Research on inflammation and its role in disease. Covers eye inflammation, personalized anti-inflammatory medicine, aging, and chronic pain links.
A research team at St. Jude Children's Research Hospital has revealed a previously unknown immune machinery underlying neutrophilic dermatosis, a group of autoinflammatory skin disorders. By mapping the biological pathways involved, the researchers identified key molecules and signaling nodes that drive inflammation and tissue damage.
A recent study reveals that overexpression of the Cd14 gene offers protection against inflammatory bowel disease in mice, enhancing intestinal barrier function. The research suggests that soluble Cd14 could be an interesting new therapeutic target for future clinical research.
A mouse study reveals that gut microbes play a crucial role in age-associated inflammation and premature death. Imbalances in the gut microbiome lead to leaky intestines and trigger inflammation. Researchers hope to develop drugs or probiotics to restore gut barrier function and reduce age-related inflammation.
Researchers at McMaster University found that imbalances in gut microbes lead to intestinal leakage, triggering inflammation, impaired immune function, and reduced lifespan. The study suggests targeting age-associated inflammation may improve immune health and reduce the risk of chronic conditions.
A new review suggests that augmenting the function of HDL cholesterol rather than increasing its concentration is crucial for protecting against cardiovascular disease. The study highlights the importance of addressing adipose tissue-associated inflammation to support the atheroprotective role of HDL.
A new study reveals a significant decrease in airway wall cells and certain inflammatory cells in smokers and mild to moderate COPD patients. The findings challenge the widely accepted description of airway inflammation in these individuals, suggesting a more complex underlying mechanism.
Researchers at Rockefeller University have discovered that changes in the vascular system and a plasma component called Factor XII may trigger Alzheimer's disease. The study suggests that targeting this process could lead to early diagnosis and new treatments for the condition.
Researchers found that adding back beneficial bacteria can help end a cycle of unchecked inflammation, suggesting a new treatment for inflammatory bowel disease. The study suggests targeting the inflammation downstream of NLRP12 with anti-inflammatory drugs or feeding specific beneficial bacteria to potentially lead to treatments.
Researchers have identified a new compound that binds to CD11b and enhances its ability to suppress TLR signaling, reducing inflammation in lupus patients. The study found that the compound can override genetic defects associated with ITGAM mutations, offering a personalized approach to treating lupus.
Researchers found that IL-21 producing CD4+ T cells contribute to joint inflammation by activating synovial fibroblasts. This discovery holds promise for targeted therapies to decrease inflammation and improve quality of life for patients.
A recent study suggests that a ketogenic diet can protect against gout flares in rats by increasing levels of ketone bodies and inhibiting the NLRP3 inflammasome. This could potentially improve treatment outcomes for humans with the disease.
Researchers developed an assay to detect autoantibodies present in rheumatoid arthritis patients, finding that memory B cells secrete these molecules. The study suggests targeting these immune system cells could lead to a cure for the disease.
Researchers have identified interleukin-1 beta (IL-1) as the trigger for inflammation during necroptosis, a recently described form of cell death. This discovery could lead to new treatments for inflammatory diseases such as psoriasis and inflammatory bowel disease by targeting IL-1.
Researchers propose a new therapy for Gaucher disease by blocking the molecule C5aR1, which drives inflammation and organ damage. The treatment may offer fewer risks and lower costs than current therapies.
A study by Ohio State University researchers found that a Mediterranean diet rich in anti-inflammatory foods such as seafood and plant-based proteins can help reduce pain associated with obesity. The study also highlights the importance of diet quality over quantity in managing weight-related pain.
Research using mutant zebrafish models human disease to show that changes in certain gut bacteria can cause intestinal inflammation. Transplanting beneficial bacteria and restoring gut neurons also cured the disease.
A new RNAi treatment has shown significant improvement in mouse models of acute uveitis and chronic diabetic inflammation without apparent side effects. The therapy targets the receptor-associated prorenin system, involved in uveitis pathogenesis.
New research uncovers a connection between Crohn's disease and spondyloarthritis, finding that IgA-coated E. coli bacteria trigger inflammation in Th17 cells. This discovery may lead to the development of diagnostic tools and therapies targeting both conditions.
Researchers at UTMB have identified inflammation as a major contributor to permanent vision loss after head trauma. Limiting inflammation may help preserve cell function and prevent nerve damage.
A study led by UT Southwestern Medical Center researchers uncovered molecular pathways behind gut bacterial imbalance during inflammatory episodes. The findings provide insights into developing new prevention and treatment strategies for conditions like IBD, colorectal cancers, and gastrointestinal infections.
Virginia Tech researchers have discovered that modifying IRAK-M protein can significantly reduce inflammation and cancer progression in pre-clinical animal models. The team's findings suggest that designing therapeutics targeting IRAK-M could be a viable strategy for preventing these diseases.
The GSG III Foundation has pledged over $1 million for a new research program at the University of Louisville, aiming to develop better methods for studying lung inflammation and explore potential therapies. The program will focus on chronic obstructive pulmonary disease (COPD), cystic fibrosis, and asthma.
A new study suggests that an anti-inflammatory diet rich in vegetables, fruits, fish, and whole grains can help prevent bone loss and fractures in post-menopausal white women younger than 63. The researchers found a correlation between lower-inflammatory diets and lower risk of hip fracture in this subgroup.
A new study reveals that individuals with Type 1 diabetes exhibit distinct gut inflammation and microbiome changes compared to those without diabetes or celiac disease. The research found specific genes associated with gut inflammation and unique combinations of gut bacteria in patients with Type 1 diabetes.
A study by MGH and ISSMS investigators has linked brain activity to cardiovascular disease, identifying a pathway from the amygdala through inflammation to cardiovascular events. Elevated amygdalar activity was strongly associated with increased risk of heart attack and stroke.
A high-fiber diet triggers microorganisms in the gut to produce short-chain fatty acids, which induce neutrophil apoptosis and resolution of inflammation. This finding has important implications for treating gout and possibly other inflammatory diseases.
Researchers discovered that replacing missing gut bacteria or restoring a key metabolite called inosine could help treat children with IPEX syndrome, an often fatal autoimmune disease. The study found that probiotic Lactobacillus reuteri and A2A receptor agonists inhibited T cell-mediated autoimmunity, extending the animals' life span.
Researchers have identified a key role for ZG16 in protecting the body from intestinal bacteria, preventing inflammation and abdominal fat accumulation. The discovery provides new insights into the mechanisms of inflammatory bowel diseases and obesity.
New research from Brigham Young University finds that running decreases pro-inflammatory molecules in the knee joint, reducing inflammation. The study suggests exercise can be a type of medicine for preventing osteoarthritis and delaying its onset.
A new study found that the mannitol challenge test may not be accurate in detecting asthma in non-clinical settings. The test's predictive value was low in the general population, highlighting the need for caution when interpreting results.
Researchers found that IL-12 has a positive effect on skin affected by psoriasis, preventing pathogenic immune cell infiltration and inhibiting inflammatory reactions. The current treatment ustekinumab neutralizes both IL-23 and IL-12, potentially leading to counterproductive effects.
Researchers discovered that targeting the TGF-β1 pathway can reduce pro-inflammatory signals and improve motor function in mice after intracerebral hemorrhage. In human patients, higher levels of TGF-β1 within the first 3 days following stroke predicted better outcomes three months into recovery.
Researchers found that diabetes causes a specific inflammation leading to heart arrhythmias. Two promising drugs inhibit this inflammatory process, reversing cardiac alterations in diabetic mice.
A recent study found that low-fat diets and regular exercise can reduce liver inflammation and scarring in patients with non-alcoholic steatohepatitis. Additionally, improved liver health was associated with enhanced kidney function in these individuals, independent of other factors such as diabetes or weight loss.
New research published in The FASEB Journal suggests that IL-10 may protect against the normal insulin resistance associated with aging. Scientists used transgenic mice to show that IL-10 helped reduce inflammation and insulin resistance in skeletal muscle, a significant step toward improving quality of life as people age.
Researchers at the University of Edinburgh found that a drug called AT7519 helps restore normal function in neutrophils, which contribute to ARDS. The treatment approach shows promise for resolving inflammation in the lung and improving patient outcomes.
Researchers identify direct link between brain inflammation and CTE, with longer football careers predicting increased inflammation and disease progression. The study suggests that treating inflammation could prevent or lessen CTE development, offering potential biomarkers for early identification.
Researchers found that nicotine activates neutrophils, leading to the release of inflammatory molecules and increased inflammation throughout the body. This discovery has implications for tobacco-related diseases and may suggest alternative forms of nicotine inhalation have detrimental effects.
A new study reveals that a protein in wheat triggers inflammation in tissues beyond the gut, contributing to the development of chronic health conditions. The consumption of ATIs may worsen symptoms of rheumatoid arthritis, multiple sclerosis, and non-coeliac gluten sensitivity.
The Pitt Urology Department has been awarded $7.7 million to investigate BPH and LUTS, aiming to develop novel preventative and therapeutic approaches. The center will focus on inflammation involved in these conditions.
New research challenges the use of ice baths after exercise, suggesting they may not reduce inflammation in muscles. The study found no significant benefit from cold water immersion on muscle inflammation compared to active recovery.
A new study has found that adalimumab (Humira) is an effective, non-steroid alternative for treating eye inflammation in patients with non-infectious uveitis. The medication targets a protein that promotes inflammation, delaying treatment failure and reducing symptoms.
Researchers at Harvard University have developed syringe-injectable mesh electronics that stably record neural activity in mice for eight months or more, opening up new possibilities for studying neuro-degenerative diseases and aging processes. The technology also enables the delivery of electrical stimulation to the brain over three m...
Macrophages have been shown to play a crucial role in enthesitis, inflammation of tendons. Researchers found that blocking JAK inhibitors can prevent the increase of STAT1 and successfully treat Achilles enthesitis. This discovery may offer new treatment options for patients with inflammatory rheumatic diseases.
Researchers found that certain essential oil compounds reduce inflammation in human cells damaged by fine particle air pollutants. The compounds, including trans-anethole and eugenol, decreased cytokine levels by up to 96%.
A new study reveals how immune cells access specific genes to fight inflammation and infections, using the cellular snowplow mechanism. The researchers found that nucleosome remodelers clear away blizzards of nucleosomes, allowing genes to be expressed.
Research identifies ACMSD enzyme as key player in regulating inflammation and its byproducts, which may contribute to depression and suicidal tendencies. The study found reduced activity of the enzyme in patients who have attempted suicide, suggesting a potential biomarker for identifying individuals at risk.
A Georgia State University researcher is investigating how changes in intestinal bacteria may lead to obesity and metabolic syndrome. He aims to understand the role of dietary fiber in altering gut bacteria and promoting inflammation.
Researchers identified a gene driving scarring in conjunctival tissue, linked to mucous membrane pemphigoid, a common cause of blinding conjunctivitis. Disulfiram treatment effectively reduced inflammation and prevented scarring in mouse models and human cells.
Researchers found that consuming five or more servings of nuts per week lowered biomarkers of inflammation, such as C-reactive protein and interleukin 6. Substituting nuts for red meat also reduced inflammatory biomarkers. The study suggests a possible mechanism by which nuts may benefit cardiometabolic health.
Researchers found that carnosol and carnosic acid inhibit two enzymes involved in inflammation, fever, and pain. These natural products are considered potential alternatives to classical anti-inflammatory and analgesic drugs with well-documented side effects.
Researchers at Georgetown University Medical Center found that resveratrol reduces neuronal inflammation and slows cognitive decline in Alzheimer's patients. The study shows that resveratrol activates proteins to decrease matrix metalloproteinase-9 levels, maintaining the blood-brain barrier.
Researchers discovered gut bacteria in the deepest reaches of failing lungs, which was previously thought to be an impossible environment for them. The more severe critical illness, the more gut bugs outnumbered usual lung bacteria.
A new study from Rice University found that patients' self-rated health is a strong predictor of morbidity and mortality, even stronger than blood tests and measurements. The researchers linked low self-rated health to high levels of herpesvirus activity and inflammation, which are associated with poor cellular immunity and disease.
Research finds duodenum-jejunum gastric bypass surgery alters gut microorganisms, leading to improved glucose tolerance and insulin sensitivity, resulting in diabetes remission. Bypass surgery also reduces inflammation in liver and fat tissue without directly affecting brain-derived neurotrophic factor (Bdnf) expression.
Researchers at Aarhus University discovered how simvastatin reduces inflammation in chronic diseases like rheumatoid arthritis and multiple sclerosis. The study found that simvastatin acts as a 'plug' in proteins retaining immune cells, reducing inflammation and improving symptoms.
Research from UC Davis Health System found that premenstrual mood changes, abdominal cramps, and breast pain are linked to inflammation, while headache is not. The study suggests that hormonal factors play a role in the onset of symptoms and may require tailored treatments.
Scientists discovered that itaconate, a natural substance produced by macrophages, acts as an antioxidant and anti-inflammatory agent. It reduces the activity of immune cells and may be used to treat pathologies caused by excessive inflammation or oxidative stress.
Johns Hopkins researchers discovered a root cause of lung damage in up to 10% of premature infants with necrotizing enterocolitis, a disorder that damages the intestine. A potential treatment, a sugar-like compound similar to breast milk, was successfully tested in mice and may one day be offered to human infants.
A study found moderate-to-severe gingivitis to be common in pregnant women, particularly among younger mothers. Regular dental care is crucial for maintaining oral health during pregnancy, as gestational age and maternal age were significant factors in gingival bleeding.