Articles tagged with Inflammation
Using precise microscopes, University of Missouri researchers identified tumor necrosis factor-α and advanced glycation end products as major contributors to blood vessel dysfunction in type 2 diabetes. This discovery could lead to new treatments for blood vessel diseases and disorders in people with type 2 diabetes.
Researchers found that fecal levels of FC and MPO can be used as surrogate markers for successful treatment outcome in IBD patients. The study also showed that elevated fecal markers are associated with relapse, but normalized FC level may indicate successful treatment.
Research reveals a common connection between cellular innate immunity and human chronic inflammatory diseases, including atherosclerosis, Type 2 Diabetes, and neurodegenerative diseases. A critical signaling network involving IRAK-1 has been identified as a potential target for diagnosis and treatment.
Srivastava aims to examine the link between aldose reductase and lung inflammation in asthma. His research group has previously demonstrated the enzyme's role in other inflammatory diseases.
Researchers at the University of Bonn discovered that oregano's active ingredient beta-caryophyllin inhibits inflammation and may help treat osteoporosis, arteriosclerosis, and chronic disorders like Crohn's disease. The substance targets cannabinoid-CB2 receptors, providing a non-intoxicating alternative to existing treatments.
Researchers from NIAMS identified a promising new target for autoimmune disease treatment, a cell-surface receptor called DR3. Blocking this receptor could slow or stop damaging inflammation characteristic of autoimmune diseases without leaving the body vulnerable to serious infections.
A study published in BioMed Central's Journal of Inflammation found that pomegranate extract reduced the production of chemicals causing inflammation in rabbits. The findings suggest that pomegranate extract may provide relief from chronic inflammatory conditions in humans.
Researchers from Case Western Reserve University School of Medicine and Penn State Hershey College of Medicine identified a novel ceramide that reduces sterile inflammation in the cornea. The nano-sized package allows for easy application as an eye drop, providing an effective alternative to steroid use.
Researchers deliver genetically engineered T-reg cells to the intestine to suppress inflammation and autoimmunity. The 'bystander' effect enables these cells to target diseased tissue, suppressing inflammatory cells and promoting healing.
A study found that a 10-day triple therapy regimen was more effective in eradicating H. pylori and reducing gastric inflammation than a 7-day regimen. However, non-compliance was higher in the 10-day group, highlighting the need for cost-benefit analysis in treatment decisions.
Research suggests tricyclic antidepressant desmethylimipramine can restore vagal function and reduce intestinal inflammation in individuals with inflammatory bowel disease and depression. Decreased vagal signaling and increased macrophage presence in the intestine are key factors in increasing susceptibility to intestinal inflammation.
Researchers found high levels of E-selectin, white blood cells, and low serum albumin levels are clear predictors of high risk for type 2 diabetes. The study used data from the Western New York Health Study and found that combining these markers increased identification of high-risk patients by 8%.
A new study by Penn State University found that snacking on pistachios significantly reduces inflammation in the body, a prominent risk factor for cardiovascular disease. Additionally, pistachio consumption has been shown to improve cholesterol levels and reduce blood pressure, making it a valuable addition to a heart-healthy diet.
A study of 1,000 adults found that childhood maltreatment is associated with increased levels of inflammation and depression in adulthood. Individuals with both conditions were at highest risk for cardiovascular disease. The early recognition of maltreatment history may help address pressing needs for care of depressed individuals.
A new study found that rats fed tart cherry powder on top of a high-fat, Western-style diet had lower body weight, fat mass, total cholesterol, triglyceride, TNF-alpha, and IL-6 levels. These findings suggest a potential link between tart cherry consumption and reduced cardiovascular risk factors.
A UC Irvine study finds that lithium chloride can slow the development of inclusion body myositis, a skeletal muscle disease affecting the elderly. The treatment reduced phospho-tau levels and motor function loss in mice, suggesting potential effectiveness for humans.
A new study found elevated markers of blood vessel inflammation in overweight Hispanic children with normal blood glucose levels, increasing their risk for type 2 diabetes and cardiovascular disease. The research highlights the need for obesity prevention strategies tailored to this high-risk population.
Researchers find a direct link between visceral fat and atherosclerosis, a condition that causes blood vessels to harden and narrow. The study suggests that anti-inflammatory medication could be used to reverse the process and reduce heart disease risk.
Researchers found that delivering the IL-22 gene to the intestines of mice with ulcerative colitis reduced inflammation and enhanced mucus production. Local delivery of the IL-22 gene also neutralized chemical-induced intestinal inflammation in normal mice, suggesting a potential therapeutic approach for UC.
A low-carb diet has been shown to reduce inflammation and blood saturated fat levels in patients with metabolic syndrome, a condition associated with diabetes and coronary heart disease. The study found that reducing carbohydrate intake led to greater improvements in inflammatory markers compared to a low-fat diet.
Researchers at UC Davis Health System have identified a novel pathway that contributes to increased inflammation of blood vessels in type 1 diabetes patients. This finding may lead to the development of new treatments to reduce cardiovascular disease risk by controlling inflammation.
A study found that 82% of entheses have a synovio-entheseal complex (SEC), which is involved in triggering inflammation in OA. The SEC's formation is linked to fibrocartilage degeneration and cell clustering, suggesting a novel mechanism for synovial inflammation.
Researchers at Case Western Reserve University discovered a natural product derived from the Amazon rainforest that prevents tissue destruction by blocking matrix metalloproteinases. The findings have potential therapeutic applications in various joint, skin, and gastrointestinal diseases.
A study found that high blood levels of C-reactive protein, a substance linked to inflammation, are associated with an increased risk for age-related macular degeneration. The research suggests that reducing C-reactive protein levels may potentially decrease the risk of AMD.
Researchers found a link between depression, latent viral infections, and increased inflammation, which may contribute to the development of cardiovascular disease. The study suggests that chronic depression can trigger a cascade of events that lead to the buildup of plaques in coronary arteries.
A study found that children with dysfunctional families and living in poor neighborhoods experience greater asthma symptoms and poorer lung function. Family support was linked to reduced inflammation, while neighborhood problems led to increased smoking and exposure to smoke.
Research suggests that disengaging from impossible goals can lower bodily inflammation levels, a potential risk factor for diseases like diabetes and heart disease. Setting new goals after giving up on an important one can also improve mental health by increasing purpose and mastery.
A new study reveals that mast cells not only cause allergic reactions but also help reduce skin damage and inflammation from sun exposure or poison oak. The discovery opens up new possibilities for treating allergies and other conditions.
Researchers at OHSU demonstrate a new technique using contrast-enhanced ultrasound and targeted microbubbles to detect inflammatory processes leading to atherosclerosis. This could enable early detection and prevention of coronary heart disease and stroke, two of the nation's most lethal diseases.
A study found that ibuprofen treatment improved cognitive function in rats with chronic liver failure by reducing inflammation and normalizing a key brain pathway. The results suggest a potential therapeutic utility of decreasing inflammation in treating hepatic encephalopathy.
A new triple combination therapy has been successful in abolishing adverse autoimmunity against insulin-producing cells in a mouse model of Type 1 diabetes. The treatment eliminated inflammation and restored normal blood glucose levels by blocking its effects on fat and muscle tissues.
A recent study by University of Illinois researchers found that individuals with better parasympathetic tone had lower levels of inflammation, as measured by C-reactive protein (CRP). Exercise has been shown to improve parasympathetic tone, leading to a quicker heart-rate recovery after physical activity.
A woman's symptoms of colitis emerged 27 years after she left the country where she was infected with a parasitic worm. Analysis revealed larvae of Strongyloides stercoralis caused her digestive issues, highlighting the importance of considering this rare disease in patients with cellular immune defects.
New data demonstrates that MabThera effectively relieves RA symptoms and improves remission rates with subsequent courses of therapy. The safety profile remains consistent even after seven courses of treatment, providing confidence for physicians to make informed treatment decisions.
Scientists at University of Bonn discover endocannabinoids regulate inflammation processes. Extracts from hemp plant also show anti-inflammatory effects, potentially leading to new treatments.
Researchers at Jefferson Medical College found that a natural substance secreted by fat cells can protect blood vessels from inflammation, a factor in heart disease. Harnessing adiponectin's properties may someday help protect against blood vessel damage in patients with obesity and diabetes.
Research suggests that people with high levels of inflammation in their blood are more likely to develop Alzheimer's disease. The study of over 600 participants found that those with elevated cytokines were nearly twice as likely to develop the disease.
A study at the University of Pittsburgh School of Medicine found that green tea's catechins protected normal and cancerous bladder cells from inflammation. The findings suggest herbal supplements from green tea could be a treatment option for various bladder conditions.
A new study suggests that balancing omega-6 and omega-3 fatty acid intake can reduce the risk of clinical depression and certain inflammatory diseases. Participants with higher levels of omega-6 and symptoms of depression had elevated markers of inflammation.
Researchers at Yale University developed a novel method to detect abnormal proteins in amniotic fluid, indicating a higher risk of delivering prematurely. The study found that these proteins are associated with inflammation and infection, allowing for earlier detection and treatment of neonatal infections.
Researchers found graded associations between psychosocial factors and inflammatory markers, with cynical distrust strongly linked to increased inflammation. The study suggests that behaviors such as smoking may mediate the link between psychosocial factors and cardiovascular disease risk.
A new study by Harvard researchers has linked periodontal disease to an increased risk of pancreatic cancer. Men with periodontal disease had a 63% higher risk of developing the disease compared to those without it, after adjusting for other factors.
Researchers developed a score based on protein markers to predict inflammation in amniotic fluid, associated with preterm delivery and infant sepsis. The 'Mass Restricted' (MR) score showed promise in identifying women at risk of preterm birth and babies with suspected or confirmed sepsis.
Research suggests that inflammatory genes may play a key role in salt-sensitive hypertension, which affects nearly one-third of Americans. The study investigates the connection between stress, inflammation, and sodium handling, with potential therapeutic implications for high blood pressure management.
Researchers have discovered a genetic risk factor for inflammatory bowel disease (IBD) that may confer protection against Crohn's disease and ulcerative colitis. The study highlights a major inflammatory pathway and identifies potential targets for therapies, including the manipulation of IL-23 pathway.
A clinical trial is underway to assess the effectiveness of Reparagen in treating moderate osteoarthritis, with findings that it 'silences' genes promoting joint damage while activating the repair gene IGF-1.
Researchers found that treating newly diagnosed GCA patients with high-dose intravenous steroids reduced long-term need for prednisone and improved recovery. Patients who received the initial treatment had fewer relapses and were able to significantly reduce their daily dose of prednisone after a year.
Researchers found that high salivary melatonin levels may be associated with lower periodontal disease severity, as measured by the community periodontal index score. This suggests that melatonin's antioxidant properties may help protect against inflammation and oxidative damage in the oral cavity.
Researchers at the University of Pennsylvania School of Medicine have found that deleting an inflammation enzyme in mice slowed the development of atherosclerosis. The study suggests that a new class of nonsteroidal anti-inflammatory drugs (NSAIDs) may benefit the heart and reduce its risk of disease.
Scientists from Boston University created a mouse model with reduced inflammation, which may lead to new treatments for conditions like arthritis and Crohn's disease. The study found that the LITAF transcription factor controls inflammation through a different pathway than the NF-kB regulator.
Researchers at Mayo Clinic have discovered an association between allergic rhinitis and the development of Parkinson's disease. The study found that people with allergic rhinitis are 2.9 times more likely to develop Parkinson's, highlighting a potential link between inflammation and the disease.
Tiny airborne particles, similar to nanoparticles, follow a rapid and efficient pathway from the nasal cavity to various regions of the brain in rats. The study found increased gene expression signaling inflammation and cellular stress response, but it is unclear if ultrafine particle buildup causes brain damage.
A study published in the Journal of Clinical Investigation found that a fatty acid binding protein called aP2 plays a crucial role in controlling inflammation in asthma. The research suggests that blocking aP2 function may be a novel approach for asthma treatment and other inflammatory lung diseases.
Researchers found that AAS abusers had statistically significant levels of gingival enlargement compared to non-users, requiring a gingivectomy for many cases. Gingival inflammation was also higher in the user group, suggesting potential long-term effects on periodontal health.
New research suggests targeting affected nerves and spinal cords may provide relief from chronic neuropathic pain. The study found changes in spinal cord neurons after sciatic nerve constriction injury, but the exact mechanisms remain unclear.
Researchers at Rutgers University propose a new approach to combat clogged arteries by attacking how bad cholesterol triggers inflammation and causes plaque buildup. Their nanolipoblockers, or NLBs, compete with oxidized LDL for macrophage attention, cutting accumulation by up to 75 percent.
Researchers found that stretching increases resistance to injury by producing nitric oxide, but inhibiting NO production eliminates protection. The study suggests that understanding how stretching works can help prevent muscle injuries and promote healthy aging.
A study published at the AACR annual meeting found that a history of allergies and asthma significantly reduces the risk of developing brain tumors. Individuals with allergies or asthma had a lower risk of glioblastoma, mid-grade anaplastic astrocytoma, and low-grade gliomas compared to those without these conditions.
A randomized study of 140 COPD patients found that a combination therapy significantly reduced inflammatory cells and improved lung function. The treatment, salmeterol/fluticasone propionate, decreased inflammation by 36% and showed improvements in lung function similar to other anti-inflammatory treatments.
Researchers developed RGD peptide liposomes to deliver dexamethasone phosphate directly to VECs at sites of inflammation, reducing arthritis severity and disease progression. The study demonstrates the potential of targeted liposomal therapy for treating rheumatoid arthritis.