Articles tagged with Transplantation
Researchers found that fecal microbiota transplantation effectively treated ulcerative colitis, with 27% of patients achieving symptom-free status. The study, which used a multi-donor approach, showed promise as an alternative treatment option for UC patients resistant to conventional therapies.
A new study found significant racial disparities in liver cancer survival rates, with black patients facing a 33% increased risk of death and being transplanted less often. The disparity is attributed to factors such as larger tumor sizes at diagnosis, lower access to care, and higher prevalence of viral hepatitis.
A subset of immune cells expressing protein CD146 is associated with the development of gastrointestinal graft-versus-host disease (GI-GVHD) after hematopoietic cell transplantation. The discovery could lead to the identification of patients at risk for GI-GVHD and personalized treatment strategies.
A new study tracks bacteria strains in stool transplants, suggesting donor-patient compatibility is crucial for success. The research could improve treatment options for conditions like ulcerative colitis and metabolic syndrome.
Research identifies 14 core gut microbes found in over 95% of people, with certain species linked to diseases like ulcerative colitis and colorectal cancer. Analysis also reveals correlations between microbiome composition and diet, as well as the impact of medications and antibiotics on the gut microbiota.
Research in female mice reveals estrogen's protective effects against renal ischemia, leading to improved survival rates and lower kidney injury. Human kidney transplant outcomes also show greater failure rates in male recipients compared to females.
A new study shows that direct-acting antiviral therapy can improve the condition of patients with severe liver damage and hepatitis C, reducing their need for a liver transplant. The treatment improved the outlook for 35% of patients, allowing them to be removed from the transplant list or no longer require a transplant.
Researchers found that high-volume lung transplant centers had lower transplantation costs and fewer early hospital readmissions. The average cost of lung transplantation was $135,622, with recipients at low-volume centers being 14% more likely to experience early readmissions.
Patients with severe liver disease face increased risk of death when treated with DAAs, according to a new study. The study highlights the need for individualized discussions between healthcare professionals and patients regarding treatment options.
A large study found that fatty liver disease is common among liver transplant recipients, with a significant increase in prevalence over time. The condition is linked to various risk factors, including high body mass index, elevated blood triglycerides, and type 2 diabetes, but does not affect short-term patient survival.
A recent study found that HPV vaccination stimulates robust immune responses in girls and young women with chronic kidney disease and dialysis, but less optimal responses among those with a kidney transplant. This highlights the need for additional research to protect kidney transplant recipients from HPV infections.
Researchers found improved survival rates for acute liver failure patients, with overall survival increasing from 67% to 75%, and survival without a transplant rising from 45% to 56%. Transplant success also improved, with survival rates reaching 96%.
A new study found that nonpathogenic viruses can be transferred during fecal transplants, but these viruses appear to be harmless to humans. The researchers analyzed fecal transplants from a single donor to three children with chronic ulcerative colitis and found mostly temperate bacteriophages were transmitted.
A study of 10,533 kidney transplant recipients found that nearly half visited an emergency department within 2 years, with younger age, female patients, and public insurance being significant risk factors. The findings highlight the need for coordinated care for this vulnerable patient population.
A survey of US citizens found that many are willing to donate a kidney, with 68% open to donating to anyone and 59% motivated by $50,000 payment. The study suggests compensating living kidney donors could alleviate the organ shortage.
A new practical manual provides guidance on combining euthanasia with organ donation after death, addressing medical and logistical aspects within Dutch law. The manual aims to educate healthcare professionals about this real option, enabling them to follow proper steps.
A new study reveals reduced racial disparities in kidney transplant outcomes between black and white recipients over the past 2 decades. The findings show improved organ survival rates for black patients, including those who received live donor or deceased donor kidney transplants.
Researchers found that saturated fat, but not unsaturated fat, raises sphingosine-1-phosphate levels in obese people, leading to inflammation and non-alcoholic steatohepatitis. This discovery may lead to new treatments to prevent liver disease in obese patients.
A new study reveals that transplant centers receiving low performance evaluations remove 60% more patients from the transplant waiting list. This suggests these centers prioritize healthier candidates over those with multiple risk factors.
A recent study published in Circulation found that cangrelor reduces the odds of major adverse cardiovascular events by 35 percent and stent thrombosis by 61 percent in women compared to standard therapy. The research provides important reassurance on the safety and efficacy of blood thinners in women.
A study found that frozen fecal transplantation (FMT) was noninferior to fresh FMT in treating recurrent or refractory C. difficile infections, indicating its potential as a reasonable treatment option. The use of frozen FMT offered advantages such as reduced cost and increased availability.
The International Society for Heart Lung Transplantation (ISHLT) has updated its listing criteria for heart transplantation, expanding eligibility to patients with HIV and hepatitis. The new guidelines also relax the BMI threshold for overweight patients with heart failure.
A study using mobile health technology has shown that patients taking kidney transplants can improve their medication adherence and blood pressure levels, leading to better patient outcomes. The innovative approach aims to reduce premature graft loss by providing personalized computer-automated monitoring systems.
Researchers have found that screening male kidney transplant candidates for prostate cancer does not prolong their survival and may even delay receiving a transplant. Elevated PSA levels detected through screening were associated with a reduced likelihood of receiving a transplant regardless of the patient's age or PSA level.
A Mayo Clinic study of 102 lung transplant patients found that those who were frail before surgery had lower survival rates at one and three years post-transplant. Frailty was associated with decreased survival and poorer outcomes.
Researchers found a prophylaxis treatment can prevent new-onset hepatitis B in children who receive livers from donors previously infected with HBV. The regimen consisted of HBV vaccine injections and immunoglobulin, maintaining high antibody levels against the virus.
A study reveals racial and ethnic differences in US patients with kidney failure accessing home dialysis, with potential factors including lack of availability, insurance barriers, and provider bias. The findings highlight the need to ensure equitable access to different dialysis modalities to improve health outcomes.
A new research study published in JAMA found that 28.8% of resident physicians screen positive for depression during their residency, highlighting an important issue in graduate medical education.
Researchers at Université de Genève found that cold exposure alters microbiota composition, leading to increased brown fat activation, improved insulin sensitivity, and weight loss. The discovery highlights the key role of Akkermansia muciniphila in regulating nutrient absorption and may lead to new anti-obesity treatments.
Recent studies have analyzed trends in blood clot formation in patients with heart-assist devices, revealing a potential decline in thrombosis rates since 2011. However, the exact impact of this trend on patient outcomes remains unclear, and experts emphasize the need for continued vigilance and research.
A new study reveals that Native Americans have decreased access to kidney transplants, leading to higher mortality rates on the waiting list. The study found that while short-term outcomes were similar, Native Americans experienced worse long-term survival outcomes compared to whites.
Researchers developed a novel 3D computer modeling system to assess compatibility of potential donor hearts with children receiving heart transplants. The new system uses MRI and CT images to predict the best donor body weight for pediatric transplant recipients, improving size matching and potentially reducing mismatched organs.
A new study comparing kidney transplantation and home hemodialysis found that transplant recipients outlived their hemodialysis counterparts by 4 times over 5 years. Elderly patients on hemodialysis had nearly a 5 times higher risk of dying compared to those with transplants, highlighting racial disparities in mortality rates.
Two studies found that a specific gut bacteria, Bifidobacterium, is positively associated with anti-tumor T cell responses and upregulates genes critical for anti-tumor responses. Fecal transplants also slowed tumor growth in mice treated with immunotherapy agents.
Researchers found that rockweed substrate drenches significantly improved postharvest shelf life of petunia and tomato transplants. In contrast, foliar sprays showed no effect on drought tolerance. The study recommends using seaweed extracts as a substrate drench to enhance plant growth.
Faecal transplants have shown an 85% success rate in treating severe infections like C difficile, outperforming standard antibiotic treatment. However, experts warn of potential risks and call for proper screening of donors, long-term trials, and monitoring to ensure safe and effective use.
Research at Mayo Clinic found that 42% of lung transplant patients exhibit depression-related emotional symptoms and 52% have depression-related physical symptoms. These findings highlight the need for interventions to reduce stress and support emotional health in patients awaiting a transplant.
A new study found that a Medicare payment model reduced the number of low-value services used by patients, with a 4.5% reduction in spending on these services. Providers targeted low-value services to lower spending, and those who previously used more of these services saw the greatest reductions.
A study found that only about one in four patients with end-stage renal disease in Georgia were referred for kidney transplant evaluation within a year of starting dialysis. The study suggests that standardized guidelines are needed to improve access to kidney transplantation.
A new study found that only one in four patients with end-stage renal disease (ESRD) in Georgia was referred to a transplant center for evaluation within one year of starting dialysis. The study also revealed substantial variation in referral rates among dialysis facilities.
A new computer-based system provides rapid, real-time feedback during facial transplant surgery, potentially improving face-jaw-teeth alignment and reducing residual deformities. The CAPE platform uses CT scans to match donor anatomy with recipient anatomy, providing unprecedented visual data for surgeons.
Studies show that certain bacterial groups in the gut can help protect against inflammation and control symptoms of UC. Researchers found that fecal microbiota transplantation with specific beneficial bacteria may be a promising treatment option for UC.
A study published in Liver Transplantation identified younger patients and those with more severe liver disease as more likely to have potential living liver donors. In contrast, older, single, divorced, or low-income patients were less likely to have a live donor volunteer for liver donation.
A psychological evaluation of nine women who received a uterus from live donors indicates they adjusted psychologically well to their new life situation during the first year. Three of the seven remaining women have delivered healthy babies, with most reporting improved relationships with their donor and increased hope for a family.
Swedish clinicians have successfully performed live births after uterus transplantation, paving the way for new treatments. The long research journey of the Swedish uterus transplant project has led to preliminary results that offer hope for women who lack a functional uterus.
A new study found that living liver donors experienced lower sexual function at evaluation phase and three months after surgery. Donor education prior to surgery may help ease concerns and improve recovery.
A new study presented at The International Liver Congress 2015 showed high rates of sustained virologic response and good tolerance when using sofosbuvir and daclatasvir-based regimens in patients with recurrent hepatitis C. These results support the use of interferon-free regimens in managing liver transplant patients infected with HCV.
A phase 3 study showed that a combination of daclatasvir, sofosbuvir, and ribavirin was effective in achieving sustained virologic response rates of over 90% in patients with HCV infection and advanced cirrhosis. The treatment was also well-tolerated, with no serious treatment-related side effects.
A new device has demonstrated its potential to preserve and improve the quality of donor livers from donation after circulatory death (DCD) for transplantation. The transportable machine perfusion Airdrive effectively maintained liver quality, reducing biliary complications and increasing graft function.
Results from the SOLAR 2 trial show that ledipasvir/sofosbuvir in combination with ribavirin is safe and effective in patients with decompensated liver disease or who have undergone liver transplantation. High sustained virologic response rates were achieved, even among treatment-experienced patients.
Preliminary results show that Civacir effectively prevents hepatitis C virus (HCV) recurrence in liver transplant patients who received antiviral therapy before their operation. The study found that Civacir provides a prophylactic efficacy in preventing HCV-reinfection, reducing the risk of graft loss.
The HCV-TARGET study shows all-oral direct-acting antiviral therapy is highly effective and well tolerated in patients with decompensated cirrhosis, with SVR rates of 75%, 77% and 81%. Liver function markers also improve during short-term follow-up.
Research demonstrates dynamic nature of fecal microbiota in FMT donors and recipients, with healthy changes sustained for up to 21 weeks after transplant. The study's findings have implications for the regulation of treatment and could influence the use of fecal transplants for a range of diseases associated with microbial imbalance.
A new study found that combining traditional assessment tools with data from nurses' assessments significantly improves the ability to predict survival in cirrhosis patients. This may help improve patient outcomes by identifying patients who can benefit from rehabilitation and intensifying their nutritional support.
A recent study published in Kidney International found that HIV-positive kidney transplant patients have superior outcomes compared to those with Hepatitis C. The three-year survival rates for HIV patients were similar to those of uninfected patients (90%), while Hepatitis C patients had a lower rate (84%).
A recent study published in Microbiome reveals that fecal microbiota transplantation can effectively treat C. difficile infections, with sustained changes observed for up to 21 weeks. The research has significant implications for the regulation of treatment and suggests that current frameworks may not be applicable.
A study found that UK patients with cystic fibrosis who received transplants had better survival rates than publicly insured Americans. The research suggests that a single-payer national health care system can provide complex, coordinated and expansive care with long-term outcomes similar to those achieved by private insurance.
HIV+ kidney transplant recipients who are not infected with HCV have similar 5-year and 10-year kidney survival rates as uninfected recipients. Patient survival among mono-infected HIV+ recipients is also comparable to uninfected recipients, while co-infected patients experience inferior outcomes.
Acute liver failure patients can now undergo live donor liver transplantation in emergency situations without compromising patient safety. The procedure has been shown to have similar postoperative complication rates and 1-, 3-, and 5-year survival rates compared to deceased donor liver transplants.
A team of UK researchers has designed Arterio-Venous Fistulae with reduced failure rates using computational simulation software from the aerospace industry. The new design aims to decrease blockages in dialysis connections, improving clinical outcomes for patients with end-stage renal disease.