Articles tagged with Inflammation
Researchers at the University of Leicester have developed a new technique to create protein-based drugs using evolutionary engineering. The method involves generating millions of variants of a protein, selecting those with improved properties, and repeating the cycle until the desired function is achieved.
Researchers at UCLA found that engineered tomatoes can reduce the negative effects of unsaturated lysophosphatidic acids (LPAs) in mice, which are linked to high cholesterol and inflammation. The tomatoes produce a peptide that mimics HDL ('good') cholesterol, stopping increases in 'bad' cholesterol and inflammation.
A new study from Hospital for Special Surgery found that achieving low disease activity within six months significantly reduces disability at two years. Patients who reached this state had better functional ability and fewer joint damages compared to those who delayed treatment.
A new study from RIKEN and Keio University reveals that Pimozide can restore steroid effects on natural helper cells in severe asthmatic patients. Researchers found that thymic stromal lymphopoietin (TSLP) induces corticosteroid resistance in these cells.
Researchers at UWM have discovered that near-infrared (NIR) and blue light can repair tissue in dramatically different ways, but both act on the same enzyme in the cell's energy supply center: the mitochondria. NIR light has been shown to improve MS symptoms in rodent models, while blue light kills bacteria that cause infection.
Researchers at Scripps Research Institute have identified key signaling proteins that contribute to the development of inflammatory diseases such as rheumatoid arthritis and psoriasis. By targeting these proteins, a new class of anti-inflammatory therapy may be developed.
A clinical trial found that HydroEye(R) improved ocular irritation symptoms and halts the progression of inflammation in moderate to severe dry eye. The study showed significant benefits for post-menopausal women, providing a safer alternative to existing dry eye treatments.
A recent study found that high-dose statins significantly reduced gum inflammation in heart disease patients within four weeks. The research also showed a close link between gum inflammation and atherosclerotic disease, suggesting that improving oral hygiene may lead to improved cardiovascular health.
A new study published in the American Journal of Pathology found that resveratrol actually worsened MS-like neuropathology and inflammation in mice. Resveratrol did not show anti-inflammatory or neuroprotective effects, contradicting previous claims about its benefits.
Researchers at Uppsala University found that combining two test methods can provide better asthma diagnosis. The combination of exhaled nitric oxide and blood eosinophil counts increases the likelihood of individuals reporting asthma symptoms or attacks.
Researchers will study TSPO's role in microglia and astrocytes to understand its function in brain injury and inflammation. The goal is to discover new therapeutic targets for treating inflammation and brain injury.
Researchers found that atorvastatin treatment decreased levels of inflammatory markers, thrombogenesis, and hyperlipidemia, suggesting its anti-inflammatory and anti-thrombotic effects. This study expanded the use of atorvastatin for acute ischemic stroke treatment by measuring multiple biomarkers.
New research finds that a subpopulation of immune cells, known as T lymphocytes, have platelets bound to their surface, reducing activation and proliferation. This discovery opens the door to potential treatments targeting platelet binding to lymphocytes.
A study by UNH researchers found no significant benefit of post-exercise ice baths in reducing muscle soreness or improving strength after intense exercise. Despite initial skepticism, lead researcher Naomi Crystal notes that moderate use of cryotherapy may still be beneficial for elite athletes.
Researchers at National University of Mexico found that prolactin can prevent chondrocyte death and associated cartilage degradation in rheumatoid arthritis models. Prolactin treatment reduced inflammation, bone erosion, joint swelling, and pain in rat models.
A study by Michigan Medicine researchers has identified five genes that play a major role in the development of Takayasu arteritis, a debilitating disease causing inflammation and damage to major blood vessels. The findings may lead to new therapeutic targets for this under-studied condition.
A multicenter clinical trial found daily omega fatty acid supplementation to be effective in improving ocular irritation symptoms and halting inflammation progression in moderate to severe dry eye patients. HydroEye clearly had a positive impact on these patients, providing safe and cost-effective relief.
Researchers at University College London found a significant association between parental divorce during childhood and elevated levels of inflammatory markers in adulthood. Children who experienced parental separation before age 16 had a 16% higher level of C-reactive protein at age 44.
Runners in a 200-mile Alpine ultramarathon experienced less muscle damage and fatigue compared to those who ran 103 miles. Protective pacing strategies, combined with sleep deprivation effects, may induce relative muscle preservation.
Frank Leo van de Veerdonk has received a 2013 ICAAC Young Investigator Award for his groundbreaking research on fungal immunology. He discovered that mutations in STAT1 are responsible for autosomal dominant chronic mucocutaneous candidiasis, a major breakthrough in diagnosing immunodeficiencies with fungal infections.
A new study from the University of Missouri contradicts claims that consuming vegetable oil promotes inflammation in humans. Researchers found no link between linoleic acid consumption and circulating indicators of inflammation.
A recent UC San Francisco study found that poor sleep quality is significantly associated with increased inflammation levels among women with coronary heart disease. Women who reported very poor or fairly poor sleep quality showed a greater increase in inflammatory biomarkers compared to men.
Researchers discovered that compounds derived from polyunsaturated fatty acids (omega-3s) reduce inflammation in acutely injured blood vessels, promoting better artery healing after procedures like angioplasty and bypass surgery. These naturally occurring compounds could improve long-term results of cardiovascular procedures.
A healthy Nordic diet is shown to lower cholesterol levels and reduce inflammation associated with pre-diabetes. The diet's emphasis on local produce, whole grains, and lean protein sources contributes to its benefits.
An Indiana University study found that a unique omega-3 supplement, Lyprinol/Omega XL, significantly improved lung function and reduced airway inflammation in asthmatics. The supplement, derived from the New Zealand green-lipped mussel, was effective in reducing symptoms and potentially improving athletic performance.
Researchers at the University of Pittsburgh found a strong association between depressive symptoms and levels of interleukin-6, an inflammatory biomarker, in COPD patients. The study suggests that systemic inflammation may play a role in depression associated with COPD.
A study published in American Journal of Human Biology found a negative relationship between inflammation markers (C-reactive protein) and progesterone levels in premenopausal rural Polish women. Estradiol and age of first menstruation were also significant predictors of C-reactive protein levels.
Researchers found that PRRT decreases inflammation in atherosclerotic plaques, as measured by DOTATATE PET/CT, suggesting potential therapeutic benefits for cardiovascular disease. The study suggests that this treatment may reduce the occurrence of heart attacks by lowering inflammation levels.
Research by University of Exeter scientists reveals that hydrogen sulfide gas reduces inflammation and swelling in arthritic joints. The study suggests H2S-based compounds may be effective in treating arthritis without uncomfortable side effects.
Researchers have discovered a cell-permeable peptide that reduces nuclear NF-ĸB activity in vascular smooth muscle cells and macrophages of aortic plaques. The peptide also inhibits lesion development in mice with a high-fat diet.
A new study from Massachusetts General Hospital found that feeding intestinal alkaline phosphatase (IAP) to mice on a high-fat diet prevents the development of metabolic syndrome and reduces symptoms in those already affected. IAP blocks inflammatory factors, reducing systemic inflammation.
Researchers found that untreated depression hinders anti-inflammatory effects of exercise and light-to-moderate alcohol consumption. Participants with depression showed no benefit in lowering C-reactive protein levels, despite normal physical activity levels.
A recent Weizmann Institute study has discovered that caspase 8 signaling enzymes, which were previously thought to only induce programmed cell death, can also activate an entirely different process in certain cells - causing inflammation more directly. This finding highlights the need for further research into the signals transmitted ...
A University of Michigan study reveals that probiotics can reverse the effect of stress on gut microbiota, reducing inflammation and alleviating symptoms of irritable bowel syndrome. The study also highlights the importance of maintaining a healthy gut microbiome through lifestyle changes.
A study from Boston University School of Medicine reveals that B cells secrete pro-inflammatory cytokines promoting insulin resistance and directly regulating inflammatory T cells. This discovery supports the exploration of FDA-approved B cell depletion drugs as novel agents to prevent obesity-associated inflammation and type 2 diabetes.
Researchers at Karolinska Institutet have identified a gene variant associated with higher production of kynurenic acid, which may explain psychotic features in bipolar disorder. The study suggests that inflammation and stress trigger the production of KYNA, leading to increased levels in patients' brains.
Researchers discovered that aspirin triggers the production of resolvins, naturally made by the body from omega-3 fatty acids, which resolve inflammation. Aspirin also modifies an inflammatory enzyme to produce longer acting resolvins with potent anti-inflammatory actions.
A new study finds that a genetic variant in the inflammation gene interleukin-6 is associated with developmental problems in females after preterm birth, but not in males. The research may help identify prevention strategies for preterm brain injury and improve understanding of how it occurs.
The conference focuses on rapidly growing fields of interest in gastrointestinal disciplines, including epithelial biology and gut microbial ecology. Scientists will explore translation of basic findings to diseases like inflammatory bowel disease and intestinal cancer.
Researchers have found that transplanted neural stem cells can migrate to the gut and develop into functional neurons, providing a promising new treatment for gastrointestinal motility disorders. Additionally, a protein called MFGE8 has been identified as an important regulator of inflammation, blocking inflammasome activity and limiti...
Researchers found that bacterial imbalance contributes to intestinal inflammation and carcinogenesis, with treatment reducing disease risk. Dysbiosis was shown to enhance intestinal inflammation and increase the risk for inflammation-associated colon cancer.
Researchers found that dysbiosis enhances intestinal inflammation and increases risk of colon cancer, but treatment with antibiotics or fecal transplantation reduces disease risk. Gut bacterial communities play a crucial role in protecting against intestinal inflammation and tumorigenesis.
A small stroke, known as a silent stroke, can cause Parkinson's disease by killing dopaminergic neurons in the substantia nigra. The study found inflammation and brain damage following the stroke, leading to neurodegeneration and potential onset of Parkinson's disease.
Researchers at Monash University used advanced microscopy techniques to visualize the movements of white blood cells in healthy and diseased kidneys. They found that leukocytes are constantly circulating through and patrolling blood vessels within healthy kidneys, but become agitated during disease, causing inflammation and kidney damage.
A team of researchers from Massachusetts General Hospital has discovered that intestinal immune cells collect and process antigens from both the bloodstream and the intestine, inducing the production of T cells that suppress inflammation. This regulatory system is crucial for preventing autoimmune disorders and inflammatory bowel disease.
Researchers at the University of Missouri have developed a new method to detect artery inflammation in pigs using targeted micro-bubbles. The technique, which has shown promising results, may help identify patients at risk for strokes and monitor the effectiveness of treatments.
A study published in the Journal of Clinical Investigation identifies a rare mutation in the DGAT1 gene as the cause of congenital diarrheal disorder. Additionally, research on natriuretic peptides reveals their role in enhancing human skeletal muscle metabolism and increasing fat oxidation.
Exosomes from mesenchymal stem cells reduce lung inflammation and prevent pulmonary hypertension in a mouse model. The findings suggest exosome research could lead to new stem cell-based therapies for chronic lung disease and other inflammatory conditions.
Researchers at The Feinstein Institute for Medical Research have discovered that extract from mung bean can reduce the release of HMGB1, thereby increasing survival rates in mice. This finding has promise for the treatment of sepsis in humans.
Researchers at Case Western Reserve University discovered that magnesium reduces inflammation by reducing NF-kB activity and subsequent cytokine production. This new insight offers a promising immunotherapeutic strategy for treating diseases such as asthma, atherosclerosis, and sepsis.
A research team at VIB has identified a new anti-inflammatory mechanism of the protein A20, which can help treat autoimmune diseases like Rheumatoid Arthritis. By understanding how A20 interacts with signaling pathways, scientists can develop new therapies to combat inflammation and disrupt the immune system's attack on its own tissues.
A University of Illinois study found that caffeine reduces brain-based inflammation associated with neurodegenerative diseases. Caffeine-treated mice recovered their ability to form new memories faster than non-caffeine-treated mice, suggesting a possible therapeutic target for mild cognitive impairment.
Researchers found that omega-3 supplementation improved the ratio of omega-6 to omega-3 fatty acids, leading to increased telomere length and reduced oxidative stress. The study suggests that omega-3 supplements may have potential in lowering the risk of age-related diseases such as coronary heart disease and Alzheimer's disease.
Scientists at Cincinnati Children's Hospital Medical Center identify a molecular pathway critical to body repair processes after injury, leading to potential new anti-fibrotic or anti-inflammatory agents. The discovery could provide a targeted intervention point in fibrotic diseases, including heart failure and muscular dystrophy.
Researchers at Dana-Farber Cancer Institute found that the protein TRPV4 is highly expressed in white fat cells, enabling them to burn calories instead of storing excess energy. The study provides a potential target for treating obesity and related metabolic diseases.
Researchers have developed a degradable polymer nanoparticle that detects biologically relevant concentrations of hydrogen peroxide, allowing for the non-invasive detection of inflammation. This method enables targeted drug delivery to diseased tissue, holding promise for treating cardiovascular diseases such as atherosclerosis.
Scientists at Emory University School of Medicine have shown that the immune system can compensate for a
Researchers at UofL School of Dentistry have discovered a way to prevent inflammation and bone loss surrounding teeth by blocking the natural signaling pathway of enzyme GSK3b. This finding has implications for preventing periodontal disease, a chronic inflammatory condition causing tooth loss.
Recent studies suggest that mesalamine and probiotics may help prevent recurrence of diverticulitis. Inflammation after an acute episode is a risk factor for recurrence, highlighting the need for new therapeutic approaches to managing the disease.
Researchers describe a new treatment approach for periodontal disease, targeting inflammation and promoting gum tissue regrowth. The controlled-release capsules release a protein that guides immune cells to the diseased area, reducing inflammation and creating an environment conducive to healing.