Research on inflammation and its role in disease. Covers eye inflammation, personalized anti-inflammatory medicine, aging, and chronic pain links.
A new discovery about the immune system may allow doctors to treat harmful inflammation that damages the brain in neurodegenerative diseases such as Alzheimer's. The finding could also be used to save patients from deadly sepsis, a full-body infection that kills hundreds of thousands of Americans every year.
A study published in Nature Communications found that an oxygen sensor in the body reduces inflammation by activating HIF-1α, which inhibits excessive immune responses. This molecular mechanism could lead to new approaches for treating chronic inflammatory diseases such as arthritis and multiple sclerosis.
Researchers at FAU have deciphered what causes life-threatening inflammation of the intestines after a stem cell transplant, identifying a protein named BATF as a central switch in donor T-lymphocytes. The discovery may lead to new therapies to influence inflammation and increase patients' chances of survival.
Researchers discover a possible direct connection between disrupted circadian clocks and increased levels of ADAM17, an enzyme that promotes inflammation and stiffens blood vessel walls. This relationship could explain why poor sleep habits contribute to cardiovascular disease risk factors.
Researchers found ustekinumab, used to treat psoriasis, also improves aortic inflammation, a key marker of cardiovascular risk. The drug resulted in a 19% improvement in aortic inflammation and significant reductions in skin inflammation.
A diet rich in saturated fat results in inflammation in the nucleus accumbens, a part of the brain that controls mood and reward. This inflammation leads to depressive, anxious, and compulsive behaviors associated with metabolic dysfunction and obesity.
Scientists discover two new feedback loops that regulate energy expenditure, with TBK1 inhibiting AMPK's role in burning fat. Deleting TBK1 from fat cells increases inflammation and weight loss.
Researchers have uncovered how an inflammation process automatically switches off in healthy cells, a discovery that could lead to stopping damage caused by uncontrolled inflammation. The study focuses on inflammasomes, which are machine-like protein complexes at the heart of inflammation and disease.
A new study published in Scientific Reports suggests that low doses of alcohol may be beneficial for brain health, reducing inflammation and improving the brain's ability to remove waste. This finding adds to growing research linking lower levels of drinking with a reduced risk of cardiovascular diseases and certain cancers.
A groundbreaking study has identified a new periodic autoinflammatory syndrome affecting the eyes, known as keratoendotheliitis fugax hereditaria. The disease is caused by a mutation in the NLRP3 gene and affects corneal endothelium, leading to temporary ocular inflammation.
Research suggests that working before and after a stroke is linked to better brain health two years post-stroke. Adult stroke survivors who were employed prior to their stroke had lower cognitive decline risk and fewer unhealthy brain changes compared to those who were unemployed.
A diet high in inflammatory foods like meats, refined grains, and sugary drinks is associated with a higher risk of developing colorectal cancer. Higher scores on the inflammatory potential index were linked to an increased risk in both men and women.
A study found an inverse correlation between waist circumference and fitness, suggesting that high fitness levels can reduce abdominal fat mass and low-grade inflammation. The researchers analyzed data from 10,976 individuals and found that higher fitness was associated with smaller waist circumferences and lower inflammation levels.
LJI researchers reveal LIGHT, a tumor necrosis factor super family member, drives skin inflammation in atopic dermatitis. The discovery provides a novel therapeutic target for the treatment of severe eczema. Therapies blocking LIGHT signaling may halt disease symptoms and reverse symptoms.
Researchers have discovered an enzyme called SNRK that regulates inflammation in white fat tissue and promotes brown fat metabolism. This finding suggests a potential new target for therapies aimed at curbing obesity and its complications.
A recent study by Mayo Clinic researchers found that most patients with suspected spinal cord inflammation of unknown cause were later diagnosed with a specific condition. The study revealed that nearly 70% of patients received an alternative diagnosis, including multiple sclerosis and vascular strokes of the spinal cord.
A new radiotracer, 18F-FDS, has been developed to identify and track bacterial infections in the lungs. The tracer was tested on mice with live bacteria or dead bacteria to induce inflammation, and it successfully differentiated between lung infection and inflammation.
Researchers at UT Southwestern Medical Center used precision editing to target metabolic pathways in the gut, reducing inflammation in mouse models of colitis. The strategy, which targets specific bacterial species, prevented or reduced inflammation without affecting healthy gut bacteria.
A team of researchers at Stanford University School of Medicine identified four on-the-market drugs that successfully quelled symptoms triggered by several overabundant proteins in patients with a rare eye disease. The findings demonstrate the potential of treating rare and complex eye conditions using precision health approaches.
A new study by NIH researchers found a molecular basis for the theory of aging, suggesting that environmental stressors can shorten lifespan. The study identified a protein called Mthl10, which helps flies defend against inflammation but ultimately shortens their life.
Researchers found that vanillin reduced psoriatic symptoms and decreased IL-17 and IL-23 protein levels in mice with induced skin inflammation. Daily doses of vanillin above 50mg/kg body weight showed significant effects.
A study by Vanderbilt University and Johns Hopkins researchers found that testosterone hinders an immune cell linked to asthma symptoms in women. This is due to the effects of testosterone on lung cells, which are more prevalent in asthmatic women than men.
Mucosal healing is crucial in treating ulcerative colitis, as it reduces the risk of colorectal cancer. The study by Flores and colleagues reaffirms that ongoing inflammation increases cancer risk and may impact surveillance colonoscopies.
A new study reveals that cigarette smoke triggers colitis, an inflammation of the colon, in mice exposed to cigarette smoke. The researchers identified CD4+ T cells and a pro-inflammatory protein as the immune cells responsible for this effect. This finding could lead to the development of new treatments for Crohn's disease.
Researchers found that triclosan accumulates in toothbrush bristles and elastomer parts, releasing it when switching toothpastes. This could lead to prolonged exposure to triclosan and its potential transformation products.
Research from Rice University found that individuals with depressive symptoms before a disaster experience increased inflammation, a major risk factor for heart disease. The study tracked participants' health markers after the 2005 Texas City petrochemical refinery explosion and found a significant increase in inflammatory markers.
High levels of inflammation in the brain can reduce neurogenesis and increase cell death, potentially increasing depression risk. Researchers found that a protein called interferon-alpha accelerates these processes.
Researchers have identified changes in molecular signaling related to neural plasticity, inflammation and neurodegeneration triggered by the psychedelic substance 5-MeO-DMT. This study suggests that classic psychedelics may induce neuroplasticity and exert antidepressant effects.
A chemically modified version of heparin shows promise in reducing brain swelling and inflammation after traumatic brain injury in mice. The new treatment, ODSH, is being tested in a Phase II clinical trial to assess its effectiveness in people with TBI.
A new study found that administering a histamine-producing probiotic reduced inflammation and suppressed colon tumors in mice. The probiotic increased expression of the enzyme histidine decarboxylase, which converts histidine to histamine, resulting in decreased glucose uptake and tumor formation.
Researchers at King's College London have identified a gene, DLG4, associated with brain damage caused by pre-term birth. The study found that DLG4 is involved in controlling the inflammatory process and may open doors for effective treatments of diseases such as cerebral palsy and autism.
Researchers found that inflammation originating from abdominal fat precedes the development of sleep apnea in adolescence. Weight loss and anti-inflammatory medication have also been shown to reduce apnea severity. The study suggests biological-based interventions may be more effective for mild to moderate cases.
A landmark trial found that a drug targeting inflammation reduced risk of major adverse cardiovascular events, including heart attacks and strokes. Participants who received the anti-inflammatory drug had a 15% lower risk of cardiovascular events compared to those on standard care.
A team of researchers discovered a way to treat severe inflammation from mosquito-borne diseases like Chikungunya and Ross River virus. They developed an NLRP3 inhibitor drug MCC950, which provided significant relief from inflammation and disease in infected mice.
The CANTOS trial found that canakinumab significantly reduced the risk of cardiovascular events and total cancer death, with dose-dependent effects on lung cancer rates. The study showed a 15% reduction in cardiovascular event risk and a 17% reduction in hospitalization for unstable angina.
Studies on red raspberries found that consuming the fruit may improve glucose control and reduce hunger. Researchers also discovered that red raspberry consumption can alter gut microbiota and show promise in reducing inflammation and obesity risk.
A four-year grant will explore nanoparticle-mediated manipulation of pro- and anti-inflammatory factors to limit intestinal inflammation and promote wound healing in IBD patients.
A drug called URMC-099 reversed liver inflammation and scarring in mice with non-alcoholic fatty liver disease. The research suggests that the drug may help treat a growing health concern in the US, affecting over 64 million people.
Scientists have identified a crucial mechanism by which cells detect and respond to DNA damage, shedding light on the body's natural surveillance systems. This discovery may help explain how the human body keeps disease in check and could lead to new therapeutic approaches for cancer prevention.
Researchers found a molecular link between obesity, inflammation, and cardiovascular diseases. Targeting thrombin with dabigatran protected mice from diet-induced obesity-related disease.
A clinical trial found that an Alzheimer's medication, galantamine, reduces inflammation and insulin resistance in patients with metabolic syndrome. The study showed a 25% decrease in inflammatory markers and improved insulin levels.
Researchers found that titanium dioxide nanoparticles can increase inflammation and damage to the intestinal mucosa in mice with colitis. Patients with colitis are recommended to avoid foods containing E171, a food additive made from titanium dioxide.
Physical activity has strong anti-inflammatory properties, playing a crucial role in chronic diseases like type 2 diabetes and cardiovascular disease. Exercise stimulates cytokines IL-6 and IL-10, inhibiting TNF-α and limiting IL-1β signalling to combat inflammation.
Researchers have identified a new target for treating inflammatory skin conditions by depleting the RIPK1 protein. This finding offers a potential 'upstream' approach to treating conditions such as psoriasis, which currently rely on immune suppressant treatments with potential complications.
Scientists at Imperial College London discovered a way to reprogram macrophages, immune cells that cause inflammation, by blocking a single enzyme. By targeting this broken metabolism, they reduced inflammation in rats and mice with human-like diseases.
Researchers developed a metric to identify dangerous blood vessel plaques from CT scans, correlating with markers of inflammation. This new measure may help doctors deploy preventative interventions for at-risk patients, offering a more effective diagnostic tool than current methods.
Researchers at Case Western Reserve University found that a high fat diet rich in plant-derived 'good' fats reduced bacterial diversity and inflammation in mice with Crohn's-like disease. This discovery could lead to new anti-inflammatory probiotics and provide hope for patients suffering from debilitating intestinal symptoms.
Gulf War veterans experience long-term side effects of their service due to exposure to chemicals like pyridostigmine bromide, DEET, and permethrin. Animal models demonstrate how these chemicals cause brain dysfunction, inflammation, and oxidative stress, leading to symptoms such as cognitive decline, memory problems, and chronic fatigue.
Post-operative ileus or bowel paralysis occurs when intestinal contents pass slowly or not at all. New research shows that monocytes help restore bowel function, contrary to initial assumptions.
Researchers found long-term retinal injury and inflammation after blast exposure, even without detectable brain damage. The retina may serve as a sensitive indicator of low-level blast injury, helping identify individuals at risk of visual impairment.
Professor Michael Sieweke has been awarded the Humboldt Professorship at TU Dresden, a prestigious grant worth up to €5 million. He will focus on mechanisms of blood formation and tissue regeneration, with potential applications in cellular therapy and immune system recovery.
Researchers at the Wyss Institute have developed a bacterial sensor that retains long-term memory of gut inflammation, detecting tetrathionate up to six months after administration in a mouse model. This innovation could lead to non-invasive diagnosis and monitoring of conditions like IBD using probiotics.
Researchers at KAUST have identified the molecular liaison responsible for promoting inflammation in endothelial tissues. They found that CD44 and PSGL-1 are key E-selectin ligands involved in this process.
Researchers at Ben-Gurion University have developed a new biomedical polymer that targets damaged tissue, reducing existing plaque and preventing further progression and inflammation. The therapy has shown promising results in mice, improving myocardial function, decreasing inflammation, and thinning arteries.
The graphene-based sensor accurately measures nitrite in exhaled breath condensate, providing a promising biomarker for inflammation in the respiratory tract. This innovation has the potential to improve asthma management, prevent hospitalizations, and reduce deaths worldwide.
A study found that Americans with systemic sclerosis had a greater imbalance of good and bad gut bacteria compared to Norwegians. The researchers believe this difference is due to genetics and diet, which could lead to new treatments by restoring balance through diet modification, probiotics, and fecal transplantation.
A recent study reveals that microRNA-223 plays a crucial role in regulating intestinal inflammation in inflammatory bowel disease. Synthetic versions of this microRNA can reduce inflammation in mice and may hold promise as a future therapy for IBD patients.
Researchers discovered a chemical signal linked to life-threatening lung inflammation, pointing towards new therapies. Blocking molecular signalling mechanisms in patients with Acute Respiratory Distress Syndrome (ARDS) alleviated lung inflammation.
Researchers discovered graphene can withstand extreme pressures, potentially increasing desalination efficiency. Graphene-based filtration membranes may enable more productive desalination processes.
A study found that pretreatment HIV levels and immune activation are linked to persistent inflammation during treatment, contradicting previous results. The research suggests that diagnosing HIV early may prevent elevated immune activation, leading to health problems like heart disease.