Research on the causes and treatment of heart disease. Covers light exposure and heart health, sex differences, heart-in-a-dish models, and cardiac risk.
A pooled analysis of 17 studies involving over 562,000 participants found that fried food consumption is associated with a heightened risk of major cardiovascular events, coronary heart disease, and heart failure. The risk increases by 3%, 2%, and 12% for every additional 114g weekly serving.
A recent study from the Buck Institute for Research on Aging reveals that tissue stiffness significantly impacts the innate immune system, contributing to the development of chronic diseases. The research suggests that cellular tension sets off an inflammatory loop, which may be targeted by new force-targeting immunotherapies.
The COVID-19 pandemic had a significant indirect impact on heart disease patients in the US and globally. Deaths from ischemic heart disease and hypertensive diseases increased during the pandemic, while cardiovascular testing disruptions were observed worldwide.
Researchers have found that a patient's nutritional status has an important prognostic value in cardiac surgery, enabling the identification of postoperative complication rates. The study identified a small group of patients with valvular heart disease as being more susceptible to malnutrition.
A new study led by Katharine McBride explores the perspectives of 28 Aboriginal women from five different communities across central and southern Australia, identifying 10 attributes that either keep or put their heart at risk. These include identity as an Aboriginal woman, healthy body and life, connectedness within family and communi...
According to Centers for Disease Control and Prevention (CDC) data, COVID-19 has surpassed heart disease as the leading cause of death in the US. This finding highlights the significant impact of COVID-19 on public health in the country.
A recent study found that only seven percent of high-risk noncardiac surgery patients underwent preoperative screening for biomarkers, leading to increased mortality and complications. Researchers emphasize the need for improved compliance with guidelines and education among physicians.
A study published in Scientific Reports reveals that mutations in a gene underlying a rare skin disorder can also lead to arrhythmogenic right ventricular cardiomyopathy, a serious heart disease. The findings indicate that the genetic underpinnings of skin disorders at birth may help predict future heart problems.
Researchers at Gladstone Institutes have identified a potential therapy for calcific aortic valve disease, which affects millions of Americans. The new drug candidate has shown promise in correcting the underlying network that leads to calcification and hardening of the valves.
A study published in PLOS Medicine found that a Mediterranean diet improved endothelial function and reduced damage to the arteries in patients with coronary heart disease. The diet, rich in monounsaturated fatty acids, was shown to reduce the risk of another heart attack by half.
Researchers at NTNU have used CRISPR to strengthen muscle cells and replicate positive exercise effects in heart-diseased rats. This gene therapy approach holds promise for treating heart disease without the need for daily medication.
The American Heart Association recommends using existing data in electronic health records to adjust health targets and provide better preventive care. Improving the nation's cardiovascular health requires reinforcing prevention efforts and leveraging expertise from multidisciplinary healthcare professionals.
A large observational study found that replacing red meat with high-quality plant foods like beans and nuts reduces the risk of coronary heart disease. Substituting whole grains, dairy products, and eggs for red meat also yields lower CHD risk.
The menopause transition is a time of increasing heart disease risk for women, with significant changes in cardiometabolic and vascular health occurring during this phase. Early intervention strategies, such as hormone therapy and lifestyle modifications, are crucial to maintaining healthy heart function and reducing cardiovascular risk.
A new algorithm developed by Rensselaer Polytechnic Institute uses chest CT images and non-imaging data to predict COVID-19 patient outcomes. The algorithm was tested on 295 patients from three hospitals and showed promising results in determining the need for ICU intervention.
A new study found a correlation between RNA-binding protein clumping and protein aggregates in the hearts of patients with RBM20 dilated cardiomyopathy. This discovery suggests that RBM20 is an RNA-binding protein granule disease similar to Lou Gehrig's disease and Alzheimer's disease.
New data from the CASCADE FH Registry highlights gaps in care for children with familial hypercholesterolemia. Children are typically diagnosed at age 9, seven years after cholesterol screening guidelines recommend it. Early treatment intervention can prevent cardiovascular disease.
A new fish oil-based medication, omega-3 carboxylic acids, did not decrease the risk of cardiac events compared to a placebo in a large phase III international study. The study found no significant differences in cardiovascular death or heart attack rates between the two groups.
A randomized controlled trial found that regular walnut consumption reduced inflammation in healthy older adults, associated with lower risk of heart disease. The study suggests walnuts' anti-inflammatory effects may provide a mechanistic explanation for cardiovascular disease reduction.
A recent study found that racial/ethnic minorities comprise only a small percentage of patients with AL amyloidosis, despite being theoretically at higher risk. Younger age and more severe illness were observed among minority patients, who were also less likely to undergo aggressive treatment with stem cell transplantation.
Research found that areas with better air quality and higher greenness measures have lower rates of heart disease deaths. The study suggests that promoting environmental policies to support increased green spaces could lead to improved cardiovascular health.
Research finds that many transgender people who receive hormone therapy already have unaddressed heart disease risk factors, including high blood pressure and high cholesterol. The study highlights the need for improved access to healthcare and cardiovascular screening for this population.
Dr. Ann Marie Schmidt has made critical contributions to understanding the connections between heart disease and diabetes through her discovery of the RAGE receptor. Her work aims to develop targeted treatments for obesity and its complications, with the potential to impact hundreds of millions of lives worldwide.
Diets high in proinflammatory foods increase heart disease and stroke risk, while anti-inflammatory diets like the Mediterranean diet lower inflammation levels. Consuming antioxidant-rich foods and limiting processed meats can help combat inflammation.
A nationwide ban on industrial trans-fatty acids in Australia's food supply could prevent around 2,000 deaths and 10,000 heart attacks over the first ten years, and up to 42,000 deaths from heart disease over a lifetime. The estimated cost of implementing this legislative measure was A$22 million during the first ten years.
Researchers found that quitting smoking at any age reduces excess risk of premature death from cardiovascular disease by about 90%. Those who quit between ages 15 to 34 had about the same risk as peers who never smoked, while those who quit later had significantly higher risks.
The COVID-19 pandemic has highlighted the complex relationship between the virus and cardiovascular health. Researchers discuss the emergence of a new cardiometabolic syndrome composed of abnormal adiposity, dysglycemia, dyslipidemia, and hypertension.
Researchers from University of Sheffield and Manchester investigate link between heart disease and vascular dementia, testing a drug used to treat arthritis as a potential therapy. The study aims to identify a new treatment for vascular dementia, which affects 15% of all dementia cases.
A recent study published in the European Heart Journal found that more than two-thirds of heart disease deaths worldwide can be prevented through healthier diets. The analysis of global data from 195 countries revealed that unhealthy eating, high blood pressure, and high cholesterol are major contributors to ischaemic heart disease.
Researchers have developed a computational approach called EpiMogrify that can predict the molecules needed to keep cells healthy in laboratory cultures. The model successfully identified molecules to maintain healthy nerve cells and heart cells, and predicted molecules that trigger stem cells to turn into specific cell types.
Researchers at UT Health San Antonio have discovered lactate, a metabolite elevated during exercise and diseases, acts as a signal to activate magnesium ions. This finding is expected to lead to the development of novel therapies for cardiovascular disease, metabolic disorders like diabetes, and other conditions.
A clinical trial found that active choice nudges led to significant increases in optimal statin prescribing for patients with heart disease, while passive nudges had no effect. The study suggests that small design changes can improve the impact of alerts, and future research will focus on clinician and patient nudges.
Researchers at Gladstone Institutes are studying how cells regulate their energy levels and exploring ways to target energy regulation processes to treat diseases such as neurodegeneration and heart failure.
A Canadian study of over 290,000 children found that those exposed to diabetes in the womb had a 50-200% higher risk of developing heart disease before age 35. The study also discovered that these children were more likely to develop high blood pressure and type 2 diabetes.
A recent study found that preventing coronary heart disease could save nearly $15 billion in GDP due to increased productivity and reduced absenteeism. The study also estimated that preventing just 10% of future cases would result in $1.5 billion in monetary gains
Researchers analyzed almost half a million individual cells to build the most extensive cell atlas of the human heart, revealing diverse cell types and intricate networks. The study promises to enable better understanding of heart disease and guide development of highly individualized treatments.
Researchers have created the first atlas of human heart cells, detailing nearly half a million cells and their functions. The database provides a new basis for studying heart disease, which is the leading cause of death worldwide.
Scientists created a comprehensive atlas of healthy human heart cells, revealing unique cell types and communication networks. The map will aid in understanding cardiovascular disease and developing personalized therapies.
Researchers have discovered a shared protein fingerprint in patients with the most severe manifestations of hypertrophic cardiomyopathy, a common inherited heart disease. This finding suggests that treatments targeting these similarities could be effective in treating multiple patient varieties.
After surviving a heart attack, women are experiencing greater declines in recurrent events than men. Despite improvements, the rate of recurrent heart attacks and death remains high among survivors.
Research suggests that witnessing a relative or neighbor manage diabetes can influence an individual's approach to self-management. Healthcare providers must consider patients' life circumstances, including financial resources, to optimize care. Asks healthcare providers to collect both quantitative and qualitative data to better under...
A collaborative study by Masonic Medical Research Institute and leading institutions reveals a comprehensive map of the human heart's cellular diversity. The findings provide valuable knowledge gaps about heart composition and function, shedding light on genetic risk factors for cardiac health.
A University of Illinois Chicago study explores the effects of COVID-19 shelter-in-place and physical distancing measures on heart disease patients' hopelessness and physical activity. Researchers will evaluate the 'Heart Up!' intervention's impact on health outcomes.
A recent study published in Nutrients found that consuming red and processed meat increases a protein compound linked to heart disease. High-heat caramelization during cooking can create compounds called advanced glycation end products (AGEs), which accumulate in the body and interfere with normal cell functions.
The Lancet report highlights that many countries are falling behind on their commitments to reduce premature deaths from chronic diseases. Despite a decline in death rates from some diseases over the past decade, others such as diabetes and lung cancer are not showing sufficient progress. The report warns that if current trends continu...
A two-year study by the University of Leeds has linked treatment of rheumatoid arthritis (RA) with improvements in vascular stiffness, an indicator of cardiovascular disease. The findings could inform management strategy for patients with RA and highlight the need to consider increased CVD risk factors.
Researchers found that men's hearts have coarser textures and a larger surface area, while women's hearts have finer grained textures. With age, differences in heart shape decreased for both sexes, but texture differences remained.
A new study from the University of Colorado School of Medicine reveals that asymptomatic Chagas patients are at a high risk of developing cardiomyopathy, a progressive heart disease. The risk more than doubles among patients with acute infections, according to the study published in JAMA Network Open.
A study published in Scientific Reports found that life expectancy for Black men in Washington, DC, was on average 17.23 years shorter than for white men, while Black women had a gap of 12.06 years. The study attributed these disparities to factors such as heart disease, homicide, cancer, and socioeconomic conditions.
A large population-based study found that acute cardiovascular events are common among adults hospitalized with influenza, with older age and underlying cardiovascular disease significantly increasing the risk. Vaccination is crucial for these patients, particularly those with cardiovascular risk factors, to prevent such complications.
Researchers discovered that a person's genetic background can alter the risk of heart disease in individuals with familial hypercholesterolemia gene variants. A low polygenic score was found to lower the risk of breast cancer and colorectal cancer in those with high-risk single-gene variants, bringing it closer to the population average.
Research suggests that providing a mitochondria-targeted antioxidant supplement to mothers with complicated pregnancies can prevent heart disease in their offspring. The study used sheep and found that MitoQ protects against fetal growth restriction and high blood pressure in adults.
Researchers used cryo-electron microscopy to capture detailed conformational changes involving the β1-adrenergic receptor and its activation mechanism. The findings provide new details for improved therapeutic treatments for cardiac disease, a leading cause of death worldwide.
A study published in Nature reveals the complex mesh of muscle fibers lining the heart impacts performance and heart failure. The research used AI to analyze 25,000 MRI scans, discovering six human DNA regions affecting fractal patterns in these fibers.
Researchers have found that the shape and structure of muscle fibres in the heart impact its performance and risk of heart failure. The study, published in Nature, reveals how these 'trabeculae' work and develop, and their importance to human health.
Researchers at UCSF have developed a smartphone-based digital biomarker to detect Type 2 diabetes, providing a potential in-home alternative to blood draws and clinic-based screening tools. The algorithm correctly identified the presence of diabetes in up to 81% of patients, offering a promising solution for widespread disease screening.
A new study estimates that 350,000 people globally died from smokeless tobacco-related illnesses in 2020, up from an estimated 258,000 in 2017. The researchers are urging governments to regulate the production and sale of smokeless tobacco products.
A new study published in the Journal of Cardiac Failure found that mental stress and anger can exacerbate heart failure by worsening diastolic function. Patients who experienced anger during the study exhibited worse baseline resting blood pressure, while most participants showed stress-provoked changes in diastolic function.
A new method, nanoproteomics, captures and measures various forms of cardiac troponin I, a biomarker of heart damage. This effective test could one day provide doctors with a better ability to diagnose heart disease, the leading cause of death in the U.S.
Research suggests that bacterial infections, as indicated by antibiotic purchases, increase the risk of coronary heart disease in individuals with type 1 diabetes. Elevated levels of bacterial lipopolysaccharides also contribute to this increased risk.