Articles tagged with Inflammation
Advanced inflamed vascular plaques associated with progressive liver disease, supporting systemic effects of chronic unresolved inflammation. Researchers test oral delivery of omega-3 fatty acids to treat inflammation without unwanted side effects.
Researchers have successfully reversed hair loss and skin inflammation in mice fed a Western diet high in fat and cholesterol. The experimental compound D-PDMP halts the production of glycosphingolipids, which are major components of skin and cell membranes.
Researchers found the portfolio diet reduces LDL cholesterol by 30%, as well as blood pressure, triglycerides, and inflammation, with a combined effect of 13% lower risk for coronary heart disease. The diet's four main components include nuts, plant protein, viscous soluble fibre, and plant sterols.
Researchers discovered altered intestinal phage communities in mice with colitis, which overlapped with healthy human phages, suggesting a potential role in IBD. The study also found specific phages linked to disease-causing bacteria, highlighting the need for further investigation into viral contributions to inflammatory diseases.
New research explains how obesity leads to harmful inflammation, causing diabetes and other health problems. The study identifies two ways to combat this inflammation: blocking harmful oxidized lipids or promoting beneficial phospholipids.
A new method tracks mechanisms causing nerve cell damage in the heart, a previously unappreciated area affected by Parkinson's disease. The research has implications for testing therapies and exploring causes of fatigue, fainting, and falling.
A new study found that the quality of LDL particles is a significant cardiovascular risk factor, with aggregation-prone LDL linked to increased risk of death. Improvements in LDL quality have been shown to be possible through cholesterol-lowering medication or healthy diet, offering new hope for cardiovascular disease prevention.
Researchers found that mice lacking the melanocortin 4 receptor exhibit increased attraction to environments associated with inflammation, nausea, or discomfort. This suggests a link between this receptor and the regulation of negative emotions.
A randomized, controlled trial found that supplemental antioxidants decreased the risk of time to first exacerbation requiring antibiotics in patients with CF. The study also showed increased circulating antioxidant concentrations and transiently decreased inflammation in the antioxidant-treated group.
A Loyola Medicine study found lax, rubbery eyelids in 53% of sleep apnea patients, associated with the most severe cases. Sleep apnea affects an estimated 34% of men and 17% of women, but up to 80% remain undiagnosed.
A new approach for treating liver cirrhosis has been found with aleglitazar, which reduces inflammation and portal hypertension in rats with cirrhosis. Aleglitazar suppresses inflammation, vasoconstriction, angiogenesis, and tumor necrosis factor overproduction in cirrhotic rats.
A new study found that rheumatoid arthritis inflammation alters brain connectivity and structure, contributing to cognitive symptoms. Higher levels of peripheral inflammation were associated with changes in the inferior parietal lobule and medial prefrontal cortex.
Researchers at Michigan State University discovered a link between intestinal inflammation, irritable bowel syndrome, and communication between sensory neurons and enteric glia. The study found that specific molecular changes spark discomfort before symptoms appear.
Researchers discovered how bronchiectasis impairs immune cells, leading to repeated lung infections. Treatments targeting these cells could reduce chest infections and improve quality of life.
Researchers discovered a naturally occurring antibody that binds to oxidized phospholipids, blocking inflammation and preventing arterial plaque formation. The antibody protected mice from atherosclerosis, aortic stenosis, hepatic steatosis, and prolonged their lives.
A new study suggests that eating mangos may be more effective than taking a comparable amount of fiber in relieving constipation. The research found that mango polyphenols helped improve gut health by reducing markers of inflammation and changing the microbiome.
A study has found that circadian rhythms influence atherosclerosis, a condition leading to heart attacks and strokes. The researchers identified the molecular mechanism controlling rhythmic arterial leukocyte migration and developed a targeted therapy to stop its recruitment in atherosclerotic areas.
Weizmann Institute of Science researchers found a natural defense mechanism that prompts the body to alleviate intestinal inflammation. Boosting signals in certain cells, such as those making up the inner lining of the gut, may help treat inflammatory bowel diseases and potentially even colon cancer.
A new mouse study suggests that the widely used antimicrobial ingredient triclosan may have adverse effects on colonic inflammation and colon cancer. Researchers found that triclosan altered gut microbiota, increased inflammation, and spurred disease development in mice.
Researchers found that triclosan causes colon inflammation and worsens colon cancer in mice, raising concerns about its safety for human consumption. The study suggests that individuals with inflammatory bowel disease or colon cancer may be more vulnerable to the chemical's adverse effects.
A Penn-led trial found that adalimumab, marketed as Humira, did not improve aortic vascular inflammation in psoriasis patients, but reduced markers of systemic inflammation and mild impairment in HDL function. The study suggests the drug may have cardiovascular benefits despite this finding.
Dr. Giorgio Trinchieri is recognized for his pioneering contributions to cytokine biology, including the discovery of interleukin-12 and its role in inflammation and immunity. His work has led to significant breakthroughs in understanding and treating cancer, inflammatory diseases, and autoimmune disorders.
Researchers discovered six cytokine signatures associated with Type 2 diabetes risk in vulnerable African American women. These biomarkers could help personalize disease risk profiles for clinical decision making.
Researchers at Michigan Medicine's Kellogg Eye Center report cases of uveal effusions and eye inflammation caused by immunotherapy treatments. Ophthalmologists emphasize the importance of referring patients with eye problems to an ophthalmologist, while oncologists should ask about medications that may be causing symptoms.
Researchers at UMass Amherst have identified a new molecular mechanism explaining the link between obesity and increased risk of colon inflammation, a major risk factor for colorectal cancer. Inhibiting an enzyme called soluble epoxide hydrolase may abolish this risk, suggesting a potential treatment for obesity-induced colonic inflamm...
Researchers found that walking the course provides significantly higher health benefits and is not associated with increased pain or inflammation. Golfing while riding a cart still offers cardiovascular benefits, but walking is the superior option.
Researchers found improved measures of cardiovascular health, beneficial changes in fat tissue, and reduced risk of diabetes in obese women with PCOS who used a hot tub regularly. Heat therapy may reverse some of the inflammation in fat that causes metabolic health impairment.
A recent Mount Sinai study reveals individuals with IBD have a 28% higher risk of developing Parkinson's disease; treated patients show significant reduction in risk after anti-TNFα therapy. The study suggests exploring anti-TNFα to prevent Parkinson's disease in high-risk individuals.
An experimental compound appears to improve stroke outcomes by reducing lingering inflammation, leading to better memory and movement in its aftermath. The compound, known as compound 21, stimulates the angiotensin type 2 receptor, which aids blood vessel dilation, minimizes cell death, and reduces inflammation.
A recent study published in JCI Insight found that gut bacteria can contribute to the development of osteoarthritis in obese individuals. The researchers discovered that a high-fat diet altered the gut microbiome, leading to inflammation and joint deterioration. However, supplementing the diet with a common prebiotic oligofructose reve...
Researchers at the University of Münster have developed a new method to study inflammatory cells in mice, allowing for genetic modification, multiplication, and visualization in living organisms. This approach reduces the number of animal experiments needed.
Dr. Charles N. Serhan received the ASIP 2018 Rous-Whipple Award for his work on molecular and cellular basis of inflammation and its resolution, recognizing his discovery of endogenous anti-inflammatory mediators that activate anti-microbial defense mechanisms.
Research reveals inflammatory airway disease (IAD) is common among racehorses, even those without respiratory signs. The study of 95 deceased racehorses found most had some degree of IAD, suggesting all horses may be exposed to inflammation.
Researchers at Trinity College Dublin have discovered a potential 'off-switch' for inflammation by identifying the molecule itaconate, which can block production of inflammatory factors and protect against lethal inflammation. This breakthrough could lead to new anti-inflammatory medicines for diseases such as arthritis and heart disease.
Researchers at the University of Manchester have found that an anti-inflammatory drug, Kineret, significantly reduces levels of inflammation in patients with ischemic strokes. The study, funded by the Stroke Association, shows promise for fast and effective treatment of stroke, but further trials are needed to confirm its effectiveness.
Research investigates the link between chronic periodontitis and age-related macular degeneration, finding a common oral pathobiont, Porphyromonas gingivalis, that can invade human retinal-pigment epithelial cells. The study reveals significant molecular links between CP and AMD.
Researchers found that a liver enzyme increases abdominal fat inflammation in obese mice, leading to insulin resistance. Soothing this inflammation improves insulin sensitivity without affecting weight.
A University at Buffalo study found that the absence of protein tristetraprolin (TTP) leads to rapid bone loss in mice, with oral bone loss increasing by nearly 20% over nine months. Overexpressing TTP reduced bone turnover by 13%. The research has implications for managing bone health in the elderly.
Researchers at UC Davis Health have identified a new molecular target, vascular endothelial growth factor A (VEGFA), that plays a major role in inflammation and airway obstruction associated with asthma. Targeting VEGFA may lead to new treatments.
A new discovery about the immune system may allow doctors to treat harmful inflammation that damages the brain in neurodegenerative diseases such as Alzheimer's. The finding could also be used to save patients from deadly sepsis, a full-body infection that kills hundreds of thousands of Americans every year.
A study published in Nature Communications found that an oxygen sensor in the body reduces inflammation by activating HIF-1α, which inhibits excessive immune responses. This molecular mechanism could lead to new approaches for treating chronic inflammatory diseases such as arthritis and multiple sclerosis.
Researchers at FAU have deciphered what causes life-threatening inflammation of the intestines after a stem cell transplant, identifying a protein named BATF as a central switch in donor T-lymphocytes. The discovery may lead to new therapies to influence inflammation and increase patients' chances of survival.
Researchers discover a possible direct connection between disrupted circadian clocks and increased levels of ADAM17, an enzyme that promotes inflammation and stiffens blood vessel walls. This relationship could explain why poor sleep habits contribute to cardiovascular disease risk factors.
Researchers found ustekinumab, used to treat psoriasis, also improves aortic inflammation, a key marker of cardiovascular risk. The drug resulted in a 19% improvement in aortic inflammation and significant reductions in skin inflammation.
A diet rich in saturated fat results in inflammation in the nucleus accumbens, a part of the brain that controls mood and reward. This inflammation leads to depressive, anxious, and compulsive behaviors associated with metabolic dysfunction and obesity.
Scientists discover two new feedback loops that regulate energy expenditure, with TBK1 inhibiting AMPK's role in burning fat. Deleting TBK1 from fat cells increases inflammation and weight loss.
Researchers have uncovered how an inflammation process automatically switches off in healthy cells, a discovery that could lead to stopping damage caused by uncontrolled inflammation. The study focuses on inflammasomes, which are machine-like protein complexes at the heart of inflammation and disease.
A new study published in Scientific Reports suggests that low doses of alcohol may be beneficial for brain health, reducing inflammation and improving the brain's ability to remove waste. This finding adds to growing research linking lower levels of drinking with a reduced risk of cardiovascular diseases and certain cancers.
A groundbreaking study has identified a new periodic autoinflammatory syndrome affecting the eyes, known as keratoendotheliitis fugax hereditaria. The disease is caused by a mutation in the NLRP3 gene and affects corneal endothelium, leading to temporary ocular inflammation.
Research suggests that working before and after a stroke is linked to better brain health two years post-stroke. Adult stroke survivors who were employed prior to their stroke had lower cognitive decline risk and fewer unhealthy brain changes compared to those who were unemployed.
A diet high in inflammatory foods like meats, refined grains, and sugary drinks is associated with a higher risk of developing colorectal cancer. Higher scores on the inflammatory potential index were linked to an increased risk in both men and women.
A study found an inverse correlation between waist circumference and fitness, suggesting that high fitness levels can reduce abdominal fat mass and low-grade inflammation. The researchers analyzed data from 10,976 individuals and found that higher fitness was associated with smaller waist circumferences and lower inflammation levels.
LJI researchers reveal LIGHT, a tumor necrosis factor super family member, drives skin inflammation in atopic dermatitis. The discovery provides a novel therapeutic target for the treatment of severe eczema. Therapies blocking LIGHT signaling may halt disease symptoms and reverse symptoms.
Researchers have discovered an enzyme called SNRK that regulates inflammation in white fat tissue and promotes brown fat metabolism. This finding suggests a potential new target for therapies aimed at curbing obesity and its complications.
A recent study by Mayo Clinic researchers found that most patients with suspected spinal cord inflammation of unknown cause were later diagnosed with a specific condition. The study revealed that nearly 70% of patients received an alternative diagnosis, including multiple sclerosis and vascular strokes of the spinal cord.
A new radiotracer, 18F-FDS, has been developed to identify and track bacterial infections in the lungs. The tracer was tested on mice with live bacteria or dead bacteria to induce inflammation, and it successfully differentiated between lung infection and inflammation.
Researchers at UT Southwestern Medical Center used precision editing to target metabolic pathways in the gut, reducing inflammation in mouse models of colitis. The strategy, which targets specific bacterial species, prevented or reduced inflammation without affecting healthy gut bacteria.
A team of researchers at Stanford University School of Medicine identified four on-the-market drugs that successfully quelled symptoms triggered by several overabundant proteins in patients with a rare eye disease. The findings demonstrate the potential of treating rare and complex eye conditions using precision health approaches.
A new study by NIH researchers found a molecular basis for the theory of aging, suggesting that environmental stressors can shorten lifespan. The study identified a protein called Mthl10, which helps flies defend against inflammation but ultimately shortens their life.
Researchers found that vanillin reduced psoriatic symptoms and decreased IL-17 and IL-23 protein levels in mice with induced skin inflammation. Daily doses of vanillin above 50mg/kg body weight showed significant effects.