Research on inflammation and its role in disease. Covers eye inflammation, personalized anti-inflammatory medicine, aging, and chronic pain links.
A randomized clinical trial found that high-dose intravenous vitamin C did not reduce organ failure, inflammation, or vascular injury in patients with sepsis and acute respiratory distress syndrome (ARDS). The study's limitations include underpowered detection of differences and insufficient dosage.
Researchers found that inflammation amplifies neurite growth in neurons involved in thermal sensations, leading to increased pain hypersensitivity. Cav2.2 calcium channel genes play a key role in this process, promoting thermosensitive neuronal activity and sensory nerve outgrowth.
Researchers found that certain flavored e-cigarette flavors, even without nicotine, can exacerbate asthma symptoms and increase tissue scarring. Flavors like Black Licorice and Banana Pudding were particularly problematic.
Researchers discovered LH dipeptide as a potent anti-inflammatory agent that inhibits the secretion of inflammatory cytokines from microglia, reducing brain inflammation and depression symptoms. Consuming foods rich in LH dipeptide may be a safe method for maintaining good mental health.
A plant-based diet has been shown to reduce inflammation and improve symptoms of rheumatoid arthritis through various mechanisms. Studies have found that plant-based diets are low in fat and high in fiber, which can reduce inflammatory markers and promote healthy gut bacteria.
A NIH-funded clinical trial found that methotrexate was more effective than mycophenolate mofetil in controlling inflammation and treatment success for patients with severe forms of uveitis. At six months, 74% of participants in the methotrexate group achieved control compared to 55% in the mycophenolate group.
A study using a blood marker of inflammation found an association between late adolescence inflammation and death among Swedish men up to age 57. The results suggest that chronic inflammation in young adulthood may increase the risk of mortality decades later.
Researchers at Stanford University School of Medicine have found that inflammation in the lungs can wake up a silent genetic defect that causes sudden onset cases of pulmonary hypertension. The study suggests that limiting potential environmental causes of lung inflammation may help prevent the development of the disease.
A Yale-led study reveals that transforming growth factor beta (TGFß) proteins trigger inflammation in endothelial cells, leading to plaque buildup and atherosclerosis. Disrupting TGFβ receptors with RNAi drug reduces inflammation and plaque effectively.
Researchers at University of California San Diego School of Medicine found that removing the enzyme PHLPP1 improves outcomes in a mouse model of sepsis. The study introduces the possibility of inhibiting PHLPP1 as a new treatment for sepsis.
A recent study by Anna M. Gruener et al., published in JAMA Ophthalmology, investigated the association between giant cell arteritis and race. The researchers found a significant association between the disorder and certain ethnic groups, with increased risk observed in African Americans, Hispanics, and individuals of mixed ancestry.
Researchers have identified a molecule called Gas6 that induces macrophages to clean up cellular debris and reduce inflammation. Boosting Gas6 levels in macrophages has been shown to resolve inflammation in mouse models of acute lung injury, holding promise for treating diseases such as heart disease, cancer, and rheumatoid arthritis.
Researchers uncover how cannabis creates potent pain-relieving molecules, targeting inflammation and offering a non-psychoactive alternative to opioids. The discovery enables the development of naturally derived pain treatments with potentially significant benefits for chronic pain sufferers.
A study led by Georgia State University researchers found that fecal miRNA can serve as a tool to assess gut microbiota healthiness and provide early clues to intestinal inflammation in mice. The findings offer new hope for diagnosing chronic gut conditions, such as inflammatory bowel disease.
A study published in Immunity reveals that the synthesis and breakdown of fats play a crucial role in asthma-related inflammation. Researchers used single-cell RNA sequencing to analyze gene expression in immune cells exposed to house dust mites, finding a unique profile of genes linked to fat metabolism.
A study has characterised two distinct populations of gut immune cells, which could help scientists develop treatments targeting inflammation while preserving healthy gut function. The 'good' cell population helps keep the gut lining healthy, while the 'bad' cells cause excessive inflammation and are associated with inflammatory diseases.
Researchers have developed a therapeutic approach that utilizes the endogenous process to turn off inflammation and promote healing in the heart muscle. Annexin A1 protein stimulates new blood vessel formation, increasing blood flow and improving cardiac function.
A recent study by I.R.C.C.S. Neuromed found that obese patients with multiple sclerosis have a greater risk of presenting higher EDSS scores and experiencing increased central inflammation. The research suggests that excessive body weight and altered lipid profiles may be associated with worsened clinical expression of the disease.
Researchers have discovered a molecule called LL-37 that changes cell behavior when infected with bacteria, triggering the production of neutrophils to destroy bacterial threats. The study's findings could lead to new approaches in treating multi-drug resistant infections.
Researchers at Duke-NUS Medical School and NHCS found that deactivating IL11 with therapeutic antibodies reverses inflammation and scarring in patients with non-alcoholic steatohepatitis (NASH). This breakthrough has implications for the development of drugs to treat NASH, a common condition affecting millions worldwide.
Research suggests that e-cigarettes can diminish the body's ability to fight viruses, including those causing the flu. Cigarettes, on the other hand, appear to increase the risk of becoming sick from the flu due to different factors.
A recent study published in the New England Journal of Medicine found that benralizumab, an asthma drug, was ineffective in reducing exacerbations in patients with moderate to very severe COPD. The study involved over 3,000 patients and showed no significant decrease in COPD exacerbation rates among those receiving benralizumab.
Research suggests DGKζ enzyme plays a role in suppressing runaway inflammation in asthma. The enzyme's deletion in mouse T cells led to reduced inflammation and airway hyper-responsiveness, two hallmarks of the disease.
A study using praliciguat to stimulate soluble guanylate cyclase found that it can inhibit inflammation and fibrosis in liver cells, suggesting a potential therapy for nonalcoholic steatohepatitis. The results also indicate that praliciguat may suppress stellate cell fibrotic transformation.
Researchers at University of Queensland discover a way to stop inflammation by inhibiting the inflammasome protein complex. This breakthrough could lead to the design of new anti-inflammatory drugs, informing treatment for chronic inflammatory diseases such as Parkinson's and Alzheimer's.
The Fondren Foundation has pledged $15 million to Houston Methodist to support the development of a comprehensive program addressing complex diseases. The new initiative will focus on advancing research and treatment for gastrointestinal disorders, immunological disorders, and food allergies.
Researchers developed a capsule-shaped photoacoustic imaging endoscope to examine intestinal changes in Crohn's disease. The device can differentiate between inflammatory and fibrotic strictures, allowing for more targeted treatment and potentially reducing adverse effects. This technology could also provide real-time diagnostic inform...
Researchers found that using psychological techniques to communicate periodontal disease risk improved dental hygiene and reduced gum inflammation over a three month period. The study also associated the intervention with improved frequency of interdental cleaning.
The study found that phenolic compounds in purple corn altered the development of fat cells and reduced inflammation and insulin resistance. Different combinations of anthocyanins showed varying effects on these biomarkers.
A University of Michigan researcher has found that the mechanics producing wheezing and crackling noises with every breath are likely a cause of injury and inflammation. This new understanding could change how lung diseases are treated and represent a paradigm shift in doctor-patient interactions.
Researchers have developed a new method for transporting medicine through the body, using a sliding molecule that can jump between polymers to deliver medication to specific organs. Laboratory tests confirm the model's effectiveness in delivering molecules to gel-like materials.
A new study reveals that a specific type of immune cell, known as T7 and T8 cells, are responsible for inflammation in eosinophilic esophagitis. The study's findings also raise questions about the safety of a popular dietary supplement called butyrate, which may exacerbate the condition.
A combination of over-the-counter antioxidants shows promise for mitigating damaging effects of heart failure with preserved ejection fraction. Treatment improved markers of vascular function and inflammation in some patients, suggesting a simple and readily available option to improve vascular health.
A new drug targeting brain inflammation, MW-151, is ready for its first round of human testing. The medication aims to block 'bad' inflammation that destroys neurons in Alzheimer's disease.
A study by WVU researchers found that exposure to white light at night causes multiple poor outcomes in cardiac arrest models, including greater cell death, more aggressive inflammation, and higher mortality rates. In contrast, dim red light had no detrimental effects.
Researchers from VIB have developed a map to model cellular dynamics, highlighting outstanding challenges and pioneering new ways of evaluating computational biology methods. This breakthrough enables the study of individual cell trajectories, revealing complex structures such as cell development in diseases.
Researchers developed a comprehensive map of cell developmental dynamics using AI, enabling the evaluation of computational biology methods. The study highlights outstanding challenges and pioneers new ways to assess trajectory inference methods, leading to improved disease understanding.
A study published in EClinicalMedicine found that preterm babies born without the haptoglobin protein have a higher risk of brain bleeding, cerebral palsy, and death. The absence of the protein may serve as a potential biomarker for increased monitoring or preventive interventions.
Researchers used advanced PET/MRI technology to analyze inflammatory processes in arteries of individuals with atherosclerotic plaques. The study found that inflammation is present at early stages of atherosclerosis, particularly in regions without developed plaques.
Guodong Zhang, a researcher at UMass Amherst, has been awarded the Young Scientist Research Award for his groundbreaking work on reducing colonic inflammation and colon cancer. His research focuses on identifying risk factors and developing new therapeutic targets and biomarkers.
A new study published in the Journal of Nutritional Biochemistry found that green tea extract reduced weight gain and inflammation in mice fed a high-fat diet. The researchers also discovered improved gut health, including more beneficial microbes and less permeability in the intestinal wall. These findings suggest that green tea may h...
Researchers at the University of Tsukuba identify diclofenac as a factor promoting cardiac reprogramming in postnatal and adult fibroblasts, while inhibiting COX-2 and suppressing inflammatory signaling. This finding has important implications for developing new therapies for cardiac regeneration in pediatric and adult patients.
Researchers have found a compound that reduces IBD symptoms in mice by blocking the activity of a gene linked to blood clotting. This compound may be a new therapeutic option for people with severe IBD or those who don't respond to current treatments.
A comprehensive analysis of 14 IBD patient groups and 1,800 intestinal biopsies pinpointed a key genetic component linked to more severe cases. The protein PAI-1 was found to exacerbate colon inflammation by targeting tPA, which protected against injury in mice
A high-fat diet and aging are associated with inflammation in heart failure, as well as changes to the gut microbiome. In mice, a calorie-dense diet altered the composition of the gut microbiome and increased neutrophils, leading to nonresolving inflammation.
Researchers identified ELMO1 as a surprising contributor to rheumatoid arthritis, which may lead to a new treatment and blood test for early detection. The discovery also challenges the understanding of genes' roles in the body.
A UMass Amherst study reveals that citrus compounds can decrease inflammation in the colon by transforming into powerful anti-inflammatory agents through gut bacteria. The research aims to develop diet-based strategies to prevent and treat colon-related diseases.
Researchers found that obstructive sleep apnea promotes a persistent low-intensity inflammatory state, damaging organs. This link could lead to more precise treatments, such as vitamin C or plant-derived antioxidants, to reverse inflammation and protect the body from future damage.
Researchers report five cases of severe tungiasis in traditional Amerindian communities, highlighting the disease's potential for life-threatening progression. Treatment with dimeticone oil has shown effectiveness in resolving inflammation and restoring mobility within a week.
Researchers have identified a therapy derived from parasitic worms that can downregulate proinflammatory pathways and reduce inflammation caused by chemotherapy. The treatment, IPSE, targets the source of inflammation, reversing damage to the bladder lining.
Researchers at University of Freiburg discover new immune cells that promote multiple sclerosis development, creating an immune cell atlas for the brain. Chronic activation of these cells may explain why the brain is chronically attacked in MS patients.
A drug derived from omega-3 fatty acids has been found to reduce osteoarthritis inflammation caused by a high-fat diet, according to researchers at Queensland University of Technology. The study also identified another effective treatment option, clodronate liposomes.
A study published in Developmental Cell reveals that TAK1 preserves endothelial cell survival in an inflammatory environment, suggesting its potential as a target for anti-angiogenic therapy. The researchers used a unique mouse model to show that TAK1 is essential for endothelial cell survival during inflammation and injury.
Research finds certain housing types and tenures associated with higher CRP levels, indicating potential link between housing conditions and inflammation. Home owners with mortgages had lower CRP than renters in the private sector.
A microbial metabolite from pomegranates, Urolithin A, has been shown to reduce inflammatory bowel disease by increasing proteins that tighten epithelial cell junctions in the gut. The researchers also found that a synthetic version of UroA, UAS03, shows therapeutic and protective effects against colitis.
A combination therapy with PCSK9-inhibitors and lipoprotein-apheresis (LA) is proposed as a potential treatment for Homozygous Familial Hypercholesterolaemic (HoFH) patients. LA has potent therapeutic effects on inflammation and related mediators.
A new study found that a probiotic supplement reduced hospitalization time and in-patient treatment for patients with mania. The results suggest that modulating the intestinal microbiota could be a new treatment avenue for patients suffering from psychiatric mood disorders.
A pilot study found that residents living in areas with high oil and gas activity showed higher blood pressure, stiffer blood vessels, and inflammation markers. The study suggests a possible connection between oil and gas development and cardiovascular disease.
A study of 7,026 patients found that persistent high residual inflammatory risk after percutaneous coronary intervention is associated with a higher risk of death from any cause or myocardial infarction within one year. High sensitivity C-reactive protein levels were used to assess the level of risk.
A multidisciplinary team of researchers from Karolinska Institutet in Sweden has developed a new anti-inflammatory drug molecule that inhibits inflammation by targeting a protein involved in the repair of oxygen damage to DNA. The discovery could lead to new treatments for inflammatory diseases such as sepsis, COPD, and severe asthma.