Articles tagged with Herpes Simplex
Researchers at Wayne State University are seeking to understand the genomic information of herpes simplex virus 1 and its interactions with host cells to develop new anti-herpes treatments. The study aims to uncover the functions of infected cell protein 0, which plays a key role in disrupting host defenses.
Researchers investigate how BAF protein defends against viral DNA attacks, discovering the virus's ability to turn off this key defensive mechanism. This understanding may lead to targeted therapies for viruses that inject DNA into cells.
Scientists have discovered a molecular switch that allows human cytomegalovirus to enter dormancy or reactivate infection. By manipulating this switch with simple drugs, HCMV can be targeted with antivirals and purged from organs before transplantation.
Researchers from USC Norris Comprehensive Cancer Center have discovered that herpesvirus proteins activate the RIG-I receptor through deamidation, a process that could be exploited to bolster immunity against infection. The study identifies the first enzyme responsible for protein deamidation in eukaryotes.
Researchers discovered that Valacyclovir can reduce HIV-1 levels independently of herpes infection, promising new avenues for drug development. The study's findings suggest the potential for a broader range of HIV-fighting drugs and could inform the design of new agents based on Valacyclovir's molecular structure.
Researchers at Albert Einstein College of Medicine have developed a new type of vaccine that prevents both active and latent infections caused by herpes simplex virus type 2 (HSV-2). The vaccine, dubbed "delta-gD-2," provides complete protection against subsequent infection in mice, suggesting it could be effective in humans.
Researchers at Saint Louis University discover a family of enzyme inhibitors that can suppress herpes simplex virus replication. The findings offer hope for new treatments that can work in combination with existing medications to completely suppress the virus.
Researchers found that herpes simplex virus 1 rearranges telomeres to improve viral replication, suggesting a molecular mechanism for viral efficiency. The study also highlights the role of telomere proteins in protecting against viral infection.
A new study found an effective treatment approach to inhibit latent herpes simplex viruses from reactivating and causing disease. The research used existing drugs, such as tranylcypromine, to block proteins involved in viral replication, reducing symptoms and shedding of the virus.
Researchers have developed a novel treatment approach for persistent viral infections like herpes by blocking the activity of host cell protein LSD1, reducing HSV infection, shedding, and recurrence. This epigenetic therapy shows promise as an antiviral strategy to control shedding and reactivation of latent virus.
Researchers at Lund University have discovered that viruses can convert their solid DNA to a liquid form, making it easier to infect cells. This temperature-dependent phase transition could lead to the development of new medicines targeting virus DNA, potentially reducing infection capability and spreading.
A recent study found that healthy individuals carry an average of five types of viruses on their bodies, with some individuals harboring up to 15 viruses. The researchers discovered seven families of viruses, including strains of herpes viruses not associated with sexually transmitted infections.
Seroprevalence of HSV-1 remains stable, while HSV-2 decreases significantly among all races, with a greater decline for white women than black women. The study found no association between the decline in HSV-2 prevalence and a decrease in neonatal herpes cases.
Researchers found that cells are constantly fighting herpes virus, even in dormant phase, leading to potential new treatments. The study used genetically modified cells and viruses to measure virus activity, revealing varying levels of infection across different cells.
A literature review found that metzitzah b'peh, a Jewish circumcision procedure involving oral suction, is likely a source of herpes simplex virus type 1 (HSV-1) transmissions in infants. The practice has been linked to severe morbidity and potentially death in newborns, highlighting the need for further research.
A new study shows that specific immune system signals repel a common parasite but also cause a dormant herpes virus to become active again in mice. The findings highlight complex interactions between infectious agents and the immune system, which can lead to unexpected consequences.
Researchers discovered that interactions with other infections later in life can trigger dormant herpes viruses to resurface and cause disease. This finding highlights the complex relationships between pathogens and the immune system, which could lead to new strategies for combating these infections.
Researchers found that human herpes simplex virus (HSV) -1 and -2 originated in chimpanzees, with HSV-1 present in humans for over 6 million years. The study suggests that HSV-2 emerged from ancient chimps around 1.6 million years ago, prior to the rise of modern humans.
Scientists have discovered that herpes virus proteins use their flexible arms to pass on viral building blocks to hijacked cell proteins, providing insight into the virus's ability to hijack cells. The study's findings may lead to new treatments for Kaposi's sarcoma, a type of cancer caused by the herpes virus.
Researchers found that young natural killer cells play a key role in preventing infectious mononucleosis caused by Epstein-Barr Virus. A potential vaccination is being explored to protect against EBV infection and reduce the risk of developing Hodgkin lymphoma.
The American College of Physicians recommends that individuals with heart disease should only receive red blood cell transfusions if they have severe anemia. Additionally, researchers found that the concept of 'healthy and overweight' is a myth, as individuals in the same BMI category can have varied metabolic features. The study's fin...
The National Institute of Allergy and Infectious Diseases is sponsoring a Phase I clinical trial for an investigational genital herpes vaccine candidate, called HSV529. The trial aims to test the safety and immune response of the vaccine in adults aged 18-40 with previous HSV-2 or HSV-1 infections.
A study of herpes simplex virus type 1 confirms the 'out-of-Africa' pattern of human migration, with African isolates clustering together and Asian viruses grouping based on sequencing of human genomes. The findings support existing analyses of human migration and provide insights into how organisms are related.
A new study reveals that fewer US adolescents have antibodies against herpes simplex virus type 1 (HSV-1), making them more susceptible to genital infections. The prevalence of HSV-1 antibodies declined among 14-19 year olds by nearly 23% and among 20-29 year olds by over 9%.
Researchers discovered how EBV infection evades detection by the immune system, triggering molecular events that turn off key proteins. This finding could lead to a vaccine that provides immunity from ever being infected with EBV.
Biochemist Alex Evilevitch measures internal pressure of HSV-1, revealing key mechanism behind herpes infection and paving way for new medicine development. The discovery could lead to universal treatment for various viral infections, including cancer-linked viruses.
Dr. Augusto Ochoa, Director of LSUHSC's Stanley S. Scott Cancer Center, has been awarded a $2.5 million NIH grant to develop new treatments for severe viral diseases, including herpes infections and cancers caused by viruses. The research aims to manipulate the immune system's response to these diseases.
Researchers at the University of Edinburgh have found a link between cold sore susceptibility and a mutated gene, revealing why some people are more prone to the virus that causes them. The study identifies IL28b as the affected gene, which plays a crucial role in mounting an immune response against the herpes simplex virus.
Researchers at Indiana University have developed a novel vaccine that effectively reduces the shedding of genital herpes virus, potentially providing a new treatment option for those affected. The vaccine, GEN-003, is one of the first to target viral shedding, which is often how the disease is spread.
Scientists at Princeton University discovered that herpes viruses may cause repetitive nerve cell firing, leading to persistent itching and pain. Understanding this mechanism could lead to improved treatments for shingles, oral, and genital herpes.
A global systematic review and meta-analysis found that newborns of mothers with bacterial infection or colonization are at higher risk for early-onset neonatal infections. The study analyzed data from 83 studies and found a significant association between maternal infection and newborn infection, with odds ratios ranging from 2.3 to 9.4.
Research suggests that inherited Human Herpesvirus 6 may be a root cause of CFS, causing cognitive dysfunction and fatigue. Antiviral drug therapy improves severe neurological symptoms in affected patients.
A study of 43,979 patient records found that emergency physicians correctly identified nearly all patients with Bell's palsy. The majority of patients with life-threatening alternative diagnoses were accurately diagnosed without advanced diagnostic tests.
Researchers discovered a high internal pressure within the human herpes simplex virus 1 that enables it to eject its DNA into a host cell's nucleus. This pressure is a key mechanism for viral infection across organisms and presents new opportunities for broad-based, mutation-resistant antiviral treatments.
Researchers discovered that herpes simplex virus type-1 (HSV-1) binds to a receptor called MARCO, which enhances its ability to infect cells and cause disease. This interaction may lead to serious health complications in people with compromised immune systems, such as atopic dermatitis.
Researchers found a link between natural killer cells and hematopoiesis in CMV-infected mice, revealing an antiviral reaction that could lead to new treatments for viral infections. This process involves the elimination of infected cells and mobilization of immune cells to combat the pathogen.
Researchers have identified CD8αα+ T cells, which reside long-term in the genital skin and mucosa, suppressing recurring outbreaks of genital herpes. These immune cells play a crucial role in preventing reactivations of the virus, making them a potential target for vaccine development.
A study found that the shingles vaccine halves the occurrence of this painful skin and nerve infection in people over 65. However, vaccination rates are low in the US, particularly among black people and those with low incomes.
Researchers at Northwestern University identified a viral protein, VP1/2, that allows herpesvirus to interact with cellular motors and speed through the nervous system. This breakthrough enables the virus to move unobstructed from skin nerves to neuron nuclei, outcompeting most other viruses.
Researchers at Albert Einstein College of Medicine have discovered a new approach for stopping herpes infections by identifying the molecular key that herpes viruses use to infect cells. The finding could lead to new drugs for treating or suppressing herpes virus infections.
A new study found that people with higher levels of infection in their blood, including cold sores, were more likely to have cognitive problems than those with lower levels. The research suggested a link between infection and increased risk of low scores on cognition tests.
King Holmes won the prestigious award for his global scientific contributions to sexually transmitted diseases and their effective treatment and prevention. His research has led to diagnostic tests and standard-of-care therapies for conditions like human papilloma virus, gonorrhea, and genital herpes.
A team of researchers has created a map of gene 'shortcuts' between all human genes, simplifying the search for disease-causing mutations. This tool, called the human gene connectome, uses GPS-like principles to predict the distance and route between any two genes.
Researchers develop a gene therapy technique to increase enkephalin, an opioid compound, in the bladder wall, reducing pain signals. The treatment approach shows promise for severe chronic pain conditions like bladder pain syndrome/interstitial cystitis.
A large study of nearly 60,000 patients with rheumatoid arthritis and other inflammatory diseases found that initiating anti-tumor necrosis factor therapies did not significantly increase the risk of herpes zoster. Corticosteroid use was associated with a higher risk of herpes zoster in this population.
Researchers from Beth Israel Deaconess Medical Center have discovered a second B-cell attachment receptor for the Epstein-Barr virus, which could lead to the development of a vaccine. The new finding also raises questions about the virus's possible relationship to malaria and autoimmune diseases.
A new study from Ohio State University found a strong link between latent herpes virus reactivation and heart disease, particularly in patients who have suffered a heart attack. The researchers detected elevated levels of inflammatory proteins and antibodies to the EBV-encoded viral protein dUTPase in these patients.
Researchers found that loneliness is associated with elevated latent herpes virus reactivation and increased inflammation-related proteins in response to acute stress. Lonelier individuals also produced more proinflammatory cytokines, such as interleukin-6 and tumor necrosis factor-alpha, which can contribute to various health conditions.
A recent study published in the Journal of Leukocyte Biology found that T-cells responsible for controlling herpes viruses are reduced significantly during new infections, allowing latent viruses to reactivate. This understanding could lead to prevention strategies and improved treatment options for people with herpes.
A large Taiwanese study of 35,871 patients with newly diagnosed shingles found no increased risk of cancer. The study suggests that enhanced surveillance for cancer after a shingles diagnosis is unnecessary, according to the authors.
Researchers have discovered a potent adjuvant that enhances the immune response to vaccines against HIV, flu, and herpes. The compound, polyethyleneimine (PEI), shows promise in mice, offering improved protection against these difficult-to-tackle diseases.
Lawrence Corey, a renowned expert in virology and immunology, has been honored with the Cubist-ICAAC Award for his pioneering work on herpes viruses, HIV, and cancer. His research has led to significant advances in antiviral therapy and vaccine development.
A study by Johns Hopkins Medicine warns that declining US infant male circumcision rates could lead to significant healthcare costs. The researchers estimate that each uncircumcised male would incur $313 more in illness-related expenses, totaling $4.4 billion over the next decade.
Research reveals long-term consequences of chronic CMV infection on the immune system, including weakened responses to other viruses and increased susceptibility to infections. The study shows that prolonged CMV presence contributes to immune ageing, making older individuals more prone to infectious diseases.
SRI International researchers are developing a topical microbicide gel to prevent HIV and HSV-2 infections in women. The novel product will utilize a patented bioadhesive polymeric platform for sustained drug delivery, aiming to limit the risk of drug resistance.
Patients treated with anti-TNF medications have a higher risk of developing herpes zoster, or shingles, than those treated with traditional DMARDs. The study suggests that prophylactic treatment may be necessary for those at risk.
Dr. Akiko Iwasaki is recognized for her groundbreaking work on tissue-specific properties of dendritic cells and the critical role of autophagy in innate immune recognition of viruses. Her research has a fundamental impact on the fields of autophagy and antiviral immunity.
Researchers found that herpes viruses and other neurotropic pathogens sabotage cell function by hijacking neuronal internal transportation networks. Viral infection elevates neuron activity and calcium levels, stopping mitochondrial motion and allowing the virus to freely travel and reproduce within infected cells.
A recent Vaccine Safety Datalink study found the shingles vaccine to be generally safe and well-tolerated in adults aged 50 and older, with a small increased risk of local reactions. The study also ruled out any increased risk for serious conditions such as cerebrovascular diseases or meningitis.
Researchers at Oregon State University are exploring the role of viruses, particularly herpes, in coral decline. A comprehensive analysis of coral genomes reveals that herpes viruses constitute a majority of the viruses found in corals.