Articles tagged with Fungal Infections
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Scientists have found a new metabolic pathway that can be disrupted with acetohydroxamic acid, preventing many plant fungi from invading the host plant. The discovery provides a new approach to pathogen control using an existing active ingredient.
Scientists from the University of Edinburgh have made a groundbreaking discovery that fungal cells can develop drug resistance through epigenetic changes, without altering their DNA sequence. This finding has the potential to revolutionize the management of fungal infections in plants and humans.
Researchers found that a Mediterranean ketogenic diet can alter specific gut fungi associated with higher Alzheimer's disease risk. The study suggests that this dietary approach may help reduce harmful fungi in the gut, potentially leading to improved mental health outcomes.
Researchers have identified the human immune system's Achilles heel for a new, effective drug against Candida auris. The fungus is especially dangerous for people with compromised immunity and can be resistant to many disinfectants and fungicides.
Researchers found that patients with acute respiratory distress syndrome (ARDS) have lower fungal diversity in their lungs, leading to more severe disease outcomes. This is because fungi can activate and regulate the immune system, contributing to inflammation and organ failure.
Researchers developed a new vaccine called 4X-SA-GP, which uses fungal β-glucan particles loaded with S. aureus proteins to stimulate antifungal immunity in mice. Vaccination induced protective T cell and antibody responses, protecting mice from staph infection.
A two-year study found that fungal spores of Colletotrichum fioriniae, the cause of bitter rot disease, reside symbiotically within apple leaves. The research suggests that the fungus is a leaf endophyte, with most spores coming from forest samples, and has important implications for fruit tree management.
The study completes the genome assembly of F. oxysporum f.sp. lini, a highly destructive fungal parasite infecting flax. This milestone contributes to the development of resistant crop varieties and aids in eliminating plant disease outbreaks.
A study of 552 older adults found 80% had at least one skin disease requiring treatment, with fungal infections and eczema being the most prevalent. The research also revealed that more than a third had multiple simultaneous skin diseases, highlighting the importance of whole body skin evaluations in this age group.
Researchers analyzed 884 fungal samples from 16 hospitals worldwide to identify clusters of genetically identical strains, suggesting the presence of more virulent and drug-resistant varieties. The study highlights the importance of monitoring hospital infection control protocols and finding effective therapies to combat Candidemia.
A team of researchers at West Virginia University has uncovered the manipulative qualities of a fungal parasite that infects cicadas, allowing it to transmit disease effectively. The fungus, Massospora, tricks male cicadas into mimicking female behavior, luring in unsuspecting males and eventually infecting them.
Researchers discovered a hybrid fungus, Aspergillus latus, in a hospital environment, which is up to three times more drug-resistant than its parental species and highly dangerous. The study aims to investigate the role of fungi in COVID-19 and improve treatment strategies.
A growing evidence suggests a fungal pathogen known as Nosema is infecting native bees worldwide, with little known about its impact on these species. This infection threatens pollination and ecosystems, as native bees contribute to agricultural crop pollination and play a crucial role in local ecosystems.
A new fungal pathogen causing bitter rot disease in New York state apples has been identified, along with a second related fungus found in other fruits. The discovery highlights the need for effective management strategies to mitigate losses up to 25% per year in affected orchards.
The GEOMAR research group has successfully discovered a marine alga from the Kiel Fjord that inhibits pathogenic bacteria and kills melanoma-type skin cancer cells with low cytotoxicity. The researchers used bioinformatics methods and machine learning tools to accelerate the discovery process, reducing it from 3-4 years to months.
Researchers have identified a link between yield decline and soilborne disease symptoms in winter squash, including stunting and root rot. The study's findings suggest that rotating out of winter squash production for at least 3-4 years can help prevent disease symptoms.
Scientists discovered that Neurospora crassa, a type of bread mould, actively mutates its own DNA to fight virus-like infections. The fungus uses a process called Repeat-Induced Point mutation (RIP) to rapidly degrade transposable elements, but this comes at a cost of considerable collateral damage.
Researchers discovered that the white mold fungus Sclerotinia sclerotiorum uses two detoxification mechanisms to overcome the mustard oil bomb in plants of the cabbage family. The fungus can grow on these plants by rendering the toxic isothiocyanates harmless.
A UCLA team successfully treated a child with disseminated coccidioidomycosis by modulating their immune system, paving the way for new treatment approaches for other severe infections. The treatment involves combining established antifungal medications with immune stimulators.
Researchers found that parasitic fungi infect cyanobacteria, reducing their growth and making them easier prey for small organisms. The fungi also serve as a food supplement for zooplankton, connecting different levels of aquatic food webs.
Research highlights the growing threat of fungal crop diseases, outstripping bacterial and viral diseases in severity and scale. The University of Exeter consortium has merged expertise to emphasize the need for new fungicides and robust agricultural systems to address this challenge.
Researchers at University of Queensland are studying bacteria and fungi in sheep faeces and pastures to discover new natural antiparasitics. The goal is to prevent multi-drug resistance and safeguard livestock, with potential benefits for the environment and farming industry.
The Verticillium wilt disease is a complex interaction between multiple microorganisms, including fungi, bacteria, and protozoa, that attack the olive tree. The infection process involves a community of microorganisms, with beneficial fungi turning harmful to the plant.
Researchers at the University of Bristol have developed a new drug formulation that significantly improves the activity of fluconazole against Candida biofilms. The study uses bacterial signals to improve fluconazole's effectiveness, offering a potential alternative to current antifungal treatments.
Researchers found that gypsy moth larvae feeding on fungal-infected poplar leaves grew faster and pupated earlier than those fed only on leaf tissue. Fungal spores contain important nutrients like amino acids, nitrogen, and vitamins, which enhance the caterpillars' performance.
Researchers have identified a gene from a wild wheatgrass relative that confers resistance to fusarium head blight in wheat. The Fhb7 gene, likely transferred from a fungus, detoxifies mycotoxins produced by Fusarium fungi and promotes broad resistance without affecting yield.
Researchers examined the oral mycobiome, discovering 139 species of fungi that live in human dental plaque, with nine strongly associated with healthy teeth. These beneficial fungi may produce compounds like xylitol, which inhibits cavity-causing bacteria.
A recent study on fungal diseases in Åland found that roadsides are a primary source of powdery mildew fungi, which can spread efficiently through the air. The researchers used advanced statistical methods to identify complex mechanisms in nature and shed light on how diseases transmit and evolve.
Researchers at the University of Exeter have identified a novel mono-alkyl chain lipophilic cation (MALC) that protects crops against fungal diseases. The compound, C18-SMe2+, inhibits fungal mitochondria and triggers a self-destruction program in fungi, while also alerting plant defense systems.
Infections are responsible for one in five childhood deaths in England and Wales, with respiratory infections leading the way. The proportion of deaths caused by infections has declined, but not among infants and young children, who saw a significant increase in cases.
A novel oral formulation of Amphotericin B has been developed to overcome dose-dependent nephrotoxicity, drug formulation costs, and parenteral administration-associated toxicities. The lead formulation has successfully completed phase 1b human clinical trials and is set to begin phase 2 trials in vulvovaginal candidiasis
Research reveals environmental reservoir dynamics play a crucial role in white nose syndrome's impact on bat populations. High levels of fungal pathogens in the environment lead to earlier, more severe infections and increased mortality in North America, whereas low levels result in delayed, less severe infections across Eurasia.
Researchers found a toxic fungus previously thought to not be infectious in the sinus tissues of a man with refractory acute lymphocytic leukemia. The team successfully treated the infection using available antifungal drugs.
Tuberculosis bacteria produce a molecule called sulfolipid-1 (SL-1) that triggers coughing in infected animals and human cells, facilitating the spread of disease. The findings could lead to new treatments to prevent tuberculosis transmission.
Researchers investigated how white blood cells respond to co-infection with fungal and viral infections. The study found that viruses can trigger a rapid expulsion of fungal cells from white blood cells, potentially weakening their ability to fight off both pathogens.
Researchers at Swansea University have published two international studies on antifungal drug resistance, which highlights the growing threat of this disease. The studies investigated different aspects of resistance and examined drug resistance in Aspergillus fumigatus, a fungus that causes life-threatening infections.
Researchers at Florida State University discovered a fungus that stabilizes key proteins involved in cancer and neurological disease signaling pathways. The natural product fusicoccin has been identified as a tool to study these networks, leading to the discovery of 14 promising protein-protein interaction targets.
Soil pathogens like Pythium ultimum spread more easily under heat and drought stress, causing widespread crop failure. Soils from Scotland are less resistant to these pathogens than those from Hungary.
Researchers have identified chickpea genes that offer robust non-host resistance to Alternaria blight, a devastating fungal disease affecting Brassica crops. The study reveals these genes can suppress fungal development and colonization in mustard plants, paving the way for blight-resistant crop varieties.
Researchers have developed a new treatment that completely kills the bacterial infection causing severe decline in lung function and death in cystic fibrosis patients. The treatment combines three antibiotics with no side effects, improving quality of life and survival chances for infected CF patients.
Researchers at Tokyo University of Science discovered that extremely low concentrations of acetic acid can alter cellular processes in rice blast fungus, leading to appressorium formation and infection. The study reveals the novel role of acetic acid in metabolic switching and cell differentiation in eukaryotic cells.
Researchers found that probiotic yeasts derived from food can reduce the virulence of non-albicans Candida species by up to 53% and prevent biofilm formation. The study suggests that these food-derived yeasts could be a safe and cost-effective alternative to current antifungal medications.
A study by Indiana University researchers found that two immune receptors, Dectin-1 and TLR2, work together to trigger an inflammatory response against fungal infections. The discovery could lead to new treatments for diseases and improve cancer immunotherapies.
Recent analysis examined safety of oral fluconazole and itraconazole in pregnant women, finding slight increases in risk of congenital heart defects and limb defects. Oral agents were not associated with increased risk of overall birth defects.
Biologists have documented the widespread presence of the notorious chytrid fungus in 80 species of frogs from lowland rainforest sites in the Peruvian Amazon. The study found that even lowland frogs with high levels of fungal infection showed no external signs of disease, suggesting they could serve as a large disease reservoir.
A six-year study has uncovered the existence of a sensor in appressoria that tells the fungus when to rupture the rice leaf. This discovery provides a platform for developing fungicides against rice blast, one of the deadliest crop killers, and could also apply to other septin-mediated fungi.
A study found high rates of 'cold-loving' fungus infection in frogs from the Peruvian Amazon, a region previously thought to be free from disease. The discovery suggests that important reservoirs of infection may exist beyond areas with high mortality rates, threatening global frog populations.
A new survey confirms that muscadine grapes are susceptible to parasitic nematodes, which can impact yield and grape quality. The study found seven types of nematodes associated with muscadines in Georgia and North Carolina.
Researchers at UMD have identified a new pathway by which liver macrophages capture fungi in the bloodstream, preventing their spread and potentially treating various types of fungal infections. This discovery has significant implications for the treatment of invasive fungal infections, which kill 1.5 million people worldwide each year.
A new study suggests that tsunamis after the Great Alaskan Earthquake of 1964 brought a tropical fungus ashore, leading to subsequent outbreaks of often-fatal infections among people in coastal regions. The fungus, Cryptococcus gattii, is typically found in warm climates but was discovered in the Pacific Northwest region.
A new compound derived from eushearilide has shown significant antibacterial properties against various disease-causing bacteria, including MRSA. This finding offers relief for immunocompromised people who are susceptible to life-threatening fungal and bacterial infections.
New research from Washington University School of Medicine shows that infectious disease specialists can significantly improve outcomes for hospitalized patients with fungal bloodstream infections. With a 20% lower risk of death and increased use of life-saving treatments, specialist consultation is crucial in reducing mortality rates.
A Dartmouth study reveals that the way human fungal pathogens form colonies can significantly impact their ability to cause disease. The researchers identified a specific mutation that causes key changes in gene function, leading to improved virulence and host damage. Understanding these characteristics is crucial for developing effect...
Researchers map distribution of deadly chytrid fungus using skin swabs, revealing four known lineages and a new one originating in Asia. The study provides key insights into the disease's origins and geographic spread.
Fungicides can negatively impact aquatic fungi growth, altering their role in decomposing organic matter and as a food source for higher trophic levels.
A new study predicts climate change will cause Valley fever's range to more than double in size this century, reaching previously unaffected areas across the western U.S. The disease is expected to become more widespread in states like Colorado, Idaho and Oklahoma.
A study published in Clinical Infectious Diseases found a significant reduction in UK ICU bloodstream infections over an 8-year period. The research used data from over 1 million patients admitted to 276 NHS adult ICUs, showing a 95% decline in MRSA infections and a 57% drop in E. coli infections.
The guideline covers the diagnosis of invasive pulmonary aspergillosis, invasive candidiasis, and three common endemic mycoses. Effective treatment depends on rapid and accurate diagnosis, with recommendations for laboratory tests such as galactomannan testing and polymerase chain reaction approaches.
Researchers have discovered fungi that flourish in people infected with C. difficile, suggesting a potential new way to treat the disease. The findings suggest that fungal species may contribute to the development of C. difficile infections and could be used as a therapeutic target.
Researchers at UTEP are studying Cryptococcus neoformans, a fungus that causes life-threatening meningitis in AIDS patients. The team aims to understand the fungus's entry into the brain and develop therapeutics to block this process and stimulate immune cells.