Articles tagged with Drug Studies
A recent study by University of Missouri researchers found that over 75% of preschool teachers want more training opportunities due to their current lack of support. The survey also revealed that many teachers experience significant stress and feel like leaving their jobs due to challenging behaviors in the classroom.
Researchers found that nicotinamide riboside supplementation prevented nerve pain in rats treated with chemotherapy, which could lead to improved outcomes for patients. The supplement increased levels of NAD+, a cell metabolite that protects against nerve damage.
Researchers analyzed data from 658 stroke patients treated with tPA before and after hospital arrival. The study found that pre-hospital clot-busting therapy resulted in lower disability rates and more patients with zero disability. Faster treatment yields better outcomes, according to the lead researcher.
Researchers found that a subgroup of NSAIDs also act strongly on another family of enzymes called caspases, which play a key role in aggressive immune responses like sepsis. The study suggests that these drugs could be repurposed to address other conditions and develop safer versions.
A three-year trial by the University of Liverpool found that liraglutide 3.0 mg reduces type 2 diabetes risk by 80% in individuals with obesity and prediabetes. Participants experienced greater sustained weight loss compared to a placebo.
A novel agent has significantly reduced episodes of swelling in patients with a rare genetic disorder. The drug, lanadelumab, works by suppressing the production of bradykinin, which causes swelling, and has been shown to be well-tolerated in a phase 1b clinical trial.
A new study found that intensive lowering of systolic blood pressure to below 120 mm Hg would prevent 107,500 deaths per year in the United States. This reduction would be primarily among men aged 75 or older.
Research found testosterone treatment improved bone density and anemia for men over 65 with low testosterone, while also increasing plaque buildup in coronary arteries. However, cognitive function remained unchanged.
Studies published in JAMA and JAMA Internal Medicine found that testosterone treatment was associated with improved bone density and anemia in men with low testosterone. However, the studies also found no significant association between testosterone treatment and improved cognitive function or reduced risk of cardiovascular problems.
A new study from Aarhus University found that children born to mothers who took anti-epilepsy medicine during pregnancy have no significant differences in doctor visits compared to those not exposed. The study also showed that the use of anti-epilepsy medicine does not affect the general health of children, including those with epileps...
A Brown University team proposes a new framework to evaluate the implementation of pre-exposure prophylaxis (PrEP) in clinical practice, identifying critical elements where patients may drop out of preventive care. The proposed nine-step process aims to improve access to PrEP and patient retention in care.
The Joslin Diabetes Center is participating in two NIH-funded clinical trials to test artificial pancreas systems that automatically monitor and regulate blood glucose levels. If successful, the trials could lead to regulatory approval for use of these devices, improving glucose control and reducing diabetes self-management burden.
Researchers are exploring a new infusion therapy that could help smooth out movement for patients with Parkinson's by providing constant levodopa levels and stimulating dopamine receptors. The therapy aims to reduce off-time and increase on-time movement, improving overall quality of life.
A study found that taking abiraterone acetate, a widely used prostate cancer drug, with a low-fat breakfast is as effective as taking it on an empty stomach, but at a significantly lower cost. The finding could save patients thousands of dollars per month.
Researchers develop plant-based therapy to prevent antibodies from forming against clotting factor VIII, a common cause of hemophilia reactions. The treatment showed promising results in dog trials, with significantly lower antibody levels and no negative side effects.
Two new studies on ACO payment models report significant reductions in postacute care spending, with no apparent decrease in quality. The Medicare Shared Savings Program saw a 9% reduction in spending by 2014, driven by decreases in hospital admissions and facility stays.
A new study found that financial barriers significantly impact medication adherence in neurology patients, with the majority of nonadherence cases attributed to costs. The study suggests that tailored strategies are needed to identify and address these issues, particularly among cognitively- and socioeconomically vulnerable populations.
Researchers have identified a potential epilepsy treatment, lorcaserin, that suppresses seizure activity in children with Dravet syndrome. The treatment was developed using a zebrafish model and showed promising results in a small clinical trial.
A team of biomedical scientists has identified a molecule that targets the EphA4 receptor, a gene associated with rapid ALS progression. The research aims to delay motor neuron death and explore potential applications in spinal cord injury, Alzheimer's disease, and some cancers.
A new ultra-low dose four-in-one pill has shown remarkable results in treating high blood pressure, with all patients experiencing significant drops in blood levels within 4 weeks. Researchers also found no side effects associated with the treatment, which could be a game-changer for patients worldwide.
A recent study published in ACS Chemical Neuroscience found that the commercial weight-loss drug lorcaserin can help reduce opioid use and cravings in rats. The researchers administered lorcaserin to rats who had been self-administering oxycodone, resulting in decreased oxycodone use and drug-seeking behaviors.
Researchers have made significant progress in understanding the mechanisms underlying RASopathies by studying zebrafish and fruit flies. They discovered that lower signaling levels can correspond to a RASopathy disease, challenging conventional wisdom that these disorders result from overactive RAS pathways.
Clinical trials are now enrolling at the University of Virginia Health System to test an artificial pancreas that automatically regulates blood-sugar levels in people with type 1 diabetes. The trials will examine safety, effectiveness, and cost as well as physical and emotional health.
Researchers have identified substantial problems with three widely cited studies on mass deworming in Africa, finding methodological issues and biased reporting. The studies initially reported positive long-term effects of mass drug administration, but a critical analysis found these claims to be overstated.
A new biologic agent, 10-1074, has shown early promise as part of a potential new strategy for treating HIV. The drug demonstrated rapid decline in viral load in infected individuals and may be effective in preventing infection in high-risk populations.
A new study by Nationwide Children's Hospital found that nearly two-thirds of US households own a pet, putting children at risk from medicine intended for pets. The researchers recommend safe storage and handling of pet medications to prevent accidental ingestion by children.
A new study found that 84% of patients with acute lymphocytic leukemia or their parents over-reported adherence to a regimen of 6-mercaptopurine, an oral maintenance therapy. Forgetfulness was the primary reason for non-adherence, and parental involvement improved adherence rates.
High-dose immunosuppressive therapy followed by stem cell transplantation has been shown to induce sustained remission in relapsing-remitting multiple sclerosis. Five years after treatment, 69% of participants had survived without progression or relapse, with some showing improvements in mobility and physical capabilities.
Researchers investigated using two approved autoimmune drugs to reduce joint swelling in mice infected with Chikungunya virus, a mosquito-borne illness with no known therapies. Fingolimid and Abatacept showed promise in stopping T cell trafficking and inflammation, potentially paving the way for new treatments.
Researchers found that ibudilast significantly reduced craving for alcohol and improved mood in participants. The medication also showed promise in reducing the pleasurable effects of alcohol.
Researchers investigated the use of abatacept, an immune cell modulator, in treating two rare forms of vasculitis: giant cell arteritis (GCA) and Takayasu's arteritis. The studies found promising results for GCA patients, with improved relapse-free survival rates and longer duration of remission compared to placebo.
Researchers argue that lax standards in human clinical trials lead to ineffective therapies and wasted resources, causing financial burdens on society. The researchers propose measures to strengthen standards, including requiring negative results from animal studies and independent expert vetting.
Researchers have identified a potential therapeutic target for managing opioid withdrawal by discovering that an existing anti-gout medication can alleviate withdrawal symptoms in opioid-dependent rodents. The study's findings suggest that this treatment could provide relief for individuals struggling with opioid addiction, and the res...
Researchers found that LSD alters perception of personal relevance and meaning, linked to serotonin receptors and brain areas involved in self-experience. The findings may lead to new targets for treating psychiatric illnesses or phobias.
Reducing Pcdh10 function leads to impaired social behavior and altered amygdala circuitry, but treatment with d-cycloserine improves social interactions. The study suggests a possible target for autism treatment and parallels the male predominance of ASD in humans.
A new automated web-based surveillance system has been demonstrated to detect potential safety problems with medical devices like the Mynx, a vascular closure device. The system, called DELTA, performs automated safety analyses and comparative effectiveness studies prospectively, sending alerts to users via email.
A study found that telepsychiatry provides similar clinical outcomes as face-to-face group sessions for patients with opioid use disorder receiving medication treatment with buprenorphine. The pilot study suggests that telepsychiatry may help extend access to medication-assisted treatment, particularly in rural areas.
A randomized trial will investigate canagliflozin's effects on kidney function decline and provide benefits to diabetic patients. The study aims to slow kidney damage and inform treatment decisions.
A new standard of care for pancreatic cancer patients has been established with a combination chemotherapy treatment, doubling five-year survival rates. The treatment, combining gemcitabine and capecitabine, was found to be effective in increasing patient survival by 29% compared to single-drug therapy.
A NIH-sponsored clinical trial found that mindfulness meditation combats anxiety by reducing stress-hormone and inflammatory responses. Participants who took a mindfulness course showed big drops in these markers, whereas those in the control group experienced worsened responses.
A UK-led clinical trial has successfully prolonged survival for pancreatic cancer patients by at least five years using a combination of chemotherapy drugs. The study found that patients who received this treatment had a 29% five-year survival rate compared to 16% for those on standard treatment.
A new stop-smoking program using personalized disease risk analysis doubled the likelihood of smokers attending a smoking cessation course. The program's success rate was found to be around 28.7% among those who attended both the taster session and the full six-week course.
A study of nearly 31,000 insured patients in the Kaiser Permanente Northern California health care system reports that nonadherence to newly prescribed diabetes medications was greater among Latino than white patients. Meanwhile, another study found a 10 percent increase in glycemic control for Latino patients who switched from languag...
The DART trial is a national immunotherapy clinical trial testing leading-edge treatments for rare cancers. Patients will receive ipilimumab and nivolumab combination therapy to fight cancer, with the goal of shrinking tumors and evaluating side effects.
A phase 3 trial found regorafenib significantly improved overall survival in patients with advanced hepatocellular carcinoma (HCC), a form of liver cancer. The study showed that regorafenib can improve survival in patients whose HCC progressed during treatment with sorafenib, an existing drug.
A study found that financial ties between researchers and the drug industry are associated with more favorable trial outcomes. The authors suggest that this could lead to biased evidence and call for increased transparency and disclosure of financial ties. More research is needed to understand the mechanisms behind these findings.
A new HIV antibody, 10-1074, has been successfully tested on humans, demonstrating high antiviral activity and favourable pharmacokinetic properties. The trial also investigated the development of resistant HIV variants, providing valuable insights into the potential treatment approach.
Researchers found that approximately one-third of adults with a previous asthma diagnosis couldn't be re-diagnosed due to spontaneous remission or misdiagnosis. The study also highlighted the importance of objective testing to confirm asthma diagnosis, suggesting that failure to use these tests may lead to misdiagnosis.
A new study from King's College London shows that cognitive behaviour therapy (CBT) strengthens specific connections in the brains of people with psychosis, associated with long-term recovery. CBT involves learning to think differently about unusual experiences and developing strategies to reduce distress and improve wellbeing.
A new study found that 33% of adults recently diagnosed with asthma did not have active asthma, and were able to stop medication. The study suggests doctors often misdiagnose patients based on symptoms alone, highlighting the need for further education on accurate diagnosis.
Researchers are conducting a £1.5 million trial to test two therapies on 390 people with Osteogenesis Imperfecta, aiming to reduce fracture risk. The six-year study will track participants for five years to assess the combination of teriparatide and zoledronic acid.
A large randomized trial found that using UVC machines can reduce the transmission of four major superbugs by a cumulative 30 percent, particularly for MRSA. The study suggests that adding UV light to standard cleaning can be an effective strategy in reducing infections in hospitals.
A study published in Journal of Addiction Medicine found that decreasing cocaine use leads to regression of unstable coronary plaques, a type of plaque most likely to cause a heart attack. Reducing cocaine use also decreases inflammation markers and improves cardiovascular health.
A phase 3 trial found that oral ferric citrate significantly boosted hemoglobin levels in patients with chronic kidney disease, correcting anemia. The treatment effect was seen as early as 1-2 weeks after starting treatment and was durable.
A Phase 1 clinical trial found that tucatinib significantly improved outcomes in heavily pretreated patients with HER2+ breast cancer. The drug demonstrated stable disease at 24 weeks or more in 27% of patients, showcasing its potential as a game-changing treatment option.
Researchers developed new performance measures to improve warfarin management, resulting in better clinical outcomes and cost savings. The study, published in Annals of Pharmacotherapy, found that these measures could prevent 48 strokes and 68 major bleeding events annually, with a potential annual savings of over $4 million.
Rettsyndrome.org has reached a milestone of $40 million in research funding for Rett syndrome treatments. The organization has funded over 40M in high-quality research grants and programs to date.
A recent study found that children born to mothers who took acid-blocking drugs during pregnancy were at least one third more likely to visit a doctor for asthma symptoms. The researchers emphasize the need for further studies to confirm this association and determine whether the medicines cause asthma in children.
Commonly prescribed acid suppression medications were linked with increased risks of intestinal infections with C. difficile and Campylobacter bacteria. Users should be vigilant about food hygiene due to the removal of stomach acid making them more susceptible to infection.
A randomized, Phase III study will enroll 600 people with suboptimal diets to evaluate the effects of a specific diet on cognitive abilities and brain health. The MIND diet, which includes foods like fish, berries, nuts, and leafy greens, aims to improve brain health by developing new dietary guidelines.