Articles tagged with Inflammation
Researchers developed targeted biodegradable nano-drones that deliver an anti-inflammatory drug to fat deposits in arteries, successfully restructuring atherosclerotic plaques to make them more stable. The treatment reduced reactive oxygen species, increased collagen, and decreased plaque necrotic core.
Researchers have developed a novel imaging technique using ferumoxytol and MRI to visualize pancreatic inflammation in patients with newly diagnosed type 1 diabetes. The study found clear evidence of ongoing inflammation in the pancreas, which could help predict disease progression and identify potential therapeutic targets.
Researchers found that umbilical cord cells activate the Akt signaling pathway, leading to increased expression of antioxidant genes like Prdx5, which reduces inflammation and promotes neural cell survival. This study suggests that umbilical cord cell therapy could be a promising treatment for stroke and other brain injuries.
A new study by the University of Rochester finds that e-cigarettes emit toxic substances harmful to lung cells, including heavy metals and nanoparticles. Flavored e-juices like cinnamon also cause more stress on lung tissue.
Researchers have developed a novel, drug-releasing wafer that patients can apply directly to their affected eyes once daily, showing twice the effectiveness of traditional eye drops in mice without causing inflammation. This innovative treatment could help patients recover faster and reduce side effects associated with current therapies.
A study found a link between grief, anger, and inflammation in partner caregivers of veterans with traumatic-brain injuries. High levels of TNF-alpha were associated with blame and anger, increasing the risk for inflammatory-related health problems.
Researchers discovered that an anti-inflammatory protein can increase plaque formation in the brain by binding to amyloid-beta and accelerating its buildup. The study suggests that Alzheimer's treatment should be tailored to patients carrying specific APOE variants, such as APOE4, which is a major genetic risk factor for the disease.
Researchers have discovered two new drug compounds that target endometriosis by interacting with estrogen receptors, reducing inflammation and tissue growth. The compounds, OBHS and CLI, showed promising results in mouse models and human cell cultures, offering a potential new approach to treating the disorder.
Researchers have discovered a new signaling intermediate, leukotriene B4, which is synthesized and released by pancreatic acinar cells. This finding provides a potential target for the development of novel therapies for pancreatitis, a common disorder that complicates many ailments.
A new study suggests that traumatic brain injury triggers long-term inflammation in the brain, causing chronic degenerative problems. The research proposes that this inflammation is a major treatable cause of brain damage after trauma.
A 12-year study found that genetic variants, combined with lifestyle factors like smoking and drinking, can lead to chronic pancreatitis. Researchers identified a specific gene variant that may fail to protect pancreatic cells from injury, increasing the risk of inflammation and scarring.
A study reveals that Mycoplasma pneumoniae CARDS toxin triggers excessive inflammation by activating NALP3, leading to tissue injury and airway narrowing. The discovery could lead to the development of therapeutic strategies to improve health in individuals with airway diseases.
A new study reveals that macrophages induce neutrophil reverse migration to resolve inflammation in wounds. Without macrophages, neutrophils remain in wounds longer, leading to recurring infections and exaggerated inflammation.
Researchers at Georgia State University and Cornell University found that promoting healthy gut microbiota can treat or prevent metabolic syndrome. The study used an improved technical approach to show that altered bacterial populations promote low-grade inflammation and metabolic syndrome.
A new study suggests that skin sensitization to food proteins, triggered by pro-inflammatory molecules like TSLP and IL-25, can lead to food allergy development. The research found that mice exposed to food antigens through the skin developed severe allergic reactions when ingested.
A University of Colorado Cancer Center study found that vitamin D upregulates GDF-15, a gene suppressing inflammation in prostate tissue. This suggests vitamin D could be used to target NFkB, promoting tumor suppression.
A study by researchers at Ludwig-Maximilians-Universität München finds that infants fed on fresh cow's milk are less prone to infection. The authors recommend alternative processing methods to preserve the protective agents found in raw milk.
Researchers at the University at Buffalo have successfully treated chronic, precancerous inflammation in the intestine using an oral biologic medication. The study found that targeting disease-promoting inflammatory cells can render them less able to cause disease, offering a promising avenue for site-specific oral therapy.
Researchers have discovered a small molecule that prevents necroptosis, a recently discovered cell death pathway linked to immune disorders. The compound 'jams the switch' on MLKL, a protein that triggers cell death, thereby preventing inflammation and promoting new treatments for inflammatory diseases.
Researchers found that excess glucose enters cells via inflammatory pathways, sparking escalating inflammation and damaging blood vessels. Lifestyle changes like exercise and weight reduction can reduce both blood sugar and inflammation.
Researchers found heme oxygenase-1 deficiency in HIV-infected brains associated with cognitive decline and increased viral load. Increasing heme oxygenase-1 expression may offer protective benefits against HIV-associated neurocognitive disorders.
Researchers at Lund University discovered inflammation and changes in the intestinal barrier function early in MS, indicating a potential link to disease progression. The study suggests that damage to the intestinal barrier may prevent the body from ending an autoimmune reaction, leading to chronic diseases like MS.
Scientists have found that punicalagin, a polyphenol in pomegranate, can inhibit neuro-inflammation in brain cells. The compound may help slow the development of diseases like Alzheimer's and Parkinson's by reducing inflammation.
The Oklahoma Medical Research Foundation has received a five-year, $14.5 million grant from the National Institutes of Health to continue its research on anthrax and its effects on humans. The project aims to identify new vaccines and drug targets by studying the human immune response to anthrax bacteria.
Researchers at UC San Diego School of Medicine found that aspirin prompts the production of 15-HETE, which converts to lipoxin to reverse inflammation. This discovery may lead to new anti-inflammatory therapies by developing drugs based on lipoxin analogues.
A new Northwestern University study finds that an intervention focused on strengthening families can reduce inflammation in children from low-income backgrounds. The training program improved parenting and communication between parents and children, leading to reduced inflammation.
A new study by Sanford-Burnham researchers identifies the NBR1 protein as a critical regulator of obesity-induced inflammation, which leads to metabolic disease. The study suggests that blocking this signal may protect against the development of metabolic disease and type 2 diabetes.
The National Psoriasis Foundation has awarded $1.05 million in research grants to 13 scientists studying new treatments and a cure for psoriasis and psoriatic arthritis. The grants will support projects focused on translating laboratory findings into improved treatments and methods for managing the diseases.
Researchers found that higher levels of C-reactive protein in maternal blood were significantly associated with an increased risk of schizophrenia in offspring. The study suggests that pregnancy-related inflammation may play a role in the development of schizophrenia, providing new insights into its biological mechanisms.
Research from UT Southwestern Medical Center found that a level of 'healthy' inflammation is necessary to prevent fatty liver and metabolic diseases. Inflammation helps remodel fat tissue, preventing the buildup of excess lipids in other tissues.
Researchers discover periodontal bacteria selectively disarm immune system, promoting dysbiosis and bone loss. The study reveals a two-pronged mechanism involving protein receptors C5aR and TLR2, which protects 'bystander' gum bacteria from clearance.
Researchers discovered that stimulating AhR in skin cells reduces inflammation in psoriasis patients, a potential new treatment approach for chronic inflammatory skin disorders. The findings suggest a novel strategy for treating psoriasis, combining immune system modulation with AhR stimulation.
A recent study published in Nutrients found that cyclists who consumed Montmorency tart cherry juice concentrate before exercise experienced less inflammation and oxidative stress. The researchers attributed the recovery benefits to the natural compounds in tart cherries, particularly anthocyanins.
Pharmacists at Jena University have developed three potential therapeutic agents that may improve the healing of inflammatory illnesses. The agents suppress a key enzyme in the body's own cascade of inflammation, specifically targeting 5-LOX, which plays a pivotal role in synthesizing leukotrienes. This breakthrough could lead to more ...
A recent study suggests that chronic disruption of circadian rhythms may contribute to inflammatory bowel disease and other harmful conditions. Consuming a high-fat, high-sugar diet can worsen the effects of circadian rhythm disruption on intestinal flora.
A University of Pennsylvania team has identified a promising new target for gum disease treatment: the complement component C3. Treating monkeys with a C3 inhibitor successfully prevented periodontitis-related inflammation and bone loss, suggesting this could be a promising drug option for humans.
A study published in the Proceedings of the National Academy of Sciences found that bullied children experience chronic, systemic inflammation that persists into adulthood. In contrast, bullies may benefit from increased social status through bullying, which can protect against increases in inflammatory markers.
A new study published in JAMA Internal Medicine found no association between resveratrol consumption and improved health outcomes. The research suggests that the supposed health benefits of resveratrol from food sources may be exaggerated or entirely unwarranted.
A study published in PLOS Pathogens found that IL-27 balances the immune response to influenza, reducing lung damage and improving recovery. The researchers discovered that well-timed IL-27 treatment can be beneficial for mice infected with a highly pathogenic influenza strain.
A low-carbohydrate diet was found to significantly reduce inflammation in patients with type 2 diabetes, whereas a traditional low-fat diet showed no similar effect. After six months, the low-carb group exhibited reduced levels of inflammatory markers and improved glucose control.
A study published in the American Journal of Respiratory Cell and Molecular Biology suggests that TNF-α, a pro-inflammatory cytokine, accelerates lung recovery and reduces scar tissue in mice with pulmonary fibrosis. The researchers found that inflammation can be beneficial during the healing process, rather than just causing scarring.
Researchers at Lomonosov Moscow State University and Pittsburgh University have identified a new biosynthetic pathway for lipid mediators, producing molecules that regulate inflammation and cell death. The study's findings could lead to the development of new anti-inflammatory drugs.
A review by Kevin J. Tracey, MD, and Clifford S. Deutschman argues that treatment for sepsis is nonspecific and limited to organ support, with no approved drugs targeting the condition. Instead, a new approach focusing on immunometabolic and neurophysiological mechanisms may be needed.
A traditional Chinese herbal remedy, Tripterygium wilfordii Hook F, has been shown to be as effective as methotrexate in treating rheumatoid arthritis. Combining the herbal remedy with methotrexate resulted in improved outcomes for patients, including significant reductions in disease activity and remission rates.
Scientists studying high-altitude trekkers found increased insulin resistance and inflammation markers after prolonged exposure to hypoxia. The study suggests possible interventions to reduce progression towards full-blown diabetes.
Silibinin from milk thistle extract reduces self-renewal of colorectal cancer stem cells, affecting cell signaling associated with inflammation. The compound also decreases levels of CSC self-renewal-promoting mRNAs.
A new study published in Blood journal found that adhering to a Mediterranean diet is associated with lower levels of platelets and white blood cells, two markers of inflammation. This eating plan is linked to reduced inflammation and heart disease risk, particularly among healthy individuals.
Researchers developed polymorphonuclear leukocyte-derived novel pro-resolving medicines (NPRMs) to deliver a lipoxin A4 analog to the site of surgery, controlling inflammation and promoting tissue and bone growth. The mini-pig model revealed significant pocket depth reductions and new bone formation in NPRM+LXA4-treated sites.
A Rutgers-led study finds acupuncture can reduce inflammation and organ injury in septic mice, with half surviving for at least a week. The treatment also triggers increased levels of dopamine, which may help alleviate other inflammatory diseases like arthritis and Crohn's disease.
Researchers have identified a rare genetic disorder that causes sporadic fevers, skin rashes, and recurring strokes in early childhood. The syndrome is caused by variants in the CECR1 gene, which impede production of a protein vital to healthy blood vessel walls.
Scientists at the University of Cambridge discovered that implant stiffness is a major cause of foreign body reactions. The team found that stiff materials trigger inflammation and cell shape changes in brain cells, leading to encapsulation with scar tissue.
A new study confirms a variant in the SERPINE1 gene is linked to cerebral palsy and death in very preterm babies. The findings add to evidence that genes may play a role in brain injury and death risk in preterm infants.
Researchers found elevated levels of translocator protein 18 kDa (TSPO) in patients with myocarditis and mice, suggesting its potential as a biomarker for heart inflammation. TSPO's role in driving disease progression and prognosis is also being explored.
Increased inflammation after infections impairs brain's ability to form spatial memories by disrupting neural circuits involved in learning and memory. The study used PET scans to measure effects of inflammation on glucose consumption in the brain, revealing a decrease in glucose metabolism in the Medial Temporal Lobe.
A study published in PLOS ONE found that DHA supplementation partially prevented metabolic damage associated with the Western diet. This led to observable changes in carbohydrate, protein, and lipid metabolism.
Researchers found that fiber activates Gpr109a receptors, which reduce inflammation in the colon and prevent cancer. Mega-doses of niacin may also help protect the colon and prevent conditions like ulcerative colitis and Crohn's disease.
Researchers developed a novel sugar-based tracer contrast agent to aid in the detection of inflamed and vulnerable artery plaques. The new tracer, fluorodeoxymannose (FDM), shows promise in targeting high-risk plaques more specifically than traditional glucose-based tracers.
Researchers at Scripps Florida Institute developed a compound that dramatically reduces joint inflammation in animal models of rheumatoid arthritis. The study showed the compound, SR2211, blocked symptoms and bone erosion in mice within eight to ten days of treatment.
Therapeutic hypothermia decreases free radical production and inflammation, improving cerebral metabolism after traumatic brain injury. However, potential negative aspects of hypothermia treatment must be further studied.
Research review highlights cranberry's unique bioactive compounds that may reduce UTI incidence, improve cardiovascular health and temper inflammation. Cranberries also show promise in supporting endothelial function and reducing arterial stiffness.