Articles tagged with Inflammation
A study by Vanderbilt University and Johns Hopkins researchers found that testosterone hinders an immune cell linked to asthma symptoms in women. This is due to the effects of testosterone on lung cells, which are more prevalent in asthmatic women than men.
Mucosal healing is crucial in treating ulcerative colitis, as it reduces the risk of colorectal cancer. The study by Flores and colleagues reaffirms that ongoing inflammation increases cancer risk and may impact surveillance colonoscopies.
A new study reveals that cigarette smoke triggers colitis, an inflammation of the colon, in mice exposed to cigarette smoke. The researchers identified CD4+ T cells and a pro-inflammatory protein as the immune cells responsible for this effect. This finding could lead to the development of new treatments for Crohn's disease.
Researchers found that triclosan accumulates in toothbrush bristles and elastomer parts, releasing it when switching toothpastes. This could lead to prolonged exposure to triclosan and its potential transformation products.
Research from Rice University found that individuals with depressive symptoms before a disaster experience increased inflammation, a major risk factor for heart disease. The study tracked participants' health markers after the 2005 Texas City petrochemical refinery explosion and found a significant increase in inflammatory markers.
High levels of inflammation in the brain can reduce neurogenesis and increase cell death, potentially increasing depression risk. Researchers found that a protein called interferon-alpha accelerates these processes.
Researchers have identified changes in molecular signaling related to neural plasticity, inflammation and neurodegeneration triggered by the psychedelic substance 5-MeO-DMT. This study suggests that classic psychedelics may induce neuroplasticity and exert antidepressant effects.
A new study found that administering a histamine-producing probiotic reduced inflammation and suppressed colon tumors in mice. The probiotic increased expression of the enzyme histidine decarboxylase, which converts histidine to histamine, resulting in decreased glucose uptake and tumor formation.
A chemically modified version of heparin shows promise in reducing brain swelling and inflammation after traumatic brain injury in mice. The new treatment, ODSH, is being tested in a Phase II clinical trial to assess its effectiveness in people with TBI.
Researchers at King's College London have identified a gene, DLG4, associated with brain damage caused by pre-term birth. The study found that DLG4 is involved in controlling the inflammatory process and may open doors for effective treatments of diseases such as cerebral palsy and autism.
Researchers found that inflammation originating from abdominal fat precedes the development of sleep apnea in adolescence. Weight loss and anti-inflammatory medication have also been shown to reduce apnea severity. The study suggests biological-based interventions may be more effective for mild to moderate cases.
A team of researchers discovered a way to treat severe inflammation from mosquito-borne diseases like Chikungunya and Ross River virus. They developed an NLRP3 inhibitor drug MCC950, which provided significant relief from inflammation and disease in infected mice.
A landmark trial found that a drug targeting inflammation reduced risk of major adverse cardiovascular events, including heart attacks and strokes. Participants who received the anti-inflammatory drug had a 15% lower risk of cardiovascular events compared to those on standard care.
The CANTOS trial found that canakinumab significantly reduced the risk of cardiovascular events and total cancer death, with dose-dependent effects on lung cancer rates. The study showed a 15% reduction in cardiovascular event risk and a 17% reduction in hospitalization for unstable angina.
Studies on red raspberries found that consuming the fruit may improve glucose control and reduce hunger. Researchers also discovered that red raspberry consumption can alter gut microbiota and show promise in reducing inflammation and obesity risk.
A four-year grant will explore nanoparticle-mediated manipulation of pro- and anti-inflammatory factors to limit intestinal inflammation and promote wound healing in IBD patients.
A drug called URMC-099 reversed liver inflammation and scarring in mice with non-alcoholic fatty liver disease. The research suggests that the drug may help treat a growing health concern in the US, affecting over 64 million people.
Scientists have identified a crucial mechanism by which cells detect and respond to DNA damage, shedding light on the body's natural surveillance systems. This discovery may help explain how the human body keeps disease in check and could lead to new therapeutic approaches for cancer prevention.
Researchers found a molecular link between obesity, inflammation, and cardiovascular diseases. Targeting thrombin with dabigatran protected mice from diet-induced obesity-related disease.
A clinical trial found that an Alzheimer's medication, galantamine, reduces inflammation and insulin resistance in patients with metabolic syndrome. The study showed a 25% decrease in inflammatory markers and improved insulin levels.
Researchers found that titanium dioxide nanoparticles can increase inflammation and damage to the intestinal mucosa in mice with colitis. Patients with colitis are recommended to avoid foods containing E171, a food additive made from titanium dioxide.
Physical activity has strong anti-inflammatory properties, playing a crucial role in chronic diseases like type 2 diabetes and cardiovascular disease. Exercise stimulates cytokines IL-6 and IL-10, inhibiting TNF-α and limiting IL-1β signalling to combat inflammation.
Researchers have identified a new target for treating inflammatory skin conditions by depleting the RIPK1 protein. This finding offers a potential 'upstream' approach to treating conditions such as psoriasis, which currently rely on immune suppressant treatments with potential complications.
Scientists at Imperial College London discovered a way to reprogram macrophages, immune cells that cause inflammation, by blocking a single enzyme. By targeting this broken metabolism, they reduced inflammation in rats and mice with human-like diseases.
Researchers developed a metric to identify dangerous blood vessel plaques from CT scans, correlating with markers of inflammation. This new measure may help doctors deploy preventative interventions for at-risk patients, offering a more effective diagnostic tool than current methods.
Researchers at Case Western Reserve University found that a high fat diet rich in plant-derived 'good' fats reduced bacterial diversity and inflammation in mice with Crohn's-like disease. This discovery could lead to new anti-inflammatory probiotics and provide hope for patients suffering from debilitating intestinal symptoms.
Gulf War veterans experience long-term side effects of their service due to exposure to chemicals like pyridostigmine bromide, DEET, and permethrin. Animal models demonstrate how these chemicals cause brain dysfunction, inflammation, and oxidative stress, leading to symptoms such as cognitive decline, memory problems, and chronic fatigue.
Post-operative ileus or bowel paralysis occurs when intestinal contents pass slowly or not at all. New research shows that monocytes help restore bowel function, contrary to initial assumptions.
Researchers found long-term retinal injury and inflammation after blast exposure, even without detectable brain damage. The retina may serve as a sensitive indicator of low-level blast injury, helping identify individuals at risk of visual impairment.
Professor Michael Sieweke has been awarded the Humboldt Professorship at TU Dresden, a prestigious grant worth up to €5 million. He will focus on mechanisms of blood formation and tissue regeneration, with potential applications in cellular therapy and immune system recovery.
Researchers at the Wyss Institute have developed a bacterial sensor that retains long-term memory of gut inflammation, detecting tetrathionate up to six months after administration in a mouse model. This innovation could lead to non-invasive diagnosis and monitoring of conditions like IBD using probiotics.
Researchers at KAUST have identified the molecular liaison responsible for promoting inflammation in endothelial tissues. They found that CD44 and PSGL-1 are key E-selectin ligands involved in this process.
Researchers at Ben-Gurion University have developed a new biomedical polymer that targets damaged tissue, reducing existing plaque and preventing further progression and inflammation. The therapy has shown promising results in mice, improving myocardial function, decreasing inflammation, and thinning arteries.
The graphene-based sensor accurately measures nitrite in exhaled breath condensate, providing a promising biomarker for inflammation in the respiratory tract. This innovation has the potential to improve asthma management, prevent hospitalizations, and reduce deaths worldwide.
A study found that Americans with systemic sclerosis had a greater imbalance of good and bad gut bacteria compared to Norwegians. The researchers believe this difference is due to genetics and diet, which could lead to new treatments by restoring balance through diet modification, probiotics, and fecal transplantation.
A recent study reveals that microRNA-223 plays a crucial role in regulating intestinal inflammation in inflammatory bowel disease. Synthetic versions of this microRNA can reduce inflammation in mice and may hold promise as a future therapy for IBD patients.
Researchers discovered a chemical signal linked to life-threatening lung inflammation, pointing towards new therapies. Blocking molecular signalling mechanisms in patients with Acute Respiratory Distress Syndrome (ARDS) alleviated lung inflammation.
Researchers discovered graphene can withstand extreme pressures, potentially increasing desalination efficiency. Graphene-based filtration membranes may enable more productive desalination processes.
A study found that pretreatment HIV levels and immune activation are linked to persistent inflammation during treatment, contradicting previous results. The research suggests that diagnosing HIV early may prevent elevated immune activation, leading to health problems like heart disease.
A research team at St. Jude Children's Research Hospital has revealed a previously unknown immune machinery underlying neutrophilic dermatosis, a group of autoinflammatory skin disorders. By mapping the biological pathways involved, the researchers identified key molecules and signaling nodes that drive inflammation and tissue damage.
A recent study reveals that overexpression of the Cd14 gene offers protection against inflammatory bowel disease in mice, enhancing intestinal barrier function. The research suggests that soluble Cd14 could be an interesting new therapeutic target for future clinical research.
A mouse study reveals that gut microbes play a crucial role in age-associated inflammation and premature death. Imbalances in the gut microbiome lead to leaky intestines and trigger inflammation. Researchers hope to develop drugs or probiotics to restore gut barrier function and reduce age-related inflammation.
Researchers at McMaster University found that imbalances in gut microbes lead to intestinal leakage, triggering inflammation, impaired immune function, and reduced lifespan. The study suggests targeting age-associated inflammation may improve immune health and reduce the risk of chronic conditions.
A new review suggests that augmenting the function of HDL cholesterol rather than increasing its concentration is crucial for protecting against cardiovascular disease. The study highlights the importance of addressing adipose tissue-associated inflammation to support the atheroprotective role of HDL.
A new study reveals a significant decrease in airway wall cells and certain inflammatory cells in smokers and mild to moderate COPD patients. The findings challenge the widely accepted description of airway inflammation in these individuals, suggesting a more complex underlying mechanism.
Researchers at Rockefeller University have discovered that changes in the vascular system and a plasma component called Factor XII may trigger Alzheimer's disease. The study suggests that targeting this process could lead to early diagnosis and new treatments for the condition.
Researchers found that adding back beneficial bacteria can help end a cycle of unchecked inflammation, suggesting a new treatment for inflammatory bowel disease. The study suggests targeting the inflammation downstream of NLRP12 with anti-inflammatory drugs or feeding specific beneficial bacteria to potentially lead to treatments.
Researchers have identified a new compound that binds to CD11b and enhances its ability to suppress TLR signaling, reducing inflammation in lupus patients. The study found that the compound can override genetic defects associated with ITGAM mutations, offering a personalized approach to treating lupus.
Researchers found that IL-21 producing CD4+ T cells contribute to joint inflammation by activating synovial fibroblasts. This discovery holds promise for targeted therapies to decrease inflammation and improve quality of life for patients.
A recent study suggests that a ketogenic diet can protect against gout flares in rats by increasing levels of ketone bodies and inhibiting the NLRP3 inflammasome. This could potentially improve treatment outcomes for humans with the disease.
Researchers developed an assay to detect autoantibodies present in rheumatoid arthritis patients, finding that memory B cells secrete these molecules. The study suggests targeting these immune system cells could lead to a cure for the disease.
Researchers have identified interleukin-1 beta (IL-1) as the trigger for inflammation during necroptosis, a recently described form of cell death. This discovery could lead to new treatments for inflammatory diseases such as psoriasis and inflammatory bowel disease by targeting IL-1.
Researchers propose a new therapy for Gaucher disease by blocking the molecule C5aR1, which drives inflammation and organ damage. The treatment may offer fewer risks and lower costs than current therapies.
A study by Ohio State University researchers found that a Mediterranean diet rich in anti-inflammatory foods such as seafood and plant-based proteins can help reduce pain associated with obesity. The study also highlights the importance of diet quality over quantity in managing weight-related pain.
Research using mutant zebrafish models human disease to show that changes in certain gut bacteria can cause intestinal inflammation. Transplanting beneficial bacteria and restoring gut neurons also cured the disease.
A new RNAi treatment has shown significant improvement in mouse models of acute uveitis and chronic diabetic inflammation without apparent side effects. The therapy targets the receptor-associated prorenin system, involved in uveitis pathogenesis.
New research uncovers a connection between Crohn's disease and spondyloarthritis, finding that IgA-coated E. coli bacteria trigger inflammation in Th17 cells. This discovery may lead to the development of diagnostic tools and therapies targeting both conditions.
Researchers at UTMB have identified inflammation as a major contributor to permanent vision loss after head trauma. Limiting inflammation may help preserve cell function and prevent nerve damage.
A study led by UT Southwestern Medical Center researchers uncovered molecular pathways behind gut bacterial imbalance during inflammatory episodes. The findings provide insights into developing new prevention and treatment strategies for conditions like IBD, colorectal cancers, and gastrointestinal infections.
Virginia Tech researchers have discovered that modifying IRAK-M protein can significantly reduce inflammation and cancer progression in pre-clinical animal models. The team's findings suggest that designing therapeutics targeting IRAK-M could be a viable strategy for preventing these diseases.