Articles tagged with Inflammation
A study by Texas AgriLife Research has linked gene PFKFB3 to metabolic inflammation that leads to diabetes. The researchers believe that a focus on nutrition can prevent or reverse the disease by activating the gene.
Researchers at Karolinska Institutet identify polyphosphate as a key player in the formation of blood clots and inflammation. The study suggests that phosphatases can break down polyphosphate, preventing both conditions.
Researchers at Imperial College London have identified TLR-2 as the trigger that leads to inflammation and damage in atherosclerosis, a condition causing heart attacks and strokes. Blocking this molecule could potentially treat atherosclerosis and reduce the risk of these diseases.
Researchers at UCI discovered a way to boost palmitoylethanolamide (PEA) levels, a potent anti-inflammatory substance. The PEA-boosting compound shows wide-scale promise as an immune-response drug treatment for allergies, illnesses and injuries.
A new study published in Nutrition Journal indicates that XanGo Juice has lowered levels of C-reactive protein (CRP) in overweight and obese people, suggesting potential benefits for heart health and diabetes. The juice also showed significant reductions in body fat percentage and BMI scores.
A recent study found that patients treated with teriparatide for 36 months had a greater increase in bone mineral density (BMD) and fewer new vertebral fractures than those treated with alendronate. The study also observed higher levels of calcium concentrations in the teriparatide group.
Researchers discovered how fish oils convert to Resolvin D2, a chemical that reduces inflammation and may treat conditions like arthritis, sepsis, and stroke. This breakthrough could lead to new treatments for diseases associated with inflammation.
Researchers discovered that dendritic cells in the lung provoke destructive T-cells that attack elastin, causing lung tissue death and emphysema. The study found a link between systemic inflammation and cardiovascular diseases associated with smoking.
LX211 controls inflammation in non-infectious uveitis, significantly reducing its recurrence rate by 50% at a dose of 0.4 mg/kg twice daily. The treatment also preserves visual acuity and reduces corticosteroid use to minimize vision loss risk.
Researchers found that aspirin and folic acid do not affect inflammation markers in patients with colorectal adenomas. However, low-dose aspirin was found to stabilize C-reactive protein levels, which may be affected by high folate intake.
A new study suggests that platelet-rich plasma (PRP) may catalyze the body's repair mechanisms at areas of injury, improving healing and shortening recovery time. However, more research is needed to determine its clinical effectiveness for chronic tendon conditions, such as tennis elbow and Achilles tendonitis.
Researchers at Medical College of Georgia say blocking a protein that battles infection may help prevent a common cause of vision loss in chronic diseases like diabetes. The protein interleukin-6 prompts inflammation, which can lead to complications such as diabetic retinopathy.
Research found a modestly increased risk of death in patients with lesser degrees of celiac disease-related symptoms. The risk was highest in the first year of follow-up, with cardiovascular disease and malignancy being the main causes of death in celiac disease.
Researchers at University of Michigan have developed a nanoemulsion lotion that sharples curbs bacterial growth and reduces inflammation in second-degree burns. The treatment shows promise in overcoming current creams' limitations, reducing bacterial growth one-thousand-fold compared to control animals.
Patients with polymyositis and dermatomyositis, autoimmune disorders causing muscle inflammation, are at higher risk of developing cardiovascular disease. The study found that immunosuppressive therapies may have a preventive effect against heart attacks, providing hope for patients hesitant to undergo treatment.
Researchers have identified a contaminant in common intravenous treatments that can trigger life-threatening inflammation in critically ill patients. Advanced glycation end products, found in albumin infusion solutions, can cause significant inflammation and death rates in mice, suggesting the need for improved patient outcomes.
Progesterone exposure may increase breast cancer risk by activating genes involved in cell adhesion, survival, and inflammation. The study reveals targets for future work in reducing progesterone's influence on breast cancer development.
A three-year study is underway to explore the link between knee inflammation and osteoarthritis. Researchers use ultrasound to identify inflammation in people over 55 with knee pain or osteoarthritis.
Dr. Haydee Bazan received a $710,000 grant from the National Institutes of Health to explore potential therapeutic approaches to heal corneal injuries. The research focuses on finding balance between signaling mechanisms that promote cellular damage or repair in the cornea.
A recent study published in International Immunopharmacology reveals that Pycnogenol inhibits the generation of COX-2 and 5-LOX enzymes associated with inflammation. This finding suggests that Pycnogenol can decrease pain and reduce inflammatory conditions by shutting down specific enzyme production.
Researchers at Case Western Reserve University School of Medicine discovered a novel connection between ITCH and NOD2 genes, which may lead to new treatments for Crohn's disease. The study highlights the potential for individually-tailored therapies for patients with the NOD2 mutation.
Two studies published in the July issue of Ophthalmology highlight the connection between normal-tension glaucoma and silent cerebral infarcts, as well as stealthy herpes simplex infections impacting corneal transplants. Silent cerebral infarfts are more common among NTG patients and can lead to rapid visual field loss.
A recent study published in PLOS Medicine reveals that inflammatory markers are more strongly associated with fatal than nonfatal cardiovascular events in elderly individuals. The study found that elevated levels of IL-6 and other inflammatory markers were linked to a higher risk of fatal heart attacks and strokes.
Researchers at UC Davis have received a $750,000 grant to investigate a novel therapeutic target for treating inflammation and diagnosing asthma. The study will use metabolomics to evaluate the effectiveness of soluble epoxide hydrolase (sEH) inhibitors in asthma treatment.
Researchers found the malfunctioning ABCG2 gene can lead to high urate levels, causing inflammation and pain. The gene is responsible for transporting urate out of the kidney and into urine, and its mutation may be linked to 10% of gout cases in Caucasians.
A study published in Brain, Behavior and Immunity found a strong association between extraversion and lower levels of inflammatory chemical interleukin 6 (IL-6), which can signal increased risk of death. The research suggests that dispositional activity may confer a survival advantage.
Researchers at NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases have discovered a new autoinflammatory syndrome, DIRA, which affects children from birth to 2 weeks of age. The disorder is caused by mutations in the IL1RN gene and can be treated with anakinra, a synthetic form of human IL-1Ra.
Researchers at Penn State College of Medicine have discovered an enzyme called meprin that plays a key role in the severity of inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease. The study found that mice lacking meprin had more severe intestinal damage, indicating that meprin reduces inflammation.
Researchers found that local intestinal inflammation induced DNA damage to lymphocytes in peripheral blood, indicating systemic genetic damage. Chromosome damage was detected in the blood before colitis onset and correlated with disease severity.
Researchers found that treating gum disease improved rheumatoid arthritis symptoms, including reduced swollen joints and morning stiffness. The study's results suggest a link between periodontal disease and rheumatoid arthritis, highlighting the importance of good oral health in overall well-being.
A new molecule has been synthesized to release hydrogen sulfide gas in a slow and sustained manner, reducing inflammation and increasing levels of the body's own anti-inflammatory molecules. This breakthrough could pave the way for the development of novel approaches to treating inflammatory disorders.
A Medical College of Georgia nurse researcher has received a two-year, $147,000 grant from the National Institute on Drug Abuse to investigate cocaine-related renal disease in African-Americans. The study aims to identify early signs of renal disease and develop targeted treatments for patients with cocaine addiction.
A study published in PNAS identified TRPA1 as playing a key role in allergic asthma and demonstrated that HC-030031 effectively treated the condition in mice. This breakthrough research could represent a new avenue of treatment for asthma.
A new University of Illinois study suggests that moderate exercise can reduce visceral fat inflammation, even without a change in diet. The benefits were apparent in both short-term and long-term studies, with significant reductions in belly fat and improved insulin sensitivity found in mice.
Researchers have developed antedrugs that effectively reduce inflammation without causing damage, surpassing the potency of conventional steroids. The new compounds, isoxazoline derivatives, were five times more potent in binding affinities to cell receptors and reducing inflammation.
Researchers at Washington University School of Medicine have developed a new compound that can detect and visualize immune cell activity, highlighting the misdeeds of the immune system. The compound, called luminol, glows blue when injected into mice with active immune inflammation.
Scientists at Goethe University report a paradigm shift in immune response regulation, revealing the crucial role of linear ubiquitin chains in nuclear factor kappa B activation. This finding may lead to structure-based drug design for targeting the NF-κB pathway in diseases such as cancer and inflammation.
A new UK study shows that using NIOX MINO to measure inflammation in asthma patients can lead to a £341-£554 annual cost saving. This is achieved by optimizing treatment, reducing visits to casualty and hospital admissions, and lowering cortisone inhaler doses.
A recent study published in SLEEP found that inflammation may be the underlying mechanism linking extreme sleep durations to poor health. Short and long sleep durations were associated with changes in inflammatory cytokines, including C-reactive protein and interleukin-6.
The American Heart Association advises consumers to aim for at least 5-10% of energy from omega-6 PUFAs, which may reduce cardiovascular risk and lower the risk for heart disease events by 24%. Omega-6 fatty acids have anti-inflammatory properties, dispelling concerns of increased inflammation and cardiovascular risk.
Researchers discovered that DNA component CpG can stimulate inflammation at low doses but block it at high doses through the enzyme indoleamine 2,3 dioxygenase. This finding holds promise for treating cancer and infections by manipulating dosage to optimize immune response.
Research found that inflammation weakens collagen caps in atherosclerotic plaques, making them more prone to rupture. The study identifies lysyl-oxidase as a potential target for preventing plaque rupture and thrombosis.
Researchers found that long-chain fats like oleic acid in olive oil increase intestinal absorption of pro-inflammatory lipopolysaccharides (LPS), promoting inflammation. This study suggests a potential link between dietary fat intake and inflammatory bowel disorders.
Researchers at Massachusetts General Hospital and University of Pennsylvania found that COX2 in mouse nerve cells plays a crucial role in pain caused by physical insult, while PDE5 inhibition may prevent hypertrophy in the mouse heart. These findings have implications for treating conditions such as postoperative and arthritic inflamma...
COX2 in brain and spinal cord nerve cells plays a crucial role in pain caused by inflammation, particularly mechanical inflammatory pain. Mice lacking COX2 in nerve cells have impaired hypersensitivity to pain caused by physical insult, suggesting COX2 is central to this type of pain.
Researchers used DTI to estimate chronic effects of optic nerve inflammation three months in advance. DTI showed a correlation between damage and lower scores on visual health tests, indicating potential predictive information for MS flare-ups.
A new study published in The FASEB Journal suggests that infected gums may be a source of inflammation leading to heart disease. Proper dental hygiene can greatly reduce the risk of atherosclerosis, stroke, and heart disease independently.
Research suggests melatonin therapy may prevent ocular inflammation in uveitis, reducing symptoms and protecting the blood-ocular barrier. Melatonin treatment has anti-inflammatory effects, potentially benefiting patients with chronic uveitis.
Researchers have discovered that alpha-1-antitrypsin (AAT) can eliminate inflammation in diabetic animals after islet transplantation, allowing the transplanted cells to survive and function for over 120 days. This breakthrough could lead to a safer and more effective treatment for type-1 diabetes patients.
A new study found that tart cherry-enriched diets lowered body weight and fat, reducing cholesterol and inflammation levels. The research suggests a direct anti-inflammation effect and may help lower heart disease risk in humans.
Researchers found strong associations between intermittent HIV treatment and higher levels of inflammation and blood-clotting biomarkers, leading to a higher risk of death from non-AIDS diseases. Interleukin-6 (IL-6) and D-dimer levels rose significantly in the intermittent-treatment group after one month.
Using precise microscopes, University of Missouri researchers identified tumor necrosis factor-α and advanced glycation end products as major contributors to blood vessel dysfunction in type 2 diabetes. This discovery could lead to new treatments for blood vessel diseases and disorders in people with type 2 diabetes.
Researchers found that fecal levels of FC and MPO can be used as surrogate markers for successful treatment outcome in IBD patients. The study also showed that elevated fecal markers are associated with relapse, but normalized FC level may indicate successful treatment.
Research reveals a common connection between cellular innate immunity and human chronic inflammatory diseases, including atherosclerosis, Type 2 Diabetes, and neurodegenerative diseases. A critical signaling network involving IRAK-1 has been identified as a potential target for diagnosis and treatment.
Srivastava aims to examine the link between aldose reductase and lung inflammation in asthma. His research group has previously demonstrated the enzyme's role in other inflammatory diseases.
Researchers at the University of Bonn discovered that oregano's active ingredient beta-caryophyllin inhibits inflammation and may help treat osteoporosis, arteriosclerosis, and chronic disorders like Crohn's disease. The substance targets cannabinoid-CB2 receptors, providing a non-intoxicating alternative to existing treatments.
Researchers from NIAMS identified a promising new target for autoimmune disease treatment, a cell-surface receptor called DR3. Blocking this receptor could slow or stop damaging inflammation characteristic of autoimmune diseases without leaving the body vulnerable to serious infections.
A study published in BioMed Central's Journal of Inflammation found that pomegranate extract reduced the production of chemicals causing inflammation in rabbits. The findings suggest that pomegranate extract may provide relief from chronic inflammatory conditions in humans.
Researchers from Case Western Reserve University School of Medicine and Penn State Hershey College of Medicine identified a novel ceramide that reduces sterile inflammation in the cornea. The nano-sized package allows for easy application as an eye drop, providing an effective alternative to steroid use.
Researchers deliver genetically engineered T-reg cells to the intestine to suppress inflammation and autoimmunity. The 'bystander' effect enables these cells to target diseased tissue, suppressing inflammatory cells and promoting healing.