Articles tagged with Inflammation
A recent study published in the New England Journal of Medicine found that benralizumab, an asthma drug, was ineffective in reducing exacerbations in patients with moderate to very severe COPD. The study involved over 3,000 patients and showed no significant decrease in COPD exacerbation rates among those receiving benralizumab.
Research suggests DGKζ enzyme plays a role in suppressing runaway inflammation in asthma. The enzyme's deletion in mouse T cells led to reduced inflammation and airway hyper-responsiveness, two hallmarks of the disease.
A study using praliciguat to stimulate soluble guanylate cyclase found that it can inhibit inflammation and fibrosis in liver cells, suggesting a potential therapy for nonalcoholic steatohepatitis. The results also indicate that praliciguat may suppress stellate cell fibrotic transformation.
Researchers at University of Queensland discover a way to stop inflammation by inhibiting the inflammasome protein complex. This breakthrough could lead to the design of new anti-inflammatory drugs, informing treatment for chronic inflammatory diseases such as Parkinson's and Alzheimer's.
The Fondren Foundation has pledged $15 million to Houston Methodist to support the development of a comprehensive program addressing complex diseases. The new initiative will focus on advancing research and treatment for gastrointestinal disorders, immunological disorders, and food allergies.
Researchers developed a capsule-shaped photoacoustic imaging endoscope to examine intestinal changes in Crohn's disease. The device can differentiate between inflammatory and fibrotic strictures, allowing for more targeted treatment and potentially reducing adverse effects. This technology could also provide real-time diagnostic inform...
Researchers found that using psychological techniques to communicate periodontal disease risk improved dental hygiene and reduced gum inflammation over a three month period. The study also associated the intervention with improved frequency of interdental cleaning.
The study found that phenolic compounds in purple corn altered the development of fat cells and reduced inflammation and insulin resistance. Different combinations of anthocyanins showed varying effects on these biomarkers.
A University of Michigan researcher has found that the mechanics producing wheezing and crackling noises with every breath are likely a cause of injury and inflammation. This new understanding could change how lung diseases are treated and represent a paradigm shift in doctor-patient interactions.
Researchers have developed a new method for transporting medicine through the body, using a sliding molecule that can jump between polymers to deliver medication to specific organs. Laboratory tests confirm the model's effectiveness in delivering molecules to gel-like materials.
A new study reveals that a specific type of immune cell, known as T7 and T8 cells, are responsible for inflammation in eosinophilic esophagitis. The study's findings also raise questions about the safety of a popular dietary supplement called butyrate, which may exacerbate the condition.
A combination of over-the-counter antioxidants shows promise for mitigating damaging effects of heart failure with preserved ejection fraction. Treatment improved markers of vascular function and inflammation in some patients, suggesting a simple and readily available option to improve vascular health.
A new drug targeting brain inflammation, MW-151, is ready for its first round of human testing. The medication aims to block 'bad' inflammation that destroys neurons in Alzheimer's disease.
A study by WVU researchers found that exposure to white light at night causes multiple poor outcomes in cardiac arrest models, including greater cell death, more aggressive inflammation, and higher mortality rates. In contrast, dim red light had no detrimental effects.
Researchers from VIB have developed a map to model cellular dynamics, highlighting outstanding challenges and pioneering new ways of evaluating computational biology methods. This breakthrough enables the study of individual cell trajectories, revealing complex structures such as cell development in diseases.
Researchers developed a comprehensive map of cell developmental dynamics using AI, enabling the evaluation of computational biology methods. The study highlights outstanding challenges and pioneers new ways to assess trajectory inference methods, leading to improved disease understanding.
A study published in EClinicalMedicine found that preterm babies born without the haptoglobin protein have a higher risk of brain bleeding, cerebral palsy, and death. The absence of the protein may serve as a potential biomarker for increased monitoring or preventive interventions.
Researchers used advanced PET/MRI technology to analyze inflammatory processes in arteries of individuals with atherosclerotic plaques. The study found that inflammation is present at early stages of atherosclerosis, particularly in regions without developed plaques.
Guodong Zhang, a researcher at UMass Amherst, has been awarded the Young Scientist Research Award for his groundbreaking work on reducing colonic inflammation and colon cancer. His research focuses on identifying risk factors and developing new therapeutic targets and biomarkers.
A new study published in the Journal of Nutritional Biochemistry found that green tea extract reduced weight gain and inflammation in mice fed a high-fat diet. The researchers also discovered improved gut health, including more beneficial microbes and less permeability in the intestinal wall. These findings suggest that green tea may h...
Researchers at the University of Tsukuba identify diclofenac as a factor promoting cardiac reprogramming in postnatal and adult fibroblasts, while inhibiting COX-2 and suppressing inflammatory signaling. This finding has important implications for developing new therapies for cardiac regeneration in pediatric and adult patients.
Researchers have found a compound that reduces IBD symptoms in mice by blocking the activity of a gene linked to blood clotting. This compound may be a new therapeutic option for people with severe IBD or those who don't respond to current treatments.
A comprehensive analysis of 14 IBD patient groups and 1,800 intestinal biopsies pinpointed a key genetic component linked to more severe cases. The protein PAI-1 was found to exacerbate colon inflammation by targeting tPA, which protected against injury in mice
A high-fat diet and aging are associated with inflammation in heart failure, as well as changes to the gut microbiome. In mice, a calorie-dense diet altered the composition of the gut microbiome and increased neutrophils, leading to nonresolving inflammation.
A UMass Amherst study reveals that citrus compounds can decrease inflammation in the colon by transforming into powerful anti-inflammatory agents through gut bacteria. The research aims to develop diet-based strategies to prevent and treat colon-related diseases.
Researchers identified ELMO1 as a surprising contributor to rheumatoid arthritis, which may lead to a new treatment and blood test for early detection. The discovery also challenges the understanding of genes' roles in the body.
Researchers found that obstructive sleep apnea promotes a persistent low-intensity inflammatory state, damaging organs. This link could lead to more precise treatments, such as vitamin C or plant-derived antioxidants, to reverse inflammation and protect the body from future damage.
Researchers have identified a therapy derived from parasitic worms that can downregulate proinflammatory pathways and reduce inflammation caused by chemotherapy. The treatment, IPSE, targets the source of inflammation, reversing damage to the bladder lining.
Researchers report five cases of severe tungiasis in traditional Amerindian communities, highlighting the disease's potential for life-threatening progression. Treatment with dimeticone oil has shown effectiveness in resolving inflammation and restoring mobility within a week.
Researchers at University of Freiburg discover new immune cells that promote multiple sclerosis development, creating an immune cell atlas for the brain. Chronic activation of these cells may explain why the brain is chronically attacked in MS patients.
A drug derived from omega-3 fatty acids has been found to reduce osteoarthritis inflammation caused by a high-fat diet, according to researchers at Queensland University of Technology. The study also identified another effective treatment option, clodronate liposomes.
A study published in Developmental Cell reveals that TAK1 preserves endothelial cell survival in an inflammatory environment, suggesting its potential as a target for anti-angiogenic therapy. The researchers used a unique mouse model to show that TAK1 is essential for endothelial cell survival during inflammation and injury.
Research finds certain housing types and tenures associated with higher CRP levels, indicating potential link between housing conditions and inflammation. Home owners with mortgages had lower CRP than renters in the private sector.
A microbial metabolite from pomegranates, Urolithin A, has been shown to reduce inflammatory bowel disease by increasing proteins that tighten epithelial cell junctions in the gut. The researchers also found that a synthetic version of UroA, UAS03, shows therapeutic and protective effects against colitis.
A combination therapy with PCSK9-inhibitors and lipoprotein-apheresis (LA) is proposed as a potential treatment for Homozygous Familial Hypercholesterolaemic (HoFH) patients. LA has potent therapeutic effects on inflammation and related mediators.
A new study found that a probiotic supplement reduced hospitalization time and in-patient treatment for patients with mania. The results suggest that modulating the intestinal microbiota could be a new treatment avenue for patients suffering from psychiatric mood disorders.
A pilot study found that residents living in areas with high oil and gas activity showed higher blood pressure, stiffer blood vessels, and inflammation markers. The study suggests a possible connection between oil and gas development and cardiovascular disease.
A study of 7,026 patients found that persistent high residual inflammatory risk after percutaneous coronary intervention is associated with a higher risk of death from any cause or myocardial infarction within one year. High sensitivity C-reactive protein levels were used to assess the level of risk.
A multidisciplinary team of researchers from Karolinska Institutet in Sweden has developed a new anti-inflammatory drug molecule that inhibits inflammation by targeting a protein involved in the repair of oxygen damage to DNA. The discovery could lead to new treatments for inflammatory diseases such as sepsis, COPD, and severe asthma.
CVID patients with enteropathy exhibit more mucosal immunodeficiency and are at risk for gut infection leading to intestinal inflammation. A novel computational approach identified Acinetobacter baumannii as a main microbe responsible for CVID enteropathy.
Researchers are exploring ways to prevent secondary cataracts, a condition that occurs when scar tissue forms in the eye after surgery. Melinda Duncan's team has made several discoveries, including molecules critical for forming PCO scar tissue, and is working on a drug to block this potentially blinding condition.
Researchers at the University of Wisconsin-Madison identified a fatty acid called butyrate as the mechanism behind certain protective effects of a high-fiber diet. Mice with Roseburia bacteria and a high-fiber diet had reduced inflammation and atherosclerosis.
A recent trial found that low-dose methotrexate did not lower cardiovascular event rates in patients at high risk for heart disease and stroke. The study, which included over 4,700 participants, showed no significant reduction in major adverse cardiovascular events compared to placebo.
A study published in Psychosomatic Medicine found that recent bereavement is associated with increased levels of inflammation and cardiovascular illness risk. Sleep disturbances exacerbated the negative effects of grief, highlighting the importance of addressing sleep issues in post-loss health interventions.
A study by Ohio State University researchers found inflammation in the brain region responsible for mood regulation after stress during pregnancy. The study used an animal model of postpartum depression to examine the possible connection between the immune system and the disorder.
A Northwestern University study found that inflammation can disrupt the body's natural sleep-wake cycle, leading to circadian sleep disorders. The research used a genetic switch to turn inflammation on and off in mice, revealing a link between inflammatory diseases and the body's clock.
A recent study published in the Canadian Medical Association Journal found that oral curcumin did not reduce inflammation or improve outcomes in patients undergoing elective abdominal aortic aneurysm repair. In fact, the study showed an increased risk of post-surgical kidney damage in patients taking curcumin.
Researchers used human organ-on-a-chip technology to investigate the mechanism of disease development and found that probiotics can cause more harm than good when the gut barrier is compromised. The study confirms that intestinal barrier disruption is the onset initiator of gut inflammation, a key factor in many diseases.
A study from Rice University found that grief can cause inflammation leading to negative health outcomes such as cardiovascular problems and premature mortality. Researchers discovered that widows and widowers with elevated grief symptoms suffered higher levels of bodily inflammation.
A new study identifies Th17 cells as drivers of periodontitis, a common disorder affecting nearly half of American adults over age 30. The research found that an unhealthy oral microbiome triggers the accumulation of these immune cells, leading to inflammation and bone loss.
Researchers at Duke University discovered a minimally invasive treatment using vagus nerve stimulation to reduce brain inflammation and cognitive decline after surgery. The study showed improved cognitive outcomes and reduced brain inflammation in mice with inflammation.
A new study by Penn State researchers found that childhood exposure to allergens can lead to persistent lung inflammation, which may contribute to the development of anxiety later in life. The study also found that episodes of labored breathing were associated with short-term anxiety.
Researchers found that NLRP12 promotes healthy gut bacteria, which produce butyrate and propionate, protecting against obesity and insulin resistance. The study suggests a potential therapeutic target for treating obesity and diabetes.
Researchers at UC San Diego School of Medicine discovered that ubiquitination influences GPCR function and promotes inflammation. Existing cancer drugs targeting enzymes involved in ubiquitination may be repurposed to treat vascular inflammation.
Researchers at Sanford Burnham Prebys Medical Discovery Institute have identified a previously unknown astrocyte subpopulation that plays a key role in driving brain inflammation. The newly discovered 'ieAstrocytes' are activated early in neuroinflammatory diseases, such as multiple sclerosis and Alzheimer's disease.
A study found that inhibiting atypical protein kinase C reduces increased vessel permeability and blocks inflammation, potentially helping protect vision in patients with eye diseases. The therapy has therapeutic potential for diabetic retinopathy, uveitis, and retinal vein and artery occlusions.
A large-scale study found that diclofenac, a common painkiller, is associated with an increased risk of major cardiovascular events such as heart attack and stroke. The study suggests that diclofenac should not be available over the counter and when prescribed, should come with a warning about its potential risks.
Researchers have identified the genetic mechanisms underlying preterm labor by studying the Nodal gene. Variations of the gene and inflammation are associated with an increased risk of premature delivery.
Researchers developed a novel imaging biomarker to quantify coronary artery inflammation, capturing changes in perivascular fat on CT angiography. This biomarker is associated with increased rates of death from any cause and cardiac causes.
Researchers at Ohio State University found a strong link between hostility in marriages and the presence of bacteria in the bloodstream, leading to inflammation. Lifestyle changes such as healthy diets and probiotics may help mitigate this effect.