Articles tagged with Cancer
Researchers at UC Irvine and IIT develop ALY101, a compound that blocks protein-protein interactions crucial for cancer and rare disease progression. The findings validate a new approach to structure-based drug design, with potential applications in monotherapy or combination regimens.
A recent study found that cancer treatment side effects significantly affect patients' and caregivers' eating habits, food preferences, and overall well-being. The research team identified six themes, including managing symptoms, losing taste, and caregiver burden.
Researchers will present breakthroughs in tumor immunology, cancer drug resistance, and early detection methods. The AACR Annual Meeting features a diverse range of studies on various aspects of cancer research.
A study in rats suggests that vitamin C supplementation can help preserve skeletal muscle after doxorubicin therapy, reducing oxidative stress and inflammation. The findings suggest vitamin C may represent a promising opportunity to reduce some of the drug's most debilitating side effects.
Researchers have discovered 23 proteins in breast milk that could indicate breast cancer, paving the way for a potential blood test. The study's findings, if confirmed, may enable earlier diagnosis and improve survival rates.
A new study found that exercising before developing cancer reduced tumor growth and cachexia symptoms in mice. Regular exercise improved cardiac structure and function, and helped slow tumor growth even after cancer was induced.
A new study suggests that cardamonin, a compound from the cardamom spice, can kill triple-negative breast cancer cells and reduce PD-L1 expression. The findings hold promise for improving cancer therapy without severe side effects.
A study analyzing blood samples from premenopausal women with breast cancer found high levels of inflammatory markers and low antioxidant levels. These findings may reveal a new diagnostic tool for the disease, with implications for identifying early stages and improving treatment outcomes.
The NCCN Annual Conference focuses on the cancer patient journey, featuring state-of-the-art practice algorithms, updates to clinical guidelines, and new therapies. Leading experts present treatment recommendations for various cancer types, including breast, colorectal, and lung cancer.
The study reveals a narrowing gap between cancer profiles in China and the USA, with converging trends in lung, breast, and colorectal cancers. China's cancer burden is expected to rise, while the US has seen reduced rates since the 1990s due to effective prevention strategies.
Research at Universidad Complutense de Madrid found that tumour cells from childhood acute lymphoblastic leukaemia (ALL) can hide in the subventricular neurogenic niche, causing relapses and preventing new neurone generation. This discovery may explain cognitive and sensory alterations in ALL survivors.
Researchers at Okayama University have created a new method to kill cancer cells using light-activated protein AR3, reducing the risk of adverse reactions. The approach uses green light to trigger apoptosis in targeted cells, offering a promising alternative to conventional treatments.
A study published in eLife suggests that accelerated epigenetic age acceleration may increase the risk of bowel cancer. Biological age measured by an epigenetic clock was found to be associated with a 12% increased risk of bowel cancer, particularly colon cancer.
A study published in JAMA Network Open found that Black patients with cancer faced significantly poorer COVID-19 outcomes, including higher hospitalization rates and death tolls. Structural racism in healthcare systems is believed to be a key factor contributing to these disparities.
A new study by University of Southampton researchers found that a third COVID-19 vaccination improves immune responses in blood cancer patients. The study showed that 92% of patients without recent anti-CD20 treatment had improved antibody responses after the third dose.
This year's Experimental Biology 2022 meeting features groundbreaking studies on COVID-19 vaccine-associated symptoms in non-menstruating people, a plant compound showing promise for alleviating food allergies, and the potential of omega-3s to boost immunotherapy's cancer-fighting power. Researchers also explore the safety of using CBD...
A Spanish national registry study found that over half of diagnosed lung cancer patients undergo biomarker testing, with a significant increase over the last five years. Nearly half of patients with positive test results received targeted treatment.
Researchers at ChristianaCare's Gene Editing Institute describe a new process for evaluating the impacts of gene edits that alter rather than completely disabling DNA code. The study validates the safety and efficacy of their novel approach for using CRISPR to improve lung cancer treatments.
Columbia University researchers have engineered a microbial encapsulation system that temporarily hides therapeutic bacteria from immune systems, allowing them to deliver drugs to tumors and kill cancer cells in mice. The system, called iCAP, controls the bacteria's surface by manipulating gene circuits.
The European Lung Cancer Congress 2022 focused on the latest advancements in lung cancer treatment, including personalized strategies for better patient care. The congress also explored emerging therapies and molecular sub-types to enhance precision medicine.
A new study published in Annals of Internal Medicine found that state laws regulating opioid prescriptions had no effect on prescribing patterns for commercially insured adults with chronic non-cancer pain. The study suggests that declines in opioid prescribing may be driven by shifting clinical guidance or other factors.
The National Comprehensive Cancer Network has published new consensus recommendations to improve the safety and efficiency of research studies involving investigational drugs. The recommendations focus on seven areas, including pharmacy workflows and collaboration with sponsors.
Research found a significant drop in new cancer diagnoses during the COVID-19 pandemic, particularly for screening cancers like breast, cervical, and colorectal cancer. The study estimates around 12,600 cancers went undetected between March 2020 and September 2020.
Researchers at Ludwig Stanford University have solved the structure of a key protein involved in immune cell signaling and blood cancers. The study reveals how mutant versions of this protein lead to continuous growth signals, driving cell proliferation and blood cancers.
Researchers at UCSF develop a new cancer treatment that targets RAS-mutated tumors by exploiting their high levels of ferrous iron. The treatment, TRX-cobimetinib, is more effective and tolerable than current treatments like cobimetinib, which can cause serious side effects in normal tissues.
A novel radioligand therapy has been shown to increase progression-free survival (PFS) and overall survival (OS) of metastatic castration-resistant prostate cancer (mCRPC) patients. Ninety-one percent of patients experienced a greater than 50% reduction in PSA values after treatment, with a median PFS of 22 months.
Scientists developed a novel approach to securely share and analyze genomic data, enabling a more nuanced understanding of heritable diseases like cancer. This 'federated analysis' method allows researchers to analyze large amounts of genomic and clinical data without compromising patient privacy.
A research team has devised a novel strategy to overcome chemotherapy resistance in cancer by boosting the pro-apoptotic BAX protein and targeting its inhibitor, BCL-XL. The two-drug combination achieved significant success against apoptosis-resistant human tumor cell lines and xenograft models, with minimal side effects.
Researchers at the Salk Institute successfully reversed aging signs in middle-aged and elderly mice using a cellular rejuvenation approach. The treatment, which involves reprogramming cells with four specific molecules, restored youthful epigenetic patterns and improved tissue function without increasing cancer risk.
Researchers created implantable beads that produce high concentrations of interleukin-2, a natural compound activating white blood cells to fight cancer. The treatment eradicated ovarian and colorectal cancer in mice within six days, paving the way for human clinical trials later this year.
Researchers found an association between certain cancers and Guillain-Barré syndrome, with people diagnosed with lymphomas, blood cancers, lung, prostate, or breast cancer having a higher risk. The study suggests that unidentified factors in several types of cancer may contribute to this increased risk.
A survey of young adult cancer survivors found that crowdfunding provides relief in paying bills, but also involves compromises such as revealing personal health details and feeling uncomfortable asking for help. The study suggests that crowdfunding could be exacerbating racial and economic disparities.
The study found that White people are more than twice as likely to get some types of cancer, including melanoma skin cancer and oesophageal bladder cancers, compared to Black, Asian or Mixed ethnic backgrounds. Black people are also more likely to get certain types of cancer, such as myeloma and prostate cancer.
Researchers will compare proton, carbon and electron radiotherapy to protect normal tissues from harm while controlling solid tumors of the gastrointestinal tract, lungs, soft tissues throughout the body, and bones. The goal is to develop a more effective treatment with shorter duration and frequency.
Researchers identified USP17 as a deubiquitinating enzyme regulating c-Myc levels and controlling cell proliferation and glycolysis. The study suggests USP17 as a potential therapeutic target for cancer treatment.
A pooled data analysis found that between 30 and 60 minutes of muscle strengthening activity per week is associated with a 10-17% lower risk of death from any cause. The J-shaped curve showed no conclusive evidence that more than an hour of this activity reduces the risk further.
A study published in Nature Cancer has found that tissue damage caused by radiation can facilitate the spread of cancer, with neutrophils playing a key role. The researchers used mice to test the effect of high doses of radiation on healthy lung tissue and found that secondary tumours formed more easily in damaged lungs.
Researchers at UNC Lineberger Comprehensive Cancer Center have developed a new therapeutic approach using a small-molecule inhibitor of the chromatin-modulatory enzyme EZH2 to target aggressive cancer cells. The treatment also targets cMyc, a prominent cancer-causing factor, and shows profound tumor killing effects.
Eating meat five times or less per week is associated with a lower overall cancer risk, according to a study published in BMC Medicine. Participants who ate meat five or less times per week had a 2% lower cancer risk compared to those who ate meat more than five times per week.
Researchers have clarified the mechanism behind activating genes in drosophila fly sex cells, which may hold clues to understanding diseases. The study's findings suggest that DNA packaging plays a crucial role in regulating gene expression, with abnormal packaging potentially leading to misregulation and disease.
Researchers at Osaka University identified a new monoclonal antibody target, R8H283, which selectively binds to cancer-specific conformational epitopes on the ubiquitous CD98 heavy chain protein in multiple myeloma cells. This selective binding allows for anti-MM effects without damaging normal host cells.
Researchers at MDI Biological Laboratory discovered that age-related chronic inflammation is caused by disruption of chromatin architecture. This leads to misexpression of genes lacking CpG islands, resulting in inflammation and loss of cellular function. The findings provide a unifying theory for the age-related degenerative diseases.
A recent review highlights the effects of different intestinal bacteria on colorectal cancer, exploring new therapies for disease prevention and treatment. Beneficial probiotics, such as Akkermansia muciniphila and Lactobacillus rhamnosus GG, exhibit anticancer properties and reduce CRC cell proliferation.
A new University of Copenhagen study reveals that well-functioning fat tissue is crucial for overall health and may help prevent diseases such as type 2 diabetes, cancer, and obesity. High levels of lifelong exercise have been shown to improve mitochondrial function in fat cells, reducing oxidative stress and damage.
A ketogenic diet has been shown to triple survival time in mouse models of pancreatic ductal adenocarcinoma when combined with chemotherapy. The diet reduces circulating glucose and depresses insulin levels, which can enhance the antitumor effects of chemotherapy.
Researchers have developed a rapid and affordable test to identify specific genetic mutations in cancer cells using SuperSelective PCR primers. This assay can detect rare mutations, enabling targeted therapy and monitoring minimal residual disease. The study demonstrates the potential of this approach for personalized cancer treatment.
A Toronto study found that certain probiotic bacteria can alter the function of immune cells and spur cancer growth in pancreatic cancer. Deletion or inhibition of a key protein enabled better treatment sensitivity and more inflammatory T cells, while activation thwarted these effects.
A new study by Virginia Commonwealth University researchers finds that triplatin is effective against triple negative breast cancer with high sulfated glycosaminoglycans (sGAG) levels. The drug accumulates inside cancer cells, causing damage and slowing tumor growth.
Researchers have identified an antibody drug that significantly improves survival rates in pet dogs with advanced prostate cancer. By targeting regulatory T cells, the treatment may offer a new hope for patients with this devastating disease.
A Ludwig Cancer Research study found that neuroblastoma tumors can be made more visible to the immune system by exploiting a specific inflammatory signaling mechanism. This discovery holds promise for improving treatment of drug-resistant childhood cancer through immunotherapy.
A new symptom management approach, WRITE Symptoms, guides patients to reflect on their symptoms and develop strategies for addressing target symptoms. Both nurse-led and self-directed versions of the tool improved women's sense of control over their symptoms after eight weeks.
Researchers have discovered that the tumor suppressor protein pVHL degrades SMAD3, inhibiting the TGF-β signaling pathway and suppressing tumour cell growth. This finding opens up new opportunities for developing cancer therapies by regulating pVHL activity.
Researchers in Japan evaluated the cost-effectiveness of adding dipstick hematuria screening to a mass health check-up program. The study found that including routine testing for hematuria would promote early detection and treatment, leading to cost savings and improved patient outcomes. This cost-effective approach has the potential t...
Researchers have identified a germline biomarker signature that can predict serious side effects in up to 3 in 10 patients undergoing anti-PD1/PDL1 therapy. The findings represent an important step toward personalizing checkpoint therapy, potentially improving patient outcomes and reducing harm.
Researchers at Gladstone Institutes and UC San Francisco have developed a CRISPR activation method that allows them to activate genes in human immune cells, revealing key regulators of cytokine production. This breakthrough accelerates immunotherapy research and may lead to more powerful cancer treatments.
A new Chinese Medical Journal study explores the risks of non-alcoholic steatohepatitis (NASH) turning into liver cancer. Early detection through simple medication and lifestyle changes can prevent NAFLD from progressing to more severe conditions, such as cirrhosis and hepatocellular carcinoma.
A Brazilian berry has been found to enhance the effectiveness of a popular cancer treatment by modifying the gut microbiome. Researchers discovered that castalagin, a polyphenol from the camu-camu fruit, improves immunotherapy response in mice with resistant cancers.
A recent study led by University at Buffalo researchers found that photobiomodulation reduces inflammation, improves blood flow and heals wounds up to 19 days faster. Light therapy accelerated skin healing from cancer radiation therapy by an average of 49-42 days.
A recent review highlights the potential of structural proteomics in understanding pathological processes and predicting drug candidates for neurodegenerative diseases. The field combines protein chemistry and mass spectrometry to determine protein structure and interactions, which can lead to breakthroughs in treating serious health c...
Researchers at Northwestern University have developed a novel microfluidic device that can efficiently harvest and sort tumor-eating immune cells from tumors. This technology has shown dramatic results in shrinking tumors in mice compared to traditional methods.