Research on inflammation and its role in disease. Covers eye inflammation, personalized anti-inflammatory medicine, aging, and chronic pain links.
Researchers from Nagoya University have identified two microRNAs that are downregulated in systemic lupus erythematosus, a disease where the immune system attacks itself. The study found that these miRNAs regulate the same set of genes through 'seed overlap' co-targeting, which negatively regulates inflammatory cytokine production.
A Rutgers study found that pregnant people with HIV have higher levels of chronic systemic inflammation and immune activation, leading to poor growth in children. The study aimed to investigate the impact on babies exposed to HIV but not infected.
Researchers found that blocking mitochondria fusion or fission triggers an inflammatory process, leading to muscular atrophy. This 'sterile inflammation' is not linked to infectious processes and has physiological relevance in mice with mitochondrial fragmentation.
Researchers have isolated two new bacterial species from patients with inflammatory bowel disease (IBD), which break down the protective mucus layer of the gut. The bacteria, Allobaculum mucilyticum and Allobaculum fili, are highly efficient at degrading intestinal mucus, leading to potent immune responses.
Scientists have found that caterpillars can be used as an alternative to rodent models for studying gut inflammation, a risk factor for colorectal cancer. The tobacco hornworm caterpillar has a high degree of similarity to the human gut structure and physiology, making it a promising model organism for future research.
Researchers at NYU Langone Health developed an iScore system that correlates inflammation levels with survival rates in patients with acute myeloid leukemia (AML), with those having low scores surviving the longest.
A recent study published in Nature Communications has found a significant imbalance in the gut microbiome of individuals with Parkinson's disease. The researchers discovered that over 30% of micro-organisms and bacterial genes tested had altered abundances, indicating a widespread imbalance in the microbiome.
Researchers at EMBL Grenoble have discovered that THC inhibits the human enzyme autotaxin, which is involved in cancer, inflammation, and pulmonary fibrosis. This finding provides new molecular insights into the therapeutic effects of medical cannabis.
A randomized controlled trial found that daily almond supplementation increased the beneficial fat molecule 12,13-DiHOME in blood plasma after intense exercise. This increase was associated with reduced muscle damage and fatigue, as well as improved recovery from exercise. The researchers suggest that polyphenols in almond skin may be ...
Collagen deposition at injured sites in the gut stimulates cellular reprogramming, converting mature cells into fetal-like cells to generate new tissue. This process has implications for understanding intestinal inflammation and potentially colorectal carcinogenesis.
Researchers at UT Health San Antonio identified a new inflammatory trigger in Alzheimer's disease and progressive supranuclear palsy, involving 'jumping genes' that form double-stranded RNA mimicking viral infections. This discovery opens new doors for understanding astrocyte biology and their role in transposable element control.
Researchers at the University of Cincinnati found a link between latent tuberculosis infection and increased inflammation in monocytes, a type of white blood cell. This connection may contribute to a higher risk of cardiovascular disease in individuals with LTBI.
Researchers discovered a previously unknown property of certain immune cells called Th17 cells, which produce the pro-inflammatory cytokine IL-1α. This finding sheds light on autoimmune diseases like rheumatoid arthritis in children and provides new insights into the defense against fungal infections.
Researchers have identified a previously unknown component of brain anatomy, dubbed SLYM, which acts as a protective barrier and immune monitoring platform. The discovery is expected to shed light on the glymphatic system's mechanisms and its potential role in brain diseases like Alzheimer's.
A team from Brigham and Women's Hospital developed FIND-seq, a method that isolates and analyzes rare astrocytes driving MS inflammation and neurodegeneration. This approach identified signaling pathways controlling the development of pathogenic astrocytes in mice and humans.
Dupilumab, an FDA-approved medication, offers new hope for patients with eosinophilic esophagitis, a rising condition in the US. The treatment reduces eosinophil counts and improves symptoms of dysphagia, leading to better endoscopic healing and histologic severity improvements.
Research from University of Virginia Health System suggests antidepressants can heighten lifelong brain changes in babies, such as autism, when combined with infection or inflammation during pregnancy. SSRIs interact powerfully with the mother's body, causing harmful changes in the placenta and developing brain.
A new study suggests that chronic dysentery is unlikely to have been the cause of Edward the Black Prince's death. Instead, experts point to alternative causes such as malaria, inflammatory bowel disease, and brucellosis, which could have contributed to his fluctuating illness.
A study published in Aging-US reveals changes in gene expression associated with age-related muscle loss and frailty. Researchers identified unique cellular subpopulations in aged and sarcopenic skeletal muscle, which may facilitate the development of new treatments for age-related frailty.
Researchers analyzed COX-2 levels and segmental chromosome aberrations in pediatric neuroblastoma tumor samples. Positive correlations between pre-CT Ch 7q gain and COX-2 expression were found, as well as negative correlations between Ch 7q gain and Ch 11q deletion.
A new study suggests that existing medicines can prevent long-term damage to the kidney and cardiovascular system caused by acute kidney injury. In mice, endothelin-blocking medicines showed promising results in reducing inflammation, blood pressure, and scarring in the kidney.
A new study suggests that olfactory viral inflammation may accelerate the onset of Alzheimer's disease by disrupting connections between the sense of smell and memory centers. Researchers found altered myelination in the olfactory tract, leading to inflammation in the hippocampus, which controls memory and learning.
A Northwestern University study found that as people age, their cerebrospinal fluid immune system becomes dysregulated, leading to cognitive impairment and neurodegeneration. The discovery provides a new clue to the process of neurodegeneration and may potentially be used to treat inflammation of the brain.
Salk scientists have developed a new therapeutic compound called FexD, which reverses gut inflammation in mouse models of inflammatory bowel disease. By activating the master regulator protein FXR, FexD reduces inflammation and restores balance to the digestive system.
Researchers found that a Mediterranean diet can improve fertility outcomes by reducing inflammation and increasing sperm quality in men. The anti-inflammatory properties of the diet may also enhance couples' chances of conception.
Researchers from Kumamoto University reveal how hematopoietic stem and progenitor cells orchestrate intestinal tissue repair through microbial signals. The study found that acute gut inflammation triggers the activation and expansion of immune progenitor cells, which migrate to lymph nodes to promote tissue repair.
Researchers found that when nursing mother mice are fed a low-fiber diet, their offspring's microbiome is permanently altered, resulting in gut inflammation and obesity. The study suggests that regular fiber intake helps fuel the microbiome, allowing diverse bacteria to thrive.
Researchers found that women experiencing prolonged mental health issues after childbirth had genetic evidence of higher immune system defense mechanism activation. The study also identified reduced antiviral immune response genes, which may offer protection from pathogens.
Researchers from the Salk Institute have found that deteriorating neurons from people with Alzheimer's disease undergo a late-life stress process called senescence, leading to brain inflammation and neurodegeneration. By targeting these senescent cells with therapeutics, scientists hope to prevent or treat Alzheimer's disease.
A study published in Journal of Clinical Immunology found that four proteins - WFDC2, GDF15, CHI3L1, and KRT19 - are associated with severe COVID-19 progression. These proteins may serve as biomarkers to predict prognosis in patients with critical COVID-19.
Researchers found that individuals with persistent asthma have higher levels of inflammation and artery plaque, which may increase heart attack or stroke risk. The study also highlights the importance of addressing risk factors for cardiovascular disease in people with persistent asthma.
A new study found that taking NSAIDs for osteoarthritis pain and inflammation may worsen joint inflammation and cartilage quality over time. Researchers used MRI-based structural biomarkers to analyze the association between NSAID use and synovitis in patients with knee osteoarthritis.
Climate change is expanding the geographic range of endemic fungal diseases, such as Valley fever, blastomycosis, and histoplasmosis, which can mimic pneumonia. Physicians are often misdiagnosing these conditions due to a lack of training and limited testing options.
Researchers are exploring how aging affects communication between bone and muscle, finding that imbalance can lead to muscle loss, falls, and bone fractures. They aim to develop novel interventions to restore this balance, potentially treating osteoporosis and sarcopenia.
A study published in Radiology found that marijuana smokers have a higher incidence of emphysema and airway inflammation compared to non-smokers and tobacco-only smokers. The researchers suggest that the unfiltered nature of marijuana smoke and longer breath-hold puffs may contribute to these findings.
Researchers discovered that a lipid called prostaglandin E2 weakens lung immune cells with age. This increased PGE2 production impairs alveolar macrophage health and leads to a suppressed immune response, making older people more vulnerable to flu infections.
Research shows COVID-19 can cause long-term changes to brain function through inflammation, affecting mood, concentration, and cognitive abilities in both young and old patients. Millions are potentially affected by this condition, also known as Long COVID.
Researchers investigated Aicardi-Goutières syndrome and found that viral RNA recognition drives uncontrolled interferon production. The immune system mistakenly attacks healthy cells due to the failure of safety mechanisms to distinguish between viral and host genetic material.
Researchers at UCalgary have discovered a potential new treatment for fibrosis, a condition that causes thickening of the gut wall and life-threatening blockage in people with Crohn's disease and ulcerative colitis. The study suggests that drugs targeting specific sensors may prevent inflammation-associated gut blockage.
A study by the University of Gothenburg found that women with inactive inflammatory bowel disease (IBD) have a higher risk of giving birth prematurely, particularly if they have microscopic inflammation in their intestinal mucosa. This association was not seen for other adverse pregnancy outcomes, such as growth restriction.
Researchers found elevated C4A levels in first-episode psychosis patients who later developed schizophrenia, correlating with increased IL-1beta and synapse density. This suggests a link between inflammation and genetic risk variants in schizophrenia.
Researchers at the University of Bonn have identified a new signaling pathway that triggers inflammatory responses in the skin after UV damage. This pathway involves the activation of p38 molecularly modifying NLRP1, a critical switch for inflammation, and initiates the assembly of inflammasomes.
Researchers have identified a class of lipids called SGDGs that decline in the brain with age and may have anti-inflammatory effects. These findings could lead to new therapeutic interventions for age-related neurological diseases. Further research will be needed to explore the role of SGDGs in human neuroinflammation.
Researchers at Cleveland Clinic are exploring the role of inflammatory cytokines in cancer treatment, with a focus on developing personalized therapies. The five-year grant will help identify potential windows for therapy and optimize treatment strategies for individual cancers.
A new drug combination of cefepime and enmetazobactam has been found to be more effective in treating complicated urinary tract infections and acute pyelonephritis than a standard treatment. The study showed that the new combination was successful in treating 79% of patients, compared to 58.9% for the conventional treatment.
A plant-based diet significantly reduced advanced glycation end-products (AGEs) by 79%, associated with weight loss and improved insulin sensitivity. The reduction in AGEs was largely attributed to decreased meat and dairy consumption, leading to a 14-pound weight loss.
Scientists discover that increased levels of enzyme alpha 1-6 fucosyltransferase (FUT8) in the colon may lead to ulcerative colitis by altering mucous layer properties, making it more permeable and sticky. Researchers believe this allows bacteria to reach epithelial cells, triggering inflammation.
A study found that in people with significant kidney disease, psoriasis does not increase the risk of heart attack. After controlling for other risk factors, researchers found no association between psoriasis and heart attacks in patients with end-stage renal disease.
Researchers at Mount Sinai's Tisch Cancer Institute have discovered a new gene, PDZK1IP1, essential to colon cancer growth. The study found that surrounding inflammation activates the super enhancer, promoting tumor cell survival and growth.
A new study by UC San Francisco researchers found that marijuana, methamphetamine, cocaine, and opiate use are associated with an increased risk of developing atrial fibrillation. Cannabis users had a 35% increased likelihood of later developing AF, similar to traditional tobacco use.
Individuals with Down syndrome experience less frequent but more severe viral infections, attributed to increased type I interferon expression. This leads to hyperactive immune responses initially, followed by overcorrection, resulting in increased vulnerability late in the viral attack.
A new CAPSTONE study aims to identify inflammatory biomarkers associated with positive and poor outcomes in patients after intracerebral hemorrhage (ICH) strokes. By analyzing patient blood and plasma samples, researchers hope to develop targeted treatments to prevent long-term brain degeneration.
A UNIGE team identified a three-step mechanism that allows our body to defend itself against hepatitis B. The complex detects the viral DNA, traps it, and inhibits the virus' chromosome.
The study found that a combination of NOX1, loss of function, and TNF leads to an abnormal increase in microfold cells, driving increased recruitment of immune cells. Reversing the defect with reactive oxygen species restored healthy gut balance. Further studies on reactive oxygen species-stem cell modulation therapy are proposed.
Researchers found pre-existing differences in gut bacteria between people with and without HIV, including decreased Bacteroides species and increased Megasphaera elsdenii. These changes were present even before infection occurred, suggesting a potential link between gut microbiome and HIV susceptibility.
Researchers at Karolinska Institutet found that intravenous omega-3 treatment improved immune function and stimulated healing of inflammation without compromising the body's response to COVID-19. The study suggests a potential new, cost-effective low-risk treatment for severe COVID-19.
Researchers identified a specific gut bacterium responsible for antibiotic-induced GVHD after stem cell transplants. A sugar supplement was found to improve gut health by distracting the bacteria from attacking mucin in the intestinal lining, reducing complications such as GVHD.
A study from UniSA researchers found associations between metabolic profiles and adverse brain findings, including lower hippocampal and grey matter volumes. People with metabolic profiles linked to obesity were more likely to have higher accumulation of iron in the brain.
The fasting-mimicking diet reduced Alzheimer's pathology in mice, including amyloid beta and tau protein levels, and showed less brain inflammation. Mice on the diet also performed better on cognitive tests, with some showing improved performance comparable to non-Alzheimer's mice.
A public consultation is launched to develop best-practice standards for diverse and inclusive healthcare datasets used in Artificial Intelligence. The project aims to reduce biases that affect patients from minoritised racial/ethnic groups, ensuring they receive accurate predictions and treatments.