Articles tagged with Cancer
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Researchers at University College London Great Ormond Street Institute of Child Heath have developed a new way to deliver drugs that can shut down cancer-promoting mutations in neuroblastoma. The nanoparticle-based treatment successfully silenced the MYCN gene, causing tumours to grow at a slower pace and prolonging survival.
Researchers have discovered a long-sought link between the mechanisms of cell division and cell adhesion, revealing a unifying control process. The study identifies CDK1 binding to talin as a key interaction, indicating a critical role in regulating cell proliferation and adhesion.
Reactive oxygen species (ROS) are naturally produced during biochemical reactions within cells. They can induce apoptosis by activating cell death pathways, but high levels can promote cell proliferation and tumor progression.
A NIST-led study comparing 27 MRI scanners found significant bias and variation in T1 measurements, which can affect diagnosing brain tumors. The study recommends establishing rigorous quality control procedures for quantitative MRI to promote confidence and stability in measurement techniques.
Biologists have identified 71 new 'imprinted' genes in the mouse genome, which tend to be more active in one parental version than the other. The discovery sheds new light on epigenetics and its importance in health and disease.
A team of researchers from KTH Royal Institute of Technology has developed a novel nanoparticle design that enhances the contrast of living tissues for X-ray fluorescence imaging. This breakthrough enables early stage tumor detection with lower doses of radiation.
Researchers have identified wild relatives of chickpea as a natural source of resistance to Ascochyta blight, a devastating disease that can cause up to 100% yield loss. These wild plants, including Cicer reticulatum and Cicer echinospermum, have been found to be resistant to the disease.
Researchers at Universitat Autonoma de Barcelona developed a novel 3D microscopy analysis to recreate human glioblastoma features. This new approach provides complete information on tumor blood vessels and immune cell interactions, aiding diagnosis and therapy development.
A new UCF study examines the connection between saltwater leeches and a major disease of sea turtles, fibropapillomatosis. The researchers found a significant association between leech presence and FP tumor development in green turtles but not in loggerhead turtles.
Scientists have devised a new method to detect and potentially treat two rare pediatric diseases, Beckwith-Wiedemann syndrome and Silver-Russell syndrome, by measuring IGF2 levels in amniotic fluid. Treatment with an FDA-approved cancer medication before birth has shown promise in normalizing fetal growth in mouse models.
A recent study by University of Utah Health researchers has identified a genetic collaborator that influences the severity of the rare disease NGLY1. The gene NKCC1 moderates disease severity, with its interaction with NGLY1 affecting various bodily functions, including tear production and fluid balance.
The study highlights the importance of combining modern scientific achievements with innovative decisions to address the growing crisis of non-communicable diseases. Key factors include promoting healthy eating behaviour, lifestyle change, and cessation of smoking to effectively manage NCDs.
A Phase 2 clinical trial has demonstrated the efficacy of cabozantinib in reducing tumor volume and pain in patients with neurofibromatosis type 1. The treatment showed a partial response in 42% of patients, with significant reductions in tumor pain intensity.
A team of physicists from the University of Trento has developed a method to compute changes in protein shape and trajectory using quantum computers. This technology has implications for understanding neurodegenerative processes and developing new treatments.
Researchers have identified ferroptosis resistance as a critical issue in cancer treatment, highlighting the need for novel therapeutic strategies. The study integrates current understanding of signaling mechanisms to develop targeted treatments for therapy-resistant cancers.
Researchers have developed reconstituted in-vitro human organs called assembloids, which precisely mimic the structure and function of human tissues. The new technology surpasses current organoid technology by modeling complex diseases like cancer and neurological disorders.
Researchers have found that a transmissible cancer affecting Tasmanian devils is shifting from an emerging disease to an endemic one, slowing its spread. The disease appears to be reaching an equilibrium, allowing the population to naturally evolve and possibly resist the cancer.
A rare case of mediastinal tuberculoma mimicking a malignant cardiac tumor was diagnosed after postoperative pathological examination. Multimodality imaging, including echocardiography and contrast-enhanced ultrasonography, played a crucial role in distinguishing the benign condition from a malignant tumor.
Scientists have developed a new approach using nanosensors to detect trace amounts of biomarkers for early-disease diagnosis. The innovation increases detection speed by four times compared to common sensing techniques, enabling rapid disease tests that can be done at home or work.
Researchers found that gene activity increases when forces are applied perpendicularly to a cell, but decreases when forces are applied along the long axis. The findings could provide insights into diseases such as fibrosis and cardiovascular disease.
Folate, magnesium, and dairy products have been found to be associated with a lower risk of bowel cancer. A diet high in fibre, fruit, and vegetables also shows promise, while garlic, onions, tea, coffee, fish, and meat may not have the same protective effect.
A Swedish study of 381 patients with low-grade brain tumors found that just 28% returned to full-time employment within a year. Factors associated with lower return rates included advanced age, functional level, and previous sick leave.
A novel MAC-tag technology protocol has been introduced for detailed understanding of protein-protein interactions and regulation of cellular networks. The protocol combines state-of-the-art methods AP-MS and BioID to identify protein-protein interactions, providing insights into disease mechanisms.
A diagnostic startup, Amplified Sciences LLC, is seeing growing interest and support for its innovations in detecting debilitating diseases. The company has received $1.1 million in seed funding and has been accepted into the National Institutes of Health's Applicant Assistance Program.
Scientists have developed an alternative approach to traditional immunohistochemistry, leveraging RNA sequencing to analyze tumor samples. The new method reveals correlations between specific biomarker genes and cancer diagnosis outcomes.
Researchers at Tokyo University of Agriculture and Technology have developed a new cell culture process that can replicate cancer cells from diseased bladder tissue in dogs, allowing for more efficient cancer research. This breakthrough method enables the diagnosis and treatment of cancer without using costly stem cell products or trad...
The European League Against Rheumatism (EULAR) has launched a Virtual Research Centre to address barriers in rheumatic and musculoskeletal disease research. The centre aims to facilitate collaborative research, provide access to resources and technology, and develop broad coalitions for innovation and training.
Scientists have revealed the first known atomic structure of a molecular machine responsible for installing critical signaling proteins into cellular membranes. The study provides new insights into how membrane proteins become established in membranes and how they change from their unstructured form to their functional form.
A new MRI technique has been developed to improve the detection of tumors by enhancing the accuracy of apparent diffusion coefficient (ADC) measurements. The technique uses a phantom designed to assess imaging quality and simulate hindered and restricted diffusion, allowing for more precise tumor differentiation.
Researchers at Kazan Federal University have developed new in vitro test systems for selecting effective antitumor drugs, which take into account the complex interactions between tumor cells and healthy tissue. The new models aim to improve primary screening of substances with antitumor activity.
Menkes disease is a rare genetic disorder caused by a copper deficiency, leading to severe brain damage and neuromuscular deficits. Researchers from Texas A¼M have found promising results using the cancer drug elesclomol to deliver copper to tissues and restore energy production.
A Drexel University study found that using broad diagnostic terms like 'autoimmune disease' alongside narrow ones helps patients communicate their experiences. This broad category simplifies explanation to family, friends, and clinicians, even with changing diagnoses.
Researchers discovered a rare disease called Langerhans cell histiocytosis (LCH) in the fossilized tail of a young dinosaur that lived in Canada 60 million years ago. The study found that the disease has survived for over 60 million years and still affects humans, particularly children under 10.
Intratumoral SD-101 injection complements low-dose cyclophosphamide in boosting innate immunity and driving potent T cell-mediated anti-tumor responses. This combination therapy improves efficacy against non-injected tumors and long-term survival, even in large tumors.
A genome-wide association study found nine gene locations associated with eating certain foods, including tofu, cheese, and tea. The study identified six genetic variants linked to at least one disease phenotype, including several types of cancer and type-2 diabetes.
A study by Florida Atlantic University found that 75% of green sea turtles with fibropapillomatosis did not survive rehabilitation despite tumor removal surgery. Tumors often regrew within 46 days, leading to prolonged rehabilitation times.
A new study published in BMJ found that middle-aged individuals who practice five healthy habits at age 50 can live an average of 34.4 more years free of chronic diseases such as diabetes, cardiovascular disease and cancer compared to those with none
Scientists at Newcastle University have made a breakthrough in understanding CYLD cutaneous syndrome, a rare genetic skin disease. Changes in the DNA of tumour cells were identified, which may provide a target for new treatments to inhibit their growth.
Researchers from CNIO developed stable long-term cultures of mouse urothelial cells, enabling the study of biological mechanisms underlying bladder cancer. They identified a small population of stem cells that gives rise to cancer, providing new insights into disease development and tissue regeneration.
Researchers prove the psychosine hypothesis correct by showing that mice with genetic mutations causing both Krabbe and Farber diseases do not develop Krabbe disease. They then test a drug known to inhibit acid ceramidase, carmofur, which modestly extends the lives of mice with a model of Krabbe disease.
Researchers develop a new imaging technology that uses laser light to distinguish between cancerous and healthy tissues during surgery, potentially eliminating the need for secondary surgeries. This innovation has the potential to save time, money, and anxiety in cancer treatment, while also reducing the economic burden of healthcare.
Researchers have sequenced the microbiome within crown gall tumors of grapevines, providing a database to assess disease stage and paving the way for new advances to combat the debilitating disease. The study sheds light on the complex interaction between the grapevine and its microbial community.
The fruit fly Drosophila melanogaster produces more Defensin, which interacts with dying tumour cells and kills them, while sparing normal cells. This finding reveals an anti-tumour role for Defensin and provides insights into the molecular mechanisms behind AMPs' killing action.
Researchers at Ruhr-Universität Bochum identified a new mechanism for deactivating switch proteins, which regulate various body processes. The discovery provides insights into disease mechanisms and could lead to the development of anti-cancer drugs.
A new study published in European Journal of Human Genetics reveals that the left-handed Z-DNA conformation plays a key role in regulating type I interferon responses, which are involved in fighting viruses and cancer. The study analyzes families with variants in the ADAR gene and confirms a biological function for the left-handed conf...
A new study published in Evolutionary Applications suggests that Devil Facial Tumour Disease (DFTD) and Devil Facial Tumour 2 (DFT2) are confined to the Channel region of Tasmania. The research credits the cooperation of local residents for identifying the geographic footprint of DFT2.
Researchers have developed a new, 3D tissue imaging technique that allows for the study of cell details without cutting tissues. This enables better diagnosis and treatment for diseases like cancer by distinguishing between subtypes.
Recent advances in stem cell biology have enabled long-term culturing of organotypic intestinal or hepatic tissues derived from tissue-resident or pluripotent stem cells. Organoids can recapitulate the in vivo architecture, functionality, and genetic signature of the corresponding tissue.
Kipoi provides free access to trained machine learning models, accelerating genomics community exchange and advancing genome research. The platform simplifies data feeding and transfer learning, making it accessible to researchers without machine learning experience.
Researchers found that being an occupant in a motor vehicle accident increases the risk of heart failure or stroke in older adults. The study used U.S. and Danish hospitalization data to confirm these findings.
Researchers use optical coherence tomography to analyze tissue samples and identify differences between malignant and healthy cells, simplifying tumor removal operations. The technology offers higher resolution than ultrasound or MRI, allowing for more accurate diagnoses and improved patient outcomes.
Researchers used protein sequence-based methods to diagnose an ancient and atypical form of Paget's disease in medieval skeletons. The study found extensive pathological changes, high disease prevalence, and low age-at-death estimations for affected skeletons.
Researchers found that Aronia berries resistant to heat during production of cornmeal porridge, retaining antioxidant content. The study highlights the potential of super berries like Aronia for functional foods like porridge.
The report highlights the expanding role of interventional inflammatory bowel disease (IBD) endoscopy in managing complex conditions, such as strictures, fistulas, and colitis-associated neoplasia. This approach can help reduce or postpone surgical resection and treat postoperative adverse events.
Researchers found that terminally ill cancer patients who have hope, positivity and family support can live well during advanced stages. The study identified a five-phase iterative process involving struggling, accepting, living with the illness, sharing the experience, and reconstructing life.
A new study by Swansea University suggests that Tasmanian Devil Facial Tumour Disease (DFTD) is unlikely to cause the extinction of the iconic species. The researchers found that the disease is more likely to fade out or coexist with devils in future, providing much-needed hope for the species' survival.
A new study published in Radiology suggests that personalized treatment plans can significantly extend the life expectancy of early-stage kidney cancer patients with risk factors for worsening kidney disease. The study used computer-based simulations to assess the impact of different treatment approaches and found that personalized str...
A new study published in PLOS Medicine found that individuals with two or more chronic diseases incur significantly higher healthcare costs compared to those with a single disease. The study analyzed data from New Zealand and estimated the annual health expenditure per person for six non-communicable disease classes.
Researchers used noncontact imaging to differentiate malignant cells and monitor treatment effectiveness, revealing mechanical properties of tumors that influence disease progression. This technique may lead to personalized therapies and more effective treatments.
A Malaysian study found that 42.6% of smokers who attended a quit clinic successfully quit, with daily cigarette count and previous attempts as key predictors. The study suggests these factors should be considered in interventions for smokers trying to quit.