Articles tagged with Fungal Infections
Researchers discovered that fluconazole treatment makes fungi sexually active, combining different resistance mechanisms and producing highly resistant offspring. This finding can help develop better drugs and overcome resistance.
A team of European researchers has identified multiple genes that are resistant to Albugo candida, a disease causing white rust in Brassicaceae family plants. The discovery was made using Arabidopsis thaliana as a model plant and has the potential to design new genetic improvement strategies for different cultivated crop species.
Researchers found that Candida albicans exploits lack of oxygen to cause disease by evading immune cells and thriving in deep-seeded body sites. The fungus uses low oxygen environments to become more virulent and causes life-threatening, systemic disease.
A new disease is killing beech trees in Ohio, Pennsylvania, and Ontario, Canada, causing dark-green bands on leaves and leading to tree death. Researchers are searching for a microbe or insect cause, using molecular techniques to compare DNA and RNA from diseased and healthy trees.
Researchers found that Candida albicans can cross the blood-brain barrier, triggering an inflammatory response and forming granuloma-type structures, leading to temporary memory impairments in mice. The findings also suggest a possible link between fungal infections and chronic neurodegenerative disorders like Alzheimer's disease.
Researchers have developed a new technique using antibodies cloned from patients who recovered from Candida infections, showing potential in treating and diagnosing these life-threatening fungal infections. The discovery could lead to the development of novel antifungal drugs through mycoBiologics, a spinout company.
Researchers have created a biotechnological tool to produce antifungal proteins in plants, offering a sustainable solution to combat fungal infections. The new compounds have shown potential in protecting crops and humans from pathogens, improving food security and human health.
Researchers from Aarhus University have made significant breakthroughs in understanding the mechanisms of yellow rust resistance in wheat. The study found that Yr15 gene produces defence responses early in infection, providing a crucial piece of information for developing disease-resistant varieties.
A new checklist of North American fungi reveals 44,488 known species, with hundreds of thousands more awaiting discovery. The comprehensive list includes both large macrofungi and tiny microorganisms, highlighting their crucial roles in ecosystem balance and human well-being.
When working ants take a sick day, they alter their social interactions to protect vulnerable members. By changing their behavior, the colony reduces the risk of fungal infection and maintains social distancing.
A study by Monash researchers has revealed the molecular mechanism behind Candida albicans' transformation into its deadly hyphal form. This process is crucial in understanding how to develop effective treatments for this fatal infection, which affects patients with weakened immune systems and has a high mortality rate.
The three-toed amphiuma, a common species in Louisiana, has shown resistance to the fungus causing amphibian populations to decline worldwide. Researchers discovered compounds that inhibited fungal growth, highlighting its unique properties and potential for protection against chytridiomycosis.
Researchers discovered a common herbicide compound inhibits key enzyme in fungal species, preventing growth and proliferation of infections. The study offers hope for new treatments to combat drug-resistant fungal diseases.
Researchers found that certain commercial herbicides can inhibit the growth of human fungal pathogens like Candida albicans and Cryptococcus neoformans. The herbicides showed synergy with itraconazole to enhance antifungal activity.
A non-pathogenic fungus can expand in the intestines of antibiotic-treated mice and enhance the severity of allergic airways disease. The study suggests that alterations in gut microbiota induced by intestinal fungi might be a previously unrecognized but potentially important risk factor for patients with asthma.
The US Department of Energy has awarded a $1.1 million grant to the University of Illinois for sorghum disease resistance research. The project aims to develop host resistance in sorghum, a key trait for lignocellulosic bioenergy production, by leveraging knowledge from corn.
Researchers found Dectin-1 critical for onset of pain in fungal infection, with inhibition blocking pain and resolving inflammation. A novel signaling mechanism was identified, from Dectin-1 to TRP channels, which could lead to new treatments for severe fungal pain.
A recent study published in the journal Ecology found that pathogens growing at higher temperatures produce offspring causing stronger infections in future hosts, creating a climate 'echo effect' across generations of pathogens. This suggests that climate change may contribute to increased disease severity and outbreaks.
Researchers studied the skin microbiome of eastern massasauga snakes to understand how environmental microbial communities promote disease resistance. Infection with snake fungal disease alters the bacterial and fungal diversity of infected snakes, making them more susceptible to the pathogen.
A fungus called Entomophthora muscae has been found to control the behavior of fruit flies, infecting their nervous system and causing them to climb to high points. The fungus feeds on the fly's fat stores before altering its behavior, eventually leading to the fly's death.
Chiung-Yu Hung receives $1.9 million grant to develop a vaccine for fungal infections, particularly valley fever caused by Coccidioides fungus. The goal is to prevent illness and save lives by stopping the spread of the infection before it occurs.
Research finds Candida krusei and Pichia kudriavzevii are genetically identical, both causing significant morbidity and mortality in immunocompromised patients. The study highlights the need for caution when using drug-resistant yeast strains in biotechnology and food applications.
Scientists analyzed 182 Candida albicans genome strains to understand its reproductive methods and genetic diversification. The study confirmed clonal reproduction but also found evidence of parasexual reproduction contributing to the pathogen's ability to adapt and evolve.
A recent study published in the journal Genetics found that the fungus Trichophyton rubrum exhibits asexual reproduction as its primary method of reproduction. The research suggests that mating between individuals is rare and requires highly specific conditions, resulting in low genetic variability within the population.
Researchers have identified a potentially new approach to treating lethal fungal infections by starving the fungi of essential nutrients. The team found that blocking the phosphate starvation response prevents the spread of infection in mice, offering a novel treatment avenue for patients with weakened immune systems.
Researchers discovered a two-step invasion process mediated by the immune system, which paradoxically promotes infection and meningitis in Cryptococcus neoformans. Monocytes act as transport vehicles for the fungus to cross into the brain, causing tumor-like lesions and meningitis.
Researchers discovered a behaviour-modifying chemical weapon produced by the fungus parasite Escovopsis, which alters leafcutter ant behavior and leads to colony collapse. The study sheds light on the complex arms race between ants and their parasitic partners.
Researchers found that climate change led to a shift in the host choice of zombie ant fungi, from leaves to twigs and bark, as tropical forests transitioned to temperate areas. The study, published in Evolution, reveals that this adaptation occurred independently in different locations around the world.
The rise in resistance to antifungal treatments mirrors the well-established threat of bacteria, which have become resistant to antibiotics. Fungal infections, including blights affecting food crops, yeast and mould-related infections in humans and livestock, can be fatal for those with underlying conditions.
Researchers found that probiotics can decrease the mortality rate of nosemosis in bees by up to 40% and are as effective as commercial probiotics. The study suggests using beneficial bacteria from healthy bee microbiota to combat this disease.
A deadly fungus, chytridiomycosis, affecting amphibian populations was traced to the Korean peninsula through genetic sequencing of 177 fungal samples. Human trade of amphibian species accelerated its global spread, with strains showing varying levels of virulence.
Researchers found that the sex composition and mating dynamics of a fruit fly community significantly impact disease transmission rates. Males faced a greater risk of infection when outnumbered by females, highlighting the importance of social context in disease spread.
Parasites have evolved to 'hack' their host's nervous system, controlling behavior and decision-making. Researchers explore the mechanisms involved, discovering compounds that act on neural circuitry, offering insights into neural control of animal behavior.
A Monash University study has identified a lethal fungus that destroys the immune cell responsible for killing it by depleting its source of nutrients. The research found that Candida albicans competes with macrophages for glucose, leading to their death.
A study led by Rutgers University scientists has found that a fungus causing devastating rice disease became harmful 21 million years ago. The researchers identified key genes and proteins that promote the infection process, offering insights into developing new fungicides and quarantines to combat crop diseases.
Researchers at the University of Birmingham have discovered a unique mechanism driving the spread of Cryptococcosis, a rare and deadly fungal infection. The 'division of labour' process relies on extracellular vesicles to coordinate behavior between individual fungal cells.
A study by University at Buffalo researchers found that drug-filled 3D printed dentures can reduce fungal growth in the mouth. The innovative technology uses microscopic capsules to release Amphotericin B, an antifungal medication, which can help prevent infection while dentures are in use.
The study demonstrates the efficacy of a single dose of NDV-3A in reducing recurrences of vaginitis in patients with RVVC, with younger patients showing higher efficacy rates. The vaccine also generates rapid and robust immune responses.
A 6-year-old boy with intestinal pseudo-obstruction and chronic health issues develops a rare fungal infection Mucor velutinosus in his central line. He is successfully treated with an antifungal drug, highlighting the importance of thorough investigation and good antibiotic stewardship.
A study published in Science reveals that some Central American frog species are recovering from a deadly fungal pathogen, with skin secretions showing improved antimicrobial defenses. The research suggests that the pathogen remains lethal, but frogs' natural defenses appear to be more effective than before the epidemic.
Researchers at UTSA investigate the potential for vaccine development against Cryptococcus, a fungus that can cause deadly fungal meningitis in immunocompromised individuals. The study highlights the need for further research to overcome current challenges in distinguishing between human and fungal cells.
Researchers have discovered that immune cells cause dangerous blood vessel blockage in response to fungal infections, leading to new therapeutic targets. The study's findings could lead to the development of treatments that prevent this blockage without inhibiting the immune system.
Researchers found that frogs surviving the chytridiomycosis epidemic developed stronger defenses against the fungus, inhibiting its growth. However, captive breeding programs face challenges in replicating these findings, highlighting the need for further research on disease dynamics and host resistance.
A new study suggests that amphibian populations in Panama have started becoming more resistant to the deadly fungal pathogen chytridiomycosis. Over 2,000 diagnostic samples show a decrease in the prevalence of the fungus since the initial epidemics occurred.
New research finds that fungi in healthy adults' gut samples correspond to species present in saliva, foods, or experimental diets. These fungi pass through the GI tract as part of digestion rather than colonizing.
A new approach using drug-like molecules is being tested to tackle fungal infections, which cause billions of illnesses and 1.5 million deaths annually. The project uses glycan-based molecules that weaken fungal cell walls, making them more visible to the immune system.
Infected 'zombie ants' do not face aggression from their nest mates, but instead continue to share food resources until they leave the nest to die. The fungus is a chronic condition for the colony, without inducing strong defensive measures.
Scientists found that Trichophyton rubrum nearly all belong to a single mating type and refuse to mate with others, even under various conditions. The fungus's high clonality may limit its ability to adapt, making it more susceptible to new antifungal medications.
Researchers have documented a strange relationship between periodical cicadas and a fungus called Massospora cicadina that hijacks their behavior and causes them to spread the fungus' spores. The infected cicadas exhibit unusual behaviors, such as wing flicking and attempting to mate with uninfected females.
Washington State University researchers are working on developing resistant spinach varieties against Fusarium wilt, a devastating disease that has been crippling farmers' crops in the Pacific Northwest. The team is testing over 600 varieties of spinach and studying their DNA to find genetic markers that reveal natural resistance.
Researchers have made breakthroughs in understanding how rust fungi infect crops and evolve virulence using latest genome sequencing technologies. The study uncovered high levels of genetic diversity between the two chromosome copies, which likely serves as the basis for rapidly evolving new rust strains.
A Phase 2 clinical trial in South Africa found that revaccination with the Bacille Calmette-Guerin (BCG) vaccine significantly reduced sustained TB infections in adolescents. An experimental subunit vaccine candidate, H4:IC31, also showed promise in preventing TB infection or disease.
Scientists have isolated a natural resistance gene, Stb6, that confers protection against Septoria tritici blotch (STB), a major threat to wheat production. The discovery holds promise for deciphering other resistance genes and developing a natural barrier to infection.
A new blood test, T2Candida Panel, detects candidemia with high accuracy, reducing time to diagnosis by nearly two days. The test shows promise in speeding up treatment and potentially improving patient survival rates.
Research classifies olive varieties by their susceptibility to anthracnose, with Picual variety found to be highly resistant. Almost all Spanish cultivars are classified as susceptible or moderately susceptible, highlighting the need for farmers to choose resistant varieties.
A new study suggests that the opening of the Panama Canal in 1914 may have led to the introduction of a deadly fungal disease, Cryptococcus gattii, into the Pacific Northwest region. The fungus, native to tropical regions, has caused outbreaks in Washington and Oregon, with symptoms including cough, shortness of breath, and confusion.
A new antifungal compound has been shown to effectively treat drug-resistant Candida auris, a major contributor to hospital outbreaks and deadly infections. The novel mechanism of action suggests the potential for broader treatment applications across fungal species.
Scientists have identified two fungal genes that cause disease in corn, which could lead to the development of more resistant hybrid varieties. The discovery provides insight into how the fungus outsmarts corn's defenses and may enable researchers to create plant varieties that can detect and resist specific pathogens.
Ants kill fungus-infected pupae to stop the pathogen's lifecycle and prevent infection in the colony. The ants detect sick colony members using chemical cues and perform 'destructive disinfection' to eliminate them.
Researchers have identified a weakness in the lethal fungus Pseudogymnoascus destructans that causes white-nose syndrome. The fungus is highly sensitive to UV light, making it susceptible to novel treatments that could save bat populations.