Research on inflammation and its role in disease. Covers eye inflammation, personalized anti-inflammatory medicine, aging, and chronic pain links.
Researchers found some improvement in macroscopic inflammation with local anesthetics, but microscopic findings did not support these results. Local anesthetics may have potential therapeutic effects on inflammatory bowel disease based on their ability to reduce neuronal activity and subsequent inflammation.
Researchers found that eating pistachios increases blood serum levels of lutein, beta-carotene, and gamma-tocopherol. These antioxidants may help lower oxidized LDL concentrations, which can contribute to inflammation and plaque buildup inside blood vessels.
A study by UC Davis researchers has identified a blood component, lipoprotein-associated phospholipase A2 (Lp-PLA2), as a predictor of coronary artery disease in African-Americans. The finding highlights the role of inflammation in vascular disease among this ethnic group and may lead to more targeted treatment approaches.
Researchers at Michigan State University discovered that cholesterol crystals form in the arterial wall and activate a biomarker called NLRP3, inducing inflammation. This early cause of inflammation could lead to new treatments targeting cholesterol crystal deposits and inflammatory biomarkers.
Researchers at Karolinska Institutet have developed a vaccine that can block the immune reaction causing atherosclerosis, reducing disease by 60-70%. The vaccine targets T cells reacting to native LDL particles, reversing previous findings on antioxidants' ineffectiveness against cardiovascular disease.
Researchers found biochemical mediators of inflammation produced by activated macrophages, which stimulate antioxidant and anti-inflammatory responses. These findings could lead to the development of new treatments for inflammatory diseases linked to omega-3 fatty acids and aspirin.
A study by Case Western Reserve University found that subjects with both high gum inflammation levels and moderate to severe prostatitis had higher PSA or inflammation levels. This suggests that inflammation outside the prostate gland may be causing an inflammatory reaction, which could explain why PSA levels can be high in prostatitis.
A dual FXR and TGR5 agonist decreases liver damage and modulates hepatic inflammation and fibrosis in a mouse model of PSC. FXR and TGR5 agonists regulate bile acids, glucose, lipids and inflammation.
Researchers have isolated a portion of the adenovirus responsible for causing pink eye, finding that its protein coating is the key to inflammation in the eyes. This discovery offers new hope for developing a treatment for this highly contagious and common condition.
Researchers have discovered that an enzyme found in white blood cells can break down carbon nanotubes into harmless components. This breakthrough finding has significant implications for the future use of carbon nanotubes in medicine, potentially rendering them harmless and reducing toxicity.
A unique St. John's wort collection curated by ARS scientists provides university collaborators with genetically diverse sources of the herb to study its medicinal potential. Researchers are screening the collection for biologically active compounds that may combat viral infections, reduce inflammation, or improve digestive health.
A novel anti-inflammatory drug, ATB-346, has shown promise in relieving inflammation symptoms while reducing bleeding and intestinal damage caused by commonly used NSAIDs. The researchers found that ATB-346 is at least as effective as naproxen in animal models and is significantly safer.
A new study found that consuming orange juice with a high-fat meal reduces oxidative stress and inflammation in blood vessels, which can contribute to heart attacks and strokes. The flavonoids naringenin and hesperidin in orange juice are believed to be the key players in this process.
Researchers found that a certain form of body fat inflammation is necessary for fat cell turnover in lean, healthy individuals. This challenges the theory that inflammation in adipose tissue only causes insulin resistance and type 2 diabetes.
Researchers found that an experimental oral drug lowered blood sugar levels and reduced inflammatory proteins in diabetic mice. The study suggests that targeting the MIF protein could be a viable therapeutic approach to treating Type 2 diabetes.
Researchers analyzed DNA from 40 diverse Echinacea populations to understand the plant's genetic diversity. The study found that the species likely originated in southern refuges on both sides of the Mississippi River and hybridized as they moved northward, leading to blurred genetic distinctions.
Researchers found that an enzyme suspected of causing inflammation has only limited role in spurring edema. A two-hit model is proposed to explain vascular permeability regulation, suggesting other drug targets for preventing or reversing inflammation and edema.
A recent UNC study found that obese children as young as 3 years old have elevated levels of C-reactive protein and other inflammatory markers, indicating a strong relationship between weight status and inflammation. The study suggests that obesity may be unhealthy for young children, even at a young age.
Researchers found that CRP concentration is associated with future risk of a wide range of common diseases, including heart attack, stroke, and various cancers. Most of these associations were explained by known risk factors such as smoking, blood pressure, and obesity.
A newly discovered gene called Brd2 has been found to play a crucial role in regulating body energy balance and protecting against Type 2 diabetes. In mice with a reduced expression of the Brd2 gene, obesity did not lead to diabetes, highlighting the importance of inflammation in this process.
A study by Texas AgriLife Research has linked gene PFKFB3 to metabolic inflammation that leads to diabetes. The researchers believe that a focus on nutrition can prevent or reverse the disease by activating the gene.
Researchers at Karolinska Institutet identify polyphosphate as a key player in the formation of blood clots and inflammation. The study suggests that phosphatases can break down polyphosphate, preventing both conditions.
Researchers at Imperial College London have identified TLR-2 as the trigger that leads to inflammation and damage in atherosclerosis, a condition causing heart attacks and strokes. Blocking this molecule could potentially treat atherosclerosis and reduce the risk of these diseases.
Researchers at UCI discovered a way to boost palmitoylethanolamide (PEA) levels, a potent anti-inflammatory substance. The PEA-boosting compound shows wide-scale promise as an immune-response drug treatment for allergies, illnesses and injuries.
A new study published in Nutrition Journal indicates that XanGo Juice has lowered levels of C-reactive protein (CRP) in overweight and obese people, suggesting potential benefits for heart health and diabetes. The juice also showed significant reductions in body fat percentage and BMI scores.
A recent study found that patients treated with teriparatide for 36 months had a greater increase in bone mineral density (BMD) and fewer new vertebral fractures than those treated with alendronate. The study also observed higher levels of calcium concentrations in the teriparatide group.
Researchers discovered how fish oils convert to Resolvin D2, a chemical that reduces inflammation and may treat conditions like arthritis, sepsis, and stroke. This breakthrough could lead to new treatments for diseases associated with inflammation.
Researchers discovered that dendritic cells in the lung provoke destructive T-cells that attack elastin, causing lung tissue death and emphysema. The study found a link between systemic inflammation and cardiovascular diseases associated with smoking.
LX211 controls inflammation in non-infectious uveitis, significantly reducing its recurrence rate by 50% at a dose of 0.4 mg/kg twice daily. The treatment also preserves visual acuity and reduces corticosteroid use to minimize vision loss risk.
Researchers found that aspirin and folic acid do not affect inflammation markers in patients with colorectal adenomas. However, low-dose aspirin was found to stabilize C-reactive protein levels, which may be affected by high folate intake.
A new study suggests that platelet-rich plasma (PRP) may catalyze the body's repair mechanisms at areas of injury, improving healing and shortening recovery time. However, more research is needed to determine its clinical effectiveness for chronic tendon conditions, such as tennis elbow and Achilles tendonitis.
Researchers at Medical College of Georgia say blocking a protein that battles infection may help prevent a common cause of vision loss in chronic diseases like diabetes. The protein interleukin-6 prompts inflammation, which can lead to complications such as diabetic retinopathy.
Research found a modestly increased risk of death in patients with lesser degrees of celiac disease-related symptoms. The risk was highest in the first year of follow-up, with cardiovascular disease and malignancy being the main causes of death in celiac disease.
Researchers at University of Michigan have developed a nanoemulsion lotion that sharples curbs bacterial growth and reduces inflammation in second-degree burns. The treatment shows promise in overcoming current creams' limitations, reducing bacterial growth one-thousand-fold compared to control animals.
Patients with polymyositis and dermatomyositis, autoimmune disorders causing muscle inflammation, are at higher risk of developing cardiovascular disease. The study found that immunosuppressive therapies may have a preventive effect against heart attacks, providing hope for patients hesitant to undergo treatment.
Researchers have identified a contaminant in common intravenous treatments that can trigger life-threatening inflammation in critically ill patients. Advanced glycation end products, found in albumin infusion solutions, can cause significant inflammation and death rates in mice, suggesting the need for improved patient outcomes.
Progesterone exposure may increase breast cancer risk by activating genes involved in cell adhesion, survival, and inflammation. The study reveals targets for future work in reducing progesterone's influence on breast cancer development.
A three-year study is underway to explore the link between knee inflammation and osteoarthritis. Researchers use ultrasound to identify inflammation in people over 55 with knee pain or osteoarthritis.
A recent study published in International Immunopharmacology reveals that Pycnogenol inhibits the generation of COX-2 and 5-LOX enzymes associated with inflammation. This finding suggests that Pycnogenol can decrease pain and reduce inflammatory conditions by shutting down specific enzyme production.
Dr. Haydee Bazan received a $710,000 grant from the National Institutes of Health to explore potential therapeutic approaches to heal corneal injuries. The research focuses on finding balance between signaling mechanisms that promote cellular damage or repair in the cornea.
Researchers at Case Western Reserve University School of Medicine discovered a novel connection between ITCH and NOD2 genes, which may lead to new treatments for Crohn's disease. The study highlights the potential for individually-tailored therapies for patients with the NOD2 mutation.
Two studies published in the July issue of Ophthalmology highlight the connection between normal-tension glaucoma and silent cerebral infarcts, as well as stealthy herpes simplex infections impacting corneal transplants. Silent cerebral infarfts are more common among NTG patients and can lead to rapid visual field loss.
A recent study published in PLOS Medicine reveals that inflammatory markers are more strongly associated with fatal than nonfatal cardiovascular events in elderly individuals. The study found that elevated levels of IL-6 and other inflammatory markers were linked to a higher risk of fatal heart attacks and strokes.
Researchers at UC Davis have received a $750,000 grant to investigate a novel therapeutic target for treating inflammation and diagnosing asthma. The study will use metabolomics to evaluate the effectiveness of soluble epoxide hydrolase (sEH) inhibitors in asthma treatment.
Researchers found the malfunctioning ABCG2 gene can lead to high urate levels, causing inflammation and pain. The gene is responsible for transporting urate out of the kidney and into urine, and its mutation may be linked to 10% of gout cases in Caucasians.
A study published in Brain, Behavior and Immunity found a strong association between extraversion and lower levels of inflammatory chemical interleukin 6 (IL-6), which can signal increased risk of death. The research suggests that dispositional activity may confer a survival advantage.
Researchers at NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases have discovered a new autoinflammatory syndrome, DIRA, which affects children from birth to 2 weeks of age. The disorder is caused by mutations in the IL1RN gene and can be treated with anakinra, a synthetic form of human IL-1Ra.
Researchers at Penn State College of Medicine have discovered an enzyme called meprin that plays a key role in the severity of inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease. The study found that mice lacking meprin had more severe intestinal damage, indicating that meprin reduces inflammation.
Researchers found that local intestinal inflammation induced DNA damage to lymphocytes in peripheral blood, indicating systemic genetic damage. Chromosome damage was detected in the blood before colitis onset and correlated with disease severity.
Researchers found that treating gum disease improved rheumatoid arthritis symptoms, including reduced swollen joints and morning stiffness. The study's results suggest a link between periodontal disease and rheumatoid arthritis, highlighting the importance of good oral health in overall well-being.
A new molecule has been synthesized to release hydrogen sulfide gas in a slow and sustained manner, reducing inflammation and increasing levels of the body's own anti-inflammatory molecules. This breakthrough could pave the way for the development of novel approaches to treating inflammatory disorders.
A Medical College of Georgia nurse researcher has received a two-year, $147,000 grant from the National Institute on Drug Abuse to investigate cocaine-related renal disease in African-Americans. The study aims to identify early signs of renal disease and develop targeted treatments for patients with cocaine addiction.
A study published in PNAS identified TRPA1 as playing a key role in allergic asthma and demonstrated that HC-030031 effectively treated the condition in mice. This breakthrough research could represent a new avenue of treatment for asthma.
A new University of Illinois study suggests that moderate exercise can reduce visceral fat inflammation, even without a change in diet. The benefits were apparent in both short-term and long-term studies, with significant reductions in belly fat and improved insulin sensitivity found in mice.
Researchers have developed antedrugs that effectively reduce inflammation without causing damage, surpassing the potency of conventional steroids. The new compounds, isoxazoline derivatives, were five times more potent in binding affinities to cell receptors and reducing inflammation.
Researchers at Washington University School of Medicine have developed a new compound that can detect and visualize immune cell activity, highlighting the misdeeds of the immune system. The compound, called luminol, glows blue when injected into mice with active immune inflammation.
Scientists at Goethe University report a paradigm shift in immune response regulation, revealing the crucial role of linear ubiquitin chains in nuclear factor kappa B activation. This finding may lead to structure-based drug design for targeting the NF-κB pathway in diseases such as cancer and inflammation.
A new UK study shows that using NIOX MINO to measure inflammation in asthma patients can lead to a £341-£554 annual cost saving. This is achieved by optimizing treatment, reducing visits to casualty and hospital admissions, and lowering cortisone inhaler doses.
A recent study published in SLEEP found that inflammation may be the underlying mechanism linking extreme sleep durations to poor health. Short and long sleep durations were associated with changes in inflammatory cytokines, including C-reactive protein and interleukin-6.
The American Heart Association advises consumers to aim for at least 5-10% of energy from omega-6 PUFAs, which may reduce cardiovascular risk and lower the risk for heart disease events by 24%. Omega-6 fatty acids have anti-inflammatory properties, dispelling concerns of increased inflammation and cardiovascular risk.