Articles tagged with Transplantation
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A new study published in PLOS Medicine has developed a 17-gene set to analyze peripheral blood samples and determine which patients are at risk of acute rejection after kidney transplantation. The test, called kSORT, was found to be highly accurate and clinically applicable, with an area under the curve of 0.93.
A new study published in the American Journal of Transplantation found that frailty significantly increases the risk of premature death in kidney transplant recipients. The study analyzed data from 537 patients and found that those who were classified as frail had a mortality rate twice that of non-frail patients.
Breakthroughs in HCV therapy suggest increased cure rates, including for patients with cirrhosis. Fecal microbiota transplantation shows promise in treating C. difficile, while drug-induced liver injury warnings are also emphasized.
The world's first child was born from a transplanted uterus, marking a major step forward in treating uterine factor infertility. The baby boy was delivered via caesarean section due to preeclampsia, but is developing normally and the mother and child are doing well.
Researchers found that hybridization can lead to increased genetic diversity in wild populations, but natural selection can ultimately remove adaptive advantages. The study suggests that hybridized populations may not be as affected by human-mediated hybridization with domesticated species.
The Mayo Clinic has developed a scoring system to identify patients who can safely bypass the intensive care unit (ICU) after liver transplantation. The study found that 54.3% of patients can be fast-tracked, with better survival rates compared to those sent to the ICU.
A study finds that older adults, women, and less educated individuals have more concerns about kidney transplantation. These concerns can lead to lower chances of getting listed for a transplant. The study aims to address these barriers to improve access to transplantation.
A study of dialysis patients found that clinicians' reported discussions about transplantation did not increase patients' likelihood of being listed, despite patient-reported discussions being associated with a nearly 3-fold increased chance. The findings suggest the need for improved patient communication and informed consent.
A recent study found that black women are less likely to want to receive kidney transplants from living donors, despite receiving more unsolicited offers from family and friends. Women were also less likely to be evaluated for a transplant, highlighting the need for targeted interventions to alleviate existing disparities.
Fecal microbiota transplantation (FMT) shows promise in treating a broad range of gastrointestinal disorders, including irritable bowel syndrome and inflammatory bowel disease. A new orally delivered community of microbes has been developed to address the challenges of FMT.
Researchers found that bacteria in the gut, rather than liver enzymes, are crucial for allowing herbivores to feed on toxic plants. Fecal transplants with microbes from creosote-eaters enabled woodrats to eat toxic creosote bushes, confirming their importance in adapting to new diets.
A new study published in the American Journal of Transplantation found that older kidney donors experience similar longevity and cardiovascular health as healthy individuals. The research, led by Dr. Peter Reese, suggests that donation does not significantly increase the risk of death or heart disease among older adults.
Researchers developed a new big data analysis technique to predict kidney transplant patient outcomes, providing doctors with valuable time to intervene. The technique uses complex algorithms to analyze hundreds of thousands of variables from blood samples, allowing for more accurate prognosis and improved patient recovery periods.
A study suggests that small changes to US kidney allocation policies can help alleviate geographic disparities in transplantation. Implementing local sharing strategies like the Statewide Sharing variance adopted by Tennessee and Florida has been shown to significantly reduce disparities, while other states saw increased disparities.
A new data analysis technique uses big data to predict poor kidney function after transplant, allowing doctors to intervene earlier and improve recovery periods. The study analyzed blood samples from 18 patients before and after transplants, revealing vital clues in molecular level data.
A study published in PLOS ONE found that feeding juvenile corals prior to transplantation significantly improved their survival rates. Coral recruits fed with a higher amount of food grew faster and larger than unfed corals, leading to higher post-transplantation survivorship.
Researchers found that smaller declines in estimated GFR are strongly associated with subsequent risk of end-stage renal disease. A new definition of kidney disease progression could shorten clinical trials and improve treatment outcomes.
Researchers found that dialysis facilities in the Southeast have lower rates of kidney transplantation due to factors such as higher poverty levels and fewer staff. In contrast, Northeastern facilities had higher rates of transplantation, suggesting regional variations in access to care.
A study found that walking can significantly improve survival rates and reduce the need for dialysis among patients with stage 3-5 chronic kidney disease. Patients who walked regularly were 33% less likely to die and 21% less likely to require dialysis compared to non-walkers.
Researchers found that urinary ethyl glucuronide (uEtG) is the strongest marker of alcohol use, detecting consumption in 31% of participants. The study suggests combining uEtG with the Alcohol Use Disorders Identification Test for better alerting doctors to potential issues.
A new pilot study published in Clinical Infectious Diseases found that using frozen stool from healthy, unrelated donors was safe and effective in treating patients with relapsing diarrhea caused by Clostridium difficile. The treatment was equally effective whether given via a colonoscope or a nasogastric tube.
Patients with lymphangioleiomyomatosis (LAM) may benefit from sirolimus, which slows disease progression and improves quality of life. However, the drug can complicate lung transplants due to potential fatal complications.
A new trial involving sofosbuvir demonstrated promising results for patients with recurring HCV post-liver transplant, achieving SVR12 in 62% of cases. Additionally, improvements in clinical conditions associated with hepatic decompensation and liver function tests were observed.
Henry Ford Hospital has implemented a kidney transplant technique using new patient safety standards coordinated by the University of Oxford. The IDEAL framework was used to develop and test the minimally-invasive procedure, which successfully transplanted kidneys in 50 recipients.
Researchers analyzed data from a center for professionalism and peer support at Boston's Brigham and Women's Hospital and found that employees continued to turn to the center for help, citing concerns about physician/scientist behavior. The interventions used were successful in creating substantive changes in behavior.
Researchers found that five out of 22 patients implanted with total artificial hearts survived until they could receive a heart transplant, with four successfully undergoing transplants and 13 still alive waiting for donor hearts. The study suggests the device may help improve patient outcomes for those in end-stage heart failure.
A new JAMA article suggests creating an unbiased review and certification process for mHealth apps to evaluate their clinical performance and data security. The authors propose multiple organizations that could be created to review and certify apps, similar to the role of Health On the Net Foundation in evaluating online medical content.
A new study found that patients with advanced cardiac insufficiency who remain active and have low levels of depression can significantly increase their chances of surviving the waiting period for a donor heart. The researchers recommend psychological counseling to help patients stay physically active and reduce symptoms of depression.
A team of Swedish researchers led by Professor Mats Brännström have successfully performed nine uterus transplants using live donors, a breakthrough in treating uterine infertility. The transplants involved five mother-daughter pairs and four close relatives, with no blood transfusions required during surgery.
The Italian Society of Nephrology and Springer are joining forces to promote renal diseases research. The new partnership aims to increase the quality and visibility of the Journal of Nephrology.
Aortic valve replacement improves symptoms but may not improve overall quality of life for high-risk patients. Researchers found rituximab to be ineffective in treating primary Sjögren's syndrome, while microsporidiosis should be considered in febrile transplant patients, especially those with unexplained illnesses.
A Japanese study found that sarcopenia, a loss of skeletal muscle mass, increases the risk of sepsis and mortality in patients undergoing live donor liver transplantation. Early nutritional support with enteral nutrition reduced sepsis rates in these patients. Treating malnutrition may reduce mortality risk following transplantation.
Researchers developed chemical agents that bind and potentially remove the anti-coagulant heparin, improving patient care. The system is biodegradable, reducing the risk of side effects.
A recent Penn Medicine study reveals that patients with hepatopulmonary syndrome may be receiving unnecessary priority on the liver transplant wait list. The study found that these patients often have poor post-transplant survival rates and that a significant proportion of them do not meet clear clinical indications for transplantation.
A study published in Health Affairs found that the FDA's median rulemaking time is 7.3 years, with cost-benefit analysis associated with additional delays. The authors recommend improving efficiency and promoting transparency to reduce regulatory burdens.
Researchers from Brigham and Women's Hospital found that blue light exposure improves alertness and performance during the day and night, reducing fatigue. The study used specialized equipment to compare the effects of blue and green light on 16 participants, showing significant improvements in alertness and reaction times.
A recent study published in Liver Transplantation found that obese liver transplant recipients with diabetes experienced higher morbidity rates due to post-transplant complications, particularly diabetes and metabolic syndrome. Despite this, obesity did not negatively affect survival rates.
A study from Brigham and Women's Hospital found that most cardiac implantable electronic devices were approved as changes to existing PMA-approved models without new clinical data. This raises concerns about patient safety, particularly for devices such as the St. Jude Medical Riata and Medtronic Sprint Fidelis defibrillator leads.
A new study reveals substantial geographic variation in waiting times for children needing kidney transplants, with local organ supply and demand affecting outcomes. The findings suggest that a broader geographic sharing of kidneys is necessary to address these disparities.
Researchers from UNSW successfully transplanted Phyllospora comosa onto two barren reef sites in Sydney, where it once thrived. The transplanted species not only survived but also reproduced, creating a potential self-sustaining population and restoring a vital habitat for marine organisms.
A UT Southwestern Medical Center study found that blocking immune system molecule interferon-gamma (IFN-γ) and matching major histocompatibility complex (MHC) genotypes can improve corneal transplant acceptance rates in mice. The strategy enhances long-term graft survival, almost guaranteeing success.
Higher body mass index (BMI) and larger waist circumference are associated with higher risk of hearing loss in women. Maintaining a healthy weight and engaging in regular physical activity can potentially delay or prevent hearing loss.
A new study reveals that US organ procurement organizations' implementation of First Person Authorization (FPA) has been inconsistent and incomplete. Despite legal backing from state laws, half the groups surveyed did not have a written policy for handling family objections.
Researchers at KIST developed a biodegradable magnesium alloy that can be used in orthopedics and plastic surgery. The alloy has been approved for clinical testing and is expected to reshape the landscape in fracture treatment.
A new study found that kidney failure patients who experienced discrimination and mistrust in healthcare had poorer quality of life. Patients who reported greater medical mistrust and lower trust in their physicians also showed decreased quality of life.
A new study finds that treatment with abatacept appears to halt the course of focal segmental glomerulosclerosis (FSGS) in patients, preventing proteinuria and promoting remission. Abatacept has been shown to be effective in treating patients with recurrent disease and those at high risk for kidney failure.
A Swedish study reveals that many heart failure patients are undertreated, with high mortality rates associated with poor pump capacity, kidney function, blood count, and lack of ACE inhibitors and beta blockers. The study suggests referring these patients to heart failure specialists for evaluation and treatment.
A study found a pill-based fecal transplant to be effective in stopping recurrent C. diff infections, achieving a 100% success rate among patients. The treatment involves taking capsules containing fecal bacteria, rebalancing the gut microbiome and preventing future infections.
A study published in Annals of Surgery found that immediate surgery reduces complications and shortens hospital stays by up to 50% compared to delaying surgery. Patients who underwent early surgery had fewer complaints and were discharged earlier, resulting in lower hospitalization costs.
A long-term study found that infants and children with congestive heart failure and genetic disorders have the lowest transplant-free survival rates. Children diagnosed after one year old with unknown cause have the best outcome, a 97% rate of transplant-free survival.
Children with inherited metabolic diseases, hypertrophic cardiomyopathy, or multiple risk factors have worse prognosis. Younger age, lower weight, congestive heart failure, and abnormal left ventricle structure are significant risk factors for death or transplantation.
Fecal microbiota transplantation (FMT) has shown remarkable cure rates for recurrent C. difficile infection, with up to 92% of patients cured and an astounding 98% secondary cure rate. FMT also treats various GI disorders, including inflammatory bowel disease and irritable bowel syndrome.
Researchers found that patients who are retired and/or disabled, working part time, or working full time are more likely to be placed on a transplant waiting list than unemployed patients. Transplant centers may restrict access due to concerns about post-transplant medical care costs and noncompliance with treatment.
Researchers found that poly(lactic-co-glycolic acid) conduit transplantation can significantly enhance the quality of sciatic nerve regeneration compared to traditional autogenous nerve grafting methods. The conduits increased maximum tensile load, stress, and elastic limit load while reducing strain.
A study found that nearly 59% of liver transplant patients experience metabolic syndrome, increasing heart disease and diabetes risks. Exercise intensity appears to be more important than duration in reducing metabolic syndrome complications.
Research reveals metabolic syndrome is common among liver transplant recipients, with exercise potentially reducing complications. The study suggests structured exercise programs during the first year after surgery could benefit patients.
Patients who received their first kidney transplant between ages 14 and 16 appear to be at increased risk for graft failure. Black adolescents have a disproportionately higher risk of graft failure compared to other age groups.
A new study published in the American Journal of Transplantation found that obese kidney failure patients who receive a kidney transplant can live longer than non-obese patients. The survival benefit is lower for severely obese individuals, but improved early post-transplant care may help mitigate this risk.
Patients who survived acetaminophen overdose have significantly lower overall health, reporting more days of impaired mental and physical health, pain, anxiety, and depression. The study also found that these patients had higher rates of substance abuse and psychiatric disease compared to non-overdose survivors and transplant recipients.
A study by researchers at Wake Forest Baptist Medical Center found that African-Americans with Medicaid are significantly less likely to receive living kidney transplants compared to those with private insurance. This disparity is attributed to various factors, including limited access to living donors and resources.