Articles tagged with Heart Disease
For patients with cerebral ataxia, researchers linked specific biochemical changes in the CHIP protein to disease characteristics. Limiting mutant CHIP protein activity may decrease symptom severity.
A large Chinese study found that insomnia symptoms are associated with a higher risk of stroke and heart attack. The research, published in Neurology, followed over 487,000 participants for an average of 10 years and found that those with insomnia symptoms were 18% more likely to develop these diseases.
Researchers developed a gene therapy combining FGF21 and ?Klotho treatments to target multiple age-related diseases. The single-formulation treatment successfully treated obesity, type II diabetes, heart failure, and renal failure in mice.
Kaiser Permanente research identifies a national trend of increasing deaths due to heart failure among US seniors, with over 647,000 people dying from heart disease in 2017. The study highlights the importance of addressing heart health in older adults as the population continues to age and grow.
Consuming fish, fruits, nuts, whole grains, olive oil, and vegetables reduces risk of mortality and diet-related diseases, while unprocessed red meats increase risk. These dietary changes may also support environmental sustainability by lowering environmental impacts.
Research found that offspring of obese rat mothers showed impaired mitochondrial function, leading to early signs of diabetes and increased susceptibility to heart disease. Exercise improved these outcomes, suggesting a potential therapeutic benefit.
New research reveals that maternal obesity accelerates the aging process in offspring, leading to increased susceptibility to diabetes and heart disease. Exercise by the offspring can help mitigate these risks, highlighting the importance of early life conditions on future health outcomes.
A new metabolic discovery by researchers at Cornell University may hold the key to fighting heart disease and Type 2 diabetes. The study identifies two enzymes that convert glucose to erythritol, a sugar alcohol, in human metabolism.
A new study published in the Journal of the American Heart Association found that sleeping less than six hours per day can significantly increase the risk of heart disease and stroke. Middle-aged adults with high blood pressure, Type 2 diabetes, or heart disease are particularly at risk, according to researchers.
A study published in CMAJ found that heart disease increases the risk of hospitalization for allopurinol-related severe skin reactions. People with specific genetic markers, such as HLA-B*5801, are at higher risk. The risk is further increased when combined with kidney disease.
Researchers at the University of Cambridge found that people who achieve weight loss of 10% or more within five years after diagnosis are more than twice as likely to go into remission. This suggests that significant calorie restriction and weight loss can reverse type 2 diabetes.
A new study found that halving red and processed meat consumption reduces LDL 'bad' cholesterol levels and heart disease risk by an average of 10%. Researchers discovered that even small changes to RPM intake can induce significant changes in LDL cholesterol, potentially reducing the risk of developing heart disease.
A study published in the Journal of the American Heart Association found that on-the-job pesticide exposure raised the risk of heart disease and stroke in Japanese American men. After 34 years of follow-up, no significant link was found between pesticide exposure and cardiovascular disease.
Individuals with familial hypercholesterolemia face a high risk of heart attack and stroke despite receiving multiple cholesterol-lowering treatments. The study found that only 52% of adults with FH meet LDL-cholesterol targets, highlighting the need for more aggressive treatment.
A study analyzing humans, chimpanzees, and gorillas reveals the human heart adapts to endurance activities by becoming larger, longer, and more elastic. However, there is a trade-off between these adaptations, making it harder for individuals with one type of adaptation to cope with the other.
A new two-minute focused cardiac ultrasound protocol can help veterinarians detect heart disease in cats earlier, potentially saving lives. The test, developed by researchers at Tufts University, has been shown to be successful in detecting moderate and severe heart disease with high accuracy.
Researchers at Penn Medicine successfully harnessed CAR T-cell therapy to target and remove activated cardiac fibroblasts, significantly reducing cardiac fibrosis and restoring heart function in mice with heart disease. The approach demonstrates potential for treating heart disease, a leading cause of death worldwide.
Researchers create biomaterial-based models of heart tissues to understand the impact of aortic valve replacement procedures on cardiac tissue remodeling. The study reveals key proteins associated with myofibroblast deactivation and offers potential for developing innovative therapies for fibrotic diseases of the heart.
A study published in PLOS Biology has identified conserved proteins and pathways in four major animal models and humans, revealing unique sets of proteins mutated in human disease states. This discovery allows researchers to select the most appropriate model systems for studying cardiac development and investigating diseases.
Research suggests that central blood pressure, measured at the aorta, can more accurately reflect heart disease risk in individuals with treatment-resistant high blood pressure. This measurement may help tailor blood pressure treatment and reduce heart disease risk for affected patients.
Researchers at CNIC discover strategies to inhibit kinase GSK3? in mice with ARVC5, reducing fibrosis and improving heart function. The study aims to translate the results to patients and investigate gene therapy strategies for potential cure.
Researchers found that modest decreases in cholesterol and blood pressure can reduce the lifetime risk of developing fatal heart and circulatory diseases, such as heart attack and stroke. A long-term reduction of 1 mmol/L LDL cholesterol and a 10 mmHg decrease in blood pressure led to an 80% lower lifetime risk.
A new study suggests that a diabetes medication called empagliflozin can protect against heart disease by regulating circulating progenitor cells and reducing inflammation. The findings from the EMPA-HEART CardioLink-6 Trial may provide the basis for new therapies for patients with heart disease complicated by diabetes.
A new Northwestern Medicine study finds total heart disease deaths increasing since 2011, with a significant portion of deaths preventable. The study's authors call for a shift in focus towards prevention to combat cardiovascular disease.
A hand-held device measures heart disease biomarkers from saliva to predict risk of heart disease, failure or heart attack. The technology has been validated in the lab with high accuracy and could help millions of potential victims take preventative steps.
Research funded by the British Heart Foundation has challenged a long-held medical myth that women experience unusual heart attack symptoms. According to the study, both men and women present with similar key symptoms, such as chest pain and nausea, highlighting the need for awareness of common warning signs.
Researchers have discovered bone-like particles in the peripheral circulation of individuals with advancing age, which may lead to vascular calcification and restricted blood flow. These particles are potentially more dangerous due to their sharp edges and could contribute to diseases such as heart attack and stroke.
Researchers found that moderate flavonoid consumption was associated with a lower risk of death from cancer and heart disease. Participants consuming about 500mg of total flavonoids per day had the lowest risk of a cancer or heart disease-related death, which is easily achievable through a balanced diet.
A new drug called volanesorsen has been shown to significantly reduce blood fat levels in people with a rare genetic disorder. In a Phase III clinical trial, participants experienced a 77% reduction in triglyceride levels, while those receiving a placebo saw a 18% increase.
The Endocrine Society recommends regularly screening older adults for heart disease and diabetes risk, prioritizing lifestyle modification as the first-line therapy. Patients with at least three metabolic risk factors should be screened annually, while those with one or two risk factors should be screened every three years.
Scientists developed a technique to study heart disease in action, enabling them to identify ways to lower plaque-forming lipoproteins. The LipoGlo system allows researchers to measure lipoproteins in tiny droplets of blood, opening up new avenues for treating cardiovascular disease.
A recent study found that university students who used their smartphones for five or more hours a day had a 43% increased risk of obesity. This prolonged cell phone use was associated with decreased physical activity and unhealthy lifestyle habits, including consuming sugary drinks and fast food.
A single viral factor released from HIV-infected cells impairs cholesterol metabolism in uninfected cells, triggering inflammation and contributing to the development of diseases such as dementia, heart disease, and diabetes. Targeted treatment may provide a longer and healthier life for people living with HIV/AIDS.
A new study found that individuals with familial hypercholesterolemia (FH) or atherosclerotic heart disease (ASCVD) experienced more cardiovascular events when they couldn't get their prescribed LDL-cholesterol lowering medication. Those whose PCSK9 inhibitors were rejected by insurance had a 16% increased risk of a cardiovascular even...
A large-scale analysis found that women and those aged less than 45 years were more likely to be under-treated compared to men and older people with CHD. Women were also less likely to be prescribed the recommended medications for daily use.
Researchers found that people on the Paleo diet had twice the amount of a key blood biomarker linked closely to heart disease. The study suggests that the diet's exclusion of whole grains may be to blame for elevated TMAO levels, which are associated with an increased risk of heart disease.
A quarter of adults aged 40+ take daily aspirin for heart disease prevention without physician's advice. Nearly half of adults 70+ report taking aspirin daily due to potential harm outweighing benefits.
A team of scientists has identified a key molecular connection between diabetes and vascular disease, finding that high blood glucose activates an enzyme that constricts blood vessels. The study aims to develop new treatments targeting this pathway for reducing vascular complications of diabetes.
Researchers found a slowdown in dietary salt intake in England since the voluntary pact was introduced in 2011, leading to an estimated 9900 extra cases of heart disease/stroke and 1500 additional stomach cancer cases by 2018. If current trends continue, this may lead to 26,000 extra cases and £1 billion in healthcare costs by 2025.
A recent analysis of clinical trials found that only a low-salt diet, omega-3 fatty acid supplements, and possibly folic acid supplements showed potential health benefits. The majority of supplements had no link to increased or decreased risk of death or heart health.
Researchers at UCalgary have identified a new cell population in pericardial fluid that helps heal injured hearts in mice and humans. This discovery could lead to new treatments for patients with damaged hearts.
Research found that young adulthood is a critical period for cardiovascular disease prevention. Elevated blood pressure and cholesterol levels in this age group are associated with an increased risk of heart disease later in life. Maintaining optimal levels of these risk factors could yield substantial lifetime benefits.
Recent evidence highlights the need for physicians to ask athletes about symptoms and family history to determine inherited conditions. Automated external defibrillators can significantly increase survival rates after sudden cardiac arrest in athletes.
A large UK Biobank study found an association between elevated systolic blood pressure and increased risk of major valvular heart disease. The study included over 329,000 individuals with genetic data and blood pressure measurements.
A global audit and survey found that cardiac rehab is available in only 55% of the world's countries, serving only 1.65 million patients, leaving a gap of over 18 million patients in need. The programs that do exist are often under-resourced, with many countries lacking cardiac rehab spots altogether.
A study in the Journal of Diabetes Investigation reveals that adults with type 2 diabetes are at a higher risk of dying from cancer compared to the general population. The research found that cancer accounted for 27.8% of deaths among those with type 2 diabetes, while heart disease was the leading cause in the general population.
Researchers reviewed gene sequences of over 70,000 people and found that only 5% of patients with a TTN gene mutation developed dilated cardiomyopathy. Despite this, subtle differences in heart function were detected in those with the mutations, suggesting that pinpointing these genes may not be a reliable predictor of heart disease.
A recent study has found a link between cardiac disease in captive gorillas and male obesity, revealing that thickening of the heart due to scarring interferes with normal heart function. Female gorillas also develop heart disease but less frequently than males, despite living longer.
Researchers found that each additional year of schooling lowered risks like smoking and depression in adulthood. Higher education also linked to reduced heart disease due to higher incomes allowing better food and healthcare access.
A study found that increased educational attainment during childhood is associated with reduced heart disease and improved cardiovascular risk factors in adulthood. The authors suggest that policies to increase educational attainment could help reduce the burden of heart disease at a population level.
A new study reveals that chronic diseases such as stroke, ischemic heart disease, and lung cancer are now the leading causes of premature death in China. The study's findings show a significant shift from communicable to chronic conditions over nearly three decades, largely due to economic growth and increasing education levels.
Adults with coronary heart disease experience faster cognitive decline in long-term studies, according to researchers. Cognitive tests reveal significant differences in verbal memory, semantic fluency, and temporal orientation among patients with angina or heart attack.
Patients with untreated white coat hypertension face a 36% increased risk of heart disease and 33% increased risk of death, finds a new study. Out-of-office blood pressure monitoring is crucial in diagnosis and management of hypertension, the researchers argue.
A new study finds that low intake of fruits and vegetables may account for millions of cardiovascular deaths worldwide, with nearly 1.8 million related to low fruit intake and 1 million related to low vegetable intake. The research highlights the need for population-based efforts to increase fruit and vegetable consumption globally.
Research funded by the British Heart Foundation found nearly 276,000 pregnancies affected by high blood pressure and 223,715 with pre-eclampsia. The study revealed a 45% increased risk of serious heart conditions for women with high blood pressure during pregnancy, and a 70% increased risk for those with pre-eclampsia.
A large-scale study found that consuming high amounts of cholesterol from eggs is associated with a higher risk of cardiovascular disease and death. The researchers also noted that even healthy diets can have negative effects when eggs are consumed excessively, emphasizing the importance of moderation and balance in daily eating habits.
Researchers at WVU discovered that higher exposure to perfluoroalkyl substances was associated with lower rates of coronary heart disease in adults with diabetes. The study, led by Kim Innes, used data from the C8 Health Project and found an inverse association between PFAS levels and heart disease risk.
Research highlights increased risk of heart and blood vessel diseases among people with HIV due to interactions between traditional and HIV-specific risk factors. Additionally, stigma and barriers to healthcare can exacerbate these risks, emphasizing the need for better awareness and patient-focused care.
Researchers at RIT are developing a computational framework to reconstruct and visualize myocardial active stress, enabling direct appraisal of cardiac function. This will help detect and localize regions with diminished contractile activity, improving diagnosis and treatment of cardiac disease.
A recent study found that the use of advanced imaging equipment like cardiac MRI is driving a significant increase in the diagnosis of Left Ventricular Non-Compaction (LVNC) in adults, raising questions about its clinical utility and potential for over-diagnosis.