Articles tagged with Inflammation
Studies in rats have found that T-cells produce reactive oxygen species (ROS) that contribute to preeclampsia complications. Researchers are exploring ways to dampen this response to reduce the risk of premature birth or worse outcomes for mother and child.
Hospitalized COVID-19 patients with high blood viscosity have a 60% higher death rate than those with low blood viscosity. The study suggests that checking for blood viscosity early on could help determine the best treatment course and improve outcomes.
A recent study discovered that brain inflammation may be a key link between Alzheimer's disease risk and sleep disturbance. The research found that age-related increases in brain inflammation can disrupt fast sleep spindles, which are crucial for long-term memory retention. This disruption contributes to age-related memory impairment i...
A new study found that opioids like morphine can cause gastric inflammation due to increased acid secretion and delayed gastric emptying. Treatment with naloxone or proton pump inhibitors like omeprazole may provide gastroprotection, improving pain management and reducing side effects.
A new study reveals that oxidative damage to telomeres can trigger cellular senescence, leading to the development of 'zombie cells'. Researchers found that damage at telomeres disrupts DNA replication and induces stress signaling pathways, contributing to age-related diseases.
Researchers have devised a way to deliver carbon monoxide to the body using stable foams that can be delivered to the digestive tract. The foams reduced inflammation of the colon and helped reverse acute liver failure in mice, offering a potential alternative to immunosuppressive treatments.
A novel single-cell RNA sequencing technique, TAS-Seq, has been developed to provide higher-precision data than current methods. The new method detects more genes and identifies highly variable genes, making it a sensitive high-throughput scRNA method.
Research at Kyoto University found that estradiol suppresses severe skin inflammation in females compared to males, revealing its therapeutic potential. The hormone regulates immune cells and reduces IL-17A and IL-1β cytokines production.
The USPSTF recommends against using beta carotene or vitamin E supplements to prevent cardiovascular disease (CVD) or cancer. Inflammation and oxidative stress play a role in both CVD and cancer, but dietary supplements have shown anti-inflammatory and antioxidative effects, leading to proposals for their use as preventive measures.
A recent review article highlights the crucial role of macrophages in the progression from acute kidney injury (AKI) to chronic kidney disease (CKD). The study suggests that targeting specific signaling pathways and altering macrophage activation can prevent renal fibrosis and CKD. Therapeutic strategies such as clodronate liposomes an...
Researchers at Ohio State University created a mathematical model that assesses the efficacy of immunomodulatory drugs in treating myocardial infarctions. The study found that certain combinations of these drug inhibitors were more efficient at reducing inflammation, offering new possibilities for improving patient outcomes.
Cases of Kawasaki disease fell in the US during the COVID-19 pandemic and remained low during masking and school closure. The findings suggest a respiratory portal of entry for the trigger agent(s), consistent with social behavior influencing exposure.
A global team led by Rutgers Cancer Institute of New Jersey has secured $25 million to study cachexia, a debilitating wasting condition responsible for up to 30% of cancer deaths. The team plans to build a deep understanding of what causes cachexia and develop novel treatments.
Researchers identified immune endothelial cells promoting inflammation and developmental endothelial cells supporting cell development, regeneration, and proliferation. The study's findings may lead to targeted treatments for lung infections and acute respiratory distress syndrome.
Researchers have identified lung-infiltrating monocytes as the key immune cells driving COVID-19's inflammatory complications. The study suggests that targeting these cells with remdesivir and baricitinib can enhance antiviral signaling and viral clearance, potentially improving patient outcomes.
A recent study found that shingles is not associated with an increased risk of dementia. The study analyzed data from Danish medical registries and found that people with shingles had a 7% lower risk of dementia compared to those without the disease.
Researchers at IRB Barcelona describe a cellular mechanism that coordinates inflammation resolution, with CPEB4 protein playing a crucial role. This regulation involves the balance between pro-inflammatory TTP and anti-inflammatory CPEB4 proteins.
Researchers at the Messerli Research Institute developed a lozenge that compensates for micronutrient deficiencies in immune cells, reducing inflammation and allergic reactions. The study showed a 45% reduction in symptom burden during peak pollen season, presenting a new approach to allergy care.
Researchers identified distinct subpopulations of keratinocytes and changes in cellular compositions that drive disease persistence. The findings raise the possibility of targeting keratinocyte metabolism in Vitiligo treatment.
Researchers at the University of Chicago's Pritzker School of Molecular Engineering have developed a version of interleukin-12 that is activated only when it reaches a tumor, reducing side effects. The new 'masked' molecule has shown promising results in eliminating cancer cells and outperforming existing immune therapies.
Researchers found that inhibiting caspase 11 reduced inflammation, tissue injury and blood clots in lung tissue of infected mice. This suggests potential therapeutic targets for treating severe COVID-19 symptoms.
Biologists at the University of Rochester have identified two key systems controlling gene expression related to longevity: circadian networks regulating negative lifespan genes and the pluripotency network controlling positive lifespan genes. This research provides new insights into understanding how longevity evolves and may lead to ...
Researchers investigated the effects of treatment with exogenous Humanin G on inflammation markers in AMD and normal retinal cells. The study found reduced levels of inflammatory proteins in AMD plasma and treated cybrids, highlighting the positive effects of Humanin G.
Researchers at Karolinska Institutet discovered that electrical stimulation of the vagus nerve promotes healing in acute inflammation by shifting the balance between inflammatory and anti-inflammatory molecules. This finding opens new avenues for treating inflammatory diseases, including autoimmune and cardiovascular conditions.
Researchers have developed a new tool to visualize leukocytes in the brain vasculature during in vivo two-photon laser scanning microscopy. The tool uses a fluorescent antibody targeting CD45, a ubiquitously expressed protein on white blood cells, allowing for tracking of circulating leukocytes over time and space.
A study published in Nature Cardiovascular Research reveals that rare T cells targeting apolipoprotein B can contribute to inflammation and atherosclerosis progression. Researchers discovered these cells resemble regulatory T cells but develop a new identity as heart disease develops.
Researchers linked dietary cholesterol to exacerbation of viral infections in mice, showing that high levels of cholesterol made mice sicker when infected with influenza. The study found that dietary cholesterol increased the number of cytokine-producing immune cells in the lungs, contributing to excessive inflammation.
A new review highlights the risks of fatty liver disease caused by metabolic dysfunction, characterized by fat accumulation in liver cells and oxidative stress. The progression of the disease can lead to inflammation, fibrosis, and cirrhosis with a high risk of hepatocellular carcinoma.
Research finds that excessive mitochondrial damage caused by alcohol exposure can lead to chronic liver disease. Mitochondrial depolarization triggers mitophagy, a process removing damaged mitochondria; however, constant removal causes additional liver tissue damage.
A randomized clinical trial found that a specific probiotic supplement accelerated the maturation of the microbiome in extremely preterm infants, leading to reduced intestinal inflammation and improved feeding tolerance. The study also showed potential benefits for reducing the risk of food allergies in these vulnerable infants.
A McMaster University research team found that Type I interferon regulates the immune response to target infected tissues, preventing bystander damage. The study used mice and COVID-19 patient data to investigate IFN's role in regulating a potentially dangerous immune response.
A study found that high blood adenosine levels at 15 days of life correlated with white matter lesions and brain injury in very low birth weight premature infants. Adenosine may play a role in oligodendrocyte maturation and neuronal development, suggesting its potential as a biomarker for complications of prematurity.
Researchers have found that flu viruses can directly infect heart cells, leading to electrical malfunctions and scarring. The study suggests that clearing the viral infection may be key to reducing flu's effects on the heart.
Researchers discovered a potential pathway linking early life infections to cardiovascular disease risk later in adulthood. High rates of infant infections were associated with elevated inflammation markers and changes to metabolic profiles.
Researchers found that hypoxia can activate immune cells called ILC2s, which respond to harmless environmental allergens and drive mucus production and inflammation in the lungs. The study identifies adrenomedullin as a new target for treating inflammatory and allergic lung diseases.
A new study suggests that supplementing a diet with Ascidiacea, also known as sea squirts, reverses some main signs of aging in animal models. The researchers found that plasmalogens, vital to body processes, decrease with age and contribute to neurodegenerative diseases like Alzheimer's and Parkinson's.
A Brazilian study analyzing data from 3,875 elderly men and women found that weak muscles combined with abdominal obesity can indicate an early sign of functional decline. The study suggests that monitoring simple actions such as sitting down, standing up, walking short distances may help identify this condition.
Research finds that intestinal inflammation liberates chemicals that nourish E. coli's growth and promote inflammation, highlighting new treatment targets for Crohn's disease. The study identifies key compounds that feed E. coli, such as phospholipids and amino acids, and shows that these compounds can enhance the bacteria's virulence.
A UCLA-led team found that an abnormally suppressed immune system, not a persistently hyperactive one, may be to blame for some cases of long COVID-19. The study suggests boosting immunity in those individuals could be a treatment option.
Researchers identified estrogen-related receptor gamma (ERR γ) as crucial for preventing pancreatic auto-digestion in mice. In humans, lower levels of ERR γ were found in cells affected by pancreatitis. These findings suggest new therapies regulating ERR γ activity could help prevent or treat these conditions.
Researchers at Terasaki Institute for Biomedical Innovation have developed a flexible, antibacterial conductive hydrogel-ePatch that accelerates wound healing with minimal side effects. The e-Patch uses silver nanowires and alginate to promote cell proliferation and migration, resulting in faster wound closure and reduced scarring.
A new study published in PLOS ONE finds that high and very high cardiovascular risk are associated with depressive symptoms, especially in women. The researchers used data from a Mediterranean Diet trial and found that participants with higher cardiovascular risk had lower depressive status scores after following the diet.
Researchers found daily e-cigarette use altered inflammatory markers in the brain, colon, and heart, while lungs showed gene expression changes; flavors influenced organ responses to infections like COVID-19.
Heart complications from COVID-19 are rare but treatable in children and young adults. The American Heart Association statement highlights the importance of ongoing research to understand long-term cardiovascular effects.
A Johns Hopkins Medicine-led study found that COVID-19-induced loss of smell is linked to inflammation-caused nerve damage, weakening odor signals to the brain. The researchers discovered more severe vascular injury and fewer axons in the olfactory bulb of patients with diminished or complete loss of smell.
A study of almost 57,000 hospitalizations with COVID-19 found acute myocarditis occurred in about two out of every 1,000 people. This rare condition is associated with more severe illness and complications, especially among those with pneumonia. The analysis suggests a need for intensive care unit admission in up to 70.5% of cases.
A new study found that older children (6–12 years, 13–17 years) and those with high inflammation markers were at highest risk of severe MIS-C. Gastrointestinal symptoms and cardiac involvement were common in affected children.
Researchers developed innovative smart sensors to test new vaccines, revealing significant discrepancies between subjective self-reports and objective measurements. The study found that side effects escalate over the first 48 hours and then stabilize, with parameters returning to pre-vaccination levels.
A study published in the Journal of Cachexia, Sarcopenia and Muscle found that BAM15 improves health outcomes for aged mice with obesity by preventing muscle loss and increasing energy expenditure. The compound helped mice lose fat, gain strength and increase physical activity.
A recent study suggests that many older adults with rheumatoid arthritis are not prescribed disease-modifying medications, despite guidelines calling for early and aggressive treatment. Only 45% of patients over 65 were prescribed these medications, highlighting the need to improve prescribing practices among primary care physicians.
Researchers found that cereal fiber, but not fruit or vegetable fibers, was associated with lower inflammation and cardiovascular disease risk in older adults. The study used data from a large cohort of elderly individuals and confirmed previous associations between dietary fiber and CVD.
A study led by Boston Children's Hospital researchers found that COVID-19 causes severe inflammation through infected immune cells. Antibodies developed during infection may sometimes contribute to inflammation.
A study found a shift in the profile of specialized lipid mediators from pro-resolving to pro-inflammatory in patients with cognitive impairment, correlating with severity of cognition impairment. The researchers identified novel mechanisms of brain health and potential therapeutic targets for slowing down Alzheimer's disease onset.
A new technique developed at the University of Birmingham uses electroencephalography (EEG) to measure brain activity in patients before surgery, predicting their likelihood of severe pain after recovery. This allows clinicians to plan additional preventative pain medication and potentially reduce chronic symptoms.
Scientists create nanoparticles coated in mannose to block production of scar-promoting protein in lung cells. The treatment holds promise for preventing severe lung scarring disease.
A study analyzing blood samples from premenopausal women with breast cancer found high levels of inflammatory markers and low antioxidant levels. These findings may reveal a new diagnostic tool for the disease, with implications for identifying early stages and improving treatment outcomes.
A recent study suggests that eating nutrient-rich prunes every day may benefit bone health in postmenopausal women by reducing inflammatory factors. The research found significant reductions in inflammatory markers in prune-eating groups compared to a control group.
Researchers at Cincinnati Children's Hospital Medical Center discovered that a combination of two anti-inflammatory drugs may prevent lung damage and asthma in infants born prematurely due to chorioamnionitis. The study used animal models, but further research is needed to confirm the results.
Research identifies genetic variants associated with reduced grey matter volume in brain regions linked to schizophrenia and autism spectrum disorders. The study suggests a potential new target for treating severe mental illnesses by targeting the IL-6 gene.
A study published in Nutrients found distinct bacteria and metabolomes associated with each personality trait, including mental energy and physical fatigue. The research team discovered unique gut bacteria profiles for different energy and fatigue traits.