Articles tagged with Herpes Simplex
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A cash transfer programme reduced HIV and HSV-2 infection prevalence by two-thirds in school-age girls, supporting changes in self-reported sexual behaviour. The intervention also showed no significant difference for individuals who dropped out of school.
A multinational study found that viral load is the single most important factor influencing risk of sexual transmission to an uninfected partner. Condom use significantly reduces risk of HIV infection and lowers viral loads to help prevent spread.
Researchers found that a new vaccine was partially effective at preventing genital herpes disease caused by HSV-1, with significant protection offered to some women. However, the vaccine did not protect women from genital disease caused by HSV-2.
A study found that genital herpes can reactivate in 'breakthrough episodes' even when taking high dose antiviral therapy, highlighting the need for new treatments to prevent onward transmission. Current antiviral therapies only reduce shedding by 50%, but don't eliminate breakthrough episodes.
Researchers at the University of Utah have identified a gene associated with frequent herpes-related cold sores. The C21orf91 gene is linked to susceptibility to HSL, and variations in this gene may predict or prevent cold sore outbreaks.
Researchers have identified a human chromosome containing a specific gene associated with susceptibility to herpes simplex labialis (HSL), the common cold sore. The study found a positive link between the frequency of outbreaks, hereditability, and the presence of a specific gene, C21orf91, on chromosome 21.
A new study found that a topical gel formulation of tenofovir significantly reduces HIV-1 transmission while also protecting against herpes simplex virus (HSV) infection. The researchers discovered that the drug's effectiveness against HSV was due to its ability to inhibit an enzyme needed for viral replication.
Researchers discovered that antiviral agents can decrease the accumulation of AD proteins β-amyloid and P-tau in HSV1-infected cells. The study suggests that these agents might be effective in slowing Alzheimer's progression, targeting a cause rather than symptoms.
Researchers have discovered a potential treatment for cancer of the immune system, targeting the Epstein Barr virus receptor EB12. The discovery was made by mapping the bio-antenna molecule and creating a blueprint of a tiny molecule that can bind to the B cell EB12 receptor, blocking its activation.
Researchers have found that shingles may be associated with an increased risk of developing multiple sclerosis, particularly in the year following a shingles attack. The study suggests that this risk is still relatively low and varies by geographical location and income.
A Kaiser Permanente study found no evidence that receiving the zoster vaccine and pneumococcal vaccine on the same day compromises the immune response necessary to protect against herpes zoster, also known as shingles. The study's findings challenge previous information in the zoster vaccine manufacturer's package insert.
Researchers found a strong association between low sunlight exposure and an increased risk of developing multiple sclerosis (MS) in people who have had infectious mononucleosis. The study, published in the April 2011 issue of Neurology, suggests that vitamin D deficiency may play a role in this association.
Researchers found that vaccine candidates were more efficacious against US-strain genital herpes, while African viruses required higher doses for similar protection. The study's findings offer hope for developing a potent vaccine to prevent HIV transmission in Africa.
A study found that individuals with asymptomatic herpes simplex virus type 2 (HSV-2) infection can still shed the virus, highlighting a high risk of transmission to unsuspecting sexual partners. This poses a significant concern for public health and patient management.
A new technique allows scientists to observe herpes simplex virus type 1 (HSV1) infections growing inside cells, revealing a mechanism by which HSV1 leads to Alzheimer's disease. Frequent interactions between viral particles and cellular amyloid precursor protein facilitate viral transport while interfering with normal APP distribution.
A team of researchers has found that tansy may be a potential treatment for herpes due to its anti-viral properties. The study revealed that compounds such as 3,5-dicaffeoylquinic acid and axillarin contribute to the plant's supposed antiviral activity.
A study published in CMAJ found patients with COPD are at a greater risk of developing shingles compared to the general population. The risk is highest for those taking oral steroids to treat COPD.
A Kaiser Permanente study found that receiving the herpes zoster vaccine reduced the risk of shingles by 55% in adults 60 years and older. The vaccine also showed effectiveness in preventing shingles in adults over 75, supporting CDC recommendations to offer it to all eligible patients.
The zoster vaccine has been shown to significantly reduce the risk of herpes zoster (shingles) in older adults, with a 55% lower incidence rate compared to unvaccinated individuals. The vaccine was also found to reduce the risk of ophthalmic herpes zoster and hospitalizations coded as herpes zoster.
Researchers have developed a 3D picture of a herpes virus protein interacting with human cellular machinery, revealing how the virus hijacks cells to spread infection. This discovery provides new insights into the mechanisms of viral replication and opens up possibilities for preventing or treating viral diseases.
CONRAD will receive funding to develop vaginal rings that provide both contraceptive and HIV prevention, addressing unintended pregnancies and HIV transmission in sub-Saharan Africa. The grant aims to improve reproductive health choices for women and prevent the spread of HIV/AIDS.
A recent study in The Lancet Infectious Diseases identified herpes simplex virus and varicella zoster virus as the most common causes of encephalitis in the UK. However, up to 85% of patients worldwide have an unknown cause, emphasizing the need for further research to improve diagnosis and treatment outcomes.
A multicenter study in Canada found that shingles affects not only physical health but also mental well-being, including sleep quality and enjoyment of life. After the acute phase, 24% of participants developed postherpetic neuralgia, a persistent pain condition.
A Phase 3 clinical trial conducted by GlaxoSmithKline and the National Institute of Allergy and Infectious Diseases found that a genital herpes vaccine was ineffective in preventing the disease in women. The study, which involved 8,323 women aged 18-30 years, showed that the vaccine had an estimated 20% effectiveness rate.
Scientists at IRB Barcelona discover that raltegravir cancels function of essential protein in herpesvirus replication, offering potential target for new drug development. Human cytomegalovirus, the most deadly and widespread herpes virus, shows vulnerability to raltegravir treatment.
Researchers found that patients taking oral antiviral medications had fewer recurrences of corneal disease and other eye-related manifestations. The study suggests that antiviral prophylaxis should be considered for patients with frequent recurrences, highlighting its potential to prevent vision loss.
Scientists at Tufts University and the University of Pennsylvania have determined the unusual structure of a key member of the herpes virus protein complex that allows it to invade cells. The research provides a new target for antiviral drugs, which could prevent the virus's access to cells.
Scientists have mapped the herpes virus protein complex that allows it to invade cells, revealing a new target for antiviral drugs. This breakthrough could lead to the development of new therapeutics to restrict herpes virus access to mammalian cells.
Princeton University researchers are developing a new method for studying brain connectivity using genetically engineered viruses. The viruses, designed by Lynn Enquist's team, travel through the nervous system, tracing connections between neurons and reporting on their activity. This approach has significant implications for understan...
A study published in Annals of Internal Medicine found that human growth hormone (HGH) improves sprint capacity in healthy recreational athletes, with effects nearly doubled in men who also received testosterone injections. The researchers also noted significant reductions in fat mass but no increase in muscle mass.
A team of researchers at the University of South Florida discovered that a common herpesvirus can integrate its DNA into human chromosomes, allowing it to be passed down through generations. This finding raises concerns about disease risk and the potential for viral reactivation in individuals born with the virus's DNA in every cell.
A study found that Epstein-Barr virus infection increases the risk of developing multiple sclerosis by many folds, implicating EBV as a contributing factor. The research followed hundreds of thousands of individuals without EBV infections over several years, providing strong evidence for a causal link.
Dr. H. Hunter Handsfield is a leading researcher in STD prevention, recognized for his work on asymptomatic gonorrhea, chlamydia screening, and expedited partner therapy. He has made significant contributions to understanding the epidemiology, clinical manifestations, treatment, and prevention of various STDs.
A new study finds that aciclovir, used to treat herpes simplex virus type 2, can reduce the risk of HIV-1 disease progression by 16% in patients co-infected with both conditions. The treatment also delays CD4 cell count decline and reduces HIV transmission.
A new study has found that acyclovir, a common medication used to treat herpes symptoms, does not reduce the transmission of HIV. The research, conducted in seven sub-Saharan countries, suggests that frequent genital herpes recurrences can increase HIV levels in the blood and genital tract.
A new study reveals that genital herpes virus type 2 (HSV-2) frequently reactsivate in the entire genital tract, rather than just one specific area. This finding has important implications for treatment and prevention strategies, suggesting a need for comprehensive approaches to suppress and limit transmission.
A five-year international study found that acyclovir suppressive therapy did not reduce the risk of HIV transmission in couples where one partner had both HIV and HSV-2. The study revealed significant reductions in plasma HIV levels and genital ulcers, but no impact on HIV transmission.
Neuroscientists combined herpes and Sleeping Beauty to deliver larger genes to brain cells, increasing the size of genetic payload by nearly tripling it. This breakthrough technology could lead to treatments for devastating brain diseases like pediatric leukodystrophies and lysosomal storage disorders.
A Kaiser Permanente study found that the chicken pox vaccine significantly reduces the risk of shingles among children. The study followed over 170,000 vaccinated children for an average of two and a half years, resulting in only 122 cases of herpes zoster.
Male circumcision significantly reduces HIV infection risk by 60% in rural Uganda men. The removal of foreskin tissue containing HIV target cells explains most of the protection. Circumcision also reduces genital ulcer disease by lowering rates of trauma-induced ulcers, not just those caused by herpes.
A recent study by Mitchell S. V. Elkind and colleagues found a possible link between cumulative exposure to five common infection-causing pathogens and an increased risk of stroke. The study followed 1,625 adults over a median of 7.6 years, with 67 participants experiencing strokes during the follow-up period.
Research reveals that even after successful treatment with acyclovir, genital herpes sores create an environment conducive to HIV infection. The study found high concentrations of specific immune cells at the site of lesions, increasing the risk of HIV transmission.
Researchers at UCSF have identified a new drug target for the herpes virus that causes Kaposi's sarcoma, which could also treat other diseases such as cancer and Alzheimer's. The new target, a protease dimer, responds well to a chemical inhibitor, offering a potential breakthrough in treating this devastating viral family.
A large analysis of six studies found that consistent condom use reduced the risk of acquiring herpes simplex virus 2 by 30%. The risk of infection decreased with increased condom use during anal or vaginal sex, and there were no significant differences in protection between men and women.
Two studies published in the July issue of Ophthalmology highlight the connection between normal-tension glaucoma and silent cerebral infarcts, as well as stealthy herpes simplex infections impacting corneal transplants. Silent cerebral infarfts are more common among NTG patients and can lead to rapid visual field loss.
Researchers discover that a secondary viral infection can trigger the reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV), leading to uncontrolled cell growth and potentially developing into cancer. Activation of specific toll-like receptors allows the virus to replicate, spreading throughout the body.
A study characterizes eczema patients most at risk for serious viral infections, including herpes simplex and vaccinia viruses. The research highlights the importance of skin-barrier defects and antimicrobial protein production in increasing susceptibility to these infections.
A recent clinical trial found that acyclovir, a widely used herpes treatment, did not reduce the risk of HIV transmission when taken by individuals with both HIV and HSV-2. However, the study did show a significant reduction in genital ulcers and modest decrease in HIV levels.
Patients who received three infusions of TYSABRI reported significant improvements in general and disease-specific measurements of quality of life (QoL) and cognitive function. Cognitive functioning was assessed by Medical Outcomes Study Cognitive Functioning Scale, with higher scores indicating improved cognition.
Researchers have identified a viral protein, VP16, as the molecular key that prompts herpes simplex virus to exit latency and cause recurrent disease. The study provides a molecular target for designing improved HSV vaccines and treatments, which could also be used in cancer therapy.
New data from Ugandan scientists find that adult male circumcision decreases rates of herpes and human papillomavirus (HPV), two most common sexually transmitted infections. Circumcision is linked to a 25% reduction in HPV risk and a third reduction in HPV risk, according to researchers at the University of Washington.
Researchers at Van Andel Research Institute ruled out transcriptional coactivators as useful herpes antiviral drug targets. The study found that the viral genes do not depend on cellular proteins called coactivators for expression, contrary to earlier models.
A study found that medically supervised male circumcision significantly reduces the risk of acquiring genital herpes (HSV-2) and human papillomavirus (HPV), but has no effect on syphilis. Circumcision was also associated with a 28% lower risk of HSV-2 infection and a 35% reduced prevalence of HPV.
Researchers have discovered a cellular process that seeks out and fights Type 1 herpes simplex virus. The study, published in Nature Immunology, found that the nuclear membrane of infected cells can unmask the virus and stimulate the immune system to disintegrate it.
A recent study published in General Dentistry suggests that childhood chicken pox caused by varicella zoster virus can lead to osteonecrosis of the jaw, a condition characterized by severe bone damage and tooth loss. The virus may also cause vision loss and other oral health problems if activated decades later.
Patients treated with infliximab and adalimumab, a type of rheumatoid arthritis medication, are at an increased risk for developing herpes zoster (shingles). A significant association was found between treatment with these monoclonal anti-TNF-α antibodies and the development of shingles.
Researchers have discovered a transient protective effect of herpesvirus infections in mice, suggesting possible benefits against bacterial pathogens. The findings, confirmed by Dr. Marcia Blackman's team, contradict previous suggestions that vaccinated individuals may experience unintended negative consequences.
Researchers have made a breakthrough in developing a new gene-targeting therapy that uses an RNA enzyme to inhibit strains of the herpes simplex virus. The technique has shown promise in experiments with mice and rabbits, but further research is needed before it can be attempted in people infected with herpes.
A study by researchers at Albert Einstein College of Medicine found a topical microbicide using RNA interference to protect against genital herpes infection for up to a week. The microbicide combines two siRNAs to offer both immediate and sustained protection, providing hope for a cost-effective therapy in developing countries.
A topical treatment using RNA interference (RNAi) has been shown to effectively prevent herpes virus transmission in mice, disabling key genes necessary for the virus's replication and host cell infection. The treatment can be applied up to a week before or after exposure, making it a promising approach for preventing sexually transmit...