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Ulcer-causing bacteria use stomach inflammation to their advantage

Researchers found that Helicobacter pylori infection leads to mild inflammation, triggering the production of sialyl-di-Lewis x sugar molecule on stomach cells. The bacteria then latch onto this molecule using a previously unknown adhesin protein, worsening inflammation and increasing survival chances.

SourceWashU Medicine·JournalScience·DateJul 25, 2002

Cancer-causing drug safe and effective in treating eye disease

Researchers found that high-dose, short-term chlorambucil treatment resulted in sustained inflammation reduction for 77% of patients with severe, non-infectious uveitis. The study's findings suggest that chlorambucil may become a preferred treatment option for these patients.

SourceUniversity of Illinois Chicago·JournalOphthalmology·DateFeb 5, 2002

Girls fare better than boys following heart surgery

A recent study found that female patients have higher levels of the anti-inflammatory cytokine IL-10 during and after heart surgery, which may explain why girls recover more easily than boys. However, no association was found between progesterone levels and patient recovery.

SourceBMC (BioMed Central)·JournalCritical Care·DateJan 16, 2002
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The anti-inflammatory effect of apoptotic bodies

Researchers explored the anti-inflammatory properties of apoptotic bodies in various diseases, including IBD and osteoarthritis. They found that these bodies can modulate immune responses and reduce inflammation, offering new therapeutic targets for treating chronic inflammatory conditions.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateJan 2, 2002

Molecular insight into wound healing

Researchers identify PPARbeta as a key gene regulator in the cellular response to inflammation and wound healing. The protein is crucial for keratinocyte differentiation and migration, enabling effective wound healing.

SourceCold Spring Harbor Laboratory·JournalGenes & Development·DateDec 14, 2001

Leeches reduce the pain of osteoarthritis

A small study found leech therapy to be effective in reducing pain from osteoarthritis, with rapid relief seen after three days and sustained effects four weeks later. The treatment produced no side effects or infections.

SourceBMJ Specialty Journals·JournalAnnals of the Rheumatic Diseases·DateSep 16, 2001

Study aims to prevent asthma

Researchers are conducting a study called Prevention of Early Asthma in Kids (PEAK) to explore the potential of early treatment in preventing asthma. The study involves enrolling children aged 2-4 with wheezing episodes and one additional risk factor, taking fluticasone or a placebo twice daily for two years.

SourceNational Jewish Health·DateSep 4, 2001
Nikon Monarch 5 8x42 Binoculars

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In first human trial, insulin shows ability to reduce components that inflame vessel walls

A new study by University at Buffalo researchers found that insulin can reduce pro-inflammatory components in the bloodstream while increasing anti-inflammatory components. The results suggest that insulin may have anti-atherosclerotic effects and potentially reduce the risk of heart attack, contrary to previous assumptions.

SourceUniversity at Buffalo·JournalThe Journal of Clinical Endocrinology & Metabolism·DateAug 8, 2001

Infliximab could prevent sight loss from Behcet’s disease

Researchers found that infliximab treatment reduced ocular inflammation and symptoms in patients with Behcet's disease, including those at risk of permanent blindness. The study suggests TNF blockade as a new therapy for sight-threatening uveitis and severe vasculitic manifestations.

SourceThe Lancet_DELETED·JournalThe Lancet·DateJul 26, 2001

Heart Inflammation Declining In The United States

A study by Johns Hopkins Medicine found that cases of life-threatening heart muscle inflammation are declining in the US, corresponding with a decline in enteroviral infections. Since 1991, myocarditis was present in less than 5% of patients biopsied each year, correlating with reduced enterovirus cases reported by the CDC.

SourceJohns Hopkins Medicine·DateNov 9, 1998

Adenovirus May Play A Role In Heart Inflammation

Researchers at Johns Hopkins Medicine found adenovirus in 71.4% of autopsied hearts from patients with viral myocarditis, a condition previously attributed to Coxsackie B enterovirus. The study suggests adenovirus and enteroviruses may work together to cause this condition.

SourceJohns Hopkins Medicine·DateNov 11, 1997
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