Articles tagged with Cancer
A new study from Penn Medicine demonstrates that RN7SL1, a naturally occurring RNA, can activate the body's own natural T cells to seek out cancer cells that have escaped recognition by CAR T cells. This approach may help improve efforts to treat solid tumors.
Researchers have developed a new therapeutic method combining synthetic CDK4/6 inhibitors with IKKβ and AKT inhibitors to treat refractory cancers. The study found that this combination therapy can improve treatment outcomes for hepatocellular carcinoma, K-Ras oncogene mutated lung cancer, and colon cancer.
A new study found that immune checkpoint inhibitors are effective against HPV-positive head and neck cancers, with a potential therapeutic vaccination approach also being explored. Researchers discovered tumor-specific CD8 T cells in tumors from patients, which could provide a proliferative burst in response to PD-1 blockade.
PLOS Medicine features five studies outlining novel strategies for detecting cancer and identifying minimal residual disease. Researchers discuss innovative approaches, including plasma cell-free DNA sequencing and urine tumor DNA detection, to distinguish between benign and malignant tumors.
Researchers developed a blood test to detect cancer early in people with NF1, a genetic disorder that affects 1 in 3,000 people worldwide. The test differentiates between benign and aggressive tumors with high accuracy and could help monitor treatment responses.
A recent study found that 20% of children with cancer infected with SARS-CoV-2 developed severe infections, compared to 1-6% in general pediatric patients. The Global Registry of COVID-19 and Childhood Cancer also showed that cancer care was disrupted, with 56% of patients having modified treatment and 45% having chemotherapy withheld.
A population-based cohort study in Canada identified mortality patterns for different types of neuroendocrine tumors (NETs), revealing varying risks of cancer-related and non-cancer death. The study found that small NETs can be safely monitored, while larger tumors may require more aggressive treatment.
Researchers at the University of Southampton have identified a unique change in B cells that allows them to receive signals from molecules called lectins, enabling tumor growth. This discovery could pave the way for new treatments and early cancer detection methods.
Research of over 18,000 mother and child pairs found that maternal obesity was associated with a heightened risk of bowel cancer in adulthood. Conditions in the womb may be key risk factors for the disease, which is expected to increase globally due to rising rates among younger adults.
Researchers at Tokyo Medical and Dental University identified a microRNA molecule that can silence specific cancer-promoting genes, overcoming resistance to certain drugs. The study found that the miRNA target multiple genes and pathways simultaneously, making its impact potent.
Researchers identified DSS1 as a critical protein in breast cancer progression and found that depleting it makes cancer cells more responsive to lower doses of anti-cancer drugs. This technique may reduce drug-induced side effects in breast cancer patients, providing a safer treatment option.
A Korean National Health Insurance System study found frequent drinking is a more important risk factor for gastrointestinal cancers than the amount of alcohol consumed per occasion. This observational study suggests that individuals who drink frequently are at higher risk of developing gastrointestinal cancers.
Scientists at the University of Illinois have developed a method to regulate the Wnt signaling pathway using blue light, allowing them to study its functions in embryonic development and cancer. This approach enables precise control over the pathway's activity, potentially leading to new treatments for tissue repair and cancer research.
A Korean population-based cohort study found that cancer, particularly multiple myeloma and leukemia, is associated with an increased risk of kidney failure. The study included approximately 825,000 patients with cancer compared to twice as many without cancer, matched on other characteristics.
Black, Hispanic, Indigenous and Asian Americans remain underrepresented in pancreatic cancer clinical trials, despite federal mandates. The lack of diversity hurts patients and science alike, with racial and ethnic minorities accounting for a disproportionate burden of pancreatic cancer cases.
A study published in Cell Reports found that a protein called 5MP can regulate abnormal cellular translation and reduce neuronal decay. By increasing 5MP levels, researchers were able to repress neuronal toxicity and enhance the lifespan of affected flies.
Researchers found that combining entinostat with immunotherapy boosted cancer remission in mice by increasing neoantigen-specific T cells. The combination therapy showed promise in the lab and is being tested in an ongoing clinical trial for people with advanced bladder cancer.
Researchers found that removing race-based adjustments from equations estimating kidney function could make Black patients ineligible for cancer treatments and lower their doses. The analysis showed that Black patients in the US are more frequently diagnosed with cancer and are more likely to die from it than white Americans.
Researchers developed a new system to track tumor cell evolution and identify resistant cells, which can be used to test treatment effectiveness. The system, ClonMapper, allows for high-resolution study of clonal dynamics during tumor evolution and treatment.
A study by Virginia Commonwealth University found that cancer patients reported lower rates of marijuana use between 2013 and 2018, with only 9% using the substance. Higher pain levels and certain demographics were linked to increased marijuana use in this population.
Scientists at University of California San Diego School of Medicine have developed a method to keep cultured hematopoietic stem cells healthy, positive news for patients seeking stem cell transplants. The findings also hint at a new way to ward off aging by super-activating the heat shock pathway.
Abnormal cells that develop into oesophageal cancer start as stomach cells and can be reprogrammed to adopt an intestinal identity. The study identified two key genes, MYC and HNF4A, that switch tissue identity from stomach to intestinal cells.
Researchers have developed a two-arm molecule that selectively depletes regulatory T cells in tumors, allowing the immune system to fight off cancers without causing autoimmune diseases. The treatment led to significant tumor shrinkage in mouse models and showed promise for human patients.
Researchers discovered that hypoxia induces regional variations in gene-expression patterns in pancreatic cancer, with specific subpopulations of cancer cells surviving under hypoxic conditions. These findings suggest a link between hypoxia and aggressive tumor behavior, highlighting the need for targeted treatments.
A new study uses viruses to induce mutations in cancer-driving proteins, shedding light on drug resistance. The LentiMutate approach could aid in developing drugs that circumvent resistance and validate new targets.
Researchers have identified promising avenues for targeted nanoparticles in cancer immunotherapy, specifically targeting the tumor microenvironment. By activating dendritic cells and macrophages, nanoparticles can relieve hypoxia and change the state of an immunosuppressive TME to immunosupportive.
Researchers at ETH Zurich have developed a multi-component molecule that interacts with collagen, allowing for the visualization of new tissue growth in the body. This breakthrough could have applications in oncology and wound healing, enabling surgeons to more accurately remove tumors and investigate tissue formation.
A randomized clinical trial found that graphic warning labels on cigarette packaging changed the perception of US smokers, making them more likely to recognize the negative consequences of tobacco use and consider quitting. However, it did not significantly increase quit attempts or reduce nicotine addiction.
A comprehensive review of keto diets found potential health risks, including increased heart disease risk, cancer risk, and adverse effects on pregnant women and kidney patients. For most people, the possible long-term benefits of a keto diet are outweighed by its potential drawbacks.
A big data study from UNSW Sydney found that Australian cancer patients kept up their pharmaceutical treatments during last year's COVID-19 lockdowns. The researchers attribute the good news to relatively low rates of COVID-19 infections in Australia, which minimally impacted cancer treatment patterns.
The American Academy of Family Physicians is investigating an 'educational' session promoting dairy products linked to increased risk of prostate cancer and other diseases disproportionately affecting African Americans. The Physicians Committee for Responsible Medicine filed a complaint, citing standards set by the Accreditation Counci...
Mayo Clinic researchers used advanced imaging technology to visualize the BRCA1-BARD1 protein complex and its interaction with chromatin. The study provides new insights into how BRCA1-BARD1 functions, which could lead to improved cancer prevention efforts and drug development.
A meta-analysis of nearly 200,000 men revealed 22 new genetic locations associated with inherited testicular germ cell tumors. The findings could help doctors identify high-risk patients and signal them to screen for the disease.
Researchers have discovered a long-sought link between the mechanisms of cell division and cell adhesion, revealing a unifying control process. The study identifies CDK1 binding to talin as a key interaction, indicating a critical role in regulating cell proliferation and adhesion.
Researchers at University College London Great Ormond Street Institute of Child Heath have developed a new way to deliver drugs that can shut down cancer-promoting mutations in neuroblastoma. The nanoparticle-based treatment successfully silenced the MYCN gene, causing tumours to grow at a slower pace and prolonging survival.
A NIST-led study comparing 27 MRI scanners found significant bias and variation in T1 measurements, which can affect diagnosing brain tumors. The study recommends establishing rigorous quality control procedures for quantitative MRI to promote confidence and stability in measurement techniques.
Reactive oxygen species (ROS) are naturally produced during biochemical reactions within cells. They can induce apoptosis by activating cell death pathways, but high levels can promote cell proliferation and tumor progression.
Biologists have identified 71 new 'imprinted' genes in the mouse genome, which tend to be more active in one parental version than the other. The discovery sheds new light on epigenetics and its importance in health and disease.
A team of researchers from KTH Royal Institute of Technology has developed a novel nanoparticle design that enhances the contrast of living tissues for X-ray fluorescence imaging. This breakthrough enables early stage tumor detection with lower doses of radiation.
Researchers have identified wild relatives of chickpea as a natural source of resistance to Ascochyta blight, a devastating disease that can cause up to 100% yield loss. These wild plants, including Cicer reticulatum and Cicer echinospermum, have been found to be resistant to the disease.
Researchers at Universitat Autonoma de Barcelona developed a novel 3D microscopy analysis to recreate human glioblastoma features. This new approach provides complete information on tumor blood vessels and immune cell interactions, aiding diagnosis and therapy development.
A new UCF study examines the connection between saltwater leeches and a major disease of sea turtles, fibropapillomatosis. The researchers found a significant association between leech presence and FP tumor development in green turtles but not in loggerhead turtles.
Scientists have devised a new method to detect and potentially treat two rare pediatric diseases, Beckwith-Wiedemann syndrome and Silver-Russell syndrome, by measuring IGF2 levels in amniotic fluid. Treatment with an FDA-approved cancer medication before birth has shown promise in normalizing fetal growth in mouse models.
A recent study by University of Utah Health researchers has identified a genetic collaborator that influences the severity of the rare disease NGLY1. The gene NKCC1 moderates disease severity, with its interaction with NGLY1 affecting various bodily functions, including tear production and fluid balance.
The study highlights the importance of combining modern scientific achievements with innovative decisions to address the growing crisis of non-communicable diseases. Key factors include promoting healthy eating behaviour, lifestyle change, and cessation of smoking to effectively manage NCDs.
A Phase 2 clinical trial has demonstrated the efficacy of cabozantinib in reducing tumor volume and pain in patients with neurofibromatosis type 1. The treatment showed a partial response in 42% of patients, with significant reductions in tumor pain intensity.
A team of physicists from the University of Trento has developed a method to compute changes in protein shape and trajectory using quantum computers. This technology has implications for understanding neurodegenerative processes and developing new treatments.
Researchers have identified ferroptosis resistance as a critical issue in cancer treatment, highlighting the need for novel therapeutic strategies. The study integrates current understanding of signaling mechanisms to develop targeted treatments for therapy-resistant cancers.
Researchers have developed reconstituted in-vitro human organs called assembloids, which precisely mimic the structure and function of human tissues. The new technology surpasses current organoid technology by modeling complex diseases like cancer and neurological disorders.
Researchers have found that a transmissible cancer affecting Tasmanian devils is shifting from an emerging disease to an endemic one, slowing its spread. The disease appears to be reaching an equilibrium, allowing the population to naturally evolve and possibly resist the cancer.
A rare case of mediastinal tuberculoma mimicking a malignant cardiac tumor was diagnosed after postoperative pathological examination. Multimodality imaging, including echocardiography and contrast-enhanced ultrasonography, played a crucial role in distinguishing the benign condition from a malignant tumor.
Scientists have developed a new approach using nanosensors to detect trace amounts of biomarkers for early-disease diagnosis. The innovation increases detection speed by four times compared to common sensing techniques, enabling rapid disease tests that can be done at home or work.
Researchers found that gene activity increases when forces are applied perpendicularly to a cell, but decreases when forces are applied along the long axis. The findings could provide insights into diseases such as fibrosis and cardiovascular disease.
Folate, magnesium, and dairy products have been found to be associated with a lower risk of bowel cancer. A diet high in fibre, fruit, and vegetables also shows promise, while garlic, onions, tea, coffee, fish, and meat may not have the same protective effect.
A Swedish study of 381 patients with low-grade brain tumors found that just 28% returned to full-time employment within a year. Factors associated with lower return rates included advanced age, functional level, and previous sick leave.
A novel MAC-tag technology protocol has been introduced for detailed understanding of protein-protein interactions and regulation of cellular networks. The protocol combines state-of-the-art methods AP-MS and BioID to identify protein-protein interactions, providing insights into disease mechanisms.
A diagnostic startup, Amplified Sciences LLC, is seeing growing interest and support for its innovations in detecting debilitating diseases. The company has received $1.1 million in seed funding and has been accepted into the National Institutes of Health's Applicant Assistance Program.
Scientists have developed an alternative approach to traditional immunohistochemistry, leveraging RNA sequencing to analyze tumor samples. The new method reveals correlations between specific biomarker genes and cancer diagnosis outcomes.
Researchers at Tokyo University of Agriculture and Technology have developed a new cell culture process that can replicate cancer cells from diseased bladder tissue in dogs, allowing for more efficient cancer research. This breakthrough method enables the diagnosis and treatment of cancer without using costly stem cell products or trad...
The European League Against Rheumatism (EULAR) has launched a Virtual Research Centre to address barriers in rheumatic and musculoskeletal disease research. The centre aims to facilitate collaborative research, provide access to resources and technology, and develop broad coalitions for innovation and training.