Researchers found that chronic inflammation caused by immune system challenges can lead to long-term neurological changes and memory problems in mice. The study suggests that this early event may be an important step in the development of Alzheimer's disease.
Researchers at UC San Diego mapped nearly 300,000 mouse cis-regulatory elements, annotating 11% of the mouse genome and identifying conserved non-coding sequences shared with humans. The study provides insights into the functional organization of genes and their regulation in different tissues and cell types.
A new study supports CT colonography as a screening tool for colon cancer in Medicare-aged patients, detecting 9.3% of abnormal growths of cells. The procedure also identified extracolonic findings in 2.9% of patients and may increase screening compliance rates by 15% if covered.
Pitt researchers suggest a vacuum-based approach to overcome the limits of conventional silicon-based semiconductor electronics. They found that electrons trapped in a semiconductor can be extracted into air, enabling low-power and high-speed transistors.
Researchers analyzed genes expressed in circulating tumor cells and found increased expression of WNT2, a known oncogene, in CTCs from mouse models and human patients. Targeting the WNT2 pathway may reduce metastatic potential, which is critical for controlling pancreatic cancer.
A new software package corrects errors in single-molecule sequencing, boosting accuracy to 99.9% and enabling complete genome assembly for large organisms like parrots. The hybrid error-correction approach combines the best of both '2nd-gen' and '3rd-gen' technologies to produce high-quality genome assemblies.
Researchers found that diving birds stay fit and active until their 30s, with high metabolisms and frequent dives producing oxidative stress. These findings provide critical insights for human aging, a topic currently dominated by short-lived animal studies.
Climate models show that warmer beach conditions and increased frequency of hot years will lead to high egg and hatchling mortality rates among leatherback sea turtles. The eastern Pacific population is projected to decline by 75% by 2100, making conservation efforts crucial for their recovery.
A Northwestern University study found that chronic pain develops when two brain sections communicate excessively, increasing the likelihood of chronic pain. Researchers predicted with 85% accuracy which participants would develop chronic pain based on brain scan data.
Researchers at Penn University have developed a method to rapidly create vasculature using 3D printed templates of filament networks, improving the function of engineered living tissues. They used a material composed of sugar and other compounds to create stable vascular systems that can be easily dissolved and replaced with cells.
The men's 100 m sprint is showing significant improvement in performance due to advancements in technology. The introduction of fully automated timing and changes to javelin specifications have contributed to these gains.
Researchers identify plasma upflows traveling at 20 km per second, suggesting 'impulsive heating' as possible cause. The study provides new insights into understanding extreme space storms and their impact on satellite communications and power grids.
Research reveals that ants farm subterranean aphids in clone groups, with over half of ant mounds containing a single species or clone. This unique farming method allows ants to actively manage diversity and abundance, maximizing honeydew yield and dietary protein.
IVF and ICSI technologies have reached a calculated total of 5 million births worldwide since 1978. The cumulative total has increased by nearly 10% this year, with over 1.5 million treatment cycles performed globally annually, producing around 350,000 babies.
Scientists at Scripps Research Institute discovered a simple and safe method to disrupt specific genes within cells, offering a potential HIV treatment. The new technique uses zinc finger nuclease proteins, which can be added directly to cells without viral delivery methods.
La Jolla Institute scientist Klaus Ley reveals a novel mechanism played a major role in inflammation. Neutrophils use sling-like membrane tethers to latch on to blood vessel walls during high blood flow, providing new insights into critical biological mechanisms underlying heart disease and other disorders.
Researchers at UCSF have discovered that a human protein called AXL drives resistance to Tarceva, which suggests that blocking the protein may prevent resistance to the cancer drug. This discovery may lead to better treatments involving precision medicines that combine Tarceva with new drugs designed to block AXL.