Articles tagged with Herpes Simplex
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A new study reveals that intestinal worm infections can change vaginal immunity and increase the likelihood of Herpes simplex virus type 2 (HSV-2) infection. The research found that targeting eosinophils can prevent this pathology, suggesting a potential solution to reduce STI severity.
Researchers have created the first patient-derived organoid model for cervical cancer, allowing them to study human papillomavirus (HPV) and its impact on cervical tissue. The model's success holds promise for advancing research into cervical biology and associated diseases.
Using human brain organoid models, researchers demonstrate various viruses cause microcephaly through different mechanisms. ZIKV and HSV-1 infections impair neuroepithelial identity and attenuate Type I interferon responses.
Researchers investigated how certain strains of herpes simplex virus (HSV-1) activate gene expression in neurons, finding that different genetic variants induce distinct patterns of gene expression. These findings may help understand why people experience varying levels of symptom severity and frequency of outbreaks.
Cold sores are triggered when herpes simplex virus reactsivate due to neuronal hyperexcitation caused by prolonged inflammation or stress. Interleukin 1 beta cytokine plays a key role in this process.
Researchers found that MB66, a vaginal film product containing monoclonal antibodies, is safe and effective in preventing HIV-1 and HSV-2. The product provided excellent antiviral protection for up to 24 hours after use, with high acceptability among women.
Scientists have identified a key gene necessary for cells to consume and destroy viruses through a process called autophagy. The study found that a gene called sorting nexin 5 (SNX5) plays a critical role in viral autophagy, suggesting that it could be used to develop broad-spectrum antiviral therapeutics.
Researchers developed a new decoding method to understand viral infections. They identified nine novel proteins encoded by herpes simplex virus type 1 (HSV-1), including the pathogenic factor piUL49, which controls the onset mechanism of herpes encephalitis. The discovery is expected to lead to new treatments for HSV encephalitis.
A new study published in Science Advances found that a drug called phenylbutyrate can help cells clear herpes simplex 1 and 2 viruses. When used in combination with acyclovir, the drug combo is more effective and reduces side effects associated with long-term use of acyclovir.
A genetically edited form of a herpes simplex virus has outperformed a leading vaccine candidate in a new study, significantly increasing antibody production and reducing viral replication. The modified live virus demonstrated cross-protection against both HSV-1 and HSV-2, suggesting an HSV-2-specific edition could be even more effective.
Researchers found that SARS-CoV-2 does not replicate in the human cornea, while Zika virus can infect corneal tissue. The study suggests COVID-19 patients with compromised immune systems may still be at risk of eye symptoms due to secondary inflammation.
A study found that herpes simplex virus type 1 infection can cause impaired neuronal differentiation and abnormal brain structure in the human fetus, contributing to long-term neurological problems. The research also identified HSV-1-infected microglia promoting inflammation and suggesting new therapeutic avenues for targeting viral re...
A new study details the damaging role of the immune system in a severe brain condition caused by herpes simplex virus. Researchers have identified specific immune cells and a signalling protein that induce brain inflammation, paving the way for targeted treatments.
Researchers at Fred Hutchinson Cancer Center developed a gene editing approach to remove latent herpes simplex virus 1, achieving a 92% reduction in the virus's presence. The method targets infected cells and nerve pathways, showing promise for a potential cure for the infection.
Researchers found that a key protein used by the varicella zoster virus to initiate infection does not operate as previously thought. The immune system can prevent infection by attacking a spot on the protein in an unexpected place, according to the study.
Researchers have discovered a new broad-spectrum method to treat human herpes viruses by targeting their physical properties rather than proteins. This approach prevents genes from leaving the virus and infecting cells, making it effective against resistant strains.
Research published in BMJ Global Health suggests that oral herpes rates are falling among European children and young people. The prevalence of the virus is declining by 1% per year, with more than two-thirds of the population testing positive for HSV-1, but risks increasing sexually in adulthood.
A new study reveals that viruses inhibit a critical protein in the body's immune system to evade detection and cause infections. This common denominator offers hope for developing antiviral treatments and vaccines.
Researchers discovered that herpes simplex virus (HSV1) targets the STING protein in brain cells to evade the immune response, promoting viral infection. This finding could lead to new antiviral treatments, particularly for immunocompromised patients with severe HSV1 brain infections.
A 3D brain-like tissue model has demonstrated a possible causal relationship between sporadic Alzheimer's disease and herpes simplex virus I infection. The model allowed researchers to observe the formation of amyloid plaques, neuronal loss, and neuroinflammation in response to HSV-1 infection.
Researchers have identified 284 open reading frames in the herpes simplex virus 1 genome, allowing for more precise study of individual genes. This breakthrough has implications for immunological therapies, such as oncolytic viruses used to treat certain tumor diseases.
Researchers found a connection between HHV-6 exposure and ME/CFS symptoms, showing how efforts to boost immune system come at physiological cost. The study provides an explanation for the common observation that ME/CFS patients report fewer viral infections after developing the disease.
Researchers from the University of South Australia have developed a nano formulation that increases curcumin's oral bioavailability by 117%, paving the way for clinical trials for Alzheimer's. The delivery method also shows promise in preventing genital herpes, with curcumin able to stop the virus and reduce inflammation.
Researchers discovered that a Mx protein, called MxB, helps cells fight viral infections by supporting mitochondrial function and integrity. The study provides new insights into the role of MxB in cellular defense against viral infections.
A severely infected patient revealed a rare genetic variation in immune deficiency, linked to CMV control. Researchers sequenced the man's genes and found a mutation in NOS2, a critical component of macrophages that kill microbes.
Researchers have developed a new antiviral material made from sugar that destroys viruses on contact, offering a non-toxic alternative to current treatments. The treatment has shown success against multiple viruses, including respiratory infections and genital herpes, and may help combat emerging viral diseases.
A study found that adult exposure to chickenpox is associated with a lower risk of developing shingles, but the protective effect does not last forever. The researchers suggest that previous assumptions about childhood varicella vaccination policy in the UK may need to be revisited.
Researchers have found that herpes simplex virus type 2 migrated to the Americas through the transatlantic slave trade, contradicting previous theories. The viruses originated in Africa around 5000 years ago and 18th century events led to their spread.
Researchers at Baylor College of Medicine report no link between increased levels of herpes virus and Alzheimer's disease, contrary to a previous study. The team also provides a new statistical and computational framework for analyzing large-scale sequencing data.
Researchers at Harvard Medical School have successfully used CRISPR-Cas9 gene editing to disrupt both latent and active herpes virus in human cells. The findings offer a model system for using gene editing in a localized way to disrupt active replication, but the challenge of delivering gene-editing therapy to neurons remains unsolved.
Researchers at Karolinska Institutet developed a new method to separate between two types of herpes virus 6A and 6B, found that MS-patients carry the virus 6A to a greater extent than healthy individuals, and that HHV-6A may be contributing factor to multiple sclerosis development
New research reveals that chromatin dynamics regulate the entire herpes virus genome's expression during infection. The discovery sheds light on the interplay between the virus and host cells, potentially leading to more effective treatments.
Researchers discovered that the pro-inflammatory cytokine IL-36? plays a crucial role in protecting against the spread of herpes virus to the nervous system. This finding could lead to improved therapeutics for genital herpes, affecting millions of women worldwide.
A team of researchers used single-cell RNA sequencing to understand herpes simplex virus type 1 (HSV-1) infections. They found that the NRF2 transcription factor slows infection progression and identified a drug, bardoxolone methyl, that inhibits HSV-1 by activating this factor.
Researchers have developed a new mathematical framework that accurately predicts the positions of proteins in the containers of all icosahedral viruses for the first time. The discovery solves a scientific mystery that has endured for half a century and paves the way for new insights into how viruses form, evolve, and infect their hosts.
Researchers at Penn Medicine have developed a vaccine that protects against genital herpes, with almost all animal subjects exposed to the virus showing sterilizing immunity. The vaccine stimulates three types of antibodies to block the virus from entering cells and ensure innate immune system protective functions are not turned off.
A new approach combines acyclovir with activated carbon particles to improve the effectiveness of a common herpes medication. The combination reduces viral load and inflammation while minimizing side effects like kidney damage.
Researchers at Yale University have developed a promising combination immune therapy to dramatically reduce the recurrence of genital herpes. The prime-and-pull strategy involves a vaccine and medicated cream that work together to block the virus from spreading.
A study of over 40,000 patients with polymyalgia rheumatica and/or giant cell arteritis found that oral steroid use significantly increased the risk of infection. The risk increased with higher doses, even at low daily doses.
A new study suggests that a probiotic-derived molecule from Bacteroides fragilis can temper the immune system and prevent fatal brain inflammation caused by herpes simplex virus infection. The findings provide an exciting proof of principle for the potential therapeutic benefits of certain prebiotics, probiotics, or synbiotics.
A study by Kellogg Eye Center reveals that herpes zoster ophthalmicus (HZO) cases tripled in 12 years, mostly affecting older adults. Shingles vaccination provides strong protection from HZO complications, but its use is not widespread.
Research found that HSV-1 and HSV-2 are mixing together to result in several new, different recombinant versions of herpes. This blurring of lines has important implications for HSV vaccine development.
Researchers have successfully created 'humanized' antibodies that can neutralize human herpesvirus 6B (HHV-6B) infection. The antibodies target the gH/gL/gQ1/gQ2 protein complex and CD134 receptor, essential for HHV-6B infection.
A new study found that a maternal vaccine can effectively protect against HSV-1 and HSV-2 infections in mouse offspring, transferring infection-fighting antibodies to their nervous system. The vaccine has shown promise in preclinical animal models and phase 1 human trials, offering new hope for preventing neonatal herpes infections.
Researchers found that vaccinated mothers can protect their newborns from neonatal herpes, a disease that can cause brain damage and death. The study also identified two scenarios that are particularly dangerous for newborns: acquiring genital herpes late in pregnancy or exposure to the virus through non-protected contact.
A study led by Georgia State University found that Ugandan youth with both HIV and sexually transmitted infections are more likely to engage in problem drinking. Co-infection rates among youth living in slums of Kampala, Uganda are significantly higher than other areas of sub-Saharan Africa.
Researchers found a significant association between schizophrenia and increased antibody levels against the Epstein-Barr virus. The study suggests that individuals with schizophrenia may be more susceptible to EBV infection due to an abnormal immune response.
A Rutgers study found that Gabapentin reduces pain and improves sexual desire and satisfaction in women with vulvodynia, a condition characterized by stinging, burning, or itching at the vaginal entry point.
A new study published in Frontiers in Aging Neuroscience suggests a causal link between herpes viruses and Alzheimer's disease, with antiviral drugs drastically reducing the risk of senile dementia in patients with severe herpes infections.
Researchers discovered that herpesvirus 6 infection before inducing EAE significantly accelerated the disease's progression in marmosets. This finding supports the hypothesis that viral infections can increase susceptibility to autoimmunity by triggering a heightened immune state.
Researchers found a close connection between Cytomegalovirus (CMV) infection and the accumulation of immune cells damaging cardiovascular tissue. The study suggests that CMV infection may be an important clinical factor in coronary heart disease, and treatment of the virus could be effective in preventing or managing the condition.
Researchers discovered a high infection rate of Purkinje neurons with HHV-6 in patients with bipolar disorder and/or severe depression. The study suggests viruses can cause cognitive disturbances leading to mood disorders, contradicting the belief that dormant viruses never cause disease.
A study found that amyloid beta protein in the brain traps and prevents herpes virus particles, protecting against infection. Chronic herpes infection may accelerate Alzheimer's progression by inducing overproduction of A-beta and causing inflammation.
A phase II clinical study of baricitinib demonstrated significant clinical improvements in SLE patients, while a randomized controlled trial showed the live attenuated shingles vaccine was well-tolerated and effective in preventing infection in stable SLE patients.
Scientists at Helmholtz Zentrum München have identified 16 virus structures that can be attacked by killer T cells, which could lead to new therapies for immunocompromised individuals and patients with autoimmune diseases. The researchers discovered these targets using an algorithm and verified them in a large group of patients.
Researchers discovered that a common topical antibiotic triggered an antiviral resistance in mice infected with herpes and other viruses. The study found increased expression of genes stimulated by interferons, suggesting a new mechanism for antiviral response.
Researchers have reconstructed the 3.1 Å structure of the HSV-2 B-capsid, expanding our understanding of its assembly mechanism. The study revealed four major conformers of the VP5 protein, which form extensive intermolecular networks and stabilize the capsid.
The study found that the CTCF protein helps herpes simplex virus regulate its own sleep-wake cycle, enabling it to establish latent infections in sensory neurons. By preventing CTCF from binding to viral DNA, the virus's ability to reactivated was weakened.
The new Shingrix vaccine has been shown to be more than 90% effective in protecting against the herpes zoster virus, which causes chickenpox and shingles. The vaccine stimulates production of immune memory cells, generating a strong and sustained protection against the virus.
Researchers identified a single gene mutation that makes some people more susceptible to viral brain infections like encephalitis. The DBR1 gene affects mRNA splicing, impairing immunity in the brain stem and leading to virus invasion.