Detecting early signs of osteoarthritis
A three-year study is underway to explore the link between knee inflammation and osteoarthritis. Researchers use ultrasound to identify inflammation in people over 55 with knee pain or osteoarthritis.
Inflammation
Articles tagged with Inflammation
Study demonstrates the anti-inflammatory properties of pine bark extract
A recent study published in International Immunopharmacology reveals that Pycnogenol inhibits the generation of COX-2 and 5-LOX enzymes associated with inflammation. This finding suggests that Pycnogenol can decrease pain and reduce inflammatory conditions by shutting down specific enzyme production.
LSUHSC's Bazan awarded ARRA grant to preserve vision
Dr. Haydee Bazan received a $710,000 grant from the National Institutes of Health to explore potential therapeutic approaches to heal corneal injuries. The research focuses on finding balance between signaling mechanisms that promote cellular damage or repair in the cornea.
Novel genetic finding offers new avenue for future Crohn's disease treatment
Researchers at Case Western Reserve University School of Medicine discovered a novel connection between ITCH and NOD2 genes, which may lead to new treatments for Crohn's disease. The study highlights the potential for individually-tailored therapies for patients with the NOD2 mutation.
Clue to normal-tension glaucoma; herpes infection and corneal transplants
Two studies published in the July issue of Ophthalmology highlight the connection between normal-tension glaucoma and silent cerebral infarcts, as well as stealthy herpes simplex infections impacting corneal transplants. Silent cerebral infarfts are more common among NTG patients and can lead to rapid visual field loss.
Inflammation markers linked more with fatal than nonfatal cardiovascular events in elderly
A recent study published in PLOS Medicine reveals that inflammatory markers are more strongly associated with fatal than nonfatal cardiovascular events in elderly individuals. The study found that elevated levels of IL-6 and other inflammatory markers were linked to a higher risk of fatal heart attacks and strokes.
UC Davis grant zeroes in on novel asthma diagnosis and treatment
Researchers at UC Davis have received a $750,000 grant to investigate a novel therapeutic target for treating inflammation and diagnosing asthma. The study will use metabolomics to evaluate the effectiveness of soluble epoxide hydrolase (sEH) inhibitors in asthma treatment.
Johns Hopkins scientists out a gene for gout
Researchers found the malfunctioning ABCG2 gene can lead to high urate levels, causing inflammation and pain. The gene is responsible for transporting urate out of the kidney and into urine, and its mutation may be linked to 10% of gout cases in Caucasians.
'Life force' linked to body's ability to withstand stress
A study published in Brain, Behavior and Immunity found a strong association between extraversion and lower levels of inflammatory chemical interleukin 6 (IL-6), which can signal increased risk of death. The research suggests that dispositional activity may confer a survival advantage.
Scientists discover new genetic immune disorder in children
Researchers at NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases have discovered a new autoinflammatory syndrome, DIRA, which affects children from birth to 2 weeks of age. The disorder is caused by mutations in the IL1RN gene and can be treated with anakinra, a synthetic form of human IL-1Ra.
Enzyme involved in inflammatory bowel disease discovered at Penn State College of Medicine
Researchers at Penn State College of Medicine have discovered an enzyme called meprin that plays a key role in the severity of inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease. The study found that mice lacking meprin had more severe intestinal damage, indicating that meprin reduces inflammation.
UCLA cancer researchers first to link intestinal inflammation with systemic chromosome damage
Researchers found that local intestinal inflammation induced DNA damage to lymphocytes in peripheral blood, indicating systemic genetic damage. Chromosome damage was detected in the blood before colitis onset and correlated with disease severity.
Treating gum disease helps rheumatoid arthritis sufferers
Researchers found that treating gum disease improved rheumatoid arthritis symptoms, including reduced swollen joints and morning stiffness. The study's results suggest a link between periodontal disease and rheumatoid arthritis, highlighting the importance of good oral health in overall well-being.
Anti-inflammatory effect of 'rotten eggs' gas
A new molecule has been synthesized to release hydrogen sulfide gas in a slow and sustained manner, reducing inflammation and increasing levels of the body's own anti-inflammatory molecules. This breakthrough could pave the way for the development of novel approaches to treating inflammatory disorders.
MCG researcher among first to receive NIH stimulus funding
A Medical College of Georgia nurse researcher has received a two-year, $147,000 grant from the National Institute on Drug Abuse to investigate cocaine-related renal disease in African-Americans. The study aims to identify early signs of renal disease and develop targeted treatments for patients with cocaine addiction.
Research in PNAS by Hydra shows that TRP ion channel drug can treat allergy-induced asthma
A study published in PNAS identified TRPA1 as playing a key role in allergic asthma and demonstrated that HC-030031 effectively treated the condition in mice. This breakthrough research could represent a new avenue of treatment for asthma.
Even modest exercise can reduce negative effects of belly fat
A new University of Illinois study suggests that moderate exercise can reduce visceral fat inflammation, even without a change in diet. The benefits were apparent in both short-term and long-term studies, with significant reductions in belly fat and improved insulin sensitivity found in mice.
'Antedrugs': A safer approach to drug therapy
Researchers have developed antedrugs that effectively reduce inflammation without causing damage, surpassing the potency of conventional steroids. The new compounds, isoxazoline derivatives, were five times more potent in binding affinities to cell receptors and reducing inflammation.
TV crime drama compound highlights immune cells' misdeeds
Researchers at Washington University School of Medicine have developed a new compound that can detect and visualize immune cell activity, highlighting the misdeeds of the immune system. The compound, called luminol, glows blue when injected into mice with active immune inflammation.
A paradigm shift in immune response regulation
Scientists at Goethe University report a paradigm shift in immune response regulation, revealing the crucial role of linear ubiquitin chains in nuclear factor kappa B activation. This finding may lead to structure-based drug design for targeting the NF-κB pathway in diseases such as cancer and inflammation.
Treating asthma with NIOX MINO offers cost savings for the UK health care system
A new UK study shows that using NIOX MINO to measure inflammation in asthma patients can lead to a £341-£554 annual cost saving. This is achieved by optimizing treatment, reducing visits to casualty and hospital admissions, and lowering cortisone inhaler doses.
Study suggests that inflammation may be the link between extreme sleep durations and poor health
A recent study published in SLEEP found that inflammation may be the underlying mechanism linking extreme sleep durations to poor health. Short and long sleep durations were associated with changes in inflammatory cytokines, including C-reactive protein and interleukin-6.
Omega-6 PUFAs and risk of cardiovascular disease
The American Heart Association advises consumers to aim for at least 5-10% of energy from omega-6 PUFAs, which may reduce cardiovascular risk and lower the risk for heart disease events by 24%. Omega-6 fatty acids have anti-inflammatory properties, dispelling concerns of increased inflammation and cardiovascular risk.
DNA component can stimulate and suppress the immune response
Researchers discovered that DNA component CpG can stimulate inflammation at low doses but block it at high doses through the enzyme indoleamine 2,3 dioxygenase. This finding holds promise for treating cancer and infections by manipulating dosage to optimize immune response.
Inflammation worsens danger due to atherosclerosis
Research found that inflammation weakens collagen caps in atherosclerotic plaques, making them more prone to rupture. The study identifies lysyl-oxidase as a potential target for preventing plaque rupture and thrombosis.
For fats, longer may not be better
Researchers found that long-chain fats like oleic acid in olive oil increase intestinal absorption of pro-inflammatory lipopolysaccharides (LPS), promoting inflammation. This study suggests a potential link between dietary fat intake and inflammatory bowel disorders.
Nerve cells in the brain and spinal cord sense pain caused by physical insult
COX2 in brain and spinal cord nerve cells plays a crucial role in pain caused by inflammation, particularly mechanical inflammatory pain. Mice lacking COX2 in nerve cells have impaired hypersensitivity to pain caused by physical insult, suggesting COX2 is central to this type of pain.
JCI online early table of contents: Jan. 5, 2009
Researchers at Massachusetts General Hospital and University of Pennsylvania found that COX2 in mouse nerve cells plays a crucial role in pain caused by physical insult, while PDE5 inhibition may prevent hypertrophy in the mouse heart. These findings have implications for treating conditions such as postoperative and arthritic inflamma...
MRI scans can predict effects of MS flare-ups on optic nerve
Researchers used DTI to estimate chronic effects of optic nerve inflammation three months in advance. DTI showed a correlation between damage and lower scores on visual health tests, indicating potential predictive information for MS flare-ups.
Scientists find link between inflamed gums and heart disease
A new study published in The FASEB Journal suggests that infected gums may be a source of inflammation leading to heart disease. Proper dental hygiene can greatly reduce the risk of atherosclerosis, stroke, and heart disease independently.
Melatonin may save eyesight in inflammatory disease
Research suggests melatonin therapy may prevent ocular inflammation in uveitis, reducing symptoms and protecting the blood-ocular barrier. Melatonin treatment has anti-inflammatory effects, potentially benefiting patients with chronic uveitis.
Well-known drug (AAT) could overcome obstacles to islet transplantation, BGU professor reports
Researchers have discovered that alpha-1-antitrypsin (AAT) can eliminate inflammation in diabetic animals after islet transplantation, allowing the transplanted cells to survive and function for over 120 days. This breakthrough could lead to a safer and more effective treatment for type-1 diabetes patients.
Research identifies new link between tart cherries and risk factors for heart disease
A new study found that tart cherry-enriched diets lowered body weight and fat, reducing cholesterol and inflammation levels. The research suggests a direct anti-inflammation effect and may help lower heart disease risk in humans.
Markers of inflammation and blood-clotting tied to hazards of intermittent HIV treatment
Researchers found strong associations between intermittent HIV treatment and higher levels of inflammation and blood-clotting biomarkers, leading to a higher risk of death from non-AIDS diseases. Interleukin-6 (IL-6) and D-dimer levels rose significantly in the intermittent-treatment group after one month.
Proteins involved in blood vessel dysfunction in type 2 diabetes are identified
Using precise microscopes, University of Missouri researchers identified tumor necrosis factor-α and advanced glycation end products as major contributors to blood vessel dysfunction in type 2 diabetes. This discovery could lead to new treatments for blood vessel diseases and disorders in people with type 2 diabetes.
Simple, inexpensive and objective tools for the assessment of mucosal inflammation: fecal markers
Researchers found that fecal levels of FC and MPO can be used as surrogate markers for successful treatment outcome in IBD patients. The study also showed that elevated fecal markers are associated with relapse, but normalized FC level may indicate successful treatment.
Key protein molecule linked to diverse human chronic inflammatory diseases
Research reveals a common connection between cellular innate immunity and human chronic inflammatory diseases, including atherosclerosis, Type 2 Diabetes, and neurodegenerative diseases. A critical signaling network involving IRAK-1 has been identified as a potential target for diagnosis and treatment.
UTMB professor wins major award from Strategic Program for Asthma Research
Srivastava aims to examine the link between aldose reductase and lung inflammation in asthma. His research group has previously demonstrated the enzyme's role in other inflammatory diseases.
Salutary pizza spice
Researchers at the University of Bonn discovered that oregano's active ingredient beta-caryophyllin inhibits inflammation and may help treat osteoporosis, arteriosclerosis, and chronic disorders like Crohn's disease. The substance targets cannabinoid-CB2 receptors, providing a non-intoxicating alternative to existing treatments.
NIAMS scientists find potential new way to block inflammation in autoimmune disease
Researchers from NIAMS identified a promising new target for autoimmune disease treatment, a cell-surface receptor called DR3. Blocking this receptor could slow or stop damaging inflammation characteristic of autoimmune diseases without leaving the body vulnerable to serious infections.
Anti-inflammatory effects of pomegranate in rabbits: A potential treatment in humans?
A study published in BioMed Central's Journal of Inflammation found that pomegranate extract reduced the production of chemicals causing inflammation in rabbits. The findings suggest that pomegranate extract may provide relief from chronic inflammatory conditions in humans.
Case Western Reserve and Penn State investigators inhibit corneal inflammation
Researchers from Case Western Reserve University School of Medicine and Penn State Hershey College of Medicine identified a novel ceramide that reduces sterile inflammation in the cornea. The nano-sized package allows for easy application as an eye drop, providing an effective alternative to steroid use.
Weizmann Institute scientists develop a new approach to treating autoimmune disease
Researchers deliver genetically engineered T-reg cells to the intestine to suppress inflammation and autoimmunity. The 'bystander' effect enables these cells to target diseased tissue, suppressing inflammatory cells and promoting healing.
Which therapy is more effective in inactivation of gastric inflammatory? 7 day or 10 day- triple?
A study found that a 10-day triple therapy regimen was more effective in eradicating H. pylori and reducing gastric inflammation than a 7-day regimen. However, non-compliance was higher in the 10-day group, highlighting the need for cost-benefit analysis in treatment decisions.
Would tricyclic antidepressants help those with inflammatory bowel disease?
Research suggests tricyclic antidepressant desmethylimipramine can restore vagal function and reduce intestinal inflammation in individuals with inflammatory bowel disease and depression. Decreased vagal signaling and increased macrophage presence in the intestine are key factors in increasing susceptibility to intestinal inflammation.
Researchers important markers of high risk of type 2 diabetes
Researchers found high levels of E-selectin, white blood cells, and low serum albumin levels are clear predictors of high risk for type 2 diabetes. The study used data from the Western New York Health Study and found that combining these markers increased identification of high-risk patients by 8%.
Nutrition research unveiled this week shows pistachios are smart for the heart
A new study by Penn State University found that snacking on pistachios significantly reduces inflammation in the body, a prominent risk factor for cardiovascular disease. Additionally, pistachio consumption has been shown to improve cholesterol levels and reduce blood pressure, making it a valuable addition to a heart-healthy diet.
Maltreatment during childhood associated with combination of inflammation and depression in adults
A study of 1,000 adults found that childhood maltreatment is associated with increased levels of inflammation and depression in adulthood. Individuals with both conditions were at highest risk for cardiovascular disease. The early recognition of maltreatment history may help address pressing needs for care of depressed individuals.
Tart cherries may reduce factors associated with heart disease and diabetes
A new study found that rats fed tart cherry powder on top of a high-fat, Western-style diet had lower body weight, fat mass, total cholesterol, triglyceride, TNF-alpha, and IL-6 levels. These findings suggest a potential link between tart cherry consumption and reduced cardiovascular risk factors.
Lithium chloride slows onset of skeletal muscle disorder
A UC Irvine study finds that lithium chloride can slow the development of inclusion body myositis, a skeletal muscle disease affecting the elderly. The treatment reduced phospho-tau levels and motor function loss in mice, suggesting potential effectiveness for humans.
Overweight Hispanic children shown to have vascular inflammation
A new study found elevated markers of blood vessel inflammation in overweight Hispanic children with normal blood glucose levels, increasing their risk for type 2 diabetes and cardiovascular disease. The research highlights the need for obesity prevention strategies tailored to this high-risk population.
The missing link between belly fat and heart disease?
Researchers find a direct link between visceral fat and atherosclerosis, a condition that causes blood vessels to harden and narrow. The study suggests that anti-inflammatory medication could be used to reverse the process and reduce heart disease risk.
Il-22 gene delivers the goods and decreases intestinal inflammation
Researchers found that delivering the IL-22 gene to the intestines of mice with ulcerative colitis reduced inflammation and enhanced mucus production. Local delivery of the IL-22 gene also neutralized chemical-induced intestinal inflammation in normal mice, suggesting a potential therapeutic approach for UC.
Low-carb diet reduces inflammation and blood saturated fat in metabolic syndrome
A low-carb diet has been shown to reduce inflammation and blood saturated fat levels in patients with metabolic syndrome, a condition associated with diabetes and coronary heart disease. The study found that reducing carbohydrate intake led to greater improvements in inflammatory markers compared to a low-fat diet.
UC Davis researchers discover novel pathway to increased inflammation in diabetes patients
Researchers at UC Davis Health System have identified a novel pathway that contributes to increased inflammation of blood vessels in type 1 diabetes patients. This finding may lead to the development of new treatments to reduce cardiovascular disease risk by controlling inflammation.
New insights into inflammation in osteoarthritis
A study found that 82% of entheses have a synovio-entheseal complex (SEC), which is involved in triggering inflammation in OA. The SEC's formation is linked to fibrocartilage degeneration and cell clustering, suggesting a novel mechanism for synovial inflammation.
Natural product discovery by Cleveland medical researchers blocks tissue destruction
Researchers at Case Western Reserve University discovered a natural product derived from the Amazon rainforest that prevents tissue destruction by blocking matrix metalloproteinases. The findings have potential therapeutic applications in various joint, skin, and gastrointestinal diseases.
Elevated inflammatory marker may be linked to increased risk of age-related eye disease
A study found that high blood levels of C-reactive protein, a substance linked to inflammation, are associated with an increased risk for age-related macular degeneration. The research suggests that reducing C-reactive protein levels may potentially decrease the risk of AMD.
Depression, aging, and proteins made by a virus may all play role in heart disease
Researchers found a link between depression, latent viral infections, and increased inflammation, which may contribute to the development of cardiovascular disease. The study suggests that chronic depression can trigger a cascade of events that lead to the buildup of plaques in coronary arteries.
Dysfunctional families and bad neighborhoods may worsen asthma in children and adolescents
A study found that children with dysfunctional families and living in poor neighborhoods experience greater asthma symptoms and poorer lung function. Family support was linked to reduced inflammation, while neighborhood problems led to increased smoking and exposure to smoke.