Articles tagged with Cancer
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The study evaluated EUS features to distinguish GISTs from leiomyomas and found that inhomogenicity, hyperechogenic spots, a marginal halo, and higher echogenicity were more frequent in GISTs. The presence of at least two of these four features had high sensitivity (89.1%) and specificity (85.7%) for predicting GISTs. A maximal diamete...
Researchers have detected 3,600 acetylation switches in 1,750 proteins, significantly expanding the number of known modifications. This discovery sheds light on how protein regulation is affected by diseases like cancer, Parkinson's, and Alzheimer's.
Survival rates for placental-site trophoblastic tumours (PSTTs) vary depending on how long ago the related pregnancy occurred. The study found that patients with stage I disease had a 10-year probability of overall survival of 90%, while those with recurrent disease or disease resistant to treatment had poor survival.
Researchers at Helmholtz Zentrum München have identified the enzyme TFIIH kinase as responsible for selectively phosphorylating RNA polymerase II, regulating the production of specific RNA molecules. This discovery sheds light on epigenetic mechanisms and their significance in cancer and disease.
The NHLBI and UnitedHealth Group collaboration aims to broaden study beyond individual diseases to address chronic diseases as they group. Early results show encouraging progress in developing portable tools and comprehensive guidelines for chronic disease management.
Dr. Michael Holick's work revolutionized the understanding of vitamin D and its role in disease prevention, redefining vitamin D deficiency as a national epidemic.
Overall median survival improved from 3.5 months in period A to 12 months in period C, despite stage of disease at presentation affecting survival. Surgical resection is the only curative treatment, but many patients present with advanced-stage disease.
A Iowa State University researcher has figured out a mechanism involved in marking where DNA instructions are located in cells. The Gcn5 protein plays a crucial role in recognizing chemically modified histones, facilitating efficient gene reading and shedding light on diseases like cancer.
Researchers found that adult cystic nephroma and mixed epithelial and stromal tumors are genetically similar and should be considered the same disease entity. This discovery will help doctors accurately diagnose the disease in patients, leading to improved patient care.
A doctoral thesis reveals that three FET genes involved in cell maturation and stress response can lead to rapid cancer development in children. The study's findings suggest that these genes' rearrangements may cause cancer cells to lose normal control mechanisms, resulting in uncontrolled growth.
A clinical decision model using MR spectroscopy can help patients avoid unnecessary biopsies and treatments by identifying whether a new lesion is due to a recurrent tumor or post-radiation changes. The technique analyzes ratios of three metabolites, including choline, creatine, and NAA, to determine the likelihood of a recurrent tumor.
A University of British Columbia study found that heart disease patients living in lower socioeconomic neighborhoods are more vulnerable to death from chronic diseases, particularly cancer. The researchers suggest that the trend may reflect the higher overall stress experienced by patients in low socioeconomic areas.
Researchers discovered a greater level of genetic complexity for diseases than thought, focusing on iminoglycinuria and hyperglycinuria disorders. The study found that up to four different pumps in the kidney determine the disorder's occurrence, suggesting a need for integrated complex genetic information.
A Purdue University researcher has created a compound that prevents replication of the SARS virus, which could lead to a treatment for the disease. The molecular inhibitor was developed through structure-based design and has been tested in laboratory settings.
Researchers have identified RMI2, a novel protein essential for genome stability and DNA repair in Bloom's syndrome. The study sheds new light on the disease's underlying mechanisms.
A new study published in J Palliative Medicine found that more than half of US hospitals offer palliative care services, but availability varies widely across the country. Not-for-profit hospitals and midwestern/western regions have seen significant growth in palliative care adoption.
A new review article highlights the potential of sirtuins to treat diseases of aging such as Type 2 Diabetes and mitochondrial disorders. Early clinical studies suggest that SIRT1 activation may lower glucose and improve insulin sensitivity.
Researchers create genetically modified mice with a switch to turn on and off disease-typical proteins in renal tissue. The model simulates the natural course of disease development and healing processes, allowing for better investigation of kidney diseases.
Associate professor C. Erec Stebbins at Rockefeller University has been awarded a prestigious EUREKA grant to exploit a 'nanosyringe' technology for delivering proteins into specific cells. The grant aims to develop therapeutic applications, including restoring tumor-suppressing proteins and treating genetic diseases.
Researchers at Mount Sinai School of Medicine have developed a new gene silencing technology that can effectively suppress transcriptional expression of targeted genes in human cells, including those linked to various diseases. This breakthrough could pave the way for preventing diseases where gene dysfunction plays a role.
A team of Johns Hopkins experts suggests that epigenetic changes occurring over a person's lifetime may explain why disease susceptibility increases with age. They found that methylation levels changed in almost one-third of individuals over an 11-year span, and family members tended to exhibit similar changes.
The University of Manchester will lead a joint planning phase for the Biobanking and Biomolecular Resources Research Infrastructure, linking European biobanks and managing millions of biological samples. The project aims to counter fragmentation in Europe and facilitate access to valuable resources for biomedical research.
A new study from Karolinska Institutet found that men who exercise regularly are less likely to die from cancer than those who don't. The researchers discovered a 33% increased survival rate among men who walked or cycled for at least 30 minutes a day, with more extensive physical activity leading to a 16% lower incidence of cancer.
A new study reveals the nitric oxide system plays a crucial role in regulating proteins and controlling cellular activity. The discovery opens up new avenues for biochemical research and potential therapeutic applications.
Researchers identified proteins that may serve as reliable biomarkers for Neurofibromatosis 1 (NF1) and its associated malignant tumors. Adrenomedullin levels were found to be significantly higher in NF1 patients and MPNST cell cultures, indicating a possible association with tumor growth.
Researchers developed a breakthrough in gene therapy for cancer using microscopic magnets to target tumours, increasing successful cell invasion. The 'magnetic targeting' method uses nanomagnets to attract cells carrying anti-cancer genes, effectively overcoming the problem of insufficient delivery.
Researchers uncover how ATM mutations cause neurodegeneration in Ataxia telangiectasia by preventing neurons from re-entering the cell cycle. This finding holds promise for developing new treatments for A-T and other neurodegenerative disorders.
A new surgical approach, called bilateral nephron-sparing surgery, has shown promise in saving both kidneys of children with bilateral Wilms tumor. This procedure involves removing the malignant tumor while sparing as much healthy kidney tissue as possible.
Researchers at Cincinnati Children's Hospital Medical Center have developed a mouse model that helps unravel the cause of fibrous, non-cancerous nerve tumors called neurofibromas. The model provides insights into the biological mechanisms underlying tumor formation and serves as a platform for therapeutic testing.
A study led by Monika Vig and Jean-Pierre Kinet found that calcium ion channels play a crucial role in triggering inflammatory responses, providing new insights into asthma and allergy symptoms. The discovery highlights the importance of CRACM1 calcium channels in mast cell activation.
Researchers at Cardiff University have made promising progress in treating tuberous sclerosis, an inherited disease that causes tumours to grow in organs. After a year of Sirolimus treatment, kidney tumour diameters shrunk by 26% on average.
Research-backed stress relief solutions, such as emWave and StressEraser, have proven benefits through double-blind clinical trials. The American Institute of Stress has recognized these programs for their innovation and effectiveness in reducing stress.
The American Society for Gastrointestinal Endoscopy has issued guidelines for treating dyspepsia, a condition affecting a fourth of the population. For patients over 50 with symptoms or alarm features, endoscopy is recommended to diagnose structural disease such as peptic ulcer disease and malignancy.
The American Urological Association has released new guidelines on managing non-muscle invasive bladder cancer, focusing on treatment outcomes and complications. The guidelines highlight the importance of accurate clinical staging and the need for further research to improve patient outcomes.
A new study published in EMBO Reports found that the order of authors on a scientific paper significantly affects perceived contribution and credit. Middle authors tend to receive less recognition and credit compared to those listed at the beginning or end of the list.
The US continues to have the highest level of health spending among OECD countries, driven by higher prices and per capita incomes. The country has fewer healthcare resources and lower utilization rates compared to other developed nations.
Mental disorders contribute significantly to the global disease burden, with a chronically disabling nature that complicates treatment and worsens outcomes. Research highlights the need for integrated mental health awareness into healthcare policy and delivery.
A recent study reveals radiologists can diagnose clinically unseen venous thromboembolic disease in cancer patients earlier by closely examining CT scans of the thorax, abdomen, and pelvis. The study identified 23 unsuspected iliofemoral DVTs and four common iliac vein involvements among 736 patients.
Researchers found radiofrequency ablation to be 93% effective in eradicating malignant kidney tumors, with minimal discomfort and no serious complications. The study's lead author suggests this treatment is an excellent option for patients who are not good operative candidates or have multiple renal tumors.
Scientists at CSIRO Australia are exploring the use of a new synchrotron to detect biochemical changes in Tasmanian devil hair that could indicate facial tumour disease. This could lead to the development of an early detection test, making quarantine strategies more efficient and effective.
A study of 125 kidney tumors treated with radiofrequency ablation showed a high cure rate and low complication rate. The procedure achieved a 93% success rate for all treated tumors, making it an alternative method for patients who are not good surgical candidates.
UC Irvine scientists use mathematical theory to understand how cancer cells alter their genetic makeup, accelerating tumor growth. The study found that tumors thrive when unstable in early stages and become stable later on, providing insight into future cancer treatments.
St. Jude researchers used a new technique to monitor the movement of DNA repair proteins as they interacted with each other and gathered at the site of damage. The study found that disruption of these proteins can cause mutations, cell death, or cancer, providing critical insights into DNA repair mechanisms.
Young males are disproportionately affected by road traffic accidents, with those under 25 nearly three times more likely to die than women in the same age group. The World Health Organisation reports an estimated 1.2 million annual deaths worldwide due to RTAs.
Researchers at Texas A&M University are studying fruit flies to understand cellular differentiation and chromosome counting. They hope to uncover mechanisms that can help shed light on human genetic maladies such as color blindness and hemophilia.
In ICU, multiple organ failure is the main cause of death, with central nervous system and cardiovascular failures being significant risk factors. In hospitals after ICU discharge, malignant tumors and exacerbation of cardiovascular disease are leading causes of death.
A Montréal research group identified two essential components of negative feedback control in hormone regulation, which are deficient in about half of pituitary tumors from Cushing disease patients. This finding provides a molecular explanation for hormone resistance and may lead to better management of the condition.
A new study found that black patients with bladder cancer are 35 percent more likely to die of the disease than white patients. Black women in particular had more aggressive tumors and lower survival rates compared to white men and women and black men.
The Microscale Life Sciences Center at ASU has been awarded a five-year $18 million grant to continue its research on cell growth and death, aiming to understand the nature of disease processes. The center will develop miniature automated systems to analyze differences between healthy and diseased body cells.
Inhibiting ERK1 enhances ERK2 activity, promoting cell proliferation, while ERK2 knockdown almost completely abolishes it. Mouse tumour cells expressing only ERK1 grow into small tumours.
A recent study found that differences in HD types across regions play a major role in determining regional survival rates. Analysis revealed no significant difference in mortality risk between EUROCARE-west and the US SEER databases when adjusting for morphology, but morphology accounted for differences in EUROCARE-UK and EUROCARE-east...
A new study from the University of Michigan finds that patients often struggle to access reliable medical information online. Librarians play a crucial role in helping patients find quality resources, providing expertise and accessing specialized databases not available to the general public.
Researchers have developed a new method for detecting brain tumours during surgery using a fluorescent compound, which significantly improves complete tumour removal rates (65% vs 36%) and survival rates without tumour progression (41% vs 21%). The technique has been shown to be safe with no significant difference in serious side effects.
Researchers are working on developing new diagnostic tools using nanotechnology to identify biomarkers for diseases. This could lead to earlier detection and more effective treatment, reducing the economic and social impact of diseases.
Researchers used Genomatix technology to identify new genes associated with renal disease, using comparative promoter analysis to predict cell junction proteins in the glomerular slit diaphragm. The approach effectively predicted a previously unrecognized molecule, which was experimentally verified.
The Australian government has pledged $50 million to support the expansion of the Walter and Eliza Hall Institute's (WEHI) research capabilities in cancer and infectious disease. This funding will enable significant expansions in the institute's research programs, focusing on targeted therapies for cancer treatment and malaria control.
Researchers found that FOP is misdiagnosed 87% of the time, taking an average of four years to be accurately diagnosed. Inaccurate diagnoses led to painful biopsies and incorrect treatments, often worsening the condition and resulting in permanent loss of mobility.
A new study has found that large sinus tumors can be successfully removed endoscopically, with a significant reduction in morbidity compared to traditional open procedures. The procedure involves using tiny scopes and cameras to remove the tumor, which was shown to have a lower recurrence rate than expected.
Research reveals PTEN regulates VGF signaling, enhancing angiogenesis and accelerating tumor growth in mice. Individuals with mutated PTEN alleles are at risk for increased tumorigenic mutations and accelerated tumor growth due to enhanced angiogenesis.
Researchers at Rice University developed a new nanoprobe that uses quantum dots to visualize proteolytic activity in vivo, solving the problem of distinguishing between disease signals and background noise. The probes are activated by enzymes associated with specific diseases, allowing for early detection and monitoring.