Research on inflammation and its role in disease. Covers eye inflammation, personalized anti-inflammatory medicine, aging, and chronic pain links.
Researchers found that dysbiosis enhances intestinal inflammation and increases risk of colon cancer, but treatment with antibiotics or fecal transplantation reduces disease risk. Gut bacterial communities play a crucial role in protecting against intestinal inflammation and tumorigenesis.
Researchers found that bacterial imbalance contributes to intestinal inflammation and carcinogenesis, with treatment reducing disease risk. Dysbiosis was shown to enhance intestinal inflammation and increase the risk for inflammation-associated colon cancer.
A small stroke, known as a silent stroke, can cause Parkinson's disease by killing dopaminergic neurons in the substantia nigra. The study found inflammation and brain damage following the stroke, leading to neurodegeneration and potential onset of Parkinson's disease.
Researchers at Monash University used advanced microscopy techniques to visualize the movements of white blood cells in healthy and diseased kidneys. They found that leukocytes are constantly circulating through and patrolling blood vessels within healthy kidneys, but become agitated during disease, causing inflammation and kidney damage.
A team of researchers from Massachusetts General Hospital has discovered that intestinal immune cells collect and process antigens from both the bloodstream and the intestine, inducing the production of T cells that suppress inflammation. This regulatory system is crucial for preventing autoimmune disorders and inflammatory bowel disease.
Researchers at the University of Missouri have developed a new method to detect artery inflammation in pigs using targeted micro-bubbles. The technique, which has shown promising results, may help identify patients at risk for strokes and monitor the effectiveness of treatments.
A study published in the Journal of Clinical Investigation identifies a rare mutation in the DGAT1 gene as the cause of congenital diarrheal disorder. Additionally, research on natriuretic peptides reveals their role in enhancing human skeletal muscle metabolism and increasing fat oxidation.
Exosomes from mesenchymal stem cells reduce lung inflammation and prevent pulmonary hypertension in a mouse model. The findings suggest exosome research could lead to new stem cell-based therapies for chronic lung disease and other inflammatory conditions.
Researchers at The Feinstein Institute for Medical Research have discovered that extract from mung bean can reduce the release of HMGB1, thereby increasing survival rates in mice. This finding has promise for the treatment of sepsis in humans.
A research team at VIB has identified a new anti-inflammatory mechanism of the protein A20, which can help treat autoimmune diseases like Rheumatoid Arthritis. By understanding how A20 interacts with signaling pathways, scientists can develop new therapies to combat inflammation and disrupt the immune system's attack on its own tissues.
Researchers at Case Western Reserve University discovered that magnesium reduces inflammation by reducing NF-kB activity and subsequent cytokine production. This new insight offers a promising immunotherapeutic strategy for treating diseases such as asthma, atherosclerosis, and sepsis.
A University of Illinois study found that caffeine reduces brain-based inflammation associated with neurodegenerative diseases. Caffeine-treated mice recovered their ability to form new memories faster than non-caffeine-treated mice, suggesting a possible therapeutic target for mild cognitive impairment.
Researchers found that omega-3 supplementation improved the ratio of omega-6 to omega-3 fatty acids, leading to increased telomere length and reduced oxidative stress. The study suggests that omega-3 supplements may have potential in lowering the risk of age-related diseases such as coronary heart disease and Alzheimer's disease.
Researchers at Dana-Farber Cancer Institute found that the protein TRPV4 is highly expressed in white fat cells, enabling them to burn calories instead of storing excess energy. The study provides a potential target for treating obesity and related metabolic diseases.
Scientists at Cincinnati Children's Hospital Medical Center identify a molecular pathway critical to body repair processes after injury, leading to potential new anti-fibrotic or anti-inflammatory agents. The discovery could provide a targeted intervention point in fibrotic diseases, including heart failure and muscular dystrophy.
Researchers have developed a degradable polymer nanoparticle that detects biologically relevant concentrations of hydrogen peroxide, allowing for the non-invasive detection of inflammation. This method enables targeted drug delivery to diseased tissue, holding promise for treating cardiovascular diseases such as atherosclerosis.
Scientists at Emory University School of Medicine have shown that the immune system can compensate for a
Researchers at UofL School of Dentistry have discovered a way to prevent inflammation and bone loss surrounding teeth by blocking the natural signaling pathway of enzyme GSK3b. This finding has implications for preventing periodontal disease, a chronic inflammatory condition causing tooth loss.
Recent studies suggest that mesalamine and probiotics may help prevent recurrence of diverticulitis. Inflammation after an acute episode is a risk factor for recurrence, highlighting the need for new therapeutic approaches to managing the disease.
Researchers describe a new treatment approach for periodontal disease, targeting inflammation and promoting gum tissue regrowth. The controlled-release capsules release a protein that guides immune cells to the diseased area, reducing inflammation and creating an environment conducive to healing.
A new study found that people with high levels of inflammation-linked protein are less likely to develop dementia and have relatives who avoid the disease. Higher protein levels were associated with a lower risk for dementia in parents and siblings, suggesting a possible genetic link.
Researchers have identified thioredoxin-interacting protein (TXNIP) as a target for therapies in diabetes and Wolfram syndrome. The molecule is involved in the initiation of local inflammation that can lead to systemic inflammation.
A recent study found that an inflammatory monocyte population plays a key role in ALS progression, suggesting it as a potential therapeutic target. Monocyte depletion reduced cellular recruitment to the spinal cord, decreased CNS cell death, and extended survival time in mice with ALS.
A UNC-led team describes a previously uncharacterized protein NLRC3 that inhibits NF-Kappa B activation and forms a novel TRAFasome complex. This discovery provides insight into mechanisms controlling inflammation and identifies potential therapeutic targets.
A 'fight' between bacteria and the immune system may lead to chronic diseases such as metabolic syndrome and inflammatory bowel disease. The study's findings highlight the importance of controlling the early environment through breastfeeding, a diverse diet, or probiotics.
A study by Massachusetts General Hospital found that HIV-infected individuals have comparable levels of arterial inflammation as those with established cardiovascular disease, despite being at lower risk. The researchers suggest that targeting monocyte activation may be a unique strategy to reduce arterial inflammation in these patients.
A new study found that Cognitively-Based Compassion Training (CBCT) improved the mental and physical health of adolescents in foster care by reducing anxiety and increasing feelings of hopefulness. CBCT also reduced inflammation levels, which is a fundamental risk factor for chronic illnesses.
Researchers use intravital two-photon imaging to track individual immune cells as they swarm into the heart muscle, causing inflammation and tissue damage. The technique allows for real-time observation of inflammation in the heart, paving the way for new therapeutic targets.
Researchers have discovered the molecular structure of calmodulin's role in regulating L-selectin shedding, allowing white blood cells to move to sites of infection or inflammation. This understanding could lead to developing drug therapies to manipulate the immune system and address disorders caused by overactive immune responses.
La Jolla Institute scientist Klaus Ley reveals a novel mechanism played a major role in inflammation. Neutrophils use sling-like membrane tethers to latch on to blood vessel walls during high blood flow, providing new insights into critical biological mechanisms underlying heart disease and other disorders.
Researchers have identified commensal bacteria that produce gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter. The discovery suggests that certain intestinal bacteria may play a role in preventing or treating inflammatory bowel diseases such as Crohn's disease.
Researchers at Cardiff University have discovered a new interaction between two well-known molecules that could lead to a beneficial therapy against necrosis and inflammation in the body. The study found that blocking the effect of Bcl-2 on calcium pumps could be an attractive target for treating pancreatitis and pancreatic cancer.
Scientists at Aarhus University have developed a new technology that conjugates glucocorticoid steroids to antibodies binding to macrophage receptors, reducing side effects and increasing potency. This intelligent medicine shows promise for treating various inflammatory diseases, including autoimmune disorders.
A study found that older adults with asthma have a higher proportion of airway inflammation compared to younger patients, despite similar treatment regimens. This could be due to underlying airway inflammation being relatively resistant to current anti-inflammatory therapies.
Scientists investigate the complex relationships between lipids and inflammation in insulin resistance, as well as the role of omega 3 fatty acids and a gene called GPR120 in fighting inflammation. Elevated levels of a protein called PGC-1alpha may delay muscle destruction in ALS patients
Researchers developed a mouse model of delirium, finding that systemic inflammation triggers short-term memory disturbance, which is reversed by treatment with donepezil. The study reconciles two long-standing hypotheses, shedding light on the condition's causes and potential treatments.
A new study shows that MR enterography outperforms CT enterography in diagnosing fibrosis and detecting active inflammation in pediatric Crohn's patients. The imaging modality offers a radiation-free alternative to traditional CT scans.
Researchers have discovered a genetic mutation that causes familial chronic diarrhea syndrome, which could lead to new treatments for similar conditions. The mutation affects the GUCY2C gene, leading to constant signaling in the intestines and potentially causing inflammation and diarrhea.
Researchers have identified a critical mechanism of neuron death in intestinal inflammation that appears relevant to IBD. Blocking the 'pannexins' molecule was shown to prevent gut neuron death in animal models.
Researchers at Brigham and Women's Hospital found that state-level resources contribute to early risk factors for heart disease in women. Wealthy states have lower levels of cardiovascular inflammation, while those with higher financial inequality have higher levels of inflammation.
A clinical study found that treating psoriasis with adalimumab significantly decreased vascular inflammation, a major risk factor for cardiovascular disease. The study also showed a 51% decrease in C-reactive protein levels among treated patients, compared to a 2% decrease in the control group.
Researchers at the University of Rochester Medical Center have developed a compound that targets RAGE, a molecular actor involved in Alzheimer's disease. The compound, FPS-ZM1, reverses amyloid deposits, restores brain blood flow, and improves learning capabilities in mice.
A new EU project, TargetBraIn, is investigating the potential of the immune system to aid in stroke recovery. The research seeks to balance the positive and negative effects of inflammation, with the goal of developing more effective treatments for this growing health issue.
Scientists developed a unique compound that blocks inflammation-causing molecules in blood cells, fueling diseases like cancer and cardiovascular disease. The compound, Phox-I, precisely targets an enzyme network, reducing ROS production without causing toxicity.
Researchers found that silencing GC-C weakens intestinal barrier, making body more susceptible to cancer. Stimulating GC-C strengthens the barrier and opposes pathological changes.
Scientists at Emory University School of Medicine identified a new group of compounds that block signals from EP2, a receptor involved in inflammation. The compounds could potentially treat neurological diseases such as epilepsy and stroke.
Scientists found that caffeoylquinic acid derivatives from mate tea induce apoptosis in human colon cancer cells, reducing markers of inflammation. The study suggests mate tea has potential as an anti-cancer agent and may be beneficial for other diseases associated with inflammation.
A study by Boston University School of Medicine researchers found a direct link between diesel exhaust particulates, house dust extract, and pulmonary inflammation that aggravates asthma. Cleaning can reduce some allergen exposure, but DEP is harder to avoid in urban environments.
A study by UC Irvine researchers found that CKD causes depletion of adhesive proteins in the intestines, leading to systemic inflammation and cardiovascular complications. The findings could lead to novel treatments to curb this inflammation and its adverse consequences.
Researchers found that high levels of inflammation significantly shorten white dialysis patients' lives, but African Americans with similar inflammation levels survive similarly. A new study aims to understand and possibly mitigate this survival difference.
Researchers discovered that oral ingestion of apple polyphenols can suppress T cell activation and ameliorate experimental colitis in mice. The study found that apple polyphenols protect against colitis via the suppression of T cell activation and/or recruitment.
A recent study published in The Lancet found that patients with autoimmune diseases are at a higher risk of developing blood clots on the lung. The research, which involved 535,000 patients, reveals that 31 out of 33 autoimmune diseases studied were associated with an increased risk of pulmonary embolism.
A study of over 500,000 patients in Sweden found that those with autoimmune disorders have a significantly increased risk of pulmonary embolism during the first year after admission, with some diseases carrying a higher risk than others. Prophylaxis may be warranted for these patients.
A simple device that filters out airborne asthma triggers during sleep can significantly improve quality of life and reduce symptoms of atopic asthma. The study found a 14-15% difference in quality of life scores between those using the device and those with a dummy device.
Scientists engineer mice to express human enzyme IKKbeta in fat tissue, significantly slowing weight gain and improving metabolism. The study suggests obesity is worse than inflammation for insulin resistance, offering new clues about the connections among obesity, inflammation, and type 2 diabetes.
Researchers discovered that crocin in saffron exerts protective effects on brain cells and prevented damage in models of MS. The study also found a link between an ancient virus and cell stress leading to inflammation in the disease.
Research at Johns Hopkins Medicine reveals that Bacteroides fragilis causes colon inflammation and increases activity of a gene called spermine oxidase (SMO), leading to DNA damage and tumor formation. A compound blocking SMO enzyme activity prevented DNA damage in cells.
Researchers at the University of Manchester have developed a computer program that can rapidly identify ideal drug combinations to prevent inflammation and combat severe diseases. By analyzing billions of potential combinations, they hope to create tailored therapies for conditions such as stroke, cancer, and Alzheimer's.
Scripps Research scientists identify a new metabolic pathway for controlling brain inflammation, suggesting anti-inflammatory drugs with tissue-specific effects. Blocking enzyme MAGL reduces brain inflammation in mice, providing protection against conditions like Alzheimer's and Parkinson's.
Researchers identified sulforaphane as a potential therapeutic to augment anti-inflammatory effects of corticosteroids in individuals with COPD. This broccoli-based compound targets Nrf2 and restores glucocorticosteroid sensitivity in macrophages from COPD patients.