Articles tagged with Inflammation
A study reveals that fat cells' immune response amplifies inflammation, driving obesity-related disease. Type I Interferons produced by fat cells trigger a vicious cycle of inflammation, which can worsen metabolic issues and increase the risk of diseases like type 2 diabetes and COVID-19.
Researchers have discovered a novel drug that selectively controls excessive inflammation, a key driver of conditions like osteoarthritis and COVID-19. APPA demonstrates anti-inflammatory potential without compromising the body's ability to fight off infections.
A transgenic mouse model of HLH has been found to be effective in treating severe COVID-19 patients by calming the 'cytokine storm', a common feature of children battling secondary HLH. Ruxolitinib showed promising results, with 90% of patients showing CT scan improvement within 14 days.
Researchers identified a novel strategy to address underlying causes of LAD1 patients' symptoms by mimicking the efferocytosis process, which was absent in these individuals. The study found that small-molecule compounds that stimulate this process alleviated signs of inflammation and promoted bone regeneration in animal models.
Four critically ill COVID-19 patients improved significantly after receiving the experimental therapeutic CAP-1002, which contains cardiosphere-derived cells. The treatment helped reduce inflammation and showed no adverse effects, with all patients discharged from the hospital.
Researchers at Salk Institute discover two genes that regulate levels of healthy fats called FAHFAs, which decrease inflammation and increase insulin sensitivity. An experimental drug successfully increases FAHFA levels by blocking the activity of these genes, offering new insights into therapies for metabolic and inflammatory diseases.
Researchers aim to identify the mechanism of whole strawberry's anti-inflammatory effects on gut health. The study will test hypotheses that whole strawberry inhibits colon inflammation by restoring gut microflora balance.
A study published in eLife found that rapamycin, an immune-suppressing drug, reduces bone loss, inflammation, and changes to oral bacteria in older mice with gum disease. The treatment also reversed clinical features of periodontal disease, suggesting a potential approach for age-related dental problems.
A study by Charité - Universitätsmedizin Berlin reveals that the amoeba Entamoeba gingivalis plays a key role in periodontitis, causing inflammation and tissue destruction. The parasite's elimination may improve treatment outcomes for patients with gum disease.
Researchers propose a new therapeutic modality for sepsis by targeting cell-free chromatin in healthy cells. The study found that three cfCh-inactivating agents improved parameters related to sepsis, including increased survival rates in mice.
Scientists studied monocytes in young and elderly individuals, finding that energy production decreases and inflammation markers increase with age. This research provides a foundation for understanding age-related changes and potential solutions to slow down vascular calcification and atherosclerosis.
MIT biological engineers develop a multitissue model of the colon and liver, revealing how different tissues contribute to inflammatory diseases. The study finds that metabolic byproducts generated by bacteria play an important role in exacerbating inflammation.
Researchers discovered how protein A20 prevents inflammation through a non-enzymatic mechanism, opening up new possibilities for treatment. The study builds upon earlier work demonstrating A20's anti-inflammatory activity and reveals its role in preventing disease development.
A recent study published in Oncotarget found that microRNA (miR) dysregulation is associated with immune cell activation, gastric inflammation, and carcinogenesis. Specifically, miR-155 upregulation is considered a key marker of chronic gastric inflammation and predisposes patients to gastric carcinogenesis.
Researchers from the University of South Australia have developed a nano formulation that increases curcumin's oral bioavailability by 117%, paving the way for clinical trials for Alzheimer's. The delivery method also shows promise in preventing genital herpes, with curcumin able to stop the virus and reduce inflammation.
Researchers at Karolinska Institutet in Sweden have discovered a link between cognitive impairment and lasting inflammation after intensive care. Elevated blood levels of HMGB1 protein were found in patients with post-intensive care syndrome (PICS), which can cause impairments in memory, attention, and problem-solving for years.
Walter and Eliza Hall Institute researchers have pinpointed immune cells called natural killer (NK) cells as an unexpected source of the inflammatory protein GM-CSF in rheumatoid arthritis. The discovery may indicate potential new therapeutic targets for reducing joint inflammation in this autoimmune disease.
Researchers at Massachusetts General Hospital used cutting-edge imaging technology to detect abnormally low levels of a key protein in the brains of young men with autism. The study suggests that these low levels may be linked to inflammation and metabolism, and could have important implications for understanding the origins of autism.
Eating a Mediterranean diet for a year boosts beneficial gut bacteria, reduces inflammation, and may help curb frailty and cognitive decline in older people. The diet is associated with increased diversity of the microbiome, improved brain function, and reduced harmful inflammatory chemicals.
Research found that optimistic patients had lower inflammation levels, reduced stroke severity, and less physical disability after three months. Optimism was linked to better disease outcomes, suggesting a positive environment can benefit recovery.
Eternygen presents preclinical study data demonstrating INDY inhibition reverses nonalcoholic steatohepatitis (NASH) in a diet-induced mouse model. The treatment also reduces liver injury and inflammation.
A study by UC Davis Health researchers found that a Western diet rich in fat and sugar can induce inflammatory skin diseases like psoriasis. The diet's components, rather than obesity, may lead to skin inflammation and its development.
Researchers have discovered that indole, a natural compound found in gut bacteria and cruciferous vegetables, can reduce inflammation and fatty deposits in the liver. This study provides hope for new treatments and preventive measures for non-alcoholic fatty liver disease (NAFLD).
A preclinical trial found that retinoid X receptor (RXR) enhances the clearance of dead cells and debris in the brain after a stroke, limiting inflammation and improving recovery. RXR activation could lead to discovery of a promising new therapeutic target for improving neurological outcomes.
Research suggests that a ketogenic diet provides health benefits in short-term, but negative effects occur after about a week. The keto diet works best in small doses, increasing tissue-protective cells called gamma delta T-cells, which lower diabetes risk and inflammation.
Researchers at the University of Freiburg have developed a light therapy approach that successfully treats severe autoimmune reactions in cancer patients. The extracorporeal photopheresis (ECP) treatment activates immune cells to stop inflammation, offering a promising alternative to cortisone therapy.
Research suggests that supplementing with short chain fatty acids can improve stroke recovery by reducing inflammation and promoting neuroinflammation. The study found that mice who drank water with added fatty acids experienced better stroke recovery, including reduced motor impairment and increased spine growth.
A new study found that delivering the TB vaccine intravenously dramatically improves its potency, offering nearly full protection against TB in monkeys. The vaccine was highly effective when administered via injection into a vein, reducing bacterial burden by 100,000-fold and inflammation in lungs to near zero.
A study by McMaster University researchers found that levels of NT-proBNP, a common cardiac blood test, can predict cardiac and vascular complications after non-cardiac surgery. The test may help doctors identify patients at risk and inform treatment decisions.
Researchers at Cincinnati Children's Hospital Medical Center discovered a new molecular process in mice that triggers T cell-driven inflammation and causes autoimmune diseases. The study found that interactions between myeloid cells and CD4-positive T cells produce excessive IL-1b, leading to auto-inflammatory diseases.
Researchers at Case Western Reserve University have discovered a crucial connection between interleukin-1α and gut microbiome function in a mouse model of Crohn's disease. Blocking this protein reduces intestinal inflammation severity, with effects comparable to steroids, which are the current gold standard treatment.
A new human autoinflammatory disease called CRIA syndrome has been discovered and identified by an Australian-US research team. The disease is caused by a mutation in the RIPK1 protein, leading to uncontrolled cell death and inflammation.
Researchers found that energy-producing mitochondria in muscles were abnormal and showed signs of oxidative damage, contributing to chronic muscle weakness. The study suggests the need for antioxidant therapies or other treatments to restore mitochondrial health.
A study by Wake Forest School of Medicine identified a dead probiotic strain that reduces age-related leaky gut and inflammation in older mice. The dead probiotic strain, Lactobacillus paracasei D3-5, extended the lifespan of roundworms and improved physical and cognitive functions in mice.
The NeutroCure project focuses on harnessing the potential of reactive oxygen species (ROS) produced by neutrophils to treat inflammatory diseases. By developing safe ROS amplifiers, the consortium aims to selectively target pathogenic inflammation and cancer cells while minimizing damage to healthy tissues.
A new treatment approach for cystic fibrosis may reduce the need for lung transplants and lower mortality rates. Researchers found that a small molecule reduced inflammation and cleared lungs of bacteria in a laboratory model.
Researchers found that mice lacking an inflammation resolution sensor developed spontaneous obesity, heart disease, and shortened lifespan, indicating impaired inflammation resolution. This study sheds light on the sensor's integrative role in managing cardiometabolic health and inflammation-resolution processes.
A study of over 200 patients with bipolar disorder found that high levels of inflammation, as measured by C-reactive protein, were significantly linked to poor cognitive performance. This suggests a potentially modifiable risk factor for cognitive deficits, and highlights the importance of addressing inflammation in treatment.
A study by Yale researchers has found that adipose B cells in belly fat unexpectedly proliferate with aging, contributing to increased inflammation and metabolic decline. The expansion can be reversed by reducing macrophage signals and removing adipose B cells.
Patients with inflammatory bowel disease are more likely to develop Parkinson's disease due to shared underlying inflammation. While the risk is small, early detection and intervention may be crucial in slowing or stopping PD progression.
A six-week treatment with low-dose oral prednisolone substantially improves pain and decreases signs of inflammation in patients with painful hand osteoarthritis. Substantial improvements in pain and function were seen, exceeding effects of currently available therapies.
A large-scale trial found that vitamin D and omega-3 fatty acid supplements had no effect on reducing markers of systemic inflammation in older US adults. However, participants with low initial fish intake saw a decrease in inflammation biomarkers after taking the omega-3 supplement.
Researchers have developed a non-invasive method to visualize kidney disease in live animals using genetically modified mice. They found that a promising chemical found in citrus fruit, G-Hes, reduces inflammation in the kidneys when fed to mice with kidney disease.
Researchers at Washington State University have identified a new therapeutic target for the treatment of gout, a common type of arthritis that causes episodes of painful and stiff joints. Blocking the signaling molecule TAK1 can suppress inflammation caused by gout, according to the study.
Researchers discover a new drug that reduces inflammation and improves heart function in genetically inherited heart disease, ACM. The treatment targets the immune system's role in disease progression.
A study published in the Journal of Investigative Dermatology found that ketogenic diets heavy in coconut oil and palm oils worsened psoriasiform-like skin inflammation in mice. In contrast, well-balanced ketogenic diets with long-chain triglycerides did not exacerbate skin inflammation.
Increased inflammatory activity found in FTD patients, associated with parkinsonism symptoms and rapid disease progression. The study also revealed a low prevalence of cancer among FTD patients, suggesting an overactive immune system may contribute to the disease.
Researchers found that coffee bean extracts reduced fat-induced inflammation and improved glucose absorption and insulin sensitivity in mice. The compounds protocatechuic acid and gallic acid showed promise as a strategy for preventing obesity-related chronic illnesses.
Researchers have identified a new class of therapy for dry eye disease by targeting anti-citrullinated protein autoantibodies (ACPA) with antibody-based eye drops. The treatment has shown statistically significant and clinically meaningful reductions in corneal damage and symptoms in patients with severe dry eye disease.
A randomized clinical trial found that high-dose intravenous vitamin C did not reduce organ failure, inflammation, or vascular injury in patients with sepsis and acute respiratory distress syndrome (ARDS). The study's limitations include underpowered detection of differences and insufficient dosage.
Researchers found that inflammation amplifies neurite growth in neurons involved in thermal sensations, leading to increased pain hypersensitivity. Cav2.2 calcium channel genes play a key role in this process, promoting thermosensitive neuronal activity and sensory nerve outgrowth.
Researchers found that certain flavored e-cigarette flavors, even without nicotine, can exacerbate asthma symptoms and increase tissue scarring. Flavors like Black Licorice and Banana Pudding were particularly problematic.
Researchers discovered LH dipeptide as a potent anti-inflammatory agent that inhibits the secretion of inflammatory cytokines from microglia, reducing brain inflammation and depression symptoms. Consuming foods rich in LH dipeptide may be a safe method for maintaining good mental health.
A plant-based diet has been shown to reduce inflammation and improve symptoms of rheumatoid arthritis through various mechanisms. Studies have found that plant-based diets are low in fat and high in fiber, which can reduce inflammatory markers and promote healthy gut bacteria.
A NIH-funded clinical trial found that methotrexate was more effective than mycophenolate mofetil in controlling inflammation and treatment success for patients with severe forms of uveitis. At six months, 74% of participants in the methotrexate group achieved control compared to 55% in the mycophenolate group.
A study using a blood marker of inflammation found an association between late adolescence inflammation and death among Swedish men up to age 57. The results suggest that chronic inflammation in young adulthood may increase the risk of mortality decades later.
Researchers at Stanford University School of Medicine have found that inflammation in the lungs can wake up a silent genetic defect that causes sudden onset cases of pulmonary hypertension. The study suggests that limiting potential environmental causes of lung inflammation may help prevent the development of the disease.
A Yale-led study reveals that transforming growth factor beta (TGFß) proteins trigger inflammation in endothelial cells, leading to plaque buildup and atherosclerosis. Disrupting TGFβ receptors with RNAi drug reduces inflammation and plaque effectively.
Researchers at University of California San Diego School of Medicine found that removing the enzyme PHLPP1 improves outcomes in a mouse model of sepsis. The study introduces the possibility of inhibiting PHLPP1 as a new treatment for sepsis.
A recent study by Anna M. Gruener et al., published in JAMA Ophthalmology, investigated the association between giant cell arteritis and race. The researchers found a significant association between the disorder and certain ethnic groups, with increased risk observed in African Americans, Hispanics, and individuals of mixed ancestry.