Articles tagged with Inflammation
Researchers found that early-life inflammation weakens the brain's ability to cope with stress, leading to adolescent depression. Microglial cells overengage with neurons, reducing glutamatergic neuronal activity.
Research suggests that telomere shortening drives intestinal inflammation in inflammatory bowel disease (IBD). Telomere erosion is positively associated with disease severity and may underlie disease recurrence.
A new experimental model using human stem cells successfully tested the impact of a next-generation anti-inflammatory drug on the brain's blood-brain barrier. The results showed that the breakdown of the barrier is more complex than previously thought and can be prevented with antioxidants.
The European Alliance of Associations for Rheumatology taskforce provides guidelines for treating severe COVID-19 with immunomodulatory therapies. The recommendations consider the individual's condition and stage of the disease, including antiviral medicines, oxygen therapy, and anticoagulation.
A new study reveals that common OTC drugs for sore throat are more harm than good, causing inflammation and damage to upper respiratory cells. Biovanta, a naturally derived drug, has been shown to reduce inflammation and treat respiratory inflammation effectively.
This autopsy study investigated skeletal muscle and myocardial inflammation in patients with COVID-19, compared to those dying from other causes. The findings suggest distinct inflammatory patterns in the two groups, which may help explain COVID-19 severity and mortality.
A study found that the Tsimane indigenous people have slower brain atrophy than Westerners, suggesting their physically active lifestyle and high-fiber diet may hold the key to slowing down aging. The researchers enrolled 746 Tsimane adults in their study and compared their brain volumes with those in three industrialized populations.
New research suggests that anti-cancer therapies can hasten cellular aging, leading to increased inflammation and fatigue in patients with head and neck cancer. Epigenetic changes associated with these treatments may contribute to age-related conditions.
A new study published in the Journal of the American College of Cardiology found that a diet proven to lower elevated blood pressure, known as the DASH diet, reduces inflammation and heart injury. The findings also showed that a low-sodium diet can improve cardiovascular risk factors in a relatively short time period.
A new study from Rice University found that widowed spouses with higher levels of bodily inflammation experienced more severe symptoms of depression three months later. The researchers identified a potential biomarker to predict who is at greatest risk for long-term repercussions of loss.
The VOYAGE study found that dupilumab reduced asthma exacerbations by 59.3% in children with uncontrolled moderate-to-severe asthma. The treatment also improved lung function within two weeks, an effect sustained for up to 52 weeks.
Researchers at Newcastle University discovered that tiny pieces of genetic material, miR-424-5p, increase in early stages of heart disease in type 1 diabetes patients. This biomarker has the potential to define additional therapeutic options to help patients with type 1 diabetes.
Researchers created a detailed cell atlas of COVID lungs, revealing a trifecta of detrimental effects: runaway inflammation, direct destruction, and impaired regeneration of lung cells involved in gas exchange. This study provides leads on why survivors experience long-term respiratory complications due to lung scarring.
A new study published in PLOS Pathogens found that mice fed a Western-style diet high in processed foods and low in fiber developed persistent infections that led to inflammation and insulin resistance. The researchers suggest that altering gut microbiota through diet may be a means of promoting health.
Recent studies point to links between environmental exposures and health risks, including respiratory problems from hog farms and inflammation caused by triclosan. Gulf War veterans may also be more susceptible to alcohol-induced liver damage due to environmental factors.
A new study in Arthritis & Rheumatology identifies specific blood markers to distinguish excessive COVID-19 inflammation from cytokine storm syndromes. This finding has significant implications for treating critically ill patients with COVID-19.
Researchers found that probiotic Lactobacillus acidophilus strain LA1 generates a rapid and sustained enhancement of the intestinal barrier, effectively treating intestinal inflammation. The study also showed that LA1 can prevent colonic inflammation formation and promote healing in mice with induced colitis.
Researchers identified serum amyloid A (SAA) as a potential biomarker for COVID-19 risk, with higher levels associated with increased inflammation, clot abnormalities, and organ damage. This biomarker could help facilitate early identification of patients requiring aggressive management and monitoring.
A new positron emission tomography (PET) tracer targeting inflammation has been shown to be safe and effective in identifying early stages of rheumatoid arthritis. The tracer rapidly clears from blood circulation and has a low radiation dose, making it suitable for patient imaging studies.
Researchers at CNIO discover that digoxin, a drug used for heart diseases, reduces inflammation and leads to significant weight loss in obese mice. The study identifies IL-17A as a causal factor of obesity, suggesting a potential therapeutic option for treating the inflammatory disease.
Researchers from NUST MISIS have created innovative multilayer coatings that synthesizes protective properties of nanoparticles, biopolymers, anticoagulants, and antibiotics. The coatings demonstrated excellent bactericidal efficacy against antibiotic-resistant bacterial strains with a prolonged antibacterial effect up to 7 days.
A recent Finnish study found that accumulating brisk and vigorous physical activity can curb adiposity-induced low-grade inflammation in children. The study, conducted among researchers from Finland and the UK, also reported no independent association between diet quality and low-grade inflammation.
COVID-19 survivors may experience blood clots due to a lingering immune response that damages blood vessels. The study found twice as many damaged blood vessel cells in COVID-19 survivors compared to healthy individuals.
Researchers investigating COVID-19's impact on the thyroid gland found atypical inflammation in 1/3 of patients after 3 months, raising concerns about potential long-term damage. The study aims to determine if this inflammation triggers permanent thyroid dysfunction.
A four-year federal grant of over $2 million is being awarded to Dr. Andrew Gewirtz at Georgia State University to investigate the role of inflammation and altered gut microbiota in the development of metabolic syndrome.
Researchers found that prenatal stress leads to significant inflammation in the fetal brain, but surprisingly, the mother's placenta and uterus remain unactivated. Instead, stress reduces gut microbial strains and functions, especially those linked to inflammation.
The Medical University of South Carolina has enrolled children with multisystem inflammatory syndrome in children (MIS-C) in a trial of remestemcel-L, a novel cellular therapy. The treatment showed significant improvement within 24 hours for two patients, offering hope for better management of the rare but life-threatening condition.
A UMass Amherst study found a positive linear relationship between tobacco smoking intensity and duration with inflammation in HIV-positive individuals. The researchers suggest that people living with HIV would benefit from quitting or reducing smoking to lower inflammation levels, which are linked to increased disease risk.
Researchers at RCSI University of Medicine and Health Sciences have discovered a new way to halt excessive inflammation by regulating Arginase-2, a protein that limits inflammatory cytokine production. This breakthrough has the potential to protect the body from tissue damage caused by inflammatory diseases.
A large-scale study published in JAMA Cardiology found that inflammatory heart disease is rare among professional athletes with mild or asymptomatic COVID-19 infection. Only five out of 789 athletes developed heart inflammation, indicating a very low incidence of heart risk after mild COVID-19.
Researchers identified three patient segments based on blood lymphocyte counts and PET/CT scan findings, indicating varying levels of disease activity. The discovery could help guide treatment and understand the underlying mechanisms associated with sarcoidosis.
Researchers at WashU Medicine have found a new way to block chronic lung diseases such as asthma and COPD by targeting the packaging of inflammatory cytokines in exosomes. By blocking the release of these packaged cytokines, they can prevent damage to the lungs and slow disease progression in mice.
Researchers identified a mechanism linking acrolein accumulation to glycocalyx modifications, damaging the blood-brain barrier. The study suggests that acrolein-modified proHPSE could be a novel drug target for post-stroke inflammation.
A new study published in Nature Communications found that high fructose diets can cause the immune system to become inflamed, leading to damage and increasing the risk of disease. The research also suggests a link between fructose consumption and obesity, type 2 diabetes, and non-alcoholic fatty liver disease.
Researchers found that people with periodontitis are at higher risk of experiencing major cardiovascular events due to associated inflammation. Active gum disease was predictive of arterial inflammation, leading to heart attacks, strokes, and other cardiovascular complications.
A new study reports that activated B. infantis EVC001 improves health outcomes in preterm infants by reducing enteric inflammation, diaper rash, and antibiotic use. The probiotic also enhances gut microbial composition and reduces pathogenic bacteria, leading to improved clinical outcomes.
Researchers developed a bioactive coating that sequentially turns on and off inflammation on bone implants under osteoporotic conditions. The coating harnesses the power of immune responses to enhance implanting efficacy without increasing the number or stimulating function of bone cells.
A new study reveals a 'weak point' in a type of gut bacteria that causes intestinal inflammation in patients with Crohn's disease. The researchers found that interfering with the bacteria's process relieved gut inflammation in a mouse model of Crohn's disease.
A growing body of evidence suggests that losing helminth parasites could contribute to aging-associated inflammation. Intentional infection with helminths or helminth-derived proteins may have anti-inflammaging properties, potentially preventing age-related diseases such as heart disease and dementia.
Research suggests that immune cells in the brain, microglia, contribute to negative mood experienced during inflammation and neurological diseases. Activating these cells can elicit a negative affective state in mice, highlighting their potential link to depression.
A specific astrocyte sub-population serves a protective, anti-inflammatory function in the brain based on signals regulated by gut bacteria. The discovery guides researchers toward innovative therapies for neurological diseases like multiple sclerosis and brain tumors.
Cholesterol crystals are identified as a primary cause of preeclampsia, triggering an inflammatory response that affects the communication between mother and foetus. This discovery may lead to more effective treatment options, including cholesterol-lowering medications.
Researchers found C. diff produces toxins causing inflammation and damage to the gut lining, allowing it to thrive in an environment with less competition for nutrients. This process enables the pathogen to utilize amino acids from collagen for growth, further promoting its survival and persistence.
Researchers at the University of Birmingham have discovered a biological imbalance between free radicals and antioxidant cells that links gum disease to chronic kidney disease. A 10% increase in gum inflammation reduces kidney function by 3%, highlighting the importance of periodontal care for patients with chronic kidney disease.
A new study published in Cancer suggests that inflammation from ADT is linked to higher levels of fatigue in prostate cancer patients. The researchers found an increase in the inflammation marker IL-6 in this group, which may contribute to symptoms.
A case of COVID-19 is reported to cause severe ocular neuropathy and panuveitis, a rare inflammatory condition affecting the uvea and retina. The condition was diagnosed in a 55-year-old male patient, who experienced sudden vision loss and pain.
Researchers identified two inflammatory pathways involving complement and the inflammasome that promote abnormal blood vessel formation in wet AMD. Blocking these pathways, including essential proteins of the inflammasome, may lead to improved therapies for this common blinding disease.
A large US study confirmed many COVID-19 complications, with pneumonia, respiratory failure, and sepsis being the most common. The study found that approximately 27% of patients developed serious conditions, while relatively low risks were associated with stroke and certain cardiovascular conditions.
A team of RUDN University biologists created a hibiscus-based dietary supplement for rainbow trout, reducing their sensitivity to ammonia pollution and improving stress resistance. The study found that the fish that received the supplement grew faster, had healthier livers, and stronger immune systems.
Researchers from RUDN University have developed a new method to analyze cytokines in nasal swabs to predict disease flow and prevent complications in asthma patients with accompanying diseases. The study found that monitoring specific cytokine profiles can help identify dangerous tendencies and allow for timely intervention.
Several patients using germicidal lamps developed painful inflammation of the cornea after exposure, prompting warnings from ophthalmologists. Manufacturer recommendations must be closely followed to prevent injury.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have created a drug that can lure stem cells to damaged tissue, improving treatment efficacy for neurological disorders. The discovery could expand the use of stem cell therapies to new conditions such as heart disease or arthritis.
Researchers have found that excessive calcium triggers inflammation in ischemic strokes, leading to worse outcomes. Targeting this calcium overload may offer a new way to control inflammation and improve patient recovery.
A recent study has discovered a link between intestinal flora and inflammation in the central nervous system of patients with multiple sclerosis. IgA B cells play a key role in this process, accumulating in the cerebrospinal fluid and brain tissue during acute flares of the illness.
A team of researchers has discovered a drug-like compound that blocks the CD14 inflammatory protein, reducing inflammation and preventing cytokine storms in laboratory tests. The compound's potential as a new treatment for inflammatory diseases, including COVID-19, is being explored in pre-clinical trials.
Researchers found that mid-range levels of an immune marker at birth are associated with the lowest risk for autism spectrum disorder. Babies born with high levels of inflammation had a higher risk of developing ASD.
A new study shows that methotrexate significantly improves physical function and reduces inflammation in adults with primary knee osteoarthritis. Patients who received methotrexate treatment had improvements in WOMAC scores and reduced inflammatory markers, while those taking glucosamine showed no significant benefits.
A new study from Cedars-Sinai found that the ACE2 enzyme, which helps coronavirus infect cells, also plays a role in gut inflammation and patient outcomes in inflammatory bowel disease. Treatment with anti-inflammatory drugs for IBD may aid recovery from COVID-19.
A new study identifies an autoimmune antibody as a cause of COVID-19 blood clots in up to half of patients. Researchers found that blocking or removing these antibodies may improve outcomes for severely ill patients.
A new clinical study demonstrates that a non-living strain of Prevotella histicola can treat systemic inflammation in mild to moderate psoriasis through oral delivery. The treatment showed significant reductions in Psoriasis Area Severity Index (PASI) and Lesion Severity Scores (LSS), with minimal side effects.