Articles tagged with Transplantation
Swedish clinicians have successfully performed live births after uterus transplantation, paving the way for new treatments. The long research journey of the Swedish uterus transplant project has led to preliminary results that offer hope for women who lack a functional uterus.
A new study found that living liver donors experienced lower sexual function at evaluation phase and three months after surgery. Donor education prior to surgery may help ease concerns and improve recovery.
A new study presented at The International Liver Congress 2015 showed high rates of sustained virologic response and good tolerance when using sofosbuvir and daclatasvir-based regimens in patients with recurrent hepatitis C. These results support the use of interferon-free regimens in managing liver transplant patients infected with HCV.
A phase 3 study showed that a combination of daclatasvir, sofosbuvir, and ribavirin was effective in achieving sustained virologic response rates of over 90% in patients with HCV infection and advanced cirrhosis. The treatment was also well-tolerated, with no serious treatment-related side effects.
A new device has demonstrated its potential to preserve and improve the quality of donor livers from donation after circulatory death (DCD) for transplantation. The transportable machine perfusion Airdrive effectively maintained liver quality, reducing biliary complications and increasing graft function.
Results from the SOLAR 2 trial show that ledipasvir/sofosbuvir in combination with ribavirin is safe and effective in patients with decompensated liver disease or who have undergone liver transplantation. High sustained virologic response rates were achieved, even among treatment-experienced patients.
Preliminary results show that Civacir effectively prevents hepatitis C virus (HCV) recurrence in liver transplant patients who received antiviral therapy before their operation. The study found that Civacir provides a prophylactic efficacy in preventing HCV-reinfection, reducing the risk of graft loss.
The HCV-TARGET study shows all-oral direct-acting antiviral therapy is highly effective and well tolerated in patients with decompensated cirrhosis, with SVR rates of 75%, 77% and 81%. Liver function markers also improve during short-term follow-up.
Research demonstrates dynamic nature of fecal microbiota in FMT donors and recipients, with healthy changes sustained for up to 21 weeks after transplant. The study's findings have implications for the regulation of treatment and could influence the use of fecal transplants for a range of diseases associated with microbial imbalance.
A new study found that combining traditional assessment tools with data from nurses' assessments significantly improves the ability to predict survival in cirrhosis patients. This may help improve patient outcomes by identifying patients who can benefit from rehabilitation and intensifying their nutritional support.
A recent study published in Kidney International found that HIV-positive kidney transplant patients have superior outcomes compared to those with Hepatitis C. The three-year survival rates for HIV patients were similar to those of uninfected patients (90%), while Hepatitis C patients had a lower rate (84%).
A recent study published in Microbiome reveals that fecal microbiota transplantation can effectively treat C. difficile infections, with sustained changes observed for up to 21 weeks. The research has significant implications for the regulation of treatment and suggests that current frameworks may not be applicable.
A study found that UK patients with cystic fibrosis who received transplants had better survival rates than publicly insured Americans. The research suggests that a single-payer national health care system can provide complex, coordinated and expansive care with long-term outcomes similar to those achieved by private insurance.
HIV+ kidney transplant recipients who are not infected with HCV have similar 5-year and 10-year kidney survival rates as uninfected recipients. Patient survival among mono-infected HIV+ recipients is also comparable to uninfected recipients, while co-infected patients experience inferior outcomes.
Acute liver failure patients can now undergo live donor liver transplantation in emergency situations without compromising patient safety. The procedure has been shown to have similar postoperative complication rates and 1-, 3-, and 5-year survival rates compared to deceased donor liver transplants.
A team of UK researchers has designed Arterio-Venous Fistulae with reduced failure rates using computational simulation software from the aerospace industry. The new design aims to decrease blockages in dialysis connections, improving clinical outcomes for patients with end-stage renal disease.
A new study reveals a significant decline in the use of available donor hearts for transplantation in the US, with a decline from 44% to 32% between 1995 and 2010. The study suggests that increased scrutiny by government agencies may be contributing to this trend.
A case report published in Open Forum Infectious Diseases reveals that a woman who underwent fecal microbiota transplant for a recurrent C. difficile infection rapidly gained weight, becoming obese. The study suggests that clinicians should avoid selecting stool donors who are overweight to minimize the risk of similar outcomes.
A recent study found that women with kidney transplants in childhood and adulthood have comparable live birth rates, premature birth rates, and small-for-gestational-age babies. The findings suggest that early onset of kidney failure and longer periods of immunosuppression do not negatively impact pregnancy outcomes.
A preliminary study found that nonmyeloablative hematopoietic stem cell transplantation improved measures of disability and quality of life in relapsing-remitting multiple sclerosis patients. The treatment also showed significant improvement in physical function, cognitive function, and a reduction in brain lesions associated with MS.
A Loyola University Medical Center study found that lung transplant patients who receive lungs from heavy drinkers are nearly nine times more likely to experience primary graft dysfunction, a life-threatening complication. These transplants also displayed poorer gas-exchange and longer ventilator stays.
Researchers found that fine root hydraulic conductance is related to transplant recovery in two Quercus species, with spring transplanting optimal for Quercus bicolor. The study suggests that understanding tree roots' behavior can inform better decisions regarding transplant timing and improve post-transplant recovery.
A novel nomogram was developed by UCLA researchers to accurately calculate the risk of disease recurrence in liver cancer patients after a liver transplant. The tool uses pre-transplant radiologic information, blood biomarkers, and pathological characteristics to predict recurrence rates.
A recent study found that cystic fibrosis patients are at a higher risk of developing ganciclovir-resistant cytomegalovirus strains due to insufficient levels of the drug in their system. This can lead to delayed or inadequate response to treatment, highlighting the need for closer monitoring and therapeutic level adjustments.
A study by researchers at Brigham and Women's Hospital found that using 3D printed models of the recipient's head improved pre-operative data, allowing surgeons to better appreciate complex anatomy and bony defects. This reduction in procedure time led to improved overall patient outcomes.
Recent research has shown that children with dilated cardiomyopathy are living longer without heart transplants, with a survival rate of 15% without transplantation. The study found that the more recent era (2000-09) had better survival rates and was associated with factors other than transplantation availability.
Late-breaking clinical studies presented at ASN Kidney Week 2014 highlight significant advances in kidney care, including the reduction of disparities in transplant referrals through a community-based intervention. Additionally, new treatments for End-Stage Renal Disease (ESRD) have shown promising results, such as ferric citrate's abi...
A 3-month course of levofloxacin following kidney transplantation did not prevent BK virus from appearing in the urine, according to a study. The intervention was associated with increased risk of adverse events like bacterial resistance.
A new study published in PLOS Medicine has developed a 17-gene set to analyze peripheral blood samples and determine which patients are at risk of acute rejection after kidney transplantation. The test, called kSORT, was found to be highly accurate and clinically applicable, with an area under the curve of 0.93.
A new study published in the American Journal of Transplantation found that frailty significantly increases the risk of premature death in kidney transplant recipients. The study analyzed data from 537 patients and found that those who were classified as frail had a mortality rate twice that of non-frail patients.
Breakthroughs in HCV therapy suggest increased cure rates, including for patients with cirrhosis. Fecal microbiota transplantation shows promise in treating C. difficile, while drug-induced liver injury warnings are also emphasized.
The world's first child was born from a transplanted uterus, marking a major step forward in treating uterine factor infertility. The baby boy was delivered via caesarean section due to preeclampsia, but is developing normally and the mother and child are doing well.
Researchers found that hybridization can lead to increased genetic diversity in wild populations, but natural selection can ultimately remove adaptive advantages. The study suggests that hybridized populations may not be as affected by human-mediated hybridization with domesticated species.
The Mayo Clinic has developed a scoring system to identify patients who can safely bypass the intensive care unit (ICU) after liver transplantation. The study found that 54.3% of patients can be fast-tracked, with better survival rates compared to those sent to the ICU.
A study finds that older adults, women, and less educated individuals have more concerns about kidney transplantation. These concerns can lead to lower chances of getting listed for a transplant. The study aims to address these barriers to improve access to transplantation.
A study of dialysis patients found that clinicians' reported discussions about transplantation did not increase patients' likelihood of being listed, despite patient-reported discussions being associated with a nearly 3-fold increased chance. The findings suggest the need for improved patient communication and informed consent.
A recent study found that black women are less likely to want to receive kidney transplants from living donors, despite receiving more unsolicited offers from family and friends. Women were also less likely to be evaluated for a transplant, highlighting the need for targeted interventions to alleviate existing disparities.
Fecal microbiota transplantation (FMT) shows promise in treating a broad range of gastrointestinal disorders, including irritable bowel syndrome and inflammatory bowel disease. A new orally delivered community of microbes has been developed to address the challenges of FMT.
Researchers found that bacteria in the gut, rather than liver enzymes, are crucial for allowing herbivores to feed on toxic plants. Fecal transplants with microbes from creosote-eaters enabled woodrats to eat toxic creosote bushes, confirming their importance in adapting to new diets.
A new study published in the American Journal of Transplantation found that older kidney donors experience similar longevity and cardiovascular health as healthy individuals. The research, led by Dr. Peter Reese, suggests that donation does not significantly increase the risk of death or heart disease among older adults.
Researchers developed a new big data analysis technique to predict kidney transplant patient outcomes, providing doctors with valuable time to intervene. The technique uses complex algorithms to analyze hundreds of thousands of variables from blood samples, allowing for more accurate prognosis and improved patient recovery periods.
A new data analysis technique uses big data to predict poor kidney function after transplant, allowing doctors to intervene earlier and improve recovery periods. The study analyzed blood samples from 18 patients before and after transplants, revealing vital clues in molecular level data.
A study suggests that small changes to US kidney allocation policies can help alleviate geographic disparities in transplantation. Implementing local sharing strategies like the Statewide Sharing variance adopted by Tennessee and Florida has been shown to significantly reduce disparities, while other states saw increased disparities.
A study published in PLOS ONE found that feeding juvenile corals prior to transplantation significantly improved their survival rates. Coral recruits fed with a higher amount of food grew faster and larger than unfed corals, leading to higher post-transplantation survivorship.
Researchers found that smaller declines in estimated GFR are strongly associated with subsequent risk of end-stage renal disease. A new definition of kidney disease progression could shorten clinical trials and improve treatment outcomes.
Researchers found that dialysis facilities in the Southeast have lower rates of kidney transplantation due to factors such as higher poverty levels and fewer staff. In contrast, Northeastern facilities had higher rates of transplantation, suggesting regional variations in access to care.
A study found that walking can significantly improve survival rates and reduce the need for dialysis among patients with stage 3-5 chronic kidney disease. Patients who walked regularly were 33% less likely to die and 21% less likely to require dialysis compared to non-walkers.
Researchers found that urinary ethyl glucuronide (uEtG) is the strongest marker of alcohol use, detecting consumption in 31% of participants. The study suggests combining uEtG with the Alcohol Use Disorders Identification Test for better alerting doctors to potential issues.
A new pilot study published in Clinical Infectious Diseases found that using frozen stool from healthy, unrelated donors was safe and effective in treating patients with relapsing diarrhea caused by Clostridium difficile. The treatment was equally effective whether given via a colonoscope or a nasogastric tube.
Patients with lymphangioleiomyomatosis (LAM) may benefit from sirolimus, which slows disease progression and improves quality of life. However, the drug can complicate lung transplants due to potential fatal complications.
A new trial involving sofosbuvir demonstrated promising results for patients with recurring HCV post-liver transplant, achieving SVR12 in 62% of cases. Additionally, improvements in clinical conditions associated with hepatic decompensation and liver function tests were observed.
Henry Ford Hospital has implemented a kidney transplant technique using new patient safety standards coordinated by the University of Oxford. The IDEAL framework was used to develop and test the minimally-invasive procedure, which successfully transplanted kidneys in 50 recipients.
Researchers analyzed data from a center for professionalism and peer support at Boston's Brigham and Women's Hospital and found that employees continued to turn to the center for help, citing concerns about physician/scientist behavior. The interventions used were successful in creating substantive changes in behavior.
Researchers found that five out of 22 patients implanted with total artificial hearts survived until they could receive a heart transplant, with four successfully undergoing transplants and 13 still alive waiting for donor hearts. The study suggests the device may help improve patient outcomes for those in end-stage heart failure.
A new JAMA article suggests creating an unbiased review and certification process for mHealth apps to evaluate their clinical performance and data security. The authors propose multiple organizations that could be created to review and certify apps, similar to the role of Health On the Net Foundation in evaluating online medical content.
A new study found that patients with advanced cardiac insufficiency who remain active and have low levels of depression can significantly increase their chances of surviving the waiting period for a donor heart. The researchers recommend psychological counseling to help patients stay physically active and reduce symptoms of depression.
A team of Swedish researchers led by Professor Mats Brännström have successfully performed nine uterus transplants using live donors, a breakthrough in treating uterine infertility. The transplants involved five mother-daughter pairs and four close relatives, with no blood transfusions required during surgery.
The Italian Society of Nephrology and Springer are joining forces to promote renal diseases research. The new partnership aims to increase the quality and visibility of the Journal of Nephrology.
Aortic valve replacement improves symptoms but may not improve overall quality of life for high-risk patients. Researchers found rituximab to be ineffective in treating primary Sjögren's syndrome, while microsporidiosis should be considered in febrile transplant patients, especially those with unexplained illnesses.
A Japanese study found that sarcopenia, a loss of skeletal muscle mass, increases the risk of sepsis and mortality in patients undergoing live donor liver transplantation. Early nutritional support with enteral nutrition reduced sepsis rates in these patients. Treating malnutrition may reduce mortality risk following transplantation.