Articles tagged with Cancer
A study by Ludwig Lausanne reveals how cancer cells convert immune cells into supporters of their growth and survival. The researchers identified β-glucosylceramide as the key lipid triggering this transformation, which can be targeted to slow or reverse tumor progression.
A study investigates the role of the TGF-β/SOX9 axis in promoting cancer migration and invasion in oral squamous cell carcinoma. The research found that CAF-induced TGF-β1 upregulates SOX9 expression, leading to increased cancer invasiveness and poor prognosis. The findings suggest a potential therapeutic target for developing novel tr...
A new study found that surgery benefits men with Stage IV breast cancer, particularly those responsive to systemic therapy. Trimodal therapy, including surgery and radiation, shows improved 5-year overall survival rates compared to systemic therapy alone.
A team of researchers from Japan has developed a platform using nanofibers to capture and control the migration of brain tumor cells, including glioblastoma multiforme. The study found that varying fiber densities can slow or speed up cell movement, leading to the creation of 'cell traps' that can restrict tumor cell growth.
Researchers create maps of senescence in heart and lung cells, comparing different types of senescent cells across the lifespan. The goal is to understand how senescent cells contribute to age-related diseases and develop therapies called senolytics.
Scientists at Osaka University developed a novel system for targeted cancer radiation therapy using gold nanoparticles labeled with astatine-211. The nanoparticles are highly toxic to cancer cells while remaining localized, minimizing damage to healthy tissues.
A study by the University of Texas Health Science Center at Houston found that individuals with cancer living in economically or medically underserved areas have a nearly twice the risk of suicide mortality compared to the general population. Mental distress from financial hardship worsened during cancer survivorship among those living...
A recent UC San Diego study has found that e-cigarette use does not help smokers stay off cigarettes, but rather increases the risk of relapse. Former smokers who switched to e-cigarettes were more likely to relapse compared to those who remained tobacco-free.
The new ESMO Clinical Practice Guideline provides comprehensive guidance on diagnosing, staging, and treating patients with metastatic breast cancer. The guideline incorporates recent clinical trial data to inform treatment choices, taking into account tumour biology and emerging targeted therapies.
A study published in JNCCN found that 45% of people with cancer prefer telemedicine over in-person visits, while general patient satisfaction scores are equally high. The research also revealed that patients preferred video conferencing over audio-only appointments and that telemedicine can reduce treatment-related costs.
A Ludwig Cancer Research study has identified a potential combination therapy for treating brain metastases of breast cancer. The treatment targets tumor-associated macrophages and microglia, immune cells found within brain metastases that cancer cells can manipulate to support their growth and survival.
A new report from the American Cancer Society reveals that over 46,000 cancer cases annually in the US could be prevented with moderate-intensity physical activity. The study found that states in the South had the highest proportion of cancers attributable to physical inactivity, while northern states had lower proportions.
A team of scientists from the University of Pittsburgh and National Cancer Institute discovered why HIV is rarely the direct cause of cancer. The research found that it requires a specific series of events involving changes in HIV and additional mutations in human genes, resulting in T cell lymphomas. However, the occurrence is rare, a...
Researchers have developed chimeric exosomes that co-activate the immune system to combat tumors. The therapy targets solid tumors, where the immune cells are often compromised, and improves treatment outcomes for patients.
Researchers conducted genomic evaluations of advanced malignancies to develop matched, individualized combination therapies. The study found that precision cancer therapy improved median overall survival rate by 3.9 months compared to standard care.
A new study reveals that childhood adversity is a major contributor to early and preventable causes of mortality and long-term physical and mental health issues. Childhood adversity was found to be associated with elevated risk for chronic diseases, including heart disease and cancer.
A study by University of New Mexico researchers found that 65% of women with a normal prior co-test had undergone re-screening within three years, far more often than recommended. Meanwhile, some women were not re-tested for over five years after a negative co-test or cytology alone, increasing their risk for poor outcomes.
A study by Nicolò Pernigoni and colleagues found that androgen-producing gut microbes in patients with advanced prostate cancer can lead to sustained tumor growth. Treating these microbes with antibiotics or fecal transplants from sensitive individuals may delay ADT resistance.
A multicenter study found cardiovascular magnetic resonance imaging to be highly accurate in diagnosing and excluding cardiac tumors. The results show that CMR provides prognostic value beyond clinical factors.
The study reveals that G6PD is associated with elevated expression of genes involved in glutathione-mediated redox metabolism, leading to chemoresistance. Patient-derived spheroids derived from clinical specimens showed diverse heterogeneity in chemoresistance against platinum-based compounds.
Researchers discovered a microRNA, miR-766-5p, that targets super-enhancers and reduces MYC expression in cancer cells, inhibiting growth rates. The study suggests this molecule could be used as an anti-cancer therapeutic to fight MYC-driven cancers.
A new study finds oesophageal cancer cases have tripled in under 50s, with increases attributed to lifestyle-related risk factors such as smoking and poor diet. The study also shows improved relative survival rates for younger patients, highlighting the importance of early diagnosis and treatment.
A recent study found that colorectal cancer diagnoses fell dramatically by 40% in a year during the COVID-19 pandemic. This decline was attributed to the suspension of screening programs and postponed non-urgent colonoscopy investigations.
Researchers analyzed protein-protein interaction data from head and neck squamous cells, breast cancer, and combined them to generate a map of protein pathways driving tumor growth. The studies identify potential new therapeutic targets and provide a resource for interpreting cancer genomic data.
Stephanie Grainger, Ph.D., awarded $2.375M grant to explore Wnt molecular pathway's role in healthy development and disease, including cancer, osteoporosis, and heart conditions.
A promising radionuclide treatment has been identified for HER2-positive breast cancer patients, combining radioactive iodine therapy with single-domain antibodies targeting the HER2 antigen. The treatment demonstrates safety and efficacy in a phase I study, paving the way for further clinical development.
A team of international researchers has unraveled the inner workings of C5aR2, a key receptor involved in inflammation and COVID-19. The study provides an additional opportunity for therapeutic targeting with new drug molecules to block its activation and inflammation response.
The study found that participants who completed the Active Living After Cancer program showed significant improvements in physical activity, six-minute walk distance, and mental health. The program is effective for minority and medically underserved cancer survivors and can be implemented through a community-based model.
A new study found that benzo(a)pyrene plays a small part in the global risk of developing PAH-associated cancer, with 89% of the risk coming from other unregulated chemicals. Degradation products formed in the atmosphere can also be more toxic than the emitted PAHs.
A large prospective study has found that hospital mortality rates for people with cancer do not appear to have reduced over time, unlike those for people with no history of cancer. The findings are based on anonymized data from over 195,000 people hospitalized in the UK.
The VCU Massey Cancer Center has established a Translational Research Center in Lung Cancer Disparities (TRACER) to address racial disparities in lung cancer. TRACER will investigate the interaction between stress, smoking, and gene expression to raise lung cancer risk in Black men.
A new study finds that left-sided breast cancer radiation therapy increases the risk of coronary artery disease in younger survivors, with a significant increase in risk seen at 10.5% for those who received left-sided radiation therapy compared to 5.8% for right-sided.
A recent study published in CANCER found that cancer significantly reduces the life expectancy of transplant recipients, particularly those who receive lung or heart transplants. The average lifespan lost due to cancer diagnosis among these patients is approximately 2.7 years.
The FIRSTMAPPP trial found that sunitinib significantly prolongs progression-free survival in patients with malignant pheochromocytoma and paraganglioma. The study demonstrated the efficacy of sunitinib as a treatment option for this rare cancer, which is commonly treated with old and toxic agents.
The KEYNOTE-716 trial shows that adjuvant pembrolizumab significantly prolongs recurrence-free survival and halves distant recurrences in stage II B/C melanoma patients. This suggests that patients with high-risk stage II melanoma should be offered adjuvant therapy.
The KEYNOTE-826 study found that adding immunotherapy to standard first-line treatment increases overall survival by eight months for patients with recurrent, persistent or metastatic cervical cancer. The addition of pembrolizumab to chemotherapy also reduced the risk of death and disease progression by 33%.
A study at ESMO Congress 2021 highlights the need for improved cancer follow-up care to address burdensome symptoms like fatigue. Patients often receive inadequate support, leading to widespread dissatisfaction.
Researchers at MD Anderson Cancer Center presented new findings on novel therapeutic approaches, including cell therapy for solid tumors and antibody drug conjugates targeting TROP2. The therapies achieved partial responses in six patients, with an overall response rate of 35.3% and disease control rate of 70.6%.
Researchers at the University of Basel have discovered a novel combination therapy approach that combines inhibiting JAK2 with targeting the MAPK signaling pathway. This dual targeting strategy has shown promising results in improving leukemia treatment outcomes by reducing blood cell production and altering disease course.
A survey of 5,589 cancer patients found widespread unawareness about immunotherapy's mechanism, efficacy, and cost. Non-oncology doctors also face challenges in keeping up with the latest developments in oncology.
Researchers study social support networks and health outcomes of over 670 Hispanic and non-Hispanic lung cancer patients to understand the Hispanic Health Paradox. The study aims to identify cultural differences in social interactions that influence health outcomes.
Researchers at Penn State have imaged a protein facilitating RNA modification, allowing them to reconstruct the process. The study reveals how a chemical tag is added to tRNA, improving its ability to translate messenger RNA into proteins.
Researchers have identified a mechanism to control R-loop regulation, which could lead to new drugs for cancer and dementia. The study found that three proteins work together in a pathway to optimize R-loop levels, with potential applications for treating various conditions.
A new DNA-based test using whole genome sequencing can identify tumour-specific markers to measure cancer levels in children's bodies. This technology has the potential to detect minimal residual disease and change treatment outcomes.
New research highlights the need for adequate communication and support for children of cancer patients. Children can experience anxiety, depression, and behavioral changes due to parental illness, yet many parents struggle to address these issues on their own.
Researchers at Ohio State University found that cancer can cause cardiac dysfunction due to the presence of free radicals, which were reversed by specific antioxidants in fruit flies and mice with tumors. The study suggests a potential new approach to treating heart problems in cancer patients.
A study conducted by Ludwig Institute for Cancer Research has shown that extremely low doses of radiation combined with existing therapies can turn
A new study found that young children with cancer are at a higher risk of permanent hearing loss due to the chemotherapy drug cisplatin. The study, published in the journal CANCER, reveals that up to 75% of children under 5 years old experienced hearing loss after treatment.
A new study by UBC researchers found that chemotherapy drug cisplatin is more likely to cause hearing loss in young children, particularly those under five years old. The study, published in Cancer, shows that the hearing of these children is impacted early during treatment and is affected to a greater extent than older children.
Research from Osaka City University reveals that hepatocellular carcinoma survival decreases as poorly differentiated tumor size increases. Tumors over 5cm have a significantly higher risk of early recurrence and spreading to other parts of the body.
Researchers have developed a new therapeutic method combining synthetic CDK4/6 inhibitors with IKKβ and AKT inhibitors to treat refractory cancers. The study found that this combination therapy can improve treatment outcomes for hepatocellular carcinoma, K-Ras oncogene mutated lung cancer, and colon cancer.
A new study from Penn Medicine demonstrates that RN7SL1, a naturally occurring RNA, can activate the body's own natural T cells to seek out cancer cells that have escaped recognition by CAR T cells. This approach may help improve efforts to treat solid tumors.
A new study found that immune checkpoint inhibitors are effective against HPV-positive head and neck cancers, with a potential therapeutic vaccination approach also being explored. Researchers discovered tumor-specific CD8 T cells in tumors from patients, which could provide a proliferative burst in response to PD-1 blockade.
Researchers developed a blood test to detect cancer early in people with NF1, a genetic disorder that affects 1 in 3,000 people worldwide. The test differentiates between benign and aggressive tumors with high accuracy and could help monitor treatment responses.
PLOS Medicine features five studies outlining novel strategies for detecting cancer and identifying minimal residual disease. Researchers discuss innovative approaches, including plasma cell-free DNA sequencing and urine tumor DNA detection, to distinguish between benign and malignant tumors.
A recent study found that 20% of children with cancer infected with SARS-CoV-2 developed severe infections, compared to 1-6% in general pediatric patients. The Global Registry of COVID-19 and Childhood Cancer also showed that cancer care was disrupted, with 56% of patients having modified treatment and 45% having chemotherapy withheld.
A population-based cohort study in Canada identified mortality patterns for different types of neuroendocrine tumors (NETs), revealing varying risks of cancer-related and non-cancer death. The study found that small NETs can be safely monitored, while larger tumors may require more aggressive treatment.
Researchers at the University of Southampton have identified a unique change in B cells that allows them to receive signals from molecules called lectins, enabling tumor growth. This discovery could pave the way for new treatments and early cancer detection methods.
Research of over 18,000 mother and child pairs found that maternal obesity was associated with a heightened risk of bowel cancer in adulthood. Conditions in the womb may be key risk factors for the disease, which is expected to increase globally due to rising rates among younger adults.
Researchers at Tokyo Medical and Dental University identified a microRNA molecule that can silence specific cancer-promoting genes, overcoming resistance to certain drugs. The study found that the miRNA target multiple genes and pathways simultaneously, making its impact potent.