Articles tagged with Fungal Infections
Researchers found that certain fungal species in tumors are linked to inflammation and reduced cell-to-cell adhesion, features associated with late-stage cancer spread. High levels of these fungi may serve as biomarkers for metastasis risk and lead to more effective treatment choices.
Researchers have isolated a new fungus, Beauveria caledonica, that can be used for biological control of banana borers and Fusarium wilt, two major threats to tropical and subtropical crops. The fungus produces a secondary compound called oosporein, which intensifies its action against the disease.
A new study found that small mammals can serve as reservoirs for fungi that cause lung infections in humans. The researchers detected fungal pathogens in the lung tissues of rodents from areas with high rates of disease.
The University of Exeter team identified a 'master regulator' that controls the formation of invasive hyphae in the fungus Zymoseptoria tritici. This discovery provides a crucial target for developing new control strategies against Septoria tritici blotch, a destructive fungal disease affecting wheat yields worldwide.
Researchers found that symbiotic fungi in reared ambrosia beetles differed from those in wild beetles, potentially leading to a new biocontrol method for preventing wilt disease. The study identified nine filamentous fungi and one yeast as symbionts, including previously undescribed species.
A new study by the University of Bern has discovered 21 highly-active metal compounds that demonstrate good activity against various resistant fungal strains. These compounds were up to 30,000 times more active against fungi than human cells.
University of Queensland researchers have discovered metal compounds with antifungal properties, showing promise in developing new treatments for resistant fungal infections. The study found that one in five metal compounds displayed activity, with low toxicity in preliminary tests.
Researchers from NAU and University of Washington collaborate to create a safe and effective vaccine for Valley Fever, a fungal infection spreading due to climate change. The project aims to address the growing threat of emerging epidemics and prevent disease through vaccination.
Scientists at University of Utah Health discovered that a fungus that causes fungal meningitis shrinks in size to better infect the brain. The 'seed' cells, which are smaller and have unique features, can colonize other organs and spread infection. Research suggests that phosphate may trigger this transformation.
A recent study finds that fungal infections during the pandemic are a significant public health problem with limited treatment options. The interaction between pathogen and host may be different in people with compromised immunity, leading to increased mortality rates among severe COVID-19 patients.
Researchers found two distinct populations of the invasive American bullfrog in Brazil, one descended from 1935 introductions and another from the 1970s. The study highlights the need for law enforcement to prevent escape from frog farms.
A new study from the University of South Australia shows that captive frogs can be protected from the deadly fungus Batrachochytrium dendrobatidis (Bd) through natural skin shedding processes. However, captivity also reduces skin bacteria diversity and richness, potentially affecting the frogs' resilience to pathogens.
Researchers uncover mechanism behind aspergillosis in critically ill patients with severe influenza or Covid-19, doubling mortality rate. The study found that immune cells and white blood cells are compromised, leading to fungal growth in respiratory tract and lungs.
A fungus called Ustilago maydis manipulates the corn plant's auxin signaling pathway by binding to a protein called Topless, suppressing certain pathways while promoting growth and division. This precise control enables the fungus to thrive in infected plants.
A new study by Johns Hopkins Medicine researchers reveals a promising genetic method for identifying hundreds of disease agents using next-generation sequencing. The Respiratory Pathogen Infectious Diseases/Antimicrobial Resistance Panel (RPIP) system shows near-comparability to traditional diagnostics in identifying pathogens.
Research shows higher concentrations of pathogenic dust landing at lower elevations in the Sierra Nevada mountains, carrying fungi and bacteria that can cause crop failures and human respiratory disease. The study highlights the increasing threat of microbe-laden dust as the Earth dries out.
A team of scientists has discovered the genetic mechanism behind the emergence of highly resistant fungal strains, such as Cryptococcus neoformans. The researchers found that transposon mobility is controlled by small interfering RNA (siRNA), and that disabling siRNA can lead to resistance.
A research team uncovered the secret of powdery mildew's success by comparing genetic compositions of 172 strains from 13 countries on five continents. The pathogen was introduced to new regions through human migration and trade, undergoing hybridization with local species to form better-adapted hybrids.
Researchers at Leibniz-HKI found that lactic acid bacteria nourish intestinal cells, promoting bacterial growth and adapting Candida's metabolism to make it less infectious. This balance restores a healthy state and prevents fungal infections.
Researchers have identified glycans in mucus that can prevent Candida albicans from causing infection. These molecules can be used to develop new antifungal medicines or make disease-causing fungus more susceptible to existing drugs.
A fungus, Moniliophthora perniciosa, causes witches' broom disease in cocoa trees by releasing cytokinin, altering plant hormone balance. The fungus then consumes lignin produced by the tree's vascular tissue after its death.
The study found that silencing cellulase enzymes increases the rate of infection but limits the pathogen's ability to spread, paving the way for new control methods. Fusarium oxysporum is a highly lethal fungus affecting over 100 crops, with its spores remaining in soil for up to 20 years.
Scientists discovered that commensal fungi like Candida albicans need to be alive and actively producing proteins to elicit a beneficial immune response. The fungus oscillates between high and low expression of the UME6 gene, signaling its benefits to the body.
A study from the University of Birmingham and National Institutes of Health found that antibiotics can lead to fungal infections by disrupting the gut's immune system. Using immune-boosting drugs alongside antibiotics may reduce health risks associated with these complex infections.
A recent study found that a single course of antibiotics disrupts the balance of gut bacteria and fungi in infants, leading to increased competition for space. This disruption can result in long-term adverse effects on human health, including antibiotic-associated diarrhea and chronic inflammatory diseases.
Researchers found six cases of drug-resistant Aspergillus fumigatus infection linked to environmental spores. The fungus, common in soil and compost, has become resistant to antifungal drugs due to agricultural use, posing a growing threat to lung health.
Researchers have discovered how fungus blocks and bursts blood vessels in the brain, allowing microbes to spread and cause meningitis. The study identifies a simple yet effective method that microbes use to escape the immune system and enter the brain.
A team of researchers developed a novel chip-based infection model to study invasive aspergillosis, a mold infection that affects the lungs. The model allows for live microscopic observation of damage caused by fungal hyphae and the response of immune cells.
Scientists have discovered a yeast self-destruct pathway, adding to evidence that unicellular organisms have programmed cell-death mechanisms. This finding could lead to new antifungal drugs targeting such mechanisms.
Scientists from around the world gather to discuss various amphibian and reptile diseases, with a focus on conservation and management strategies. The conference aims to identify solutions to mitigate the impact of these diseases on herpetofauna populations, which are currently experiencing alarming extinction rates.
Research reveals extracellular vesicles facilitate coordinated responses among pathogenic fungal cells, enabling them to overcome host defenses. The discovery could lead to the development of more effective therapies to combat fungal infections.
A study by Charité researchers found that fungal pathogens benefit from cooperative relationships, exchanging metabolites and becoming tolerant to anti-fungal drugs. This mechanism also provides growth advantages for metabolically competent cells, reducing their susceptibility to hundreds of antimicrobial substances.
A study found that higher doses of antibiotics are needed to eliminate bacterial infections with other microbes present. Researchers developed a model of the human airways to replicate poly-microbial infections, which often persist despite treatment in people with cystic fibrosis and other lung diseases.
Researchers at Weill Cornell Medicine found that certain Candida albicans yeast strains produce a potent toxin called candidalysin, which damages immune cells and triggers pro-inflammatory responses. The study suggests a possible way to personalize treatments for IBD patients by targeting these high-damaging strains.
A new UMaine study shows that a specific combination of pathogens and drugs can effectively treat fungal lung infections. Researchers found that Pseudomonas aeruginosa works with fluconazole to eliminate drug tolerance and clear Candida albicans infection, suggesting that nutrient availability can impact treatment efficacy.
Researchers have identified a key gene that confers stripe rust resistance in bread wheat, providing hope for improving crop yields and ensuring global food security. The discovery was made possible by the assembly of the highest-quality genome to date for bread wheat using advanced DNA sequencing techniques.
Researchers at Johns Hopkins Medicine discovered a critical step in the molecular circuitry of immune cells that mobilizes the immune system to fight off foreign invaders. The findings, published in iScience, shed light on subtle genetic variations among human populations that may explain individual responses to infections.
Researchers discovered that Candida albicans stimulates human immune cells to release microRNAs, triggering increased fungal growth. The fungus exploits human immune defenses by releasing signal molecules recognized by special immune cells.
Researchers have sequenced the genome of Candida glabrata, a deadly yeast infection that's resistant to antifungal drugs. The study found genes associated with virulence and drug resistance, shedding light on how the pathogen spreads and evolves.
A new study found that fungal infections result in significant healthcare spending, with direct costs of $6.7 billion and secondary infections contributing to a total of $37.7 billion in U.S. national health care expenses. Fungal infections doubled hospital costs, patient stays, and mortality risk.
A recent study has identified a family of proteins involved in yeast infections, which pose risks to both humans and crops. The research found that variations in these proteins can disrupt the signalling function that leads to filamentation, impeding its progress.
A preclinical study by Weill Cornell Medicine researchers reveals that a specific group of fungi residing in the intestines can protect against intestinal injury and influence social behavior in mice. The findings suggest a novel signaling system connecting fungi in the gut to their host's cells, including immune cells and neurons.
Research reveals that approximately 3 out of 4 Fusarium infections of northern Vietnamese bananas are caused by F. tardichlamydosporum and F. odoratissimum, with wild bananas potentially acting as a sink for the disease. The study's findings suggest that concrete measures can be taken to control the future spreading of the disease.
Researchers have discovered a spray-induced gene silencing technique that effectively controls late blight, a devastating disease affecting potatoes and tomatoes. This environmentally friendly method has potential to reduce the usage of chemical pesticides and can be quickly adapted for new targets.
A young diplodocid dinosaur with abnormal bony protrusions in its neck bones may have suffered from a fungal respiratory infection similar to aspergillosis. The study provides the first evidence of an avian-style respiratory infection in a non-avian dinosaur.
A recent study by the University of Florida-led team found that common Southeastern US trees are not threatened by exotic fungi carried by wood-boring beetles. The 10-week experiment involved 55 species of Eurasian beetles and over 100 fungi samples, with none causing significant damage to saplings.
The University of Texas at San Antonio has established a San Antonio-based Coccidioidomycosis Collaborative Research Center (SA-CCRC) focused on developing therapeutics and vaccines against coccidioidomycosis. The center will support applied clinical research and house an extended network of experts from partnering institutions.
Research from the University of Georgia reveals that compounds used to fight fungal diseases in plants are causing resistance to antifungal medications used to treat people. The study found 12 strains of Aspergillus fumigatus resistant to both agricultural and clinical azole fungicides, suggesting a link between environmental and human...
The NIH is supporting research on coccidioidomycosis, also known as Valley Fever, with three new awards totaling over $4.5 million. Researchers will focus on developing diagnostics, therapeutics, and vaccines to combat the disease, which affects thousands of people in the US each year.
Researchers at MUSC found that fungal infections are common in cirrhosis patients, often resistant to antibiotics. Patients with cirrhosis are immunocompromised and need proactive infection management.
The four-year programme will investigate the chemical signatures that trigger immunity in fungal infections, which kill an estimated 1.6 million people worldwide annually. By understanding these signatures and how fungi disguise them, researchers hope to uncover the origins of antifungal immunity.
Scientists at UC Berkeley developed a new structure prediction method that modeled 500 secreted proteins in fungal pathogen Magnaporthe oryzae. The method revealed novel sequence-unrelated effectors and common folds among plant pathogens.
A recent study published in The Lancet Respiratory Medicine found that COVID-19 patients in ICUs have a high risk of developing invasive fungal secondary infections. In fact, the MYCOVID study revealed that 22% of intubated and mechanically ventilated COVID-19 patients in ICUs had proven or probable invasive pulmonary aspergillosis and...
A comprehensive diagnostic guide for Volutella blight has been published by the American Phytopathological Society. The guide provides a detailed review of the three fungal pathogens causing Volutella blight and compares its diagnostic traits with other boxwood fungal diseases.
Researchers at Michigan Medicine have developed a new genetic tool to study Candida auris, revealing key factors behind its shape-shifting abilities and drug resistance. The study could aid in understanding the fungus's transmission on hospital surfaces.
Research reveals a lag of 5-10 years between reduced fungicide use and decrease in fungicide-resistant pathogens. The study's findings provide insights into the impact of fungicide resistance on global distributions of pathogens.
Researchers have identified fragments of genetic material in Candida fungus that do not encode proteins but are specifically expressed during distinct stages of the infection process. These long non-coding RNA molecules show high specificity and differ between species, making them a potential target for new treatments.
Researchers developed an AI program that accurately identified patients at risk of serious illness due to blood infections, with an accuracy rate of 82%. The technology has the potential to serve as an early warning system for doctors, enabling them to rank patients based on their risk level.
Scientists discovered that fungal endophytes convert chitin to chitosan, a natural plant defense activator, to evade host defense. This conversion enables the fungus to live in symbiotic association with grasses, protecting them from biotic and abiotic stresses.
Researchers have discovered that certain strains of Aspergillus can be used to degrade aflatoxins in crops, reducing the risk of food contamination. This biological control method utilizing biocontrol products is currently the most effective way to produce safe and healthy foods and feeds.