Research on cancer as a disease, from cause to care. Covers tumor biology, small-cell lung cancer, cancer-linked stroke risk, and cancer center research.
The Montefiore Einstein Cancer Center received a $2.9 million grant to train physicians and scientists to conduct clinical and translational oncology research, focusing on addressing health inequities in the Bronx. Scholars will engage in interdisciplinary research projects with community outreach and engagement.
A recent study found that germline genetic testing after cancer diagnosis is underutilized, with rates significantly lower among Asian, Black, and Hispanic patients compared to non-Hispanic whites. The study, published in JAMA, suggests disparities in access to genetic testing by race.
Researchers analyzed BORIS mutations and protein expression in breast cancer tissue samples, finding frequent mutations associated with breast carcinoma progression. The study suggests the BORIS gene as a potential biomarker for breast cancer.
Researchers updated their protein localization prediction model, MULocDeep, to provide more targeted predictions for biological discoveries. The tool helps researchers design more effective experiments and advance scientific discoveries related to drug development and treating diseases like epilepsy.
Researchers at Karolinska Institutet have identified how memory killer cells are formed and found a correlation between their presence in cancer tissue and improved survival rates in people with melanoma. The study suggests that harnessing the potential of these cells could lead to more effective immunotherapy.
The SISAQOL-IMI Consortium establishes an international consensus on patient-reported outcomes in cancer trials, aiming to improve the use of PROs. The new standards will enhance patient involvement and ensure the relevance of recommendations to the patient community.
Late-onset cognitive impairment emerged in adult childhood cancer survivors decades after diagnosis and treatment. Modifiable health behaviors and chronic health conditions significantly increase this risk.
The ATOM Coalition aims to improve cancer medicine availability and increase the capacity of lower-income countries to diagnose and manage cancer. The coalition prioritizes generic and biosimilar medicines for cancer treatments, targeting countries with high mortality rates.
Researchers found that MALAT1 inhibition decreased BRAF RNA and protein levels, while increasing correlation with MAPK-associated genes. MALAT1-ASO treatment also reduced melanoma cell growth and tumor size in xenograft models.
A team of researchers from CSI Singapore has identified a transcription factor, TOX2, as a potential target for treating Natural Killer/T-cell Lymphoma (NKTL), an Epstein-Barr virus-associated cancer with poor treatment outcomes. The study found that TOX2 is overexpressed in NKTL patients and negatively associated with patient survival.
Researchers found that formalin fixation does not significantly alter the polarimetric properties of brain tissue, making it suitable for training machine-learning models. The study suggests that formalin-fixed brain tissue specimens can provide high-quality data for rapid and accurate diagnostic imaging in surgery.
Researchers developed a strategy targeting RNA recycling enzymes to prevent harm from cancer genes MYC, JUN and MIR155. This approach showed promise in slowing tumor growth in cancer patients.
Researchers tracked immune cell clusters in the aging mouse prostate using highly multiplexed immune profiling. Early adulthood sees myeloid cells, while between 6-12 months old, there's a profound shift to T and B lymphocyte-dominance. The study reveals new insight into prostatic inflammaging and the window for interventions.
A literature review found that dietary nitrate from vegetables may prevent cardiovascular disease, while nitrate from meat and water may pose a cancer risk. Experts emphasize the need for clarification in current guidelines and more research to distinguish fact from fiction.
Researchers from China explore the mechanisms of action and clinical data of bispecific antibodies, which have shown promise in increasing cytotoxicity against cancerous cells and enhancing immune response towards tumor clearance. Several bsAbs are being evaluated in phase I-III clinical trials for lung cancer treatment.
Researchers have developed an automated calling algorithm for determining B and T cell clonality from NGS data with greater sensitivity than previous models. The new model increases the assay's sensitivity in detecting clonality, allowing for more accurate diagnosis and monitoring of lymphoproliferative disorders.
A team led by Professor Timo Betz has developed a 3D cell culture chamber to grow muscle and other tissue using high-resolution microscopy. The new system will enable scientists to mimic the mechanical situations that confront various living tissues in serious conditions, reducing animal testing and costs.
A team of DGIST researchers led by Professor Kyungmoo Yea developed an antibody that effectively alleviates chemotherapy-induced cancer cachexia. The new treatment approach enhances patient response to continuous anti-cancer therapy, improving quality of life and restoring skeletal muscles and fat tissues.
The number of US cancer survivors with self-reported functional limitations has more than doubled since 2000, according to the study. Cancer survivors without functional limitations have seen relatively little growth over the same period.
Research finds military veterans exposed to low doses of chemical warfare agents have higher rates of mortality from genitourinary diseases and deaths attributable to alcohol. However, overall cancer incidence is not significantly associated with Porton Down attendance.
A study by Tufts University researchers reveals how DNA repair can fail near expanded repeats, leading to mutations and disease. The team found that certain proteins play a crucial role in stabilizing the DNA during repair.
A new advanced artificial intelligence system has been developed in the UK that can accurately identify protein patterns within individual cells. The HCPL system uses a deep-learning model to quickly and accurately determine subcellular structures where proteins are present.
A new laser-based breathalyzer using artificial intelligence can detect COVID-19 in real-time with excellent accuracy. The technology, powered by frequency comb spectroscopy and machine learning, analyzes the unique chemical fingerprint of each breath sample to identify specific health conditions.
Scientists at CNIO identify succinylation as a poorly studied mechanism in cancer research; mutated DLST protein prevents succinylation, leading to pseudohypoxia and tumor growth. Succinylation is crucial for protein function and may be linked to various diseases.
The gene LRRC4 regulates synapse formation, stability and excitatory transmission, playing a crucial role in learning, memory formation and storage. It also has key implications in neuronal disorders and aggressive brain and spinal cord cancer.
Researchers developed a virtual framework to investigate the effectiveness of optoacoustic tomography for breast cancer screening in people with darker skin. The results confirmed that tumors can be harder to locate in individuals with darker skin, highlighting the need to optimize imaging systems to mitigate racial bias.
Researchers have identified three types of bacteria associated with natural purple photosynthetic bacteria that show strong anticancer efficacy. The bacteria can thrive in hypoxic tumor environments and trigger the immune system to kill tumor cells.
The study shows that zolbetuximab delays tumor progression and improves overall survival by 25% compared to chemotherapy alone. Patients with CLDN18.2-positive tumors responded well to the treatment, indicating a new clinically relevant biomarker for gastric cancer.
Researchers developed a new probe to measure pH levels in cells, revealing a constant conversion rate from endosomes to lysosomes. The probe's ability to track pH changes enables faster diagnosis and potential treatments for lysosomal diseases.
Researchers found that T cells can self-activate by puckering their cell membrane, boosting function and slowing tumor growth in a mouse model. This discovery could inspire new anti-tumor therapeutics and provide insights into treating autoimmune diseases.
A new study found that quitting smoking before a lung cancer diagnosis is associated with higher survival rates. Former smokers who stopped smoking years before their diagnosis had significantly longer survival than current and former smokers diagnosed with non-small cell lung cancer.
A low-cost antibacterial regimen can prevent acute radiation dermatitis, a common skin problem affecting up to 95% of radiation therapy patients. The treatment involves using chlorhexidine and mupirocin nasal ointment twice daily, with no adverse effects or severe cases reported.
A new study by Silent Spring Institute and University of California, Berkeley found over 100 product types contain Prop 65 VOCs, posing significant health risks. The analysis revealed more than 5,000 tons of toxic chemicals are released from consumer products in homes and workplaces every year.
Cancer caregivers from lower-income households are more likely to experience debt and work loss compared to non-cancer caregivers. This can lead to increased economic burden, stress, and a reduced ability to retire on time.
A University of Houston team has discovered new biomarkers for early detection of bladder cancer, including D-dimer and IL-8, which may identify disease progression. The study's findings could lead to a simple urine test as the new standard for bladder cancer diagnosis.
An international study of 1,044 patients with head and neck squamous cell carcinoma found that combining radiotherapy with chemotherapy significantly improves survival rates compared to radiotherapy alone. The benefit was particularly notable in patients between 65-79 years old with good general health.
Researchers at Tokyo Medical and Dental University identify a novel focal adhesion remodeling process that strengthens cell-matrix adhesion in response to genotoxic stress. This mechanism involves the replacement of FAK with FRNK, leading to increased firm cell attachment.
A new Raman probe, 9CN-JCR, has been developed for detecting multiple enzyme activities in heterogeneous biological tissues. The probe exhibits high sensitivity and multiplexing ability, making it a promising tool for cancer diagnosis and research.
Researchers found deaths from gallstone disease increased in younger populations and those with Medicaid after Medicaid expansion, highlighting the need for proactive prevention over reactive emergency care. A new healthcare model emphasizing primary care and prevention is proposed to address these inequities.
A new study by Uppsala University and hospital reveals a link between neurodevelopmental disorders and an increased risk of testicular cancer, specifically seminoma. The study found that men with these conditions are more likely to develop cancer at a younger age and may have advanced disease at diagnosis.
Researchers uncover the critical link between cellular energy levels and mitochondrial damage through protein FNIP1. The study reveals that FNIP1 enables communication between AMPK and TFEB, instructing genes to remove damaged mitochondria and create new ones.
A high-coverage genome analysis of two transmissible cancer lineages in Tasmanian devils reveals that DFT2 has a significantly higher mutation rate than DFT1. The study provides new insights into the evolutionary history and epidemiological implications of these contagious cancers.
Two contagious cancers, devil facial tumour 1 (DFT1) and 2 (DFT2), affecting Tasmanian devils have been tracked to understand their origins and evolution. Researchers found DFT2 is a faster-growing cancer with rapid mutations, posing a significant threat to the species.
A recent study led by Dr Rachael Rigby from Lancaster University found that delays in stoma reversal surgery do not impact on risk of complications or commensal microflora loss, atrophy, or scarring. However, a higher degree of microflora loss is associated with an increased risk of complications.
A multicenter study found stereotactic radiosurgery to be highly effective in controlling vestibular schwannoma growth in NF2 patients while maintaining serviceable hearing. The procedure was also shown not to cause radiation-related tumor development or malignant transformation, addressing long-standing concerns.
A modelling study suggests that specifying menu calorie counts is likely to reduce obesity-related cancers and healthcare costs in the US. The policy could prevent 28,000 new cancer cases and 16,700 cancer deaths, as well as save $1.48 billion in medical costs.
A University of Colorado at Boulder research team has discovered a protein crucial for repairing DNA in cancer cells, which they found can be selectively targeted to kill cancer cells without harming healthy ones.
Researchers found a 14.4% decline in new cancer diagnoses in 2020 compared to prior years, correlating with stay-at-home orders during the COVID-19 pandemic. The study estimates that around 200,000 people may have had undiagnosed or untreated cancer cases during this time.
Researchers found that a protein associated with liver cancer, ATF4, protects the liver by promoting the expression of SLC7A11, which suppresses ferroptosis and slows liver cancer progression. This unexpected result could inspire new treatments for preventing liver disease and cancer.
Researchers develop mechanical nanosurgery to destroy tumour cells from within, reducing GBM tumour size universally, including in TMZ-resistant cases. The treatment uses magnetically controlled carbon nanotubes to provide mechanical stimulation, damaging cellular structures and causing tumour cell death.
Researchers have discovered a non-invasive way to isolate tumor-reactive lymphocytes from blood, opening up new treatment options for cancer patients. This breakthrough could potentially bypass radiation therapies and harsh chemotherapy drugs, making it a more viable option for hospitals.
A study led by Tokyo University of Science researchers identified Dectin-1's role in promoting colorectal cancer by enhancing PGE2 production and suppressing IL-22BP expression. The study used mouse models and clinical samples to validate the findings, which have immediate clinical implications for CRC patients.
A team of scientists created a new, fast, and precise method for analyzing cells in tissue samples from cancer patients without the need for a trained pathologist. The method uses artificial intelligence to evaluate data produced by a technique called real-time deformability cytometry.
Researchers at Penn State found that broccoli's aryl hydrocarbon receptor ligands bind to a protein in mice, promoting gut health and reducing disease. This interaction activates various activities that affect intestinal cell functions, leading to improved gut barrier function and resilience.
A population-based study found that pregnancy-associated cancers have a higher overall 5-year mortality rate compared to non-pregnancy associated cancers. The study highlights the need for improved cancer screening and treatment options during pregnancy.
Researchers have developed a new method called Nano-tRNAseq to measure both the abundance and modification of tRNA molecules in a single step. This technology has significant advantages over conventional techniques, offering rapid, cost-effective, and high-throughput analysis with single-molecule resolution.
A team of scientists from City University of Hong Kong and HKUST discovered novel, tridimensional compounds with high anticancer activity and low toxicity. These compounds can overcome drug resistance in cancer cells by inducing a different cell death pathway.
Scientists at the University of Colorado Anschutz Medical Campus identified protein FAM193A as a key component of a mechanism suppressing tumor growth. The discovery offers new potential for cancer therapies targeting p53, a frequently mutated gene in human cancers.
Researchers discuss cortactin's impact on cancer progression by modulating the Wnt5a/ROR1 signaling pathway. Cortactin expression is found in various cancers, including breast and chronic lymphocytic leukemia, suggesting its potential role in promoting metastasis.
A new fluorescent probe, TiY, has been developed to selectively target and kill cancer stem cells, which are responsible for tumor growth. The probe can be used to simultaneously diagnose and treat cancer, offering a promising approach to improving cancer treatment outcomes.