Articles tagged with Congenital Heart Disease
A Johns Hopkins-led study shows that many heart disease features are better explained by the body's responses to genetic damage rather than the damage itself. The research used a miniaturized catheter to compare healthy and diseased mouse hearts, revealing evolving adaptations that worsen symptoms over time.
The new guidelines provide recommendations for diagnosing and treating heart valve disease, covering common disorders such as mitral valve prolapse and aortic stenosis. It also addresses rare ailments, provides advice on evaluating and treating adults, teens, and pregnant women with defective valves.
Researchers have generated mice with human apoE3 or apoE4 genes, showing that apoE3 promotes nerve cell outgrowth while apoE4 does not. This study provides new insights into the biological effects of apoE variants and may offer a common mechanism for their adverse effects on neurodegenerative diseases.
Researchers found that a specific gene variant, e4, is linked to higher risk of intracerebral hemorrhages (ICH), a severe form of stroke, in African Americans. The study also revealed that these strokes occur at an earlier age in African Americans compared to whites.
Researchers at Duke University have developed a genetically engineered enzyme treatment to address Pompe disease, a condition causing skeletal, heart, and lung muscle destruction. The new therapy will be tested in infants with the most severe symptoms first.
A new study has identified a common functional problem in enlarged heart disease that causes sudden death in athletes, regardless of the genetic cause. This finding suggests that a single therapeutic approach may be effective for all victims of hypertrophic cardiomyopathy (HCM), a leading cause of sudden death in young adults.