Articles tagged with Fungal Infections
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Researchers developed a yeast-based tool that can detect fungal pathogens responsible for major human disease, agricultural damage, and food spoilage. The one-component biosensor is extremely low-cost, easy to use, and doesn't require cold-storage facilities, making it a game-changer for global pathogen surveillance.
Scientists have identified a new fungal skin disease affecting European wild snakes for the first time. The study, led by the Zoological Society of London, confirms that snake fungal disease (SFD) is present in UK and Czech Republic snakes, posing no risk to humans or livestock.
Researchers found that Candida tropicalis infection intensifies Crohn's disease symptoms in mice by modulating gut bacteria and triggering inflammation. The study suggests anti-fungal medications could be beneficial in combating debilitating symptoms of the disease.
A team of international scientists has identified a critical gene-regulating protein, Bdf1, essential for the survival of Candida albicans. Compounds that bind to this target can disrupt fungal growth, opening the way for novel drug treatments. The discovery offers a promising alternative to existing antifungal therapies.
Researchers identified natural genomic variation in Cryptococcus neoformans, influencing prevalence and disease severity. The study found specific variants associated with clinical isolates linked to known virulence factors.
Dr. Jack Edwards, a leading researcher at LA BioMed, has been recognized with the Rhoda Benham Award for his continuous outstanding contributions to medical mycology. His work focuses on understanding fungal diseases, aiming to develop new anti-fungal agents and immunotherapies to prevent life-threatening infections.
Researchers found that fungal infections like bunch rot and powdery mildew alter the chemical composition of wine, changing its aroma. Bunch rot infection increased fruity and floral notes, while powdery mildew decreased vanilla-like notes, resulting in lower aroma ratings.
A new study from the University of Helsinki suggests that climate change may increase the damage caused by a naturally circulating fungal disease in Norway spruce trees. The researchers found that future climate changes can alter the impact of forest pathogens, highlighting the need for further research on this topic.
Researchers found that intestinal fungi exacerbate liver disease and can be protected against by antifungal treatment. Fungi overgrowth leads to inflammation, which kills liver cells and promotes disease progression.
A study led by Bernd Schnabl found that chronic alcohol intake increases fungal populations in the intestine and levels of β-glucan in the bloodstream, leading to liver inflammation. Treating mice with anti-fungal agents prevented liver disease, supporting further research into the fungal microbiome's role in alcohol-related liver damage.
Research finds that tulip bulbs from the Netherlands are carrying a fungal pathogen resistant to key antifungal therapy, Voriconazole. The discovery raises concerns for immunocompromised patients and highlights the need for vigilance in preventing the spread of resistance.
Researchers at the University of Tsukuba have uncovered a molecular mechanism that coordinates growth spurts in filamentous fungi. The team discovered that cellular calcium levels oscillate, triggering the assembly of actin chains that guide vesicles to the site of growth.
The invasive Batrachochytrium salamandrivorans fungus has led to mass mortality of fire salamanders in the Netherlands, Belgium, and Germany. Only 13% of infected salamanders survive over a 10-day period, highlighting the high risk of extinction.
Biologists and veterinarians across the US are working with Illinois researchers to identify, understand and treat snake fungal disease. The team has developed a nebulizer treatment that shows promise in preventing the spread of infection, but more research is needed to determine its effectiveness.
A team from CRAG has found that the regulation of protein activity through SUMOylation is crucial for plants to protect themselves against fungal infections. Plants with compromised SUMOylation show increased susceptibility to necrotrophic fungal infections.
Researchers found that Candida yeast infections contribute to bowel difficulties in men with schizophrenia. Probiotics also decreased delusions and hallucinations in participants without a history of yeast infections. Larger studies are needed to validate these findings and determine their effectiveness for women with schizophrenia.
Scientists discovered a novel virus that weakens fungal incompatibility, allowing for transmission of unrelated viruses. This breakthrough could aid in controlling fungal diseases using viruses as a strategy.
Researchers at the University of Arizona have developed a promising method to prevent aflatoxin contamination in crops, which could improve food security in developing countries. The transgenic corn plants produce small RNA molecules that suppress toxin production when infected with a fungus.
A study published in JAMA Dermatology ranks the top 10 most disabling skin diseases globally, with dermatitis and acne at the top. The research also highlights the disproportionate impact of non-cancer skin conditions on global health.
The study provides evidence that a new investigational drug (SCY-078) may help to cure Candida auris infections. The fungus is multidrug-resistant and has been linked to invasive infections with high death rates globally.
A UT doctoral candidate won a competition presenting research on the impact of droplet size and orifice number on fungus control in cotton. The study found no significant difference in disease control or yield between treated and untreated cotton.
A comprehensive review of Bufonidae family compounds reveals their largely unexplored potential for new drug discovery. The study highlights the critical need for conservation efforts due to declining amphibian populations.
A new report calls for improved fungal disease diagnosis to reduce antibiotic resistance. Inadequate attention to fungal infections leads to overprescription of antibiotics, resulting in harmful resistance and increased healthcare costs. The report highlights four clinical situations where fungal disease misdiagnosis worsens the problem.
Researchers at the University of York have identified genetic markers for disease tolerance in UK ash trees, suggesting they may be able to withstand a devastating fungal infection. This discovery could contribute to breeding new varieties of ash that are tolerant to the disease.
A newly discovered virus infecting the fungus that causes white-nose syndrome in bats could help scientists track its spread. The variation in the viral genome provides clues about how the disease is moving, enabling researchers to better understand its epidemiology.
Scientists at Technical University of Munich have discovered an important mechanism in the body's defenses against fungi. Vav proteins play a key role in regulating the innate antifungal immunity pathway, particularly when CARD9 is present.
A team of scientists at Brown University has made key discoveries about the body's natural immune response to fungal infections. They found that specific receptors on white blood cells signal the cells to take action against the fungus, and manipulating these receptors may help develop new therapies to combat growing drug resistance.
Fungal skin infections are commonly misdiagnosed due to difficulty distinguishing between various skin conditions. Misdiagnosis can result in incorrect therapy selection and worsening symptoms, according to a survey by GW dermatologist Adam Friedman.
A new study warns that the UK's fungal asthma problem is much worse than previously thought, with an estimated 300,000 adult cases. Invasive fungal infections, such as invasive aspergillosis and Candida bloodstream infections, are common and often fatal if left untreated.
A new species of fungal disease, Curvularia malina, has been identified on short-cut Bermuda and Zoysia grasses in southern US golf courses. The disease can cause black spots and reduce turf aesthetic quality, but proper diagnosis and management practices can mitigate its impact.
Researchers at the University of Exeter have discovered that asexual spores of the ash dieback fungus can germinate on leaves or infect seedlings via soil, spreading the disease more quickly than previously thought. This finding reveals additional routes for the fungus's spread and increases the risk to trees and ecosystems.
A University of Exeter study found no evidence that climate change is linked to a fungal disease affecting coffee crops. Researchers tested the hypothesis that climate change increased the probability of favorable weather conditions for CLR, but rejected the hypothesis due to other factors contributing to the disease outbreak.
A recent study published in Current Biology shows that the type of yeast used to make bread is less similar to the type that causes fungal infections than previously thought. This discovery may lead to the development of targeted drugs with limited side effects.
A new study found that spraying barley crops with an RNA molecule inhibits fungus growth, while the plant's vascular system transports it to distant infection sites. The researchers also identified a key protein involved in the process.
Researchers discovered that trans-kingdom small RNAs can protect crops from fungal pathogens, including the causal agent of 'Cotton Cancer'. The study found that specific sRNAs can be expressed in cotton cultivars to confer resistance to Verticillium wilt disease.
The US Preventive Services Task Force (USPSTF) recommends latent TB infection screening in primary care settings, but challenges remain in identifying high-risk patients. Current tools are insufficient to predict progression from latent to active disease, hindering personalized medicine for those with latent TB infection.
Researchers identified Mp1p as a key virulence factor in Talaromyces marneffei, allowing it to survive in macrophages and cause disease. The protein's homologs were also found to contribute to pathogenicity, highlighting a potential target for treatment.
Researchers have discovered two distinct growth forms of Candida auris, a fungus resistant to multiple antifungal drugs, which can cause fatal infections in hospital patients. The strain's ability to cause disease is surprisingly high, rivaling that of the most invasive Candida species.
Researchers have identified a potential antifungal mechanism by targeting mitochondrial respiration in pathogenic fungi, which could enable combination therapy with fluconazole and prevent drug resistance. The approach has shown promise in treating severe invasive fungal infections, including those caused by Candida albicans.
Researchers have discovered the DNA of a fungus that causes black Sigatoka disease in bananas, which could lead to more effective disease control methods. The findings provide insights into the interaction between the fungus and banana plants, offering opportunities for developing resistant banana crops.
Valley fever, caused by Coccidioides immitis and Coccidioides posadasii, affects over 150,000 people annually. Early diagnosis is crucial to prevent unnecessary tests and treatment, reducing the impact of complications. Pregnant women, immunocompromised individuals, and those with diabetes are at high risk for severe outcomes.
A new study by University of Maryland School Medicine researchers has identified key aspects of the Mucorales fungi that may lead to treatment development. The fungus invades weakened immune systems, causing sometimes-deadly mucormycosis infections.
Researchers have identified molecular pathways required for the development of mucormycosis, a fatal infection in patients with weakened immune systems. The study provides new insights into the evolution of Mucorales fungi and offers potential therapeutic targets.
A research team found that a fungus, Pneumocystis carinii, plays a more important role in pneumonia than previously thought. The fungus was detected in piglets of all ages and appeared to proliferate before bacterial pathogens, suggesting it may be a 'door opener' for secondary infections.
Researchers at Ohio State University have identified a potential gene-based treatment for Candida albicans, which can cause deadly hospital-acquired bloodstream infections. By targeting the CBLB gene, the immune system can be boosted to effectively combat the infection.
Scientists developed a novel algorithm to predict synergistic antifungal drug combinations for treating drug-resistant fungal infections. The algorithm, NLLSS, integrates various information types and experimentally validated 7 out of 13 predicted combinations for Candida albicans, providing new treatment options.
Two studies suggest that frogs' ability to withstand high temperatures can help them survive disease outbreaks, such as the deadly fungus Batrachochytrium dendrobatidis. Climate change may outpace deforestation as a habitat threat in tropics, and species with high thermal tolerance are less susceptible to infection.
The updated guidelines highlight the importance of early diagnosis and treatment for invasive aspergillosis, a potentially deadly fungal infection. New therapies, including isavuconazole and posaconazole, have improved care, but aggressive diagnosis is still critical.
Researchers found that fendiline hydrochloride can stimulate patient's own white blood cells to fight cryptococcosis more effectively. The compound may inhibit the survival of Cryptococcus neoformans, a pathogen causing fatal infections in immunocompromised patients.
A new rain frog species, Pristimantis pluvialis, has been described from Amazonian Peru and the Amazonian foothills of the Andes. The discovery highlights the need for continued study of tropical regions to uncover new species.
Researchers will study pollinators at various sites to identify the insects responsible for spreading mummy berry disease and investigate how variations in insect visitation affect resistance levels among blueberry varieties. The study aims to reduce reliance on fungicides and help growers cope with the disease.
A global study by TGen found six new species of Histoplasma fungus, linked to bat evolution, which causes histoplasmosis and poses a deadly risk to HIV and other immunocompromised patients. The disease is known for its high mortality rate in Latin America and is becoming more frequent globally.
A newly compiled database of insect-fungi interactions has revealed that 65 percent of insect orders can be infected by fungi and Oomycetes. Sap-sucking insects, such as cicadas, are the most frequently attacked by fungi due to their specialized mouth parts for sucking sap.
Researchers found that fungi acquired a protein from a virus that hijacked their cell division control machinery, allowing them to grow and divide uncontrollably. This discovery could lead to the development of new antifungal drugs that target only fungal cells, not plant or animal hosts.
Researchers discovered that fungal spores can infect human immune cells, allowing them to transport themselves and cause systemic infections. The discovery sheds light on the ecological adaptation of Aspergillus terreus and its potential for detrimental effects in human infections.
A Polish Academy of Sciences team devised a chemical sensor to detect fungi in just a few minutes, reducing detection time from days to hours. The sensor uses D-arabitol, a compound indicating fungal presence, detected with high certainty even in the presence of interfering substances.
Scientists at TGen tracked the likely origins and dispersal of Valley Fever using genomic analysis technologies, revealing a history spanning 2 million years. The study identifies two distinct species of the fungus Coccidioides and estimates their divergence dates, providing insights into future outbreak tracking.
A study found that commercial bumble bee pollination operations coincided with infections and declines in wild bumble bees. The fungus, N. bombi, was present in the US as early as 1980, well before wild bumble bee species began to decline.
A recent study published in HortScience provides new recommendations to increase the stock of blight-resistant American chestnut trees. Genetic engineering is proposed as a solution, with the addition of one gene, oxalate oxidase, protecting the tree from the fungus. The study also examined optimized propagation protocols using activat...
Researchers at Purdue University have found that the fungus Moniliophthora roreri reproduces clonally rather than sexually, producing billions of spores that destroy cocoa pods. This discovery could help improve cacao breeding programs and develop resistant cultivars.