Research on cancer as a disease, from cause to care. Covers tumor biology, small-cell lung cancer, cancer-linked stroke risk, and cancer center research.
Researchers at Northwestern University identified a new evolutionarily conserved RNAi-based form of cell death called Death Induced by Survival gene Elimination (DISE), which targets essential survival genes in cancer cells. This mechanism is ancient and effective against all cancers tested.
Researchers developed three new two-photon probes that can visualize organelles in cells, enabling better understanding of cellular functions and tissue imaging. The probes are designed to detect pH levels, viscosity, and ionic species, providing more specific insights into cell viability and treatment responses.
Researchers have developed a new approach to treating invasive bladder cancer, combining chemotherapy and immunotherapy, which may preserve quality of life. In a phase 2 clinical trial, approximately 43% of patients achieved complete response without surgical removal of the bladder.
Researchers have discovered that brain tumors manipulate immune cells called neutrophils to promote tumor growth and suppress anti-cancer responses. The study identifies key mechanisms by which the tumor microenvironment converts neutrophils into immunosuppressive agents, providing new avenues for treating gliomas and brain metastases.
The American Society for Radiation Oncology announced the winners of its new combination therapy challenge, which aims to improve prostate cancer treatments using relugolix in combination with radiation therapy. The three winning research proposals will receive funding over four to five years.
A Rice University-led team of researchers has been awarded $45 million to develop a new sense-and-respond implant technology that could improve immunotherapy outcomes for patients with difficult-to-treat cancers. The technology, called THOR, aims to provide real-time data from the tumor environment to guide more effective therapies.
Scientists from IRB Barcelona have revealed how chromosomal instability activates a signalling pathway known as JAK/STAT, promoting caspase activity and DNA injury. This damage allows cells to escape from the primary tumour, thereby leading to metastasis.
Researchers identified potential therapeutic targets for Alzheimer's disease and other conditions using a new approach combining AI-driven target identification with protein phase separation analysis. The study provides insights into the role of protein phase separation in human disease and its potential as a therapeutic target.
Researchers at Mayo Clinic discovered that senescent macrophages in the lung promote tumor growth by blocking the immune system's response to abnormal cell growth. Eliminating these senescent cells delays tumor formation, suggesting a potential therapeutic target for cancer treatment.
Researchers discovered that fine-tuning mitochondrial energy production reduces melanoma tumor growth and enhances immune response in mice. The study reveals that manipulating mitochondrial electron transport increases expression of immune genes and makes tumor cells more visible to killer T cells.
Researchers found that combining adoptive T cell therapy with a personalized cancer vaccine improved control of the disease in 12 out of 17 patients with late-stage ovarian cancer. The treatment was also safe and relatively well-tolerated, with median overall survival time exceeding six months for most patients.
Researchers found that beta-blockers can revive exhausted killer T cells, making them better cancer fighters. The study discovered a link between the sympathetic stress response and immune system response to cancer.
A team at DGIST discovered a method to enhance magnetic nanoparticle penetration into cancer cells, improving therapeutic effects. Rotational magnetic fields aid in chain disassembly and propulsion of magnetic nanoparticles, increasing cellular absorption and treatment efficacy.
Veratramine from Veratrum japonicum significantly inhibits prostate cancer cell proliferation and survivability. The research team also found that veratramine increases ATM/ATR protein expression and suppresses Akt protein, leading to decreased tumor size and toxicity in immunodeficient mice.
Researchers found that inhibiting isocitrate dehydrogenase in T cells leads to transformation into memory cells with enhanced anti-tumor activity. This discovery could improve CAR-T and other adoptive cell therapies by overcoming exhaustion.
Researchers found higher 5-year survival rates among Kaiser Permanente patients compared to National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) estimates. Improved screening rates, cancer treatment pathways, and coordinated care may have contributed to these higher survival rates.
Researchers developed a technology to rapidly screen genetic edits in immune cells, identifying a new combination that improves their effectiveness against cancers. By combining multiple genes into long DNA stretches and testing thousands of combinations, scientists discovered that different CARs can be optimized by different factors.
The City of Hope will lead the way in integrating complementary therapies into cancer care, supporting holistic treatment for patients. The Cherng Family Center's research and clinical programs aim to advance evidence-based standards for integrative oncology, creating an international destination for its transformational work.
A first-of-its-kind study by LSU Health New Orleans found that chronic diseases, such as hypertension and diabetes, explained nearly two-fifths of the racial disparity in COVID-associated hospitalizations. Non-Hispanic Black cancer patients had a higher prevalence of chronic diseases and were more than twice as likely to live in high-p...
Researchers found that a combination of AXL and EGFR inhibitors can suppress tumor growth and prevent relapse in patients with certain cancers. The study clarifies the novel regulatory mechanism by which AXL stimulates YAP via the EGFR-LATS1/2 axis.
CityU and AFCR have signed a MoU to promote cutting-edge cancer-related innovative inventions and commercialization. The partnership aims to foster the development of biomedicine and related innovation, with world-leading scholars from Harvard Medical School attending the inaugural 'Innovation Series in Biomedicine' forum.
A recent special issue investigates the molecular mechanisms behind cancer's malignant phenotype, exploring topics such as metabolic reprogramming and tumor heterogeneity. The findings aim to contribute to the development of mechanism-based approaches for cancer treatment.
A systematic review found that antidepressants are equally effective and safe for patients with both depression and physical health issues as those without. The study suggests that treating these patients with antidepressants can improve quality of life and reduce the course of physical disease.
This review summarizes six common RNA modifications, including m6A, m5C, m1A, m7G, Ψ, and A-to-I editing, which play crucial roles in various human diseases. The authors discuss the mechanisms of these modifications and their targeting by small molecule inhibitors.
A new study from the University of Michigan found significant language-based disparities in patients' access to cancer care. English-speaking callers were able to get information on next steps 94% of the time, while Spanish-speakers and Mandarin-speakers were only connected at 38% and 28% respectively.
A team of Chinese and UK researchers has identified superoxide dismutase 1 (SOD1) as a potential target for reversing drug resistance in ovarian cancer. By using nanoparticles to deliver siRNA that reduces SOD1 levels, the study showed reduced growth and decreased resistance to cisplatin in female mice.
Research published in BMJ Oncology reveals a global increase of 79% in new cancer cases among those under 50 between 1990 and 2019. Breast cancer accounted for the highest number of early onset cases, while cancers of the windpipe and prostate rose the fastest.
Researchers developed a targeted microRNA therapy that slowed cancer tumor growth in a 21-day study. The therapy, which combines a delivery system with modified microRNA-34a, suppressed the activity of genes driving cancer and resistance to other therapies.
A study of 11.7 million adults in Ontario, Canada, reveals that COVID-19 infection is associated with significantly higher mortality rates among cancer patients who do not receive prioritized critical care treatment.
A novel liquid biopsy technology developed by UCSC Assistant Professor Daniel Kim's lab leverages RNA 'dark matter' to enhance cancer diagnosis. The test detects both protein-coding and repetitive noncoding RNAs in the blood, showing improved sensitivity for early-stage cancer detection.
A new study finds that cost-cutting policy changes, mobile apps, and psychological strategies can increase medication adherence by nearly 1.5 times among breast cancer survivors. The study also highlights the importance of managing side effects through physical therapy, exercise, and behavioral counseling.
A recent study by Osaka Metropolitan University researchers has discovered the anti-cancer effects of Kencur extract and its main active ingredient, ethyl p-methoxycinnamate (EMC). The findings indicate that EMC suppresses cancer cell growth at both cellular and animal levels.
Researchers found that ketogenic diets delay tumour growth but accelerate cachexia, a wasting syndrome that worsens disease prognosis. Dexamethasone may help optimise benefits by delaying cachexia.
Researchers found AI chatbot responses to top cancer queries are generally accurate but lack actionable information. These limitations suggest relying on chatbots for supplementary purposes rather than primary medical information.
Researchers from Brigham and Women's Hospital evaluated ChatGPT's recommendations for cancer treatment aligned with National Comprehensive Cancer Network (NCCN) guidelines. They found that approximately one-third of the chatbot's responses were non-concordant, highlighting its limitations in clinical decision-making.
Researchers found that certain anti-cancer compounds cause distinct nucleolar shapes and stress, which can be measured using a new classification system. This discovery could lead to improved understanding of why some drugs fail in clinical trials, providing a potential tool for identifying promising drug candidates.
Researchers at the Salk Institute discovered that high-fat diets change gut bacteria and bile acids, leading to inflammation and affecting intestinal stem cell replenishment. The altered bile acids cause inflammation and increase cancer risk in mice.
Researchers have discovered that estrogen promotes tumor growth in ERα-negative cancers, such as triple-negative breast cancer. Anti-estrogenic therapies, when combined with immune checkpoint inhibitors, drastically suppress tumor progression in mice models.
A new US study shows that e-cigarettes can help people quit smoking by reducing cravings and the number of cigarettes smoked. The naturalistic approach used in this study provides evidence that e-cigarettes are a valuable tool for adult smokers who have failed previous attempts to quit.
Researchers used base editors to introduce specific combinations of activating and inactivating mutations into healthy organoids, creating realistic models for various types of cancer. This allows for further investigation into the development and treatment of cancer, with potential applications including testing new drugs.
Researchers developed a natural product-inspired small molecule that binds to the cellular chaperone cyclophilin A, disrupting oncogenic signaling and tumor growth in several human cancer models. The approach could be used to target additional KRAS mutants and other cancer drivers.
A new study finds that people who adhere to a Mediterranean lifestyle have a lower risk of all-cause and cancer mortality. The study, led by La Universidad Autónoma de Madrid and Harvard T.H. Chan School of Public Health, analyzed data from 110,799 participants and found an inverse association between adherence to the Mediterranean lif...
Chronic disease medications impair the body's ability to regulate core temperature, increasing the risk of heat-related illness in elderly patients. Exercise and improved fitness levels can help mitigate these effects, but bodily impairments from chemotherapy and medications may limit exercise capacity.
Researchers have identified four metabolism-related biomarkers linked to an increased risk of metastatic prostate cancer in Black men. These biomarkers could lead to improved testing and treatments for this high-risk population, who are more than twice as likely to die from the disease.
A large long-term study found that good cardiorespiratory fitness in young men is associated with a significantly lower risk of developing nine specific cancers, including a 40% reduced risk of liver cancer. Higher fitness was also linked to lower risks of rectal, pancreatic, and bowel cancers.
Researchers successfully recreated lung cancer patient's internal environment using hydrogel and 3D bioprinting, preserving specific lung cancer subtype and genetic mutation characteristics. The study enables precise drug evaluation and personalized treatment options for lung cancer patients with underlying diseases.
A promising molecular diagnostic tool uses a single biomarker to detect primary bladder cancer in patients with hematuria, showing high sensitivity and accuracy. The noninvasive test offers advantages such as shorter turnaround time and efficient analysis of results.
Researchers find immunotherapy treatment anti-CTLA-4 leads to greater survival in mice with glioblastoma and discover new way cells kill cancer by triggering microglia, specialized immune cells in the brain. This breakthrough could lead to more effective treatments for human brain cancer.
A Harvard T.H. Chan School of Public Health study found that chronic exposure to fine particulate air pollutants (PM2.5) and nitrogen dioxide (NO2) increases the risk of colorectal and prostate cancers in older adults. NO2 exposure was also associated with an increased risk of breast cancer, while PM2.5 exposure had mixed results.
Researchers found that ranolazine, a heart medication, slows down tumor progression and increases visibility of melanoma cells to the immune system. This combination could improve response rates for immunotherapies in patients with melanoma.
A study of 15,000 adults found that alcohol consumption and risky drinking behaviors were prevalent among cancer survivors. The findings highlight the need for additional research to address the emerging concern of alcohol consumption in cancer patients.
A biomolecule has been engineered to selectively target and remove mucins from cancer cells, reducing tumor growth and increasing survival in lab-grown human cancer cells and mouse studies. This discovery could play a significant role in future therapies for cancer, as mucins are associated with many diseases.
A study in Cancer Medicine reveals that access to assisted suicide does not decrease conventional suicide among patients with cancer. In fact, the percentage of cancer-associated deaths by assisted suicide increased over time, while conventional cancer-related suicides showed a downward trend.
A Kaiser Permanente study found that drinking alcohol after a breast cancer diagnosis does not impact a patient's prognosis. The research used data from over 4,500 women diagnosed with invasive breast cancer and tracked their lifestyle changes and outcomes over 11 years.
Researchers developed an AI model called OncoNPC that can analyze genetic data to predict cancer type and origin. The model accurately classified at least 40% of tumors with unknown origin, leading to a 2.2-fold increase in eligible patients for targeted treatments.
Moderate and vigorous aerobic physical activity combined with muscle-strengthening activity may lower mortality risk. Higher levels of moderate and vigorous aerobic activity are associated with lower cancer and all-cause mortality rates.
Researchers at Uppsala University developed a new method to identify mutations in childhood brain tumors, medulloblastoma. The study found that these mutations can affect how cancer cells respond to certain drugs, suggesting a potential for precision medicine.
Researchers analyzed data from 230,000 individuals with second primary cancers, revealing higher mortality rates among Black and Hispanic populations compared to whites. The study highlights the need for targeted research on survival disparities in multiple primary cancer survivors.
Researchers highlight the need for effective treatment strategies for adenoid cystic carcinoma (ACC) of the head and neck, which is a highly malignant tumor with variable localizations. Proton therapy shows decisive advantages in long-term survival rates for ACC.
A study by Harvard T.H. Chan School of Public Health found that chronic exposure to fine particulate air pollutants (PM2.5) and nitrogen dioxide (NO2) may increase non-lung cancer risk in older adults, with significant associations with colorectal and prostate cancers.