compound. Filgotinib, a selective JAK-1 inhibitor, showed significant benefits in reducing joint swelling and improving disease activity compared to placebo.
Early treatment with stimulant medication has strong protective effects against mood disorders, conduct disorders, substance use disorders, driving impairments, and academic failure in children and young adults with ADHD. The study found that three participants needed to be treated to prevent one from developing serious outcomes.
A study of 427 young African women found that 95% initiated PrEP but use fell after three months, with only 9% maintaining high adherence. Tailored support strategies are needed to maintain PrEP use and optimize protection against HIV acquisition.
A vaginal ring that releases an antiviral drug has been shown to reduce the risk of HIV by 39% in a study of over 1,400 women in southern and eastern Africa. The study found that participants used the ring more consistently than in previous trials, with higher adherence rates.
A recent study by Yale researchers has identified middle-aged adults as a vulnerable population to serious falls due to medication use. Polypharmacy and the simultaneous use of benzodiazepines, muscle relaxants, and prescription opioids increase fall risk.
A US study found that engaging disenfranchised men who have sex with men living with HIV in the US is possible, but achieving and maintaining viral suppression remains a challenge. Despite some progress, many participants still face personal, practical, and structural barriers to achieving success.
Researchers found music to be as effective as midazolam in lowering anxiety before anesthetic procedures. The study used Marconi Union's 'Weightless' song and noise-canceling headphones to reduce anxiety levels.
A recent study published in the British Journal of Anaesthesia found that people with diabetes taking gliflozin medications are at risk of ketoacidosis during surgery. Euglycaemic ketoacidosis can be deceiving, presenting with normal blood sugar levels, and may be missed easily by clinicians.
A recent review explores how artificial intelligence can improve the success of clinical trials. AI-based models can help with trial design, patient recruitment, and monitoring adherence, potentially boosting success rates by up to 30%.
A recent study found that nearly 11% of high school seniors reported misusing prescription drugs in the past year, with 44% relying on multiple sources. This increases the risk of substance use disorders and other issues.
A systematic review of menstrual cups suggests they are a safe option for menstruation management. The review found similar leakage levels to disposable pads or tampons, with some studies showing significant less leakage. Practice, peer support, and training are key to initiation and adoption.
A clinical trial is underway to treat acid attack victims with a revolutionary new approach using collagenase enzyme. The treatment aims to restore sight by softening the underlying tissue and allowing stem cells to repair damage.
A large-scale clinical trial has demonstrated that cannabis-based medication can effectively reduce the rate of relapse in individuals with cannabis dependency. Participants treated with nabiximols used significantly less illicit cannabis and showed improvements in physical and psychological well-being.
Rimegepant, a novel gepant therapy, demonstrates significant relief from acute migraine pain and associated symptoms in a large-scale clinical trial. The study found that rimegepant effectively blocks the CGRP pathway, providing a new option for people with migraine not helped by existing medications.
A new study suggests that larger drug trials are necessary for Alzheimer's disease due to the limitations of current trials. The researchers analyzed data from over 1,120 people with no cognitive difficulties and found a consistent pattern of cognitive development in those who had beta-amyloid in the brain.
Researchers at Pitt/UPMC are testing a technique called red cell exchange transfusion to prolong life and slow organ damage in sickle cell disease patients. The SCD-CARRE trial aims to determine whether red cell exchange can lower deaths and reduce hospitalizations.
A study at Boston Medical Center found that symptom-triggered medication dosing for neonatal opioid withdrawal syndrome reduces hospital stay length and unnecessary medication exposure. Infants treated with this approach had a median stay of 10.5 days, compared to 17 days for fixed-schedule treatment.
A new clinical trial will test the effects of the anti-obesity drug setmelanotide on participants with Bardet-Biedl syndrome or Alström syndrome, two rare genetic disorders that include obesity as a symptom. The trial aims to assess the drug's ability to lead to significant weight loss in these individuals.
A recent study found that decentralized collaboration in scientific research can increase the robustness of findings, particularly in drug-gene interactions. Independent groups using different methods are less prone to peer pressure and more likely to replicate results accurately.
A new study in Hawaii tallies nearly 82 human infections from the rat lungworm parasite over a decade, highlighting snails and slugs as primary carriers. Meanwhile, research on bednet monitoring reveals high variability in household use, which could be contributing to declining efficacy in malaria prevention.
A study at ESMO World Congress on Gastrointestinal Cancer 2019 found that a more flexible dosing regimen for regorafenib improves patients' quality of life while maintaining its efficacy. The reduced and intermittent dose groups showed numerical improvements in tolerance to side effects such as fatigue and hand-foot syndrome.
A review of studies indicates that pre-eclampsia can lead to persistent cardiovascular issues in women. Researchers are now calling for long-term cardiovascular screening for women with a history of the condition.
A type of blood pressure lowering medication called calcium-channel blocker may be linked to an increased risk of a bowel condition called diverticulosis. The study found that genetic variants related to this type of drug were associated with a higher risk of the condition.
The study demonstrated the potential of body-on-a-chip systems to transform the drug discovery process by accurately predicting cardiotoxic mechanisms and replicating in vivo results. The findings support the use of in vitro models to evaluate temporal pharmacokinetic/pharmacodynamic relationships.
Researchers from Mount Sinai highlight the importance of multidimensional data for stratifying a complex disease like asthma. Carefully designed, integrated multi-'omic' studies could accelerate precision medicine for asthma patients by defining asthma subtypes through transcriptomics and other omic approaches.
A new study found that one in five US adults experience harm because of someone else's drinking, with women more likely to report financial and family problems. Heavy drinking was linked to increased risk of harassment, threats, and driving-related harm.
A study of over 3,000 US counties found 412 high-risk areas with high opioid overdose mortality and low treatment capacity. Strategies to increase primary care clinician capacity and employment opportunities in these counties are recommended.
A review of 117 efforts to reduce low-value care found that most measured only the reduction of test and treatment use, while few assessed intended patient benefits or unintended consequences. Only half of ongoing studies aim to measure patient-reported outcomes, highlighting a need for more comprehensive evaluation.
Researchers found a consistent cholesterol-lowering effect for soy protein across all 46 trials, contradicting the FDA's proposed revocation of its health claim. The study's findings support the original FDA claim and highlight the benefits of incorporating soy into a plant-based diet.
A survey of orthopaedic providers found that they frequently recommend prescribing a nine-day supply of oxycodone after surgery, exceeding current guidelines. Despite knowledge gaps, the study highlights the need for evidence-based guidelines to curb overprescribing and patient harm.
The PHOENIx MDR-TB study compares the safety and efficacy of delamanid and isoniazid in preventing active MDR-TB disease in at-risk contacts. The trial will enroll approximately 5,610 participants across 12 countries.
Researchers at Lund University have made significant strides in developing a potential drug to combat preeclampsia, a life-threatening condition affecting millions of pregnant women worldwide. The study's findings confirm the therapeutic effects of alpha-1-microglobulin and suggest a promising path forward for patients with the disease.
A large multicentre randomised trial found no improvement in delivery rates with frozen embryo transfers compared to traditional fresh transfers. The study suggests that a general freeze-all strategy may not be beneficial for women with regular menstrual cycles.
Researchers call for long-term randomized deprescribing trials to explore whether reducing or eliminating anticholinergic medication use can improve cholinergic neurotransmission and reduce dementia risk. If successful, this approach could be a more feasible intervention than increasing physical activity or controlling diabetes.
A study published in JAMA Ophthalmology found that one-third of ophthalmic patients have discrepancies between clinician notes and EHR-generated medication lists. This inconsistency may lead to avoidable medication errors, threatening patient safety.
Researchers at Huntsman Cancer Institute discovered a new experimental drug, selinexor, which may block a crucial survival pathway exploited by myelofibrosis cells. A clinical trial has been designed to examine the drug's effectiveness in patients with myelofibrosis.
A new study found that even people with well-controlled epilepsy are at risk of sudden unexpected death in epilepsy (SUDEP). Researchers analyzed cases referred to the North American SUDEP Registry and found that sleep deprivation, skipping medication, and lack of seizure activity were common factors contributing to SUDEP.
A large-scale genetic study of diverse populations found that genetic mutations contributing to chronic diseases like diabetes vary across ethnicities. The research highlights the importance of including diverse populations in genetic studies to develop effective treatments for debilitating diseases.
A groundbreaking drug has shown significant growth benefits for children with achondroplasia, a genetic bone disorder affecting about one in every 25,000 infants. The four-year study found that the drug vosoritide increased height by up to 50% per year and was well-tolerated with no adverse effects on body proportion.
A four-year study found that vosoritide increased the average annual growth rate of children with achondroplasia by nearly 2 centimeters per year, bringing it close to average stature. The treatment also showed sustained effects and was generally well-tolerated.
A multicenter trial found that linagliptin reduced albuminuria but had no significant effect on eGFR or cardiovascular risk in patients with diabetes. The study also suggested that stratifying patients with nephrotic-range proteinuria could lead to better outcomes.
Researchers attach a removable lock to an arthritis drug to reduce systemic immune suppression and neutralization, making it safer and more effective. The modified form of the antibody shows promise in treating rheumatoid arthritis with fewer infections and less development of anti-infliximab antibodies.
Researchers tested a medication reservoir implant in 220 patients with wet age-related macular degeneration, finding it safe and effective in reducing the need for injections. The study showed significant improvements in eyesight, with patients able to see farther than before, and a longer time between refills.
A study analyzed medicine prices in Russia, finding a significant decrease since 2015, with generic prices nearing reference prices. Regulatory measures implemented in the Russian Federation have contributed to improving access to medicines.
The HOPE study demonstrates that low-dose prednisolone significantly improves pain symptoms and function in patients with painful hand osteoarthritis. The study found that prednisolone reduces synovitis and improves physical component scale and patient global assessment, making it a suitable target for treatment.
A systematic review found that serotonin and norepinephrine reuptake inhibitors (SNRIs) led to more harmful events compared to placebos in older adults. Antidepressants like SSRIs may increase the risk of falls, highlighting the need for careful consideration when prescribing these medications.