Research on inflammation and its role in disease. Covers eye inflammation, personalized anti-inflammatory medicine, aging, and chronic pain links.
Scientists from Boston University created a mouse model with reduced inflammation, which may lead to new treatments for conditions like arthritis and Crohn's disease. The study found that the LITAF transcription factor controls inflammation through a different pathway than the NF-kB regulator.
Researchers at Mayo Clinic have discovered an association between allergic rhinitis and the development of Parkinson's disease. The study found that people with allergic rhinitis are 2.9 times more likely to develop Parkinson's, highlighting a potential link between inflammation and the disease.
Tiny airborne particles, similar to nanoparticles, follow a rapid and efficient pathway from the nasal cavity to various regions of the brain in rats. The study found increased gene expression signaling inflammation and cellular stress response, but it is unclear if ultrafine particle buildup causes brain damage.
A study published in the Journal of Clinical Investigation found that a fatty acid binding protein called aP2 plays a crucial role in controlling inflammation in asthma. The research suggests that blocking aP2 function may be a novel approach for asthma treatment and other inflammatory lung diseases.
Researchers found that AAS abusers had statistically significant levels of gingival enlargement compared to non-users, requiring a gingivectomy for many cases. Gingival inflammation was also higher in the user group, suggesting potential long-term effects on periodontal health.
New research suggests targeting affected nerves and spinal cords may provide relief from chronic neuropathic pain. The study found changes in spinal cord neurons after sciatic nerve constriction injury, but the exact mechanisms remain unclear.
Researchers at Rutgers University propose a new approach to combat clogged arteries by attacking how bad cholesterol triggers inflammation and causes plaque buildup. Their nanolipoblockers, or NLBs, compete with oxidized LDL for macrophage attention, cutting accumulation by up to 75 percent.
Researchers found that stretching increases resistance to injury by producing nitric oxide, but inhibiting NO production eliminates protection. The study suggests that understanding how stretching works can help prevent muscle injuries and promote healthy aging.
A study published at the AACR annual meeting found that a history of allergies and asthma significantly reduces the risk of developing brain tumors. Individuals with allergies or asthma had a lower risk of glioblastoma, mid-grade anaplastic astrocytoma, and low-grade gliomas compared to those without these conditions.
A randomized study of 140 COPD patients found that a combination therapy significantly reduced inflammatory cells and improved lung function. The treatment, salmeterol/fluticasone propionate, decreased inflammation by 36% and showed improvements in lung function similar to other anti-inflammatory treatments.
Researchers developed RGD peptide liposomes to deliver dexamethasone phosphate directly to VECs at sites of inflammation, reducing arthritis severity and disease progression. The study demonstrates the potential of targeted liposomal therapy for treating rheumatoid arthritis.
Researchers used PET scans to monitor artificially induced lung inflammation in healthy volunteers, allowing for less invasive testing of potential anti-inflammatory drugs. The new imaging process may help diagnose inflammatory lung diseases and improve clinical trials.
A new proteomic profiling test can detect preterm birth risk in 20-30 minutes, predicting delivery times of four days or less. The test uses fresh amniotic fluid samples and is faster than current methods.
Researchers have developed a new test that can predict fetal complications from intrauterine inflammation/infection, providing faster results and higher accuracy than traditional methods. The test uses proteomic profiling of amniotic fluid to identify biomarkers of inflammation, allowing for early intervention and potentially reducing ...
Researchers found that high white blood cell counts were associated with an increased risk of cancer mortality, even after controlling for other factors. The association was strongest for lung cancer and suggested that aspirin may have a greater protective effect against cancer for those with high WBC counts.
Researchers at UVA Health System are investigating a novel approach to combat chronic kidney disease by targeting inflammation with adenosine drugs. Preliminary results show promising decreases in inflammation, urinary protein loss, and kidney scarring.
Researchers found that exposure to fine particle air pollution and a high-fat diet together contribute to the development of atherosclerosis in laboratory mice. The study suggests that even low concentrations of air pollution may accelerate the progression of atherosclerosis, particularly among those with risk factors.
Researchers at Children's Hospital of Philadelphia developed a novel technique to attach therapeutic genes to bare metal stents, reducing inflammation and restenosis. The study used animal models and found significantly lower restenosis with the new stents compared to conventional ones.
Research suggests that low-dose carbon monoxide can act as an anti-inflammatory agent, reducing the production of interleukin-12 and short-circuiting disease-causing inflammation in ulcerative colitis. Non-smokers with inflammatory bowel disease should not rely on smoking to alleviate symptoms.
Researchers found that patients with severe periodontitis have elevated levels of small-dense LDL in their blood, which increases the risk of heart disease. The study also suggests that platelet activating factor acetylhydrolase may play a role in this increased risk.
A study using mouse models found that B. pertussis toxin inhibits neutrophil recruitment, delaying antibody-mediated clearance and allowing repeated infection. Another study identified thrombospondin-1 as a novel mediator of ischemic damage in the kidney, which may be a target for drugs to reduce kidney failure risk.
A recent study by Mayo Clinic researchers suggests that sinusitis is a leading cause of chronic cough, affecting an estimated 23 million Americans annually. The study found that 37.1% of patients suspected of having sinusitis were ultimately diagnosed with the condition as the cause of their chronic cough.
Researchers have discovered that eating fatty foods can dampen inflammation in the gut by stimulating the production of cholecystokinin, a hormone that sends signals to the brain and immune cells. This process may provide a way to reduce inflammatory complications after surgery.
Researchers have discovered the SEPS1 (Selenoprotein S) gene's role in inflammation, which is a common component of many human disorders. The study found that a genetic variation in the SEPS1 gene can lead to higher levels of inflammation and increased risk of diseases like cardiovascular disease and Type 2 diabetes.
Researchers have discovered a synthetic protein, P60 PLAD, that powerfully inhibits arthritis symptoms in mice. The study suggests that this protein could represent an advantage over current treatments, which directly block tumor necrosis factor alpha by binding to both TNFRs and inhibiting beneficial actions mediated by TNFR-2.
A study of 32 patients with heart failure found that those experiencing depression had nearly twice the levels of tumor necrosis factor alpha (TNF-alpha) in their blood. This increase was associated with worsened heart function, as TNF-alpha promotes inflammation and reduces the heart's ability to pump blood effectively.
Researchers found that 97% of patients achieved control over ocular inflammation after one month of treatment with the new drug. Additionally, 82% were able to taper their dose of steroid prednisone without experiencing increased side effects.
Researchers discovered that CD11b-positive macrophages play a crucial role in the development of lymphangiogenesis in the cornea during inflammatory conditions. These macrophages transform into endothelial cells or stimulate the division of existing lymphatic cells, leading to the formation of new lymph vessels.
A new protein called ABIN-1 has been discovered that can prevent the death of liver cells in people with hepatitis. Researchers have shown that an extra dose of ABIN-1 provides a double protective effect against inflammation and cell death, offering new hope for treating liver disorders.
Cholesterol crystals can expand and burst in arteries, triggering a natural clotting process that shuts down the artery. This discovery adds another dimension to the inflammation theory, suggesting that the crystallization of cholesterol is a key factor in cardiovascular disease.
A new imaging technology has shown promise in detecting pancreatic inflammation in type 1 diabetes, allowing for early prediction of disease progression and response to treatment. The technique uses magnetic nanoparticles and MRI to identify inflamed pancreatic islets, potentially reducing the need for invasive biopsies.
Researchers at the University of Rochester Medical Center will investigate how to manipulate intracellular signaling pathways to reduce inflammation in blood vessels, a key factor in heart disease. The team aims to develop new treatments by targeting proteins involved in the inflammatory response.
Researchers at Washington University School of Medicine found that cathepsin G regulates neutrophil secretion of inflammatory chemicals, leading to tissue and cartilage damage in joints. Inhibiting this enzyme has attractive potential as a therapeutic target for treating arthritis.
Researchers discovered a protein in the eye that prevents the immune system from responding to foreign invaders, protecting delicate tissue. The F4/80 molecule plays a crucial role in 'immune privilege,' preventing inflammation and immune activation in privileged sites.
Researchers found TNF inhibits conversion of DHEAS to DHEA, leading to local androgen deficiency in RA patients. The study highlights the need for early anti-TNF antibody therapy in treating this inflammatory disease.
COPD researchers found a correlation between increased lung inflammation and reduced histone deacetylase activity, which may explain the disease's resistance to steroids. Low doses of theophylline, a tea leaf substance, could help restore HDAC activity and reverse resistance.
Research suggests that obesity can exacerbate asthma due to reduced lung function, chronic inflammation, and hormonal changes. The study found increased levels of pro-inflammatory hormones like leptin in obese individuals with asthma.
Researchers used a novel transgenic strategy to create ProC mice with low protein C levels, which spontaneously developed thrombosis and inflammation. The study found that maternal ProC is required for sustaining pregnancy, highlighting the role of protein C in development and disease.
Researchers found that high oxygen levels can weaken a protective mechanism triggered by hypoxia, leading to increased lung damage. The study suggests that therapeutic activators targeting the A2AR signaling pathway may mitigate these effects.
A study found that socially isolated men have higher levels of inflammatory markers, including interleukin-6, which are linked to cardiovascular disease. The researchers suggest that social connections may be beneficial for heart health and that men with lower social involvement have the highest levels of IL-6.
Researchers found that inflammatory proteins produced by fat tissue are linked to increased risk of heart disease, including high blood pressure and high cholesterol. The study suggests that modifying these proteins through medication could lower heart disease risk.
Researchers identified a new class of aspirin-triggered bioactive lipids called resolvins, which inhibit inflammatory cell migration and activation. Omega-3 fatty acid consumption may reduce inflammation by promoting the production of these anti-inflammatory compounds.
Rheumatoid arthritis patients with swelling in large joints, vasculitis, lung disease, or high ESR levels have a significantly increased risk of dying from heart conditions. The study suggests that systemic inflammation promotes this risk and hypothesizes that closely monitoring and controlling inflammation may decrease the risk.
Researchers found that TLR9-induced protection is mediated through type I IFN induction, which suppresses inflammation. Type I IFN has a protective role in colon injury and protects against colonic inflammation.
Researchers have developed a novel method called MR scoring to rapidly detect preterm birth from inflammation and infection in women. The test uses biomarkers Human neutrophil defensin 1, Human neutrophil defensin 2, Calgranulin C and Calgranulin A to identify women at risk of premature delivery with high sensitivity and specificity.
A study found that fine particulate matter from brake wear and engine emissions increases inflammatory cells, clotting pathways, heart rhythm variability, and red blood cell volume in drivers. Exposure to pollution causes cardiovascular risks through effects on the heart rhythm and blood clotting pathways.
Researchers identified four severity classifications of chronic rhinosinusitis, including patients with polyps and high levels of eosinophils having the worst disease. The study suggests using a 'fingerprint of inflammation' obtained from a simple blood test to categorize patients and guide treatment.
Researchers found evidence of ongoing inflammatory process in autistic brains, particularly in regions involving microglia and astroglia. Cytokine and chemokine levels were abnormally elevated, suggesting localized inflammation within the brain.
Researchers have found brain inflammation associated with autism, suggesting immune activation plays a role in the disorder. The study's findings support the theory that immune activation is involved in autism, but further research is needed to understand its benefits and drawbacks.
A new antibody treatment has shown promise in slowing or halting Crohn's disease by blocking the production of inflammatory proteins. The treatment was safe and effective in reducing symptoms in patients with active Crohn's disease.
A study published in JAMA found that metabolic syndrome is associated with poor cognitive outcomes in elderly individuals. Participants with the metabolic syndrome and high inflammation showed a significant increase in cognitive impairment and four-year decline in cognitive testing scores compared to those without the metabolic syndrome.
A five-year study of over 2,600 elders found a significant link between the metabolic syndrome and cognitive decline. Elders with both the syndrome and high levels of inflammation showed a higher risk of cognitive decline, highlighting the importance of addressing cardiovascular risk factors to prevent dementia.
A multidisciplinary team is investigating the impact of inflammation on taste and smell function, with potential therapeutic interventions for chemosensory dysfunction. The studies aim to improve diagnosis and treatment targeting for patients with conditions like chronic rhinosinusitis and radiation-induced taste loss.
Researchers found that prostacyclin (PGI) protects against atherosclerosis, while thromboxane A2 (TXA2) promotes its development. TP antagonists and molecules with PG-like activity may aid in atherosclerosis prevention, aligning with previous work on low-dose aspirin therapy.
A study by Mayo Clinic researchers found that high-sensitivity C-reactive protein (hs-CRP) is associated with the presence of atherosclerotic plaques in the arteries, even if symptoms are absent. Elevated hs-CRP levels may indicate an increased risk of cardiovascular events like heart attacks.
Researchers found that growth hormone reduces STAT3 activation, modulates cellular apoptosis and proliferation, and improves weight gain in mice with colitis. The study suggests using growth hormone as a new therapeutic approach to improve growth and intestinal healing in IBD.
A20, an enzyme that regulates the immune system's response to bacterial infections, prevents over-reactions of the immune system to blood infections known as sepsis. The research shows A20 also controls the immune reaction that can cause inflammatory bowel disease.
Researchers discovered a link between aneurysm formation and the activation of an asthma inflammation gene. Blocking this pathway may prevent or slow aneurysm progression, potentially using anti-inflammatory drugs used in cardiovascular disease treatment.
A study found increased levels of C-reactive protein (CRP) in the blood of patients with rheumatoid arthritis (RA), even those without autoantibodies. The findings suggest that early inflammation is a key factor in RA development, potentially serving as a predictive marker for future symptomatic inflammation.
A study suggests that women undergoing infertility treatment who have periodontal disease may experience higher levels of gingival inflammation and bleeding, which could impact the success of fertility treatments like ovulation induction medication. Maintaining good oral hygiene is crucial to prevent these issues.