Articles tagged with Inflammation
Researchers have discovered a genetic mutation that causes familial chronic diarrhea syndrome, which could lead to new treatments for similar conditions. The mutation affects the GUCY2C gene, leading to constant signaling in the intestines and potentially causing inflammation and diarrhea.
Researchers at Brigham and Women's Hospital found that state-level resources contribute to early risk factors for heart disease in women. Wealthy states have lower levels of cardiovascular inflammation, while those with higher financial inequality have higher levels of inflammation.
Researchers have identified a critical mechanism of neuron death in intestinal inflammation that appears relevant to IBD. Blocking the 'pannexins' molecule was shown to prevent gut neuron death in animal models.
A clinical study found that treating psoriasis with adalimumab significantly decreased vascular inflammation, a major risk factor for cardiovascular disease. The study also showed a 51% decrease in C-reactive protein levels among treated patients, compared to a 2% decrease in the control group.
Researchers at the University of Rochester Medical Center have developed a compound that targets RAGE, a molecular actor involved in Alzheimer's disease. The compound, FPS-ZM1, reverses amyloid deposits, restores brain blood flow, and improves learning capabilities in mice.
A new EU project, TargetBraIn, is investigating the potential of the immune system to aid in stroke recovery. The research seeks to balance the positive and negative effects of inflammation, with the goal of developing more effective treatments for this growing health issue.
Scientists developed a unique compound that blocks inflammation-causing molecules in blood cells, fueling diseases like cancer and cardiovascular disease. The compound, Phox-I, precisely targets an enzyme network, reducing ROS production without causing toxicity.
Researchers found that silencing GC-C weakens intestinal barrier, making body more susceptible to cancer. Stimulating GC-C strengthens the barrier and opposes pathological changes.
Scientists at Emory University School of Medicine identified a new group of compounds that block signals from EP2, a receptor involved in inflammation. The compounds could potentially treat neurological diseases such as epilepsy and stroke.
Scientists found that caffeoylquinic acid derivatives from mate tea induce apoptosis in human colon cancer cells, reducing markers of inflammation. The study suggests mate tea has potential as an anti-cancer agent and may be beneficial for other diseases associated with inflammation.
A study by Boston University School of Medicine researchers found a direct link between diesel exhaust particulates, house dust extract, and pulmonary inflammation that aggravates asthma. Cleaning can reduce some allergen exposure, but DEP is harder to avoid in urban environments.
A study by UC Irvine researchers found that CKD causes depletion of adhesive proteins in the intestines, leading to systemic inflammation and cardiovascular complications. The findings could lead to novel treatments to curb this inflammation and its adverse consequences.
Researchers found that high levels of inflammation significantly shorten white dialysis patients' lives, but African Americans with similar inflammation levels survive similarly. A new study aims to understand and possibly mitigate this survival difference.
Researchers discovered that oral ingestion of apple polyphenols can suppress T cell activation and ameliorate experimental colitis in mice. The study found that apple polyphenols protect against colitis via the suppression of T cell activation and/or recruitment.
A recent study published in The Lancet found that patients with autoimmune diseases are at a higher risk of developing blood clots on the lung. The research, which involved 535,000 patients, reveals that 31 out of 33 autoimmune diseases studied were associated with an increased risk of pulmonary embolism.
A study of over 500,000 patients in Sweden found that those with autoimmune disorders have a significantly increased risk of pulmonary embolism during the first year after admission, with some diseases carrying a higher risk than others. Prophylaxis may be warranted for these patients.
A simple device that filters out airborne asthma triggers during sleep can significantly improve quality of life and reduce symptoms of atopic asthma. The study found a 14-15% difference in quality of life scores between those using the device and those with a dummy device.
Scientists engineer mice to express human enzyme IKKbeta in fat tissue, significantly slowing weight gain and improving metabolism. The study suggests obesity is worse than inflammation for insulin resistance, offering new clues about the connections among obesity, inflammation, and type 2 diabetes.
Research at Johns Hopkins Medicine reveals that Bacteroides fragilis causes colon inflammation and increases activity of a gene called spermine oxidase (SMO), leading to DNA damage and tumor formation. A compound blocking SMO enzyme activity prevented DNA damage in cells.
Researchers discovered that crocin in saffron exerts protective effects on brain cells and prevented damage in models of MS. The study also found a link between an ancient virus and cell stress leading to inflammation in the disease.
Researchers at the University of Manchester have developed a computer program that can rapidly identify ideal drug combinations to prevent inflammation and combat severe diseases. By analyzing billions of potential combinations, they hope to create tailored therapies for conditions such as stroke, cancer, and Alzheimer's.
Scripps Research scientists identify a new metabolic pathway for controlling brain inflammation, suggesting anti-inflammatory drugs with tissue-specific effects. Blocking enzyme MAGL reduces brain inflammation in mice, providing protection against conditions like Alzheimer's and Parkinson's.
Researchers identified sulforaphane as a potential therapeutic to augment anti-inflammatory effects of corticosteroids in individuals with COPD. This broccoli-based compound targets Nrf2 and restores glucocorticosteroid sensitivity in macrophages from COPD patients.
A new study published in Immunity reveals that preventing necroptosis in keratinocytes is crucial for preventing skin inflammation. The research found that sensitization of keratinocytes to RIP3-mediated cell death triggers skin inflammation, which could be linked to various chronic or acute skin conditions.
Researchers at North Carolina State University have discovered that blocking the epidermal growth factor receptor can prevent rapidly progressive glomerulonephritis, a rare and debilitating kidney disease. The study also showed that certain drugs inhibiting EGF receptors may reverse the harmful effects of the disease.
Researchers identified a new type of T cell that can produce acetylcholine, a neurotransmitter that blocks inflammation. This discovery suggests a novel approach to treating inflammatory and autoimmune diseases by targeting the nerves and T cells.
Researchers used MRI and PET/CT to prove the efficacy of dalcetrapib in preventing atherosclerosis progression and reducing vascular inflammation over 24 months. The study found significant reductions in atherosclerotic disease progression and arterial inflammation, suggesting a promising new treatment for cardiovascular disease.
A recent study discovered that a PSMB8 gene mutation causes Japanese autoinflammatory syndrome with lipodystrophy. The researchers identified the specific mechanism of the mutation and its impact on human health.
The American Thoracic Society has issued guidelines on interpreting fractional exhaled nitric oxide (FENO) levels in various clinical settings. FENO can detect eosinophilic airway inflammation, determine corticosteroid responsiveness, and monitor airway inflammation to guide treatment decisions.
Researchers found that African-American endothelial cells produce nearly 90% more microparticles during inflammation than Caucasian cells. This increased production is associated with higher levels of hypertension in individuals.
A new study found that a nasal spray containing capsaicin from chili peppers reduces symptoms of non-allergic rhinitis. The study showed participants experienced faster relief after using the spray, on average within one minute.
A new assessment tool, SNOT-16, has been found to effectively evaluate the quality of life in adult patients with acute rhinosinusitis. The modified questionnaire assesses symptom severity and frequency, demonstrating validity and responsiveness.
A five-year study found that rheumatoid arthritis patients are at higher risk of cardiovascular disease due to inflammation. Treatment with disease-modifying antirheumatic drugs (DMARDs) reduced the risk, while certain risk factors such as diabetes and high blood pressure predicted new events.
Mayo Clinic researchers are investigating why knee osteoarthritis disproportionately affects women. The study will analyze human tissues discarded during knee replacement surgery for possible biological differences in pain fibers and hormone receptors between female and male patients.
Researchers discovered that chloroquine represses inflammation by activating glucocorticoid signaling, providing a blueprint for new strategies to treat autoimmune diseases. Lysosomal functioning also plays a role in regulating glucocorticoid signaling.
A study at Ohio State University found that omega-3 supplements decreased anxiety and inflammation in healthy medical students by 20% and 14%, respectively. The results suggest that increasing omega-3 intake through diet may be a more effective approach than supplementation for overall health benefits.
A study published in Journal of Cardiovascular Nursing found that heart failure patients who followed doctor's advice for self-care had lower levels of myocardial stress and systemic inflammation. This suggests that effective self-care behaviors can influence health outcomes through multiple cardioprotective means.
Long-term exposure to air pollution can lead to physical changes in the brain and negative effects on learning, memory, and mood. Mice exposed to polluted air showed reduced cell complexity, inflammation, and depressive-like behaviors.
A study by Boston University School of Medicine shows that the quality of fat tissue, not just its quantity, contributes to inflammation and vascular disease in obese individuals. The research identified that 30% of obese subjects demonstrated reduced fat inflammation, less insulin resistance, and similar vascular function.
Researchers from Boston University School of Medicine found that traditional Korean medicine SCRT treatment alleviates asthma-like pulmonary inflammation via suppression of specific chemokines or proteins. The study, published online in Annals of Allergy, Asthma & Immunology, suggests a potential mechanism for reduced inflammation.
Researchers at Case Western Reserve University discovered a genetic factor that regulates obesity-induced inflammation contributing to chronic health problems. By controlling levels of Kruppel-like factor 4 (KLF4) in macrophages, they may develop a novel treatment for obesity and its complications such as diabetes and heart disease.
Researchers identified a new probiotic bacteria-derived soluble protein that provides therapeutic protection against intestinal inflammation. The protein, p40, was delivered to the colon and protected mice from colitis through an EGFR-dependent mechanism.
A University of Illinois professor chaired a committee that recommends providing at least 50% of normal caloric intake, including higher protein, to reduce inflammation and promote brain repair in TBI patients. The guidelines aim to improve recovery rates for veterans and individuals with other traumatic brain injuries.
A new polymer-based system for imaging inflammation associated with wear debris shows promise in detecting early stages of bone loss in joint replacement implants. The system can also tether anti-inflammatory drugs to prevent further damage.
Georgia Health Sciences University researchers are exploring whether low levels of interleukin-1 receptor antagonist (IL-1ra) can identify children at risk for developing type 1 diabetes. They also plan to investigate using IL-1 inhibitors to prevent the disease.
Researchers found that drinking tart cherry juice daily can significantly reduce inflammation and cardiovascular risk in overweight adults. A cherry diet also reduced atherosclerosis and other heart disease risk factors in mice, with improved cardiovascular health leading to a 65% reduction in early death.
A recent study suggests that breast cancer patients experiencing persistent fatigue may have an imbalance in their autonomic nervous system, leading to accelerated aging. Researchers found that fatigued patients showed higher levels of stress hormones and lower parasympathetic activity compared to non-fatigued patients.
Scientists mimic the body's natural mechanism of fighting inflammation by using natural human microparticles to deliver anti-inflammatory therapeutics. This new approach could have application for various inflammatory diseases, including arthritis and temporomandibular disorders.
Researchers at Goethe University Frankfurt have elucidated a new signaling pathway in the immune system that regulates inflammation and chronic dermatitis. The discovery provides new avenues for therapeutic intervention and potential targeted therapy for patients with unclear origin.
Researchers found obese teens had higher C-reactive protein levels, insulin resistance, and homocysteine levels, indicating chronic inflammation and oxidative stress. Poor dietary quality, low in fresh produce and dairy products, was common among both groups.
Researchers found caspase enzymes control microglial activation, triggering inflammation and neuronal death in neurodegenerative diseases. Caspase inhibitors showed promise in reducing activated microglia and inflammation in mice.
A study by Indiana University School of Medicine found that tanning bed radiation can cause severe skin reactions, including toxic epidermal necrolysis, a life-threatening condition. The researchers advise caution when using tanning beds to treat undiagnosed skin conditions.
Researchers identify thymic stromal lymphopoietin (TSLP) as a key driver of Th2 inflammation in human breast and pancreatic tumors. TSLP from cancer cells or fibroblasts fuels Th2 inflammation, promoting tumor growth.
A University of Colorado study explores the relationship between hypoxia and inflammation, finding that a protein called HIF plays a key role in the body's response to low oxygen levels. The research may help patients who undergo organ transplants or suffer from infections or cancer
A recent study found that magnesium sulfate significantly reduced neonatal brain injury associated with maternal inflammation or infection in rats. The findings suggest that magnesium therapy may be beneficial in human preterm deliveries linked to maternal/fetal inflammation.
Researchers developed an intravitreal, bioerodible implant that delivers dexamethasone to the back of the eye chamber. The study found significant improvements in intraocular inflammation and visual acuity with a single dose of the implant.
Studded winter tires grind away at road surfaces, generating dust particles linked to inflammation and diseases such as heart disease. Researchers found specific protein changes in cells related to road dust exposure, which could help understand the link between pavement dust and heart disease.
Researchers discovered a specific enzyme inhibitor, delta-protein kinase C, that can help control lung inflammation by protecting the lungs from neutrophil-mediated damage. This could lead to new therapeutic targets for treating acute respiratory distress syndrome and reducing morbidity and mortality associated with sepsis and trauma.
Researchers at Johns Hopkins Children's Center discover that the CFTR protein regulates inflammation and cell death in emphysema, potentially leading to new treatments. Decreases in CFTR expression correspond to increased buildup of ceramide, a trigger of inflammation and cell death.
Researchers have discovered a protein that can prevent chronic tissue inflammation and boost the immune system. The therapeutic vaccine has been shown to effectively treat conditions like multiple sclerosis and rheumatoid arthritis.