Research on inflammation and its role in disease. Covers eye inflammation, personalized anti-inflammatory medicine, aging, and chronic pain links.
A study of high-intensity interval training in women with rheumatic disease found significant reductions in arthritic inflammation and improvements in cardiovascular health. Participants experienced less inflammation, increased oxygen intake, and a small reduction in BMI after ten weeks of twice-weekly sessions.
Researchers have developed a dynamic 'smart' drug that targets inflammation in a site-specific manner, reducing side effects. The new anti-inflammatory molecule reduces local inflammation while avoiding normal inflammatory processes, potentially improving treatment outcomes for immunosuppressed patients and those undergoing chemotherapy.
Researchers found elevated cytokine levels in blood and brain of individuals with suicidality, distinguishing them from non-suicidal patients. This study contributes to understanding the role of immune system dysfunction in major psychiatric disorders, potentially leading to more personalized medicine.
Inflamed kidney cells produce an enzyme that consumes tryptophan, activating a stress response and inducing autophagy to clear damaged protein. The IDO-GCN2 pathway provides natural protection against inflammation-induced kidney damage, offering new potential treatment targets.
Researchers found that a lower dose of modified poliovirus therapy is more effective in treating glioblastoma brain tumors, resulting in fewer side effects. The therapy has been shown to be safe with minimal side effects related to localized brain inflammation.
As we age, our gut's immune system regulator IL-6 increases, leading to chronic low-grade inflammation and a weakened barrier, making us more susceptible to infections and diseases.
A new study suggests that Symprove, a live multi-strain probiotic drink, can reduce intestinal inflammation in patients with ulcerative colitis. The results show significant reductions in faecal calprotectin levels and improvements in symptoms without observed side effects.
Researchers at Case Western Reserve University found that treating gum disease can improve prostate inflammation symptoms and quality of life for men with prostatitis. The study, which treated 27 men with moderate to severe gum disease, showed significant improvements in PSA levels and symptom scores.
A UTMB study shows that augmenting a gas naturally in our bodies, hydrogen sulfide, can reduce the severity of respiratory syncytial virus (RSV) infection. The researchers found that providing a drug that triggers a steady release of this gas blocks RSV viral replication and inflammation.
Researchers have identified the calcium sensing receptor (CaSR) as the potential root cause of asthma, a disease affecting 300 million people globally. Calcilytics, originally developed for osteoporosis, show promise in reversing asthma symptoms by manipulating CaSR.
Researchers analyzed saliva of cirrhosis patients to predict inflammasions and hospitalization, revealing a new target for research. The study found that oral microbiota reflects changes in gut microbiota in cirrhosis with hepatic encephalopathy.
A new study published in the American Journal of Pathology shows that inflammation plays a causal role in Lyme disease's neurologic changes, and anti-inflammatory drugs like dexamethasone may prevent these effects. Researchers found that dexamethasone prevented many neuropathologic effects, while meloxicam was generally ineffective.
The study found a significant association between periodontitis and cardiovascular disease, particularly among men and younger individuals. Researchers suggest that alternative therapies, such as cholesterol-lowering medication, may prevent both oral infections and cardiovascular inflammation.
A study led by researchers from Mount Sinai Hospital shows that a nanotherapeutic medicine can halt the growth of artery plaque cells and suppress inflammation, leading to reduced heart attack risk. The therapy uses high-density lipoprotein (HDL) to target inflamed immune cells in arterial plaques.
Researchers aim to improve stability of transplanted regulatory T cells using computational modeling and analysis. The goal is to develop new treatment options for diseases characterized by excessive inflammation.
Scientists at the University of Manchester discovered that inflammation in the brain causes and worsens damage after a stroke, contradicting previous theories. The study found that inflammasomes such as NLRP3 are not involved in brain injury caused by stroke, but rather NLRC4 and AIM2 inflammasomes contribute to this damage.
Scientists have discovered a combination of fullerene derivatives and glucosamine that reduces cell damage and inflammation after a stroke. This breakthrough could lead to the development of new treatments for cerebrovascular accidents.
Researchers identify small molecules that program stem cells to target specific areas in the body. These compounds enable targeted delivery of stem cells to diseased or damaged tissue, reducing inflammation.
Scientists have identified Interleukin 4 (IL-4) as a promising treatment for psoriasis, a chronic autoimmune disease. By inhibiting specific immune cells, IL-4 reduces inflammation and improves skin conditions in patients.
Emulsifiers found in processed foods can alter the gut microbiota composition and induce intestinal inflammation, promoting the development of inflammatory bowel disease and metabolic syndrome. The study suggests that avoiding excess food consumption is crucial, as low-grade inflammation from an altered microbiota can lead to overeating.
Researchers developed targeted biodegradable nano-drones that deliver an anti-inflammatory drug to fat deposits in arteries, successfully restructuring atherosclerotic plaques to make them more stable. The treatment reduced reactive oxygen species, increased collagen, and decreased plaque necrotic core.
Researchers have developed a novel imaging technique using ferumoxytol and MRI to visualize pancreatic inflammation in patients with newly diagnosed type 1 diabetes. The study found clear evidence of ongoing inflammation in the pancreas, which could help predict disease progression and identify potential therapeutic targets.
Researchers found that umbilical cord cells activate the Akt signaling pathway, leading to increased expression of antioxidant genes like Prdx5, which reduces inflammation and promotes neural cell survival. This study suggests that umbilical cord cell therapy could be a promising treatment for stroke and other brain injuries.
A new study by the University of Rochester finds that e-cigarettes emit toxic substances harmful to lung cells, including heavy metals and nanoparticles. Flavored e-juices like cinnamon also cause more stress on lung tissue.
Researchers have developed a novel, drug-releasing wafer that patients can apply directly to their affected eyes once daily, showing twice the effectiveness of traditional eye drops in mice without causing inflammation. This innovative treatment could help patients recover faster and reduce side effects associated with current therapies.
A study found a link between grief, anger, and inflammation in partner caregivers of veterans with traumatic-brain injuries. High levels of TNF-alpha were associated with blame and anger, increasing the risk for inflammatory-related health problems.
Researchers discovered that an anti-inflammatory protein can increase plaque formation in the brain by binding to amyloid-beta and accelerating its buildup. The study suggests that Alzheimer's treatment should be tailored to patients carrying specific APOE variants, such as APOE4, which is a major genetic risk factor for the disease.
Researchers have discovered two new drug compounds that target endometriosis by interacting with estrogen receptors, reducing inflammation and tissue growth. The compounds, OBHS and CLI, showed promising results in mouse models and human cell cultures, offering a potential new approach to treating the disorder.
Researchers have discovered a new signaling intermediate, leukotriene B4, which is synthesized and released by pancreatic acinar cells. This finding provides a potential target for the development of novel therapies for pancreatitis, a common disorder that complicates many ailments.
A new study suggests that traumatic brain injury triggers long-term inflammation in the brain, causing chronic degenerative problems. The research proposes that this inflammation is a major treatable cause of brain damage after trauma.
A 12-year study found that genetic variants, combined with lifestyle factors like smoking and drinking, can lead to chronic pancreatitis. Researchers identified a specific gene variant that may fail to protect pancreatic cells from injury, increasing the risk of inflammation and scarring.
A study reveals that Mycoplasma pneumoniae CARDS toxin triggers excessive inflammation by activating NALP3, leading to tissue injury and airway narrowing. The discovery could lead to the development of therapeutic strategies to improve health in individuals with airway diseases.
A new study reveals that macrophages induce neutrophil reverse migration to resolve inflammation in wounds. Without macrophages, neutrophils remain in wounds longer, leading to recurring infections and exaggerated inflammation.
Researchers at Georgia State University and Cornell University found that promoting healthy gut microbiota can treat or prevent metabolic syndrome. The study used an improved technical approach to show that altered bacterial populations promote low-grade inflammation and metabolic syndrome.
A new study suggests that skin sensitization to food proteins, triggered by pro-inflammatory molecules like TSLP and IL-25, can lead to food allergy development. The research found that mice exposed to food antigens through the skin developed severe allergic reactions when ingested.
A University of Colorado Cancer Center study found that vitamin D upregulates GDF-15, a gene suppressing inflammation in prostate tissue. This suggests vitamin D could be used to target NFkB, promoting tumor suppression.
A study by researchers at Ludwig-Maximilians-Universität München finds that infants fed on fresh cow's milk are less prone to infection. The authors recommend alternative processing methods to preserve the protective agents found in raw milk.
Researchers at the University at Buffalo have successfully treated chronic, precancerous inflammation in the intestine using an oral biologic medication. The study found that targeting disease-promoting inflammatory cells can render them less able to cause disease, offering a promising avenue for site-specific oral therapy.
Researchers have discovered a small molecule that prevents necroptosis, a recently discovered cell death pathway linked to immune disorders. The compound 'jams the switch' on MLKL, a protein that triggers cell death, thereby preventing inflammation and promoting new treatments for inflammatory diseases.
Researchers found that excess glucose enters cells via inflammatory pathways, sparking escalating inflammation and damaging blood vessels. Lifestyle changes like exercise and weight reduction can reduce both blood sugar and inflammation.
Researchers found heme oxygenase-1 deficiency in HIV-infected brains associated with cognitive decline and increased viral load. Increasing heme oxygenase-1 expression may offer protective benefits against HIV-associated neurocognitive disorders.
Researchers at Lund University discovered inflammation and changes in the intestinal barrier function early in MS, indicating a potential link to disease progression. The study suggests that damage to the intestinal barrier may prevent the body from ending an autoimmune reaction, leading to chronic diseases like MS.
Scientists have found that punicalagin, a polyphenol in pomegranate, can inhibit neuro-inflammation in brain cells. The compound may help slow the development of diseases like Alzheimer's and Parkinson's by reducing inflammation.
The Oklahoma Medical Research Foundation has received a five-year, $14.5 million grant from the National Institutes of Health to continue its research on anthrax and its effects on humans. The project aims to identify new vaccines and drug targets by studying the human immune response to anthrax bacteria.
Researchers at UC San Diego School of Medicine found that aspirin prompts the production of 15-HETE, which converts to lipoxin to reverse inflammation. This discovery may lead to new anti-inflammatory therapies by developing drugs based on lipoxin analogues.
A new Northwestern University study finds that an intervention focused on strengthening families can reduce inflammation in children from low-income backgrounds. The training program improved parenting and communication between parents and children, leading to reduced inflammation.
A new study by Sanford-Burnham researchers identifies the NBR1 protein as a critical regulator of obesity-induced inflammation, which leads to metabolic disease. The study suggests that blocking this signal may protect against the development of metabolic disease and type 2 diabetes.
The National Psoriasis Foundation has awarded $1.05 million in research grants to 13 scientists studying new treatments and a cure for psoriasis and psoriatic arthritis. The grants will support projects focused on translating laboratory findings into improved treatments and methods for managing the diseases.
Researchers found that higher levels of C-reactive protein in maternal blood were significantly associated with an increased risk of schizophrenia in offspring. The study suggests that pregnancy-related inflammation may play a role in the development of schizophrenia, providing new insights into its biological mechanisms.
Research from UT Southwestern Medical Center found that a level of 'healthy' inflammation is necessary to prevent fatty liver and metabolic diseases. Inflammation helps remodel fat tissue, preventing the buildup of excess lipids in other tissues.
Researchers discover periodontal bacteria selectively disarm immune system, promoting dysbiosis and bone loss. The study reveals a two-pronged mechanism involving protein receptors C5aR and TLR2, which protects 'bystander' gum bacteria from clearance.
Researchers discovered that stimulating AhR in skin cells reduces inflammation in psoriasis patients, a potential new treatment approach for chronic inflammatory skin disorders. The findings suggest a novel strategy for treating psoriasis, combining immune system modulation with AhR stimulation.
A recent study published in Nutrients found that cyclists who consumed Montmorency tart cherry juice concentrate before exercise experienced less inflammation and oxidative stress. The researchers attributed the recovery benefits to the natural compounds in tart cherries, particularly anthocyanins.
Pharmacists at Jena University have developed three potential therapeutic agents that may improve the healing of inflammatory illnesses. The agents suppress a key enzyme in the body's own cascade of inflammation, specifically targeting 5-LOX, which plays a pivotal role in synthesizing leukotrienes. This breakthrough could lead to more ...
A recent study suggests that chronic disruption of circadian rhythms may contribute to inflammatory bowel disease and other harmful conditions. Consuming a high-fat, high-sugar diet can worsen the effects of circadian rhythm disruption on intestinal flora.
A University of Pennsylvania team has identified a promising new target for gum disease treatment: the complement component C3. Treating monkeys with a C3 inhibitor successfully prevented periodontitis-related inflammation and bone loss, suggesting this could be a promising drug option for humans.
A study published in the Proceedings of the National Academy of Sciences found that bullied children experience chronic, systemic inflammation that persists into adulthood. In contrast, bullies may benefit from increased social status through bullying, which can protect against increases in inflammatory markers.
A new study published in JAMA Internal Medicine found no association between resveratrol consumption and improved health outcomes. The research suggests that the supposed health benefits of resveratrol from food sources may be exaggerated or entirely unwarranted.
A study published in PLOS Pathogens found that IL-27 balances the immune response to influenza, reducing lung damage and improving recovery. The researchers discovered that well-timed IL-27 treatment can be beneficial for mice infected with a highly pathogenic influenza strain.
A low-carbohydrate diet was found to significantly reduce inflammation in patients with type 2 diabetes, whereas a traditional low-fat diet showed no similar effect. After six months, the low-carb group exhibited reduced levels of inflammatory markers and improved glucose control.