Lenabasum has been shown to improve skin symptoms in patients with amyopathic dermatomyositis, demonstrating significant reductions in inflammation and disease severity. The study's findings suggest that lenabasum is a well-tolerated treatment option for refractory skin disease.
SourceElsevier·JournalJournal of Investigative Dermatology·TypeRandomized controlled/clinical trial·DateSep 21, 2022
A study found that most people with long COVID (persistent symptoms) recover within 12 months. However, some patients still experience symptoms and may benefit from seeing a rheumatologist for autoimmune disorder assessment.
A study at the University of Helsinki found that periodontitis has a particular link with diabetes and accelerates its progression. The research highlights the importance of considering general and oral health as a whole in healthcare to achieve better treatment outcomes.
A new study finds that consistently losing an hour and a half of sleep per night can negatively impact immune stem cells, leading to increased inflammation and cardiovascular disease. Even after catching up on sleep, the effects of disrupted sleep remain long-lasting.
Scientists have identified WASH protein complex as a gatekeeper of neutrophil-driven inflammation, potentially leading to new treatments for conditions like sepsis and arthritis. The study reveals that WASH regulates the release of antimicrobial molecules, which can harm healthy cells if released excessively.
The study reveals that SARS-CoV-2 infection alters hepatocyte metabolism towards glycolysis, while impairing mitochondrial activity, leading to liver damage. Metformin is proposed as a potential therapeutic option to attenuate SARS-CoV-2 infection in patients with fatty liver.
A new study led by NYU researchers has developed a topical gel that targets the succinate receptor to suppress inflammation, reduce bacterial imbalance, and prevent bone loss. The treatment has shown promise in reducing gum disease symptoms, including inflammation and tooth loss.
A University of Illinois study shows rumen-protected lysine can improve uterine health in dairy cows during the transition period. The supplement reduced genes involved in inflammatory proteins and increased genes keeping the uterus clean, leading to less inflammation and improved reproductive outcomes.
A lab study found that high cholesterol intake worsens fatty liver disease progression by driving inflammation and scarring. The researchers also discovered long-lasting dysfunction in immune cells responsible for fighting liver damage. Moderation is key to maintaining a healthy diet, according to the study's findings.
A study led by Singapore scientists found that Neisseria, a genus of bacteria once considered harmless, can cause infections in patients with bronchiectasis, asthma, and COPD. The research team identified a specific subgroup of Neisseria called N. subflava as the main culprit behind worsening disease outcomes.
A Rutgers study finds CBD improves glucose disposal, burns energy, and enhances bone density in estrogen-deficient mice. The compound also reduces inflammation and boosts beneficial gut bacteria.
A study at Washington State University has identified sulfatase-2 as a critical protein driving damage caused by rheumatoid arthritis. The discovery sheds light on molecular processes behind inflammation in the disease and could lead to improved treatments.
Researchers found that high blood pressure induced in young mice led to significant bone loss and osteoporosis-related damage comparable to older mice. The study suggests a possible link between inflammation, high blood pressure, and accelerated bone aging in humans.
A new study found that exposure to diesel exhaust fumes had more pronounced effects on females than males, with changes in blood components related to inflammation, infection, and cardiovascular disease. The research involved ten healthy volunteers who breathed filtered air and polluted air at varying concentrations.
A substance produced by gut microorganisms, TMAO, can lead to scarring and vascular damage in scleroderma. The Western diet rich in meat contributes to TMAO formation, which reprograms cells to become scar-forming myofibroblasts.
The TMDU research team successfully transplanted a mini organoid into a patient with Ulcerative Colitis, showing potential for a radical cure. The treatment uses the patient's own cells and minimally invasive colonoscopy, reducing transplant rejection risk and laparotomy needs.
A new study from Harvard Medical School reveals that patients who recover well after cardiovascular surgery exhibit precise paths for white blood cell and platelet counts. These trajectories can be used to monitor recovery in a personalized way, enabling clinicians to intervene earlier when necessary.
A recent study found that COVID-19 infection significantly increases the risk of myocarditis compared to vaccination, with a 11-fold higher risk in unvaccinated individuals. The study analyzed nearly 43 million people in England and found that COVID-19 vaccine-associated myocarditis is rare.
Researchers at Cedars-Sinai Medical Center have developed a new method to identify which human gut microbes contribute to inflammatory diseases. By analyzing protein levels in blood serum, the team discovered specific bacteria that trigger immune activation and inflammation.
Buck scientists introduce mechanoimmunology, a new discipline that explores the role of physical forces in immune cell responses. The study reveals that mechanical cues tune immune cell behavior, potentially leading to new treatments for various disorders.
A study at Tulane University found that recently formed stroke plaques contain messenger RNA that causes inflammation and degrades a protective cap, leading to rupture. This discovery could lead to new tools to stop strokes from happening and develop new drugs or diagnostics to prevent heart attacks and strokes.
A small clinical trial found that OP-101 substantially reduced the risk of death and need for a ventilator in severely ill adults hospitalized with COVID-19. The treatment also showed significant benefits in decreasing biomarkers of inflammation and brain injury, suggesting potential for treating long COVID-related symptoms.
Researchers developed nanoparticles to deliver anti-inflammatory payloads directly to inflamed blood vessels, significantly increasing survival chances and delaying rupture onset. Targeting specific NF-kappaB subunits improved therapeutic effects with fewer adverse effects.
Researchers at Aston University have developed a new approach to tackle one of the underlying causes of asthma, not just its symptoms. The treatment, which targets the structural changes made by asthmatic airways, shows promising results in mice, reducing symptoms within two weeks and returning airways to near normal.
Researchers identified toll-like receptor (TLR) signaling as a novel pathway regulating GLI3 expression, which plays a role in inflammatory cytokine production and cancer. They found that IRF3 directly binds to the GLI3 promoter region, increasing its expression upon TLR4 stimulation.
A new study from UC Davis links air pollution exposure to increased inflammation and decreased cardiac regulation in children. Elevated markers of interleukin-6 and lower cardiac autonomic regulation were found in blood samples of healthy children aged 9-11 who lived near areas with high levels of PM2.5 during wildfires.
Researchers found that higher suPAR levels were associated with increased risk of blood clot formation in COVID-19 patients. Combining suPAR and D-dimer may improve predicting who is at high or low risk of blood clots, enabling targeted therapies to prevent critical outcomes.
Researchers at KAIST developed a novel fusion protein drug, αAβ-Gas6, which efficiently eliminates amyloid beta (Aβ) without causing inflammatory side effects. The study showed that αAβ-Gas6 promoted the robust uptake of Aβ without inflammation and neurotoxicity.
Researchers found higher levels of brain cell damage and inflammation markers in women with severe preeclampsia compared to those with uncomplicated pregnancies. The study used health record data from the Rochester Epidemiology Project and explored extracellular vesicles as potential early risk indicators.
Researchers from NUS Medicine developed a probiotic that detects antibiotic-induced microbiome imbalance and regulates bile salt metabolism to prevent Clostridioides difficile infection. The probiotic significantly reduced CDI in laboratory models, demonstrating a 100% survival rate and improved clinical outcomes.
A new study found that gout patients who suffered from a heart attack or stroke were twice as likely to have had a gout flare in the 60 days prior to the event. Gout flares are also associated with a transient increase in cardiovascular events, particularly among those with pre-existing heart disease.
A new study from Duke University suggests that consuming more fiber can lead to improved gut health, regardless of the specific supplement used. Participants who had been eating the least amount of fiber before the study showed the greatest benefit from supplements.
A new study found that consuming green tea extract for four weeks can lower blood sugar levels, improve gut health, and decrease inflammation in healthy individuals and those with metabolic syndrome. Researchers observed a significant reduction in fasting blood glucose levels and decreased gut permeability.
A team from Osaka University developed a silicon-based agent that generates hydrogen when reacting with water, reducing inflammation and symptoms of ulcerative colitis in a mouse model. The study suggests the Si-based agent may be an effective treatment method for this disease.
A team of researchers has discovered that malignant tumors accumulate lipid delivery molecules called LDL and attract immune suppressor cells called neutrophils, leading to tumor progression. The study also shows that targeting the LOX-1/oxidized LDL axis may be a promising strategy for treating both cancer and cardiovascular disease.
Researchers identified common cellular mechanisms and dysfunctional processes driving post-COVID lung disease, similar to idiopathic pulmonary fibrosis. The study found shared gene expression patterns and endoplasmic reticulum stress as early triggers of both conditions.
Studies in rats have found that T-cells produce reactive oxygen species (ROS) that contribute to preeclampsia complications. Researchers are exploring ways to dampen this response to reduce the risk of premature birth or worse outcomes for mother and child.
A new study found that COVID-19 patients are at a higher risk of developing cardiovascular diseases and diabetes in the months following infection. The risk of diabetes returns to baseline levels within 23 weeks, while cardiovascular disease risk decreases after 7 weeks.
Hospitalized COVID-19 patients with high blood viscosity have a 60% higher death rate than those with low blood viscosity. The study suggests that checking for blood viscosity early on could help determine the best treatment course and improve outcomes.
A recent study discovered that brain inflammation may be a key link between Alzheimer's disease risk and sleep disturbance. The research found that age-related increases in brain inflammation can disrupt fast sleep spindles, which are crucial for long-term memory retention. This disruption contributes to age-related memory impairment i...
A new study found that opioids like morphine can cause gastric inflammation due to increased acid secretion and delayed gastric emptying. Treatment with naloxone or proton pump inhibitors like omeprazole may provide gastroprotection, improving pain management and reducing side effects.
A new study reveals that oxidative damage to telomeres can trigger cellular senescence, leading to the development of 'zombie cells'. Researchers found that damage at telomeres disrupts DNA replication and induces stress signaling pathways, contributing to age-related diseases.
Researchers have devised a way to deliver carbon monoxide to the body using stable foams that can be delivered to the digestive tract. The foams reduced inflammation of the colon and helped reverse acute liver failure in mice, offering a potential alternative to immunosuppressive treatments.
A novel single-cell RNA sequencing technique, TAS-Seq, has been developed to provide higher-precision data than current methods. The new method detects more genes and identifies highly variable genes, making it a sensitive high-throughput scRNA method.
Research at Kyoto University found that estradiol suppresses severe skin inflammation in females compared to males, revealing its therapeutic potential. The hormone regulates immune cells and reduces IL-17A and IL-1β cytokines production.
The USPSTF recommends against using beta carotene or vitamin E supplements to prevent cardiovascular disease (CVD) or cancer. Inflammation and oxidative stress play a role in both CVD and cancer, but dietary supplements have shown anti-inflammatory and antioxidative effects, leading to proposals for their use as preventive measures.
A recent review article highlights the crucial role of macrophages in the progression from acute kidney injury (AKI) to chronic kidney disease (CKD). The study suggests that targeting specific signaling pathways and altering macrophage activation can prevent renal fibrosis and CKD. Therapeutic strategies such as clodronate liposomes an...
Researchers at Ohio State University created a mathematical model that assesses the efficacy of immunomodulatory drugs in treating myocardial infarctions. The study found that certain combinations of these drug inhibitors were more efficient at reducing inflammation, offering new possibilities for improving patient outcomes.
Cases of Kawasaki disease fell in the US during the COVID-19 pandemic and remained low during masking and school closure. The findings suggest a respiratory portal of entry for the trigger agent(s), consistent with social behavior influencing exposure.
A global team led by Rutgers Cancer Institute of New Jersey has secured $25 million to study cachexia, a debilitating wasting condition responsible for up to 30% of cancer deaths. The team plans to build a deep understanding of what causes cachexia and develop novel treatments.
Researchers identified immune endothelial cells promoting inflammation and developmental endothelial cells supporting cell development, regeneration, and proliferation. The study's findings may lead to targeted treatments for lung infections and acute respiratory distress syndrome.
Researchers have identified lung-infiltrating monocytes as the key immune cells driving COVID-19's inflammatory complications. The study suggests that targeting these cells with remdesivir and baricitinib can enhance antiviral signaling and viral clearance, potentially improving patient outcomes.
Researchers at IRB Barcelona describe a cellular mechanism that coordinates inflammation resolution, with CPEB4 protein playing a crucial role. This regulation involves the balance between pro-inflammatory TTP and anti-inflammatory CPEB4 proteins.
A recent study found that shingles is not associated with an increased risk of dementia. The study analyzed data from Danish medical registries and found that people with shingles had a 7% lower risk of dementia compared to those without the disease.
Researchers at the Messerli Research Institute developed a lozenge that compensates for micronutrient deficiencies in immune cells, reducing inflammation and allergic reactions. The study showed a 45% reduction in symptom burden during peak pollen season, presenting a new approach to allergy care.
Researchers identified distinct subpopulations of keratinocytes and changes in cellular compositions that drive disease persistence. The findings raise the possibility of targeting keratinocyte metabolism in Vitiligo treatment.
Researchers at the University of Chicago's Pritzker School of Molecular Engineering have developed a version of interleukin-12 that is activated only when it reaches a tumor, reducing side effects. The new 'masked' molecule has shown promising results in eliminating cancer cells and outperforming existing immune therapies.
Researchers found that inhibiting caspase 11 reduced inflammation, tissue injury and blood clots in lung tissue of infected mice. This suggests potential therapeutic targets for treating severe COVID-19 symptoms.
Researchers investigated the effects of treatment with exogenous Humanin G on inflammation markers in AMD and normal retinal cells. The study found reduced levels of inflammatory proteins in AMD plasma and treated cybrids, highlighting the positive effects of Humanin G.
Researchers at Karolinska Institutet discovered that electrical stimulation of the vagus nerve promotes healing in acute inflammation by shifting the balance between inflammatory and anti-inflammatory molecules. This finding opens new avenues for treating inflammatory diseases, including autoimmune and cardiovascular conditions.