Articles tagged with Transplantation
A study found that frozen fecal transplantation (FMT) was noninferior to fresh FMT in treating recurrent or refractory C. difficile infections, indicating its potential as a reasonable treatment option. The use of frozen FMT offered advantages such as reduced cost and increased availability.
The International Society for Heart Lung Transplantation (ISHLT) has updated its listing criteria for heart transplantation, expanding eligibility to patients with HIV and hepatitis. The new guidelines also relax the BMI threshold for overweight patients with heart failure.
A study using mobile health technology has shown that patients taking kidney transplants can improve their medication adherence and blood pressure levels, leading to better patient outcomes. The innovative approach aims to reduce premature graft loss by providing personalized computer-automated monitoring systems.
Researchers have found that screening male kidney transplant candidates for prostate cancer does not prolong their survival and may even delay receiving a transplant. Elevated PSA levels detected through screening were associated with a reduced likelihood of receiving a transplant regardless of the patient's age or PSA level.
A Mayo Clinic study of 102 lung transplant patients found that those who were frail before surgery had lower survival rates at one and three years post-transplant. Frailty was associated with decreased survival and poorer outcomes.
Researchers found a prophylaxis treatment can prevent new-onset hepatitis B in children who receive livers from donors previously infected with HBV. The regimen consisted of HBV vaccine injections and immunoglobulin, maintaining high antibody levels against the virus.
A study reveals racial and ethnic differences in US patients with kidney failure accessing home dialysis, with potential factors including lack of availability, insurance barriers, and provider bias. The findings highlight the need to ensure equitable access to different dialysis modalities to improve health outcomes.
A new research study published in JAMA found that 28.8% of resident physicians screen positive for depression during their residency, highlighting an important issue in graduate medical education.
Researchers at Université de Genève found that cold exposure alters microbiota composition, leading to increased brown fat activation, improved insulin sensitivity, and weight loss. The discovery highlights the key role of Akkermansia muciniphila in regulating nutrient absorption and may lead to new anti-obesity treatments.
Recent studies have analyzed trends in blood clot formation in patients with heart-assist devices, revealing a potential decline in thrombosis rates since 2011. However, the exact impact of this trend on patient outcomes remains unclear, and experts emphasize the need for continued vigilance and research.
A new study reveals that Native Americans have decreased access to kidney transplants, leading to higher mortality rates on the waiting list. The study found that while short-term outcomes were similar, Native Americans experienced worse long-term survival outcomes compared to whites.
Researchers developed a novel 3D computer modeling system to assess compatibility of potential donor hearts with children receiving heart transplants. The new system uses MRI and CT images to predict the best donor body weight for pediatric transplant recipients, improving size matching and potentially reducing mismatched organs.
A new study comparing kidney transplantation and home hemodialysis found that transplant recipients outlived their hemodialysis counterparts by 4 times over 5 years. Elderly patients on hemodialysis had nearly a 5 times higher risk of dying compared to those with transplants, highlighting racial disparities in mortality rates.
Two studies found that a specific gut bacteria, Bifidobacterium, is positively associated with anti-tumor T cell responses and upregulates genes critical for anti-tumor responses. Fecal transplants also slowed tumor growth in mice treated with immunotherapy agents.
Researchers found that rockweed substrate drenches significantly improved postharvest shelf life of petunia and tomato transplants. In contrast, foliar sprays showed no effect on drought tolerance. The study recommends using seaweed extracts as a substrate drench to enhance plant growth.
Faecal transplants have shown an 85% success rate in treating severe infections like C difficile, outperforming standard antibiotic treatment. However, experts warn of potential risks and call for proper screening of donors, long-term trials, and monitoring to ensure safe and effective use.
Research at Mayo Clinic found that 42% of lung transplant patients exhibit depression-related emotional symptoms and 52% have depression-related physical symptoms. These findings highlight the need for interventions to reduce stress and support emotional health in patients awaiting a transplant.
A new study found that a Medicare payment model reduced the number of low-value services used by patients, with a 4.5% reduction in spending on these services. Providers targeted low-value services to lower spending, and those who previously used more of these services saw the greatest reductions.
A new study found that only one in four patients with end-stage renal disease (ESRD) in Georgia was referred to a transplant center for evaluation within one year of starting dialysis. The study also revealed substantial variation in referral rates among dialysis facilities.
A study found that only about one in four patients with end-stage renal disease in Georgia were referred for kidney transplant evaluation within a year of starting dialysis. The study suggests that standardized guidelines are needed to improve access to kidney transplantation.
A new computer-based system provides rapid, real-time feedback during facial transplant surgery, potentially improving face-jaw-teeth alignment and reducing residual deformities. The CAPE platform uses CT scans to match donor anatomy with recipient anatomy, providing unprecedented visual data for surgeons.
Studies show that certain bacterial groups in the gut can help protect against inflammation and control symptoms of UC. Researchers found that fecal microbiota transplantation with specific beneficial bacteria may be a promising treatment option for UC.
A study published in Liver Transplantation identified younger patients and those with more severe liver disease as more likely to have potential living liver donors. In contrast, older, single, divorced, or low-income patients were less likely to have a live donor volunteer for liver donation.
A psychological evaluation of nine women who received a uterus from live donors indicates they adjusted psychologically well to their new life situation during the first year. Three of the seven remaining women have delivered healthy babies, with most reporting improved relationships with their donor and increased hope for a family.
Swedish clinicians have successfully performed live births after uterus transplantation, paving the way for new treatments. The long research journey of the Swedish uterus transplant project has led to preliminary results that offer hope for women who lack a functional uterus.
A new study found that living liver donors experienced lower sexual function at evaluation phase and three months after surgery. Donor education prior to surgery may help ease concerns and improve recovery.
A new study presented at The International Liver Congress 2015 showed high rates of sustained virologic response and good tolerance when using sofosbuvir and daclatasvir-based regimens in patients with recurrent hepatitis C. These results support the use of interferon-free regimens in managing liver transplant patients infected with HCV.
A phase 3 study showed that a combination of daclatasvir, sofosbuvir, and ribavirin was effective in achieving sustained virologic response rates of over 90% in patients with HCV infection and advanced cirrhosis. The treatment was also well-tolerated, with no serious treatment-related side effects.
The HCV-TARGET study shows all-oral direct-acting antiviral therapy is highly effective and well tolerated in patients with decompensated cirrhosis, with SVR rates of 75%, 77% and 81%. Liver function markers also improve during short-term follow-up.
A new device has demonstrated its potential to preserve and improve the quality of donor livers from donation after circulatory death (DCD) for transplantation. The transportable machine perfusion Airdrive effectively maintained liver quality, reducing biliary complications and increasing graft function.
Results from the SOLAR 2 trial show that ledipasvir/sofosbuvir in combination with ribavirin is safe and effective in patients with decompensated liver disease or who have undergone liver transplantation. High sustained virologic response rates were achieved, even among treatment-experienced patients.
Preliminary results show that Civacir effectively prevents hepatitis C virus (HCV) recurrence in liver transplant patients who received antiviral therapy before their operation. The study found that Civacir provides a prophylactic efficacy in preventing HCV-reinfection, reducing the risk of graft loss.
Research demonstrates dynamic nature of fecal microbiota in FMT donors and recipients, with healthy changes sustained for up to 21 weeks after transplant. The study's findings have implications for the regulation of treatment and could influence the use of fecal transplants for a range of diseases associated with microbial imbalance.
A new study found that combining traditional assessment tools with data from nurses' assessments significantly improves the ability to predict survival in cirrhosis patients. This may help improve patient outcomes by identifying patients who can benefit from rehabilitation and intensifying their nutritional support.
A recent study published in Kidney International found that HIV-positive kidney transplant patients have superior outcomes compared to those with Hepatitis C. The three-year survival rates for HIV patients were similar to those of uninfected patients (90%), while Hepatitis C patients had a lower rate (84%).
A recent study published in Microbiome reveals that fecal microbiota transplantation can effectively treat C. difficile infections, with sustained changes observed for up to 21 weeks. The research has significant implications for the regulation of treatment and suggests that current frameworks may not be applicable.
A study found that UK patients with cystic fibrosis who received transplants had better survival rates than publicly insured Americans. The research suggests that a single-payer national health care system can provide complex, coordinated and expansive care with long-term outcomes similar to those achieved by private insurance.
Acute liver failure patients can now undergo live donor liver transplantation in emergency situations without compromising patient safety. The procedure has been shown to have similar postoperative complication rates and 1-, 3-, and 5-year survival rates compared to deceased donor liver transplants.
HIV+ kidney transplant recipients who are not infected with HCV have similar 5-year and 10-year kidney survival rates as uninfected recipients. Patient survival among mono-infected HIV+ recipients is also comparable to uninfected recipients, while co-infected patients experience inferior outcomes.
A team of UK researchers has designed Arterio-Venous Fistulae with reduced failure rates using computational simulation software from the aerospace industry. The new design aims to decrease blockages in dialysis connections, improving clinical outcomes for patients with end-stage renal disease.
A new study reveals a significant decline in the use of available donor hearts for transplantation in the US, with a decline from 44% to 32% between 1995 and 2010. The study suggests that increased scrutiny by government agencies may be contributing to this trend.
A case report published in Open Forum Infectious Diseases reveals that a woman who underwent fecal microbiota transplant for a recurrent C. difficile infection rapidly gained weight, becoming obese. The study suggests that clinicians should avoid selecting stool donors who are overweight to minimize the risk of similar outcomes.
A recent study found that women with kidney transplants in childhood and adulthood have comparable live birth rates, premature birth rates, and small-for-gestational-age babies. The findings suggest that early onset of kidney failure and longer periods of immunosuppression do not negatively impact pregnancy outcomes.
A preliminary study found that nonmyeloablative hematopoietic stem cell transplantation improved measures of disability and quality of life in relapsing-remitting multiple sclerosis patients. The treatment also showed significant improvement in physical function, cognitive function, and a reduction in brain lesions associated with MS.
A Loyola University Medical Center study found that lung transplant patients who receive lungs from heavy drinkers are nearly nine times more likely to experience primary graft dysfunction, a life-threatening complication. These transplants also displayed poorer gas-exchange and longer ventilator stays.
Researchers found that fine root hydraulic conductance is related to transplant recovery in two Quercus species, with spring transplanting optimal for Quercus bicolor. The study suggests that understanding tree roots' behavior can inform better decisions regarding transplant timing and improve post-transplant recovery.
A novel nomogram was developed by UCLA researchers to accurately calculate the risk of disease recurrence in liver cancer patients after a liver transplant. The tool uses pre-transplant radiologic information, blood biomarkers, and pathological characteristics to predict recurrence rates.
A recent study found that cystic fibrosis patients are at a higher risk of developing ganciclovir-resistant cytomegalovirus strains due to insufficient levels of the drug in their system. This can lead to delayed or inadequate response to treatment, highlighting the need for closer monitoring and therapeutic level adjustments.
A study by researchers at Brigham and Women's Hospital found that using 3D printed models of the recipient's head improved pre-operative data, allowing surgeons to better appreciate complex anatomy and bony defects. This reduction in procedure time led to improved overall patient outcomes.
Recent research has shown that children with dilated cardiomyopathy are living longer without heart transplants, with a survival rate of 15% without transplantation. The study found that the more recent era (2000-09) had better survival rates and was associated with factors other than transplantation availability.
A 3-month course of levofloxacin following kidney transplantation did not prevent BK virus from appearing in the urine, according to a study. The intervention was associated with increased risk of adverse events like bacterial resistance.
Late-breaking clinical studies presented at ASN Kidney Week 2014 highlight significant advances in kidney care, including the reduction of disparities in transplant referrals through a community-based intervention. Additionally, new treatments for End-Stage Renal Disease (ESRD) have shown promising results, such as ferric citrate's abi...
A new study published in PLOS Medicine has developed a 17-gene set to analyze peripheral blood samples and determine which patients are at risk of acute rejection after kidney transplantation. The test, called kSORT, was found to be highly accurate and clinically applicable, with an area under the curve of 0.93.
A new study published in the American Journal of Transplantation found that frailty significantly increases the risk of premature death in kidney transplant recipients. The study analyzed data from 537 patients and found that those who were classified as frail had a mortality rate twice that of non-frail patients.
Breakthroughs in HCV therapy suggest increased cure rates, including for patients with cirrhosis. Fecal microbiota transplantation shows promise in treating C. difficile, while drug-induced liver injury warnings are also emphasized.
The world's first child was born from a transplanted uterus, marking a major step forward in treating uterine factor infertility. The baby boy was delivered via caesarean section due to preeclampsia, but is developing normally and the mother and child are doing well.
Researchers found that hybridization can lead to increased genetic diversity in wild populations, but natural selection can ultimately remove adaptive advantages. The study suggests that hybridized populations may not be as affected by human-mediated hybridization with domesticated species.
The Mayo Clinic has developed a scoring system to identify patients who can safely bypass the intensive care unit (ICU) after liver transplantation. The study found that 54.3% of patients can be fast-tracked, with better survival rates compared to those sent to the ICU.
A study finds that older adults, women, and less educated individuals have more concerns about kidney transplantation. These concerns can lead to lower chances of getting listed for a transplant. The study aims to address these barriers to improve access to transplantation.
A study of dialysis patients found that clinicians' reported discussions about transplantation did not increase patients' likelihood of being listed, despite patient-reported discussions being associated with a nearly 3-fold increased chance. The findings suggest the need for improved patient communication and informed consent.