Articles tagged with Inflammation
Researchers at UC Davis Health developed a new treatment that simultaneously blocks IL-6 and TNF cytokines, providing superior protection against acute graft-versus-host-disease severity and mortality. The dual-cytokine blockade approach did not impair beneficial graft-versus-tumor effects.
Researchers at Washington State University discovered that combining gallic acid with stretching decreases inflammation markers and improves protein production in arthritic cartilage cells. This finding suggests a potential new procedure for treating osteoarthritis by growing healthy cartilage tissue.
A small clinical trial found that high-pressure hyperbaric oxygen treatment resolved severe COVID-19 breathing difficulties faster than standard therapy, with significant improvements in oxygen saturation and reduced risk of complications. However, further larger trials are needed to confirm the treatment's effects on survival.
Researchers discover novel compound AD732 with anti-inflammatory and analgesic properties, outperforming standard NSAIDs while causing minimal harm. The compound may be a safer alternative for treating pain and inflammation in difficult diseases like ulcerative colitis and Crohn's disease.
Researchers found that defibrotide suppresses neutrophil release of NETs and reduces downstream blood-clotting in mice with antiphospholipid syndrome. The treatment neutralizes toxic histones, preventing activation of blood vessel cells.
Metabolic disorders, such as inflammation and insulin resistance, are key elements in the development of anxiodepressive disorders in obese individuals. Diet high in sugar and saturated fats leads to these changes in the brain, increasing the risk of depression and anxiety.
A new study links the composition of gut microbiome before infection to HIV susceptibility and progression. Men who contracted HIV in the early days of the pandemic had a greater relative abundance of pro-inflammatory vs. anti-inflammatory gut microbes, which contributed to their increased risk of developing AIDS.
The Liberty Asthma VOYAGE trial found that dupilumab significantly reduced the rate of severe exacerbations by nearly 60% and improved lung function and asthma control in children ages 6 to 11. Dupilumab was also shown to be safe, with minimal adverse reactions.
Researchers discover a unique subset of group 3 innate lymphoid cells that circulate in the bloodstream and infiltrate the brain, sparking inflammation in conditions like MS. Countering their activity could be a new therapeutic strategy for such conditions.
A new study published in the Journal of Experimental Medicine showed that a fast-tracked stroke drug, 3K3A-APC, protected mice from injury to the brain's white matter, a leading cause of dementia. The drug may also be effective in slowing down progression of cognitive impairment.
A team of researchers at UC Davis Health has developed a novel PET imaging-based tool to detect liver inflammation in non-alcoholic fatty liver disease. The tool uses dynamic PET imaging and mathematical modeling to measure glucose transport from blood to liver tissue, allowing clinicians to quantify liver inflammation.
New research from RCSI shows that an irregular body clock can drive inflammation in the body's immune cells, leading to chronic diseases like heart disease and diabetes. Macrophages without a body clock take up more glucose and produce inflammatory products.
A new study from Ohio State University suggests that giving social support to others is essential for boosting one's health. The research found that people who were available to provide social support experienced lower inflammation levels, whereas those who only received support did not show the same benefits.
New research found that physical activity is linked to lower microglial activation, a key factor in Alzheimer's disease pathology. The study, published in JNeurosci, suggests that exercise may help reduce inflammation and improve cognitive aging in older adults with more severe AD pathology.
A new study has identified the CCR2 gene as a key player in the progression of type 1 diabetes. The research found that lower blood levels of CCL-2, a ligand for CCR2, were associated with increased immune cell recruitment to the pancreas, leading to islet cell destruction.
A study analyzing data from 109 COVID-19 patients found that obesity is the key factor associated with endothelial dysfunction, a condition increasing heart attack and stroke risk. The results suggest an 17% higher cardiovascular risk for obese patients compared to those of normal weight.
A new study found that people who consumed an anti-inflammatory diet rich in fruits, vegetables, beans, and tea or coffee had a lower risk of developing dementia. The research showed that each one-point increase in dietary inflammatory score was associated with a 21% increase in dementia risk.
Researchers found that geriatric cotton rats given ibuprofen cleared RSV more quickly than those without the drug. Ibuprofen improved immune response by lowering aging-related inflammation, suggesting a potential role for the drug in providing lasting immunity against RSV.
Researchers identified two distinct clusters of patients with Prurigo nodularis: those with increased inflammation and those with a higher likelihood of spinal disease. This study suggests that personalized treatment approaches can be tailored to specific patient profiles.
A new study by Boston Children's Hospital researchers found that tissue-resident memory T cells in joints anchor themselves after a flare and wait for another trigger to react. Deleting these cells prevents arthritis flares from occurring, opening up new therapeutic avenues for rheumatoid arthritis treatment.
Itepekimab, a novel monoclonal antibody, has been found to be safe and effective in treating moderate-to-severe asthma. In a phase 2 trial, it significantly improved lung function and reduced asthma control events compared to placebo.
Researchers have discovered a new type of skin cell, TIFFs, that may play a role in inflammatory skin diseases such as scleroderma. These cells were found to interact with immune cells and expand in response to inflammation, leading to an exaggerated response and fibrosis.
During the pandemic, registrations for alcoholic hepatitis and deceased donor liver transplants increased by over 50%, associated with rising alcohol sales. Alcoholic hepatitis can lead to permanent scarring and long-term damage if left untreated, highlighting the need for public health interventions around excessive alcohol consumption.
Scientists at Gladstone Institutes discovered that non-convulsive epileptic activity drives chronic brain inflammation in Alzheimer's models, which can be reversed by eliminating protein tau or using the anti-epileptic drug levetiracetam. This link between brain networks and immune cells may hold promising treatments for Alzheimer's di...
A recent study has discovered genetic markers associated with high levels of lipopolysaccharide (LPS) in the blood, a toxin linked to sepsis and cardiovascular diseases. The research also found a connection between LPS levels and blood coagulation disorders, such as thromboembolism and stroke.
Researchers uncover nitric oxide's dual effects on pathogens: direct destruction and prevention of excessive immune response. This discovery could lead to new treatments for infections and inflammatory diseases.
A preclinical study found that blocking the Bach1 protein slowed brain cell deterioration in Parkinson's disease. The researchers identified a potent inhibitor of Bach1 called HPPE, which protected cells from inflammation and oxidative stress, and showed promise as a potential therapeutic target.
Researchers at Osaka University studied mice with mutations in ADAR1 and found that impaired Z-RNA recognition contributed to abnormal growth, organ development, and chronic inflammation. This study highlights the importance of proper RNA editing and its relation to Aicardi-Goutières syndrome.
A new study published in Science Translational Medicine found that male placentas have increased immune activation and receive fewer anti-COVID antibodies from their mothers. This may help protect male fetuses but pose risks to the fetus and child.
A recent University at Buffalo study found that patients using proton pump inhibitors (PPIs) for heartburn had smaller probing depths in their gums, indicating less severe gum disease. The researchers suggest that PPIs' side effects may be linked to reduced periodontitis severity.
Researchers at UC San Diego School of Medicine report that children with multisystem inflammatory syndrome in children (MIS-C) have normal T cell responses to the COVID-19 virus, contrary to previous hypotheses. This suggests that MIS-C may not be caused by an abnormal immune response to the virus.
A study published by the American College of Cardiology found a significant inverse relationship between oral health and COVID-19 severity, as well as delayed recovery and increased inflammation in patients with cardiovascular diseases. Researchers recommend maintaining good oral hygiene to prevent or decrease COVID-19 disease severity.
A pre-clinical study by University of Illinois Chicago researchers shows that a drug targeting specific immune pathways can prevent lung damage and death in mice infected with the SARS-CoV-2 virus. The study suggests targeted treatments may be more suitable for COVID-19 patients than broad immune suppressants.
Researchers found that liver transplant recipients who contracted COVID-19 recovered faster and with less severe inflammation compared to heart or kidney recipients. The study suggests testing certain immunosuppressants to treat COVID-19 patients, regardless of their transplant status.
Researchers found glycerin, a natural ingredient in many skin lotions, reduces psoriasis symptoms by calming scaly patches and promoting healthy skin cell maturation. The study's results support anecdotal reports from patients with psoriasis, providing objective evidence of glycerin's effectiveness in combatting the condition.
A recent study found that pediatric patients with Multisystem Inflammatory Syndrome (MIS-C) who received initial IVIG plus Infliximab had improved cardiac outcomes, reduced need for additional therapies, and faster resolution of inflammation. The updated care pathway recommends this intensified therapy for all MIS-C patients.
A new treatment approach targets angiogenesis, inflammation, and oxidative stress in glioblastoma multiforme, reducing tumor volume and growth by up to 89%. The combination of LAU-0901, Elovanoids, and Avastin shows promise in improving survival rates for patients with this deadly cancer.
Researchers have discovered toxic DNA buildup in the eyes of patients with geographic atrophy, a devastating form of age-related macular degeneration. Common HIV drugs or safer alternatives, such as Kamuvudines, may block inflammation and protect against retinal cell death, offering new hope for treatment.
A clinical trial conducted by TTUHSC researchers found that corneal epithelial stem cell-derived eye drops significantly improved symptoms of severe dry eye disease, with patients experiencing a 23% improvement in SPEED questionnaire scores and a 17.1% improvement in OSDI scores. No adverse reactions were reported during the 12-week tr...
Researchers have found that synthetic bile acid Nor-UDCA directly affects the immune system and reduces inflammation in chronic-inflammatory liver disease. The therapy also guides misdirected CD8-T cells back onto their correct path, allowing them to resume their normal function.
A team of international researchers has unraveled the inner workings of C5aR2, a key receptor involved in inflammation and COVID-19. The study provides an additional opportunity for therapeutic targeting with new drug molecules to block its activation and inflammation response.
A study found that 73% of hospitalized COVID-19 patients developed delirium, leading to lasting cognitive impairment and increased need for skilled nursing care. The disease itself, sedatives, and inflammation can contribute to this outcome.
A common blood test could identify patients with schizophrenia at high risk for cardiovascular disease, enabling early intervention. Elevated white blood cell counts are suspected to be a signal, and a large-scale analysis of over 20,000 patients will examine its associations.
A new gene delivery system promotes healing in rat models by preventing inflammation and bone degradation after tooth replantation. The study found that teeth treated with the system showed significantly greater dental root thickness and fewer osteoclasts, leading to improved success rates.
A large-scale trial will assess the effects of cocoa supplements and multivitamins on aging, including inflammatory factors and genetic changes. Researchers aim to determine if cocoa consumption can reduce age-related health issues such as heart disease, stroke, and cancer.
Researchers have found that blocking DHPS, an enzyme necessary for activating elF5A, can reduce inflammation and improve glucose control in mice. The study suggests macrophages play a key role in inflammation in obesity, and targeting this pathway may be a promising approach to treating the condition.
Researchers at Nanyang Technological University have developed a 3D model of the human artery blood vessel wall to study atherosclerosis. The model, called an 'arterial wall-on-a-chip', helps understand how cholesterol and inflammatory cells contribute to the disease.
A biomedical sciences researcher is studying the impact of environment on gut microbiota, immunity, and inflammation in a novel mouse model system. The goal is to define changes in the gut microbiota and mucosal immune system in relation to intestinal inflammation and colon cancer.
A study of 68 patients found that most had good long-term outcomes with minimal complications, while others faced significant risks. The research provides insights into the potential consequences of COVID-19 multisystem inflammatory syndrome in children.
A study published in the Journal of Clinical Investigation found that infection triggers the expression of a protein called IL-33, leading to overgrowth of air spaces and increased mucus production. The researchers suggest that blocking this process could prevent chronic lung damage caused by viral infections.
The study found that patients with low risk of exacerbations do not benefit from low to moderate dose inhaled corticosteroids, while high doses are associated with severe side effects. Tailoring treatment according to patient characteristics, such as age and blood cell count, can minimize over- and underuse of inhaled corticosteroids.
A study published in the Journal of Clinical Investigation has identified an enzyme called secreted phospholipase A2 group IIA as a key mechanism driving COVID-19 severity. The enzyme is found to be associated with increased mortality rates, particularly when its levels are high, and could provide a new therapeutic target for reducing ...
Researchers found that prostaglandin E2 protects epithelial cells from cell death by binding to EP4 receptors. This activation counteracts intestinal inflammation progression and may prevent bacterial penetration.
A multicenter randomized trial showed acupuncture improved symptoms of moderate to severe CP/CPPS, with effects lasting over 24 weeks. Acupuncture was more effective than sham therapy in reducing symptoms and improving quality of life for men with chronic prostatitis/chronic pelvic pain syndrome.
Researchers review advancements in biosensing technologies for neonatal sepsis diagnosis, highlighting the need for faster and more accurate methods. Biosensors offer a promising solution, detecting multiple parameters simultaneously with high sensitivity and accuracy.
A University at Buffalo-led study found that photobiomodulation therapy sped up recovery from burns and reduced inflammation in mice by activating endogenous TGF‐beta 1, a protein controlling cell growth and division. The findings may improve therapeutic treatments for burn injuries worldwide.
A new process for making RNA has been developed by researchers at the University of Massachusetts Amherst, yielding purer and more abundant RNA at a fraction of the cost. This breakthrough removes the largest stumbling block on the path to next-generation RNA therapeutic drugs.
A study from the University of South Carolina's Environmental Health & Disease Laboratory found that andrographolide successfully restored bacteriomes and viromes, increasing beneficial bacteria and decreasing harmful bacteria. The treatment also decreased gut inflammation and neuroinflammation in veterans with Gulf War Illness.
Researchers from Tokyo Medical and Dental University found that IgA deficiency causes substantial inflammation in the ileum of mice, making them susceptible to disease. The study reveals IgA plays a protective role in maintaining gut health by regulating microorganisms.
Researchers studied inflammation's role in scarring of the central nervous system in three diseases: multiple sclerosis, aquaporin-4 antibody positive neuromyelitis optica spectrum disorder, and myelin oligodendrocyte glycoprotein antibody associated disorder. In MS, scars lead to nerve fiber degeneration and slow worsening of disabili...