Articles tagged with Inflammation
Researchers found that people with periodontitis are at higher risk of experiencing major cardiovascular events due to associated inflammation. Active gum disease was predictive of arterial inflammation, leading to heart attacks, strokes, and other cardiovascular complications.
A new study reports that activated B. infantis EVC001 improves health outcomes in preterm infants by reducing enteric inflammation, diaper rash, and antibiotic use. The probiotic also enhances gut microbial composition and reduces pathogenic bacteria, leading to improved clinical outcomes.
Researchers developed a bioactive coating that sequentially turns on and off inflammation on bone implants under osteoporotic conditions. The coating harnesses the power of immune responses to enhance implanting efficacy without increasing the number or stimulating function of bone cells.
A new study reveals a 'weak point' in a type of gut bacteria that causes intestinal inflammation in patients with Crohn's disease. The researchers found that interfering with the bacteria's process relieved gut inflammation in a mouse model of Crohn's disease.
A growing body of evidence suggests that losing helminth parasites could contribute to aging-associated inflammation. Intentional infection with helminths or helminth-derived proteins may have anti-inflammaging properties, potentially preventing age-related diseases such as heart disease and dementia.
A specific astrocyte sub-population serves a protective, anti-inflammatory function in the brain based on signals regulated by gut bacteria. The discovery guides researchers toward innovative therapies for neurological diseases like multiple sclerosis and brain tumors.
Research suggests that immune cells in the brain, microglia, contribute to negative mood experienced during inflammation and neurological diseases. Activating these cells can elicit a negative affective state in mice, highlighting their potential link to depression.
Cholesterol crystals are identified as a primary cause of preeclampsia, triggering an inflammatory response that affects the communication between mother and foetus. This discovery may lead to more effective treatment options, including cholesterol-lowering medications.
Researchers found C. diff produces toxins causing inflammation and damage to the gut lining, allowing it to thrive in an environment with less competition for nutrients. This process enables the pathogen to utilize amino acids from collagen for growth, further promoting its survival and persistence.
Researchers at the University of Birmingham have discovered a biological imbalance between free radicals and antioxidant cells that links gum disease to chronic kidney disease. A 10% increase in gum inflammation reduces kidney function by 3%, highlighting the importance of periodontal care for patients with chronic kidney disease.
A new study published in Cancer suggests that inflammation from ADT is linked to higher levels of fatigue in prostate cancer patients. The researchers found an increase in the inflammation marker IL-6 in this group, which may contribute to symptoms.
A case of COVID-19 is reported to cause severe ocular neuropathy and panuveitis, a rare inflammatory condition affecting the uvea and retina. The condition was diagnosed in a 55-year-old male patient, who experienced sudden vision loss and pain.
Researchers identified two inflammatory pathways involving complement and the inflammasome that promote abnormal blood vessel formation in wet AMD. Blocking these pathways, including essential proteins of the inflammasome, may lead to improved therapies for this common blinding disease.
A large US study confirmed many COVID-19 complications, with pneumonia, respiratory failure, and sepsis being the most common. The study found that approximately 27% of patients developed serious conditions, while relatively low risks were associated with stroke and certain cardiovascular conditions.
A team of RUDN University biologists created a hibiscus-based dietary supplement for rainbow trout, reducing their sensitivity to ammonia pollution and improving stress resistance. The study found that the fish that received the supplement grew faster, had healthier livers, and stronger immune systems.
Researchers from RUDN University have developed a new method to analyze cytokines in nasal swabs to predict disease flow and prevent complications in asthma patients with accompanying diseases. The study found that monitoring specific cytokine profiles can help identify dangerous tendencies and allow for timely intervention.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have created a drug that can lure stem cells to damaged tissue, improving treatment efficacy for neurological disorders. The discovery could expand the use of stem cell therapies to new conditions such as heart disease or arthritis.
Several patients using germicidal lamps developed painful inflammation of the cornea after exposure, prompting warnings from ophthalmologists. Manufacturer recommendations must be closely followed to prevent injury.
Researchers have found that excessive calcium triggers inflammation in ischemic strokes, leading to worse outcomes. Targeting this calcium overload may offer a new way to control inflammation and improve patient recovery.
A recent study has discovered a link between intestinal flora and inflammation in the central nervous system of patients with multiple sclerosis. IgA B cells play a key role in this process, accumulating in the cerebrospinal fluid and brain tissue during acute flares of the illness.
A team of researchers has discovered a drug-like compound that blocks the CD14 inflammatory protein, reducing inflammation and preventing cytokine storms in laboratory tests. The compound's potential as a new treatment for inflammatory diseases, including COVID-19, is being explored in pre-clinical trials.
Researchers found that mid-range levels of an immune marker at birth are associated with the lowest risk for autism spectrum disorder. Babies born with high levels of inflammation had a higher risk of developing ASD.
A new study shows that methotrexate significantly improves physical function and reduces inflammation in adults with primary knee osteoarthritis. Patients who received methotrexate treatment had improvements in WOMAC scores and reduced inflammatory markers, while those taking glucosamine showed no significant benefits.
A new study from Cedars-Sinai found that the ACE2 enzyme, which helps coronavirus infect cells, also plays a role in gut inflammation and patient outcomes in inflammatory bowel disease. Treatment with anti-inflammatory drugs for IBD may aid recovery from COVID-19.
A new study identifies an autoimmune antibody as a cause of COVID-19 blood clots in up to half of patients. Researchers found that blocking or removing these antibodies may improve outcomes for severely ill patients.
A new clinical study demonstrates that a non-living strain of Prevotella histicola can treat systemic inflammation in mild to moderate psoriasis through oral delivery. The treatment showed significant reductions in Psoriasis Area Severity Index (PASI) and Lesion Severity Scores (LSS), with minimal side effects.
Researchers have found a significant decline in average body temperature among healthy adults worldwide, with a drop of 0.09°F per year over the past two decades. The study, conducted in Bolivia and the US, suggests that improved hygiene, clean water, vaccinations, and medical treatment may be contributing factors.
A study published in Science Translational Medicine found that tryptophan, an amino acid present in turkey, combined with certain probiotics, can help individuals with celiac disease heal and manage symptoms. The research suggests targeting tryptophan metabolism in the gut may offer a potential therapy for better symptom control.
Research shows that childhood maltreatment affects girls more than boys, leading to higher levels of low-grade inflammation. Girls who experienced abuse at a young age are at risk for significant health problems later in life.
Researchers discovered that MG53 blocks inflammation and protects lungs from flu-induced death in mouse studies, offering a potential new therapy for the top-10 cause of global deaths. The treatment prevents excessive inflammation without affecting the virus itself.
A study from the University of Queensland found that a gene controlling inflammation increases the risk of obesity. Researchers discovered that variations in this gene lead to excessive inflammation in fat tissue, contributing to weight gain. By turning off the gene in mice, they were able to prevent weight gain and reduce diabetes risk
A high-fibre diet has been found to offset chronic gastrointestinal damage caused by radiotherapy, reducing radiation-induced inflammation in the digestive system. This contradicts long-held clinical recommendations that advise a restricted fibre diet for cancer patients undergoing radiotherapy treatment.
Researchers developed an optoelectronic implant that stimulates sensory neurons with light, inducing mild inflammation in animals. This study shows a neuroimmune interaction between pain and inflammation, offering new insights into future treatments.
A recent study published in iScience found that Δ9-tetrahydrocannabinol (THC) suppressed inflammation in the colon, preventing the onset of cancers caused by a carcinogen. THC treatment also prevented the development of colon cancers in mice.
A RUDN geneticist discovered that a bifidobacterial surface protein can stop excessive inflammation in COVID-19 patients. The protein's fragment has shown effective binding to TNF-α, a key factor of inflammation, opening a prospect for developing new anti-inflammatory drugs.
A new study found that depression is associated with increased inflammation and metabolic changes, but not anxiety. The research used blood samples from over 300 people with depression and anxiety to identify biochemical markers, revealing distinct patterns of lipid metabolism and immune system involvement.
A new study from Northwestern University finds that COVID-19 patients on ventilators are at risk of permanent nerve damage due to prone positioning. The study reveals that 12% to 15% of the most severely ill patients have experienced such injuries.
Researchers at Rutgers University are exploring the link between uncontrolled inflammation and microglial cells in the brain, aiming to develop new therapies for neurodegenerative diseases. The team is designing nanomedicines that can target microglia to tamp down inflammation and protect neurons.
A recent study has found a significant link between thyroid inflammation and anxiety disorders. Patients with anxiety were found to have thyroid gland inflammation that could be reduced by taking ibuprofen, suggesting that thyroid function may play an important role in the development of anxiety.
Researchers at Texas A\(M University have created a therapeutic derived from turmeric that reduces ocular inflammation in dogs with uveitis. The treatment bypasses intestinal and ocular barriers for improved absorption, offering a safer alternative to current medications.
Researchers discovered a type of long-lived immune cell that can provoke chronic inflammation in IBD patients, leading to abdominal pain and damage. The inflammatory T RM cell subtype may also escape into the bloodstream, affecting other parts of the body.
Researchers at UIC have discovered that blood vessel cells play a crucial role in programming macrophages to reduce inflammation and promote tissue repair. The study found that Rspondin3, a protein released by blood vessels, helps guide the programming of macrophages.
A Rutgers-Newark study discovered that lysozyme in the gut stimulates inflammation in some people with ulcerative colitis, leading to ulcers and sores in the large intestine. The study may help develop future treatments for inflammatory bowel disease by gaining insights into immune balance.
The study found that macrophages play a critical role in muscle inflammation, fibrosis, and regeneration. Researchers believe that therapeutic manipulations of these cells hold promise for promoting muscle injury repair and improving outcomes for individuals with muscular dystrophy.
Researchers create device to grow highly oxygen-intolerant bacteria in lab studies, revealing protective effects on human colon. They found that Faecalibacterium prausnitzii produces butyrate, which reduces inflammation and calms immune response.
Researchers used 3D brain organoids to model inflammation's effect on the blood-brain barrier, finding significant changes that contribute to its dysfunction. The study suggests these organoids can help understand disease mechanisms and optimize treatment strategies.
Researchers have found genes related to inflammation and stress that may help tailor treatments for depression. These findings support the idea that patients with treatment-resistant depression have heightened inflammation compared to those who respond to medication.
A new study from La Jolla Institute for Immunology reveals that a metabolic enzyme called ADA2 inhibits inflammation in blood vessels and restrains the immune system. The researchers found that ADA2's loss stimulates a robust innate immune response, which can lead to harmful inflammation.
Inflammageing, an age-associated phenomenon of increased general inflammation, may inhibit overall immunity and reduce vaccination efficacy in older people. Strategies to mitigate related effects include senolytic drugs or anti-inflammatory therapies.
Researchers found that CBD can help reduce cytokine storm and excessive lung inflammation caused by COVID-19. The study suggests that CBD may enable lungs to recover from damage, potentially reducing the need for mechanical ventilation.
Researchers have developed a technology to obtain microvesicles from human stem cells, showing significant biological activity and therapeutic potential. The induced microvesicles can reduce the intensity of immune response and may be used to treat inflammations and autoimmune syndromes.
A high-fat diet combined with antibiotic use significantly increases the risk of developing pre-IBD. The study suggests that this combination disrupts mitochondria in cells of the large intestinal lining, leading to gut inflammation and a vicious cycle of replacing good bacteria with harmful microbes.
A comprehensive review of COVID-19's non-respiratory effects reveals high rates of blood clots, kidney failure, and neurological symptoms. The review highlights the need for clinicians to consider COVID-19 as a multisystem disease requiring treatment beyond respiratory support.
A Basel study found that COVID-19 patients' lungs have insufficient levels of lopinavir and hydroxychloroquine to fight the virus. The drugs, previously thought to be potential treatments, were shown to be ineffective due to inflammation blocking their absorption.
The study found that oat and rye bran fibres support beneficial gut microbiota growth, improving cholesterol metabolism, gut barrier function, and reducing liver inflammation. Diets enriched with either bran type attenuated weight gain associated with a high-fat diet.
Administering the MMR (measles, mumps, rubella) vaccine could serve as a preventive measure to dampen septic inflammation associated with COVID-19 infection. Vaccination has no contraindications and may be especially effective for healthcare workers who can easily be exposed to COVID-19.
Walter and Eliza Hall Institute researchers used advanced imaging to visualize MLKL's role in necroptosis, a form of cell death triggered by inflammation. They found that inherited variants of MLKL are connected to human inflammatory diseases and have been subject to evolutionary pressures.
A study led by University College London found that elite athletes who adopted simple oral health measures reported reduced negative effects on performance related to poor oral health. The behaviour change programme improved oral health behaviours and reduced symptoms of gum inflammation, leading to improved sporting performance.
Research from Kumamoto University reveals HTLV-1's mechanism of causing inflammation and cancer through viral gene HBZ's impact on immune cell reactivity to cytokines. The study found that IL-6 has suppressive effects on HBZ-induced pathogenicity, while its deficiency further promotes Treg differentiation.
A new study reveals that poor oral health can exacerbate gut inflammation in IBD patients, potentially leading to reduced quality of life and surgery. The research suggests that promoting oral health could improve clinical outcomes in IBD, making it a crucial aspect of total body health.