Articles tagged with Inflammation
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The study found that macrophages play a critical role in muscle inflammation, fibrosis, and regeneration. Researchers believe that therapeutic manipulations of these cells hold promise for promoting muscle injury repair and improving outcomes for individuals with muscular dystrophy.
Researchers create device to grow highly oxygen-intolerant bacteria in lab studies, revealing protective effects on human colon. They found that Faecalibacterium prausnitzii produces butyrate, which reduces inflammation and calms immune response.
Researchers used 3D brain organoids to model inflammation's effect on the blood-brain barrier, finding significant changes that contribute to its dysfunction. The study suggests these organoids can help understand disease mechanisms and optimize treatment strategies.
Researchers have found genes related to inflammation and stress that may help tailor treatments for depression. These findings support the idea that patients with treatment-resistant depression have heightened inflammation compared to those who respond to medication.
A new study from La Jolla Institute for Immunology reveals that a metabolic enzyme called ADA2 inhibits inflammation in blood vessels and restrains the immune system. The researchers found that ADA2's loss stimulates a robust innate immune response, which can lead to harmful inflammation.
Inflammageing, an age-associated phenomenon of increased general inflammation, may inhibit overall immunity and reduce vaccination efficacy in older people. Strategies to mitigate related effects include senolytic drugs or anti-inflammatory therapies.
Researchers found that CBD can help reduce cytokine storm and excessive lung inflammation caused by COVID-19. The study suggests that CBD may enable lungs to recover from damage, potentially reducing the need for mechanical ventilation.
Researchers have developed a technology to obtain microvesicles from human stem cells, showing significant biological activity and therapeutic potential. The induced microvesicles can reduce the intensity of immune response and may be used to treat inflammations and autoimmune syndromes.
A high-fat diet combined with antibiotic use significantly increases the risk of developing pre-IBD. The study suggests that this combination disrupts mitochondria in cells of the large intestinal lining, leading to gut inflammation and a vicious cycle of replacing good bacteria with harmful microbes.
A comprehensive review of COVID-19's non-respiratory effects reveals high rates of blood clots, kidney failure, and neurological symptoms. The review highlights the need for clinicians to consider COVID-19 as a multisystem disease requiring treatment beyond respiratory support.
A Basel study found that COVID-19 patients' lungs have insufficient levels of lopinavir and hydroxychloroquine to fight the virus. The drugs, previously thought to be potential treatments, were shown to be ineffective due to inflammation blocking their absorption.
The study found that oat and rye bran fibres support beneficial gut microbiota growth, improving cholesterol metabolism, gut barrier function, and reducing liver inflammation. Diets enriched with either bran type attenuated weight gain associated with a high-fat diet.
Administering the MMR (measles, mumps, rubella) vaccine could serve as a preventive measure to dampen septic inflammation associated with COVID-19 infection. Vaccination has no contraindications and may be especially effective for healthcare workers who can easily be exposed to COVID-19.
Walter and Eliza Hall Institute researchers used advanced imaging to visualize MLKL's role in necroptosis, a form of cell death triggered by inflammation. They found that inherited variants of MLKL are connected to human inflammatory diseases and have been subject to evolutionary pressures.
A study led by University College London found that elite athletes who adopted simple oral health measures reported reduced negative effects on performance related to poor oral health. The behaviour change programme improved oral health behaviours and reduced symptoms of gum inflammation, leading to improved sporting performance.
Research from Kumamoto University reveals HTLV-1's mechanism of causing inflammation and cancer through viral gene HBZ's impact on immune cell reactivity to cytokines. The study found that IL-6 has suppressive effects on HBZ-induced pathogenicity, while its deficiency further promotes Treg differentiation.
A new study reveals that poor oral health can exacerbate gut inflammation in IBD patients, potentially leading to reduced quality of life and surgery. The research suggests that promoting oral health could improve clinical outcomes in IBD, making it a crucial aspect of total body health.
A study reveals that fat cells' immune response amplifies inflammation, driving obesity-related disease. Type I Interferons produced by fat cells trigger a vicious cycle of inflammation, which can worsen metabolic issues and increase the risk of diseases like type 2 diabetes and COVID-19.
Researchers have discovered a novel drug that selectively controls excessive inflammation, a key driver of conditions like osteoarthritis and COVID-19. APPA demonstrates anti-inflammatory potential without compromising the body's ability to fight off infections.
A transgenic mouse model of HLH has been found to be effective in treating severe COVID-19 patients by calming the 'cytokine storm', a common feature of children battling secondary HLH. Ruxolitinib showed promising results, with 90% of patients showing CT scan improvement within 14 days.
Researchers identified a novel strategy to address underlying causes of LAD1 patients' symptoms by mimicking the efferocytosis process, which was absent in these individuals. The study found that small-molecule compounds that stimulate this process alleviated signs of inflammation and promoted bone regeneration in animal models.
Four critically ill COVID-19 patients improved significantly after receiving the experimental therapeutic CAP-1002, which contains cardiosphere-derived cells. The treatment helped reduce inflammation and showed no adverse effects, with all patients discharged from the hospital.
Researchers at Salk Institute discover two genes that regulate levels of healthy fats called FAHFAs, which decrease inflammation and increase insulin sensitivity. An experimental drug successfully increases FAHFA levels by blocking the activity of these genes, offering new insights into therapies for metabolic and inflammatory diseases.
Researchers aim to identify the mechanism of whole strawberry's anti-inflammatory effects on gut health. The study will test hypotheses that whole strawberry inhibits colon inflammation by restoring gut microflora balance.
A study published in eLife found that rapamycin, an immune-suppressing drug, reduces bone loss, inflammation, and changes to oral bacteria in older mice with gum disease. The treatment also reversed clinical features of periodontal disease, suggesting a potential approach for age-related dental problems.
A study by Charité - Universitätsmedizin Berlin reveals that the amoeba Entamoeba gingivalis plays a key role in periodontitis, causing inflammation and tissue destruction. The parasite's elimination may improve treatment outcomes for patients with gum disease.
Researchers propose a new therapeutic modality for sepsis by targeting cell-free chromatin in healthy cells. The study found that three cfCh-inactivating agents improved parameters related to sepsis, including increased survival rates in mice.
Scientists studied monocytes in young and elderly individuals, finding that energy production decreases and inflammation markers increase with age. This research provides a foundation for understanding age-related changes and potential solutions to slow down vascular calcification and atherosclerosis.
MIT biological engineers develop a multitissue model of the colon and liver, revealing how different tissues contribute to inflammatory diseases. The study finds that metabolic byproducts generated by bacteria play an important role in exacerbating inflammation.
Researchers discovered how protein A20 prevents inflammation through a non-enzymatic mechanism, opening up new possibilities for treatment. The study builds upon earlier work demonstrating A20's anti-inflammatory activity and reveals its role in preventing disease development.
A recent study published in Oncotarget found that microRNA (miR) dysregulation is associated with immune cell activation, gastric inflammation, and carcinogenesis. Specifically, miR-155 upregulation is considered a key marker of chronic gastric inflammation and predisposes patients to gastric carcinogenesis.
Researchers from the University of South Australia have developed a nano formulation that increases curcumin's oral bioavailability by 117%, paving the way for clinical trials for Alzheimer's. The delivery method also shows promise in preventing genital herpes, with curcumin able to stop the virus and reduce inflammation.
Researchers at Karolinska Institutet in Sweden have discovered a link between cognitive impairment and lasting inflammation after intensive care. Elevated blood levels of HMGB1 protein were found in patients with post-intensive care syndrome (PICS), which can cause impairments in memory, attention, and problem-solving for years.
Walter and Eliza Hall Institute researchers have pinpointed immune cells called natural killer (NK) cells as an unexpected source of the inflammatory protein GM-CSF in rheumatoid arthritis. The discovery may indicate potential new therapeutic targets for reducing joint inflammation in this autoimmune disease.
Researchers at Massachusetts General Hospital used cutting-edge imaging technology to detect abnormally low levels of a key protein in the brains of young men with autism. The study suggests that these low levels may be linked to inflammation and metabolism, and could have important implications for understanding the origins of autism.
Eating a Mediterranean diet for a year boosts beneficial gut bacteria, reduces inflammation, and may help curb frailty and cognitive decline in older people. The diet is associated with increased diversity of the microbiome, improved brain function, and reduced harmful inflammatory chemicals.
Research found that optimistic patients had lower inflammation levels, reduced stroke severity, and less physical disability after three months. Optimism was linked to better disease outcomes, suggesting a positive environment can benefit recovery.
A study by UC Davis Health researchers found that a Western diet rich in fat and sugar can induce inflammatory skin diseases like psoriasis. The diet's components, rather than obesity, may lead to skin inflammation and its development.
Eternygen presents preclinical study data demonstrating INDY inhibition reverses nonalcoholic steatohepatitis (NASH) in a diet-induced mouse model. The treatment also reduces liver injury and inflammation.
Researchers have discovered that indole, a natural compound found in gut bacteria and cruciferous vegetables, can reduce inflammation and fatty deposits in the liver. This study provides hope for new treatments and preventive measures for non-alcoholic fatty liver disease (NAFLD).
A preclinical trial found that retinoid X receptor (RXR) enhances the clearance of dead cells and debris in the brain after a stroke, limiting inflammation and improving recovery. RXR activation could lead to discovery of a promising new therapeutic target for improving neurological outcomes.
Research suggests that a ketogenic diet provides health benefits in short-term, but negative effects occur after about a week. The keto diet works best in small doses, increasing tissue-protective cells called gamma delta T-cells, which lower diabetes risk and inflammation.
Researchers at the University of Freiburg have developed a light therapy approach that successfully treats severe autoimmune reactions in cancer patients. The extracorporeal photopheresis (ECP) treatment activates immune cells to stop inflammation, offering a promising alternative to cortisone therapy.
Research suggests that supplementing with short chain fatty acids can improve stroke recovery by reducing inflammation and promoting neuroinflammation. The study found that mice who drank water with added fatty acids experienced better stroke recovery, including reduced motor impairment and increased spine growth.
A new study found that delivering the TB vaccine intravenously dramatically improves its potency, offering nearly full protection against TB in monkeys. The vaccine was highly effective when administered via injection into a vein, reducing bacterial burden by 100,000-fold and inflammation in lungs to near zero.
A study by McMaster University researchers found that levels of NT-proBNP, a common cardiac blood test, can predict cardiac and vascular complications after non-cardiac surgery. The test may help doctors identify patients at risk and inform treatment decisions.
Researchers at Cincinnati Children's Hospital Medical Center discovered a new molecular process in mice that triggers T cell-driven inflammation and causes autoimmune diseases. The study found that interactions between myeloid cells and CD4-positive T cells produce excessive IL-1b, leading to auto-inflammatory diseases.
Researchers at Case Western Reserve University have discovered a crucial connection between interleukin-1α and gut microbiome function in a mouse model of Crohn's disease. Blocking this protein reduces intestinal inflammation severity, with effects comparable to steroids, which are the current gold standard treatment.
A new human autoinflammatory disease called CRIA syndrome has been discovered and identified by an Australian-US research team. The disease is caused by a mutation in the RIPK1 protein, leading to uncontrolled cell death and inflammation.
Researchers found that energy-producing mitochondria in muscles were abnormal and showed signs of oxidative damage, contributing to chronic muscle weakness. The study suggests the need for antioxidant therapies or other treatments to restore mitochondrial health.
A study by Wake Forest School of Medicine identified a dead probiotic strain that reduces age-related leaky gut and inflammation in older mice. The dead probiotic strain, Lactobacillus paracasei D3-5, extended the lifespan of roundworms and improved physical and cognitive functions in mice.
The NeutroCure project focuses on harnessing the potential of reactive oxygen species (ROS) produced by neutrophils to treat inflammatory diseases. By developing safe ROS amplifiers, the consortium aims to selectively target pathogenic inflammation and cancer cells while minimizing damage to healthy tissues.
A new treatment approach for cystic fibrosis may reduce the need for lung transplants and lower mortality rates. Researchers found that a small molecule reduced inflammation and cleared lungs of bacteria in a laboratory model.
Researchers found that mice lacking an inflammation resolution sensor developed spontaneous obesity, heart disease, and shortened lifespan, indicating impaired inflammation resolution. This study sheds light on the sensor's integrative role in managing cardiometabolic health and inflammation-resolution processes.
A study of over 200 patients with bipolar disorder found that high levels of inflammation, as measured by C-reactive protein, were significantly linked to poor cognitive performance. This suggests a potentially modifiable risk factor for cognitive deficits, and highlights the importance of addressing inflammation in treatment.
A study by Yale researchers has found that adipose B cells in belly fat unexpectedly proliferate with aging, contributing to increased inflammation and metabolic decline. The expansion can be reversed by reducing macrophage signals and removing adipose B cells.
Patients with inflammatory bowel disease are more likely to develop Parkinson's disease due to shared underlying inflammation. While the risk is small, early detection and intervention may be crucial in slowing or stopping PD progression.
A six-week treatment with low-dose oral prednisolone substantially improves pain and decreases signs of inflammation in patients with painful hand osteoarthritis. Substantial improvements in pain and function were seen, exceeding effects of currently available therapies.
A large-scale trial found that vitamin D and omega-3 fatty acid supplements had no effect on reducing markers of systemic inflammation in older US adults. However, participants with low initial fish intake saw a decrease in inflammation biomarkers after taking the omega-3 supplement.
Researchers have developed a non-invasive method to visualize kidney disease in live animals using genetically modified mice. They found that a promising chemical found in citrus fruit, G-Hes, reduces inflammation in the kidneys when fed to mice with kidney disease.