Research on cancer as a disease, from cause to care. Covers tumor biology, small-cell lung cancer, cancer-linked stroke risk, and cancer center research.
Researchers from Osaka University have discovered a way to deliver antisense oligonucleotides to their targets inside cancer cells by opening specific calcium permeable channels. The new compound, L687, promotes efficient uptake of ASO into cancer cells, suppressing target gene activity and enhancing ASO efficacy.
A study by NUS scientists found that a chemical produced when cells break down glucose can cause DNA faults indicating higher cancer risk. High levels of this chemical, methylglyoxal, may be controlled with medicines and a good diet.
Researchers have gained new insights into the development of cells, their communication with each other, and regulation at the gastro-esophageal junction. The study reveals complex cellular communication and signaling pathways, which has significant implications for understanding, preventing, and treating gastrointestinal diseases.
Researchers discovered a key resistance mechanism to Wnt inhibitors in pancreatic and colorectal cancers, identifying FBXW7 mutations as the culprit. This breakthrough could lead to personalized treatments for cancer patients who have previously been unresponsive to existing therapies.
Researchers at IRB Barcelona have identified 'coldspots' in the cancer genome with lower mutation rates, linked to low DNA methylation. This discovery could facilitate targeted therapies and diagnostic tools to monitor specific genomic regions and prevent cancer development.
A systematic review of 41 randomized clinical trials suggests that late-stage cancer incidence can be a suitable alternative end point to cancer-specific mortality in some cancer types, but not others. This finding has implications for multicancer screening tests and may change the way these trials are designed.
Most cancer drugs granted accelerated approval show no benefit in overall survival or quality of life within five years. Patients should be informed about the limited effectiveness of these drugs.
A simple urine test can reduce the number of cystoscopies required to follow up high-risk bladder cancer patients by more than half. The test monitors for recurrence of bladder cancer by measuring levels of five target mRNAs and was found to be effective in picking up cancer recurrence before any disease was visible through a cystoscopy.
A simple blood test every five years is sufficient to screen low-risk men for prostate cancer, according to new research. Researchers found that only 0.13% of men with low PSA levels developed cancer after a decade.
Global prostate cancer cases are projected to double from 1.4 million in 2020 to 2.9 million by 2040, with low- and middle-income countries seeing the highest increases. The number of annual deaths is predicted to rise by 85%, mainly in LMICs due to under-diagnosis.
Recent trials have shown that testing for tumour DNA in the blood can identify advanced bladder cancer patients who are less likely to relapse after surgery, allowing doctors to target treatments more effectively.
Researchers found that discontinuing specialist follow-up care for patients with slow-growing CLL had no negative impact on survival, hospital visits or infections. Most patients who ended follow-up developed minor infections treated with antibiotics.
Researchers at Kyushu University identified a new type of tumor cell population, steroids-producing nodules (SPNs), which lead to cortisol-producing adenomas. The study provides clues into the formation and maintenance of the human adrenal cortex.
Polybrominated diphenyl ether exposure significantly associated with cancer mortality and all-cause mortality. Further studies needed to replicate findings and understand underlying mechanisms.
Researchers from Osaka University found that exposure to environmental carcinogens and psychological distress decrease emotional wellbeing in Japanese people, with a 0.0064-year decrease for radon and 0.97 years for psychological distress. The study suggests that reducing exposure to these chemicals can help promote longer, happier lives.
Low HPV vaccine uptake among US adults aged 27-45 is a concern, particularly for men and Hispanic individuals. Experts stress the need to address disparities in vaccination rates to prevent cancer cases.
A randomized controlled trial found that filters, coupled with a digital health program, reduced urinary arsenic levels by 47% in households relying on well water. The study, conducted in American Indian communities, also showed significant increases in household use of filtered water for drinking and cooking.
A genetic variant reducing IKZF1 expression increases B-cell ALL risk in Hispanic/Latino kids, with ancient DNA tracing its emergence ~13,000 years ago from Indigenous American ancestors.
Researchers uncover how EBV infects host genome, leading to tumor formation and finding novel therapeutic targets. EBV-host interactions reveal epigenomic rewiring, dysregulated gene expression, and potential cancer treatment.
A large cohort study found that longer durations of exclusive breastfeeding were associated with a lower risk of childhood B-cell precursor-acute lymphoblastic leukemia. The study's results suggest potential biologic mechanisms underlying this association and inform the need for further research on preemptive interventions.
Researchers at RCSI have identified a new treatment option for multiple myeloma by combining venetoclax with 5-azacytidine. This combination shows enhanced efficacy across various patient samples and has the potential to expand treatment options for those resistant to standard care.
Researchers suggest a follow-up colonoscopy within defined periods after abnormal stool-based screening test results. The proposed measure aims to address low current performance rates and produce reliable results.
Organoid technology holds great potential for clinical applications, particularly in cancer. Patient-derived tumor organoids effectively recapitulate the histopathologic characterization of parental tumors and exhibit a degree of preservation of genomic features.
Researchers have developed a new tool to help clinics recruit patients from more communities by analyzing nearby hospitals serving diverse populations. The approach aims to increase accessibility and diversity in cancer trials, with the potential to improve patient outcomes.
Researchers have discovered a new immunotherapy approach to overcome resistant leukemia by targeting the mutated TP53 gene. Combining pharmacological therapies with genetically engineered CAR T-cells increases effectiveness against cancer cells, offering promising strategies for patients with resistant disease.
The Pediatric Cancer Research Foundation has expanded its leadership team with the appointment of Danielle Fragalla as CEO and Jeri Wilson as Vice President of Development, Principal Gifts. The foundation aims to accelerate research breakthroughs in pediatric cancer care, having granted $46 million to leading researchers so far.
NeXT Personal assay detects up to ~1,800 somatic variants specific to the patient's tumor with a detection threshold of 1.67 PPM and 99.9% specificity. The assay showed linearity over a range of 0.8 to 300,000 PPM.
A randomized controlled trial found that exercise programmes reduced fatigue and improved quality of life for patients with metastatic breast cancer. The study showed the greatest benefit among younger patients, but also suggested that supervised exercise can be beneficial for all patients with advanced disease.
The ALEXANDRA/IMpassion030 phase 3 trial found that adding atezolizumab to chemotherapy after surgery did not improve survival for early-stage triple-negative breast cancer patients. Researchers also found no benefit in different sub-groups, such as those with lymph node spread and PD-L1 positive cancer.
Researchers identified a case of chronic inflammatory bowel disease after a blood stem cell transplant, linked to a genetic mutation in the recipient's body. Genetic analysis revealed that the donor carried a similar mutation, which triggered an autoimmune response.
A study by IRB Barcelona and Sant Joan de Déu Hospital reveals three distinct patterns explaining the occurrence of second cancers in children, including a mutational footprint from chemotherapy. The research advances understanding of pediatric cancer and highlights the importance of clinical data sharing.
A KAIST-Seoul National University Hospital research team has developed a computational workflow that predicts metabolites and metabolic pathways associated with somatic mutations in cancers. The workflow uses genome-scale metabolic models and mutation data to identify altered metabolic pathways that contribute to cancer progression.
A Phase III clinical trial showed that cancer patients who received specialized mental health support experienced lasting improvements in quality of life, reduced pain, depression, and fatigue. The intervention also led to lower risk of cardiovascular disease in family caregivers and substantial cost savings for the healthcare system.
A recent study published in the Journal of Veterinary Medicine found no significant correlation between canine lymphoma and proximity to environmental toxins. Researchers used data from Morris Animal Foundation's Golden Retriever Lifetime Study to map dog home addresses to radon zones and fracking wells, but did not find a link.
Researchers at the University of Southern Denmark have discovered a new function of the MYC protein, which plays a crucial role in cancer cell growth and division. The study shows that MYC can activate genes on both promoters and enhancers, driving cancer progression.
Researchers discovered that lung cancer cells can persist in the presence of cigarette smoke due to a protein pump called ABCG2, which clears damaging molecules from the cells. This mechanism could also contribute to resistance to pharmaceutical treatments in cancer cells.
Researchers developed protein-based microcapsules to enhance aptamer sensors, enabling direct detection of target molecules in biological samples. The system demonstrates robust protection against harmful proteins and simultaneous real-time sensing of multiple targets.
ISB researchers identify NKG2A-biased immune responses as protective against decreased inflammation and increased survival rates in various disease contexts. The study suggests potential therapeutic targets for modifying immune responses across diseases.
Children's Hospital Los Angeles will develop innovative stem cell approaches to treat children and adolescents with recurrent solid tumors using CAR T-cell therapy. The new approach targets B7H3, an immune marker on cancer cells, to identify and destroy them.
The European LeukemiaNet has published two-part guidelines for adult acute lymphoblastic leukemia treatment, covering diagnostics, prognostic factors, response assessments, and comprehensive management. These recommendations are based on a decade of systematic work by European experts, improving the prognosis of adult patients with ALL.
A study of 34,500 patients found racial and ethnic disparities in locally advanced rectal cancer treatment outcomes may be influenced by unidentified biological or social factors. Non-Hispanic Black patients were more likely to experience poorer outcomes.
A team of Rice University researchers has developed a platform for integrating DNA and RNA data from single-cell sequencing with greater speed and precision. The method, MaCroDNA, relies on a classical algorithm to identify matching pairs of data and outperformed state-of-the-art technologies in accuracy measurements.
Researchers have discovered that certain volatile compounds emitted by microbes and food can alter epigenetic states in neurons and other eukaryotic cells. Exposure to these compounds can slow down neurodegeneration and cancer, while also affecting plant growth and responses to stress.
The COVID-19 pandemic has widened socioeconomic disparities in death at home and access to specialized palliative care for cancer patients. The study found that these disparities were amplified, highlighting the need for equitable and consistent care access.
A team of researchers from Wayne State University and the Barbara Ann Karmanos Cancer Institute have received a five-year, $9.6 million grant to improve the identification and clinical management of hereditary and multiple primary cancers in African Americans. The study aims to overcome barriers to genetic testing in this population.
Researchers highlight difficulties in targeting metastatic tumors and propose two- and three-drug combinations to achieve effective tumor control. They also emphasize the need for simultaneous blocking of primary driving oncogene, evolving resistance mechanism, and secondary survival pathway.
A recent study by Cold Spring Harbor Laboratory researchers reveals that chronic stress can increase cancer's ability to spread. By mimicking chronic stress in mice with cancer, the team discovered that stress causes neutrophils to form sticky web-like structures called NETs, making body tissues more susceptible to metastasis.
A study published in JAMA Oncology revealed a significant decline in US cancer incidence during the first 10 months of the pandemic. The research found 134,395 potentially undiagnosed cancer cases between March and December 2020, highlighting an unusual drop in all-site cancer incidence.
Men with low sperm count or none have a higher risk of developing cancer, including at younger ages, compared to fertile men. Families of azoospermic men have a significantly increased risk of five cancers, while families of oligozoospermic men have a higher risk of colon, bone and joint, and testicular cancers.
Researchers developed a novel machine learning-based approach to analyze diffuse reflectance spectroscopy data, achieving higher accuracies and speeds than existing methods. The 'wavelength-independent regressor' model overcomes use-error limitations by incorporating diverse datasets, making it suitable for clinical settings.
Scientists at CeMM Research Center have discovered a new method to mark proteins for destruction, potentially treating diseases like cancer. The technique uses 'intramolecular bivalent glues' to alter the protein's surface, triggering targeted protein degradation via ubiquitin ligases.
Scientists have discovered that pancreatic cancer hijacks the brain-building protein Engrailed-1, leading to faster and deadlier metastasis. By targeting this aberrant protein, researchers may be able to develop personalized therapies and slow cancer progression.
A recent study has uncovered 145 genes crucial for genome stability, shedding light on genetic factors influencing human health over a lifespan. The research highlights the potential of SIRT inhibitors as a therapeutic pathway for cohesinopathies and other genomic disorders.
A team of physicists and veterinary scientists at Purdue University has developed a method to detect chemoresistance in cancer patients using biodynamic imaging (BDI). This technique measures the motions inside cancer cells and how they respond to chemotherapy, identifying patients who will not respond to treatment. The study shows pro...
A new study from the University of Ottawa proposes using vanoxerine, a drug initially developed for cocaine addiction, to potentially treat advanced colon cancer. Vanoxerine has been found to suppress cancer stem cell activity in colon cancer patients' tissues and tumours implanted in laboratory animals. The drug works by interfering w...
A small, wearable ultrasound sticker can monitor organ stiffness and detect subtle changes that signal disease progression. The device has been shown to identify early signs of acute liver failure in rats and may one day help doctors diagnose internal organ failure more effectively.
Researchers propose a novel augmentation regimen, IPIAD, combining five generic non-oncology drugs with standard chemotherapy for pancreatic ductal adenocarcinoma. The IPIAD regimen uses repurposed drugs like irbesartan and azithromycin to potentially slow disease growth and improve outcomes.
Researchers identified mechanisms that cause ponatinib to harm the heart and found a promising treatment that could reverse this process. The treatment protects heart cells without diminishing the tumor-fighting efficacy of the drug.
A recent study found that only half of hookah packages included the required nicotine warnings, two years after federal regulation was implemented. The study led by Boston University School of Public Health researcher Dr. Jennifer Ross highlights the importance of warning labels in communicating health risks to consumers.
A study of 2.9 million Korean adults found that quitting smoking at any age reduced the risk of cancer, particularly lung cancer, after 10 years. Early cessation before middle age led to a substantial risk reduction in lung cancer.