Articles tagged with Inflammation
A new Penn Medicine study suggests that clinically depressed older individuals without other inflammatory conditions do not have elevated levels of inflammation. The study found no significant difference in bloodstream levels of inflammatory markers between depressed and healthy individuals.
Researchers at UConn Health found that deleting TRPM2 from macrophages in mice reduced atherosclerosis by inhibiting the TRPM2–CD36 inflammatory axis. This approach prevented foamy macrophages and alleviated inflammation in arteries.
A National Jewish Health-led study found that over a third of identified genetic risk factors for asthma are associated with altered function of airway epithelium. The research discovered genetic changes in genes related to mucus production and type 2 inflammatory pathways, increasing asthma risk.
This year's Experimental Biology 2022 meeting features groundbreaking studies on COVID-19 vaccine-associated symptoms in non-menstruating people, a plant compound showing promise for alleviating food allergies, and the potential of omega-3s to boost immunotherapy's cancer-fighting power. Researchers also explore the safety of using CBD...
Researchers developed a novel approach to diagnose, monitor, and predict the course of myocarditis using CMR parameters and AI. The goal is to provide personalized counseling for athletes and optimize treatment options.
Researchers identified common features of pediatric antiphospholipid syndrome, a rare autoimmune disease causing inflammation and recurring blood clots. Nearly half of children with APS experienced recurrent blood clots despite treatment, highlighting the need for early diagnosis and prevention.
A comprehensive literature review found that consuming plant-based alpha-linolenic acid (ALA) rich in walnuts and flaxseeds can lower cardiovascular disease risk by 10% and fatal coronary heart disease risk by 20%. ALA may also benefit heart health when combined with other omega-3s.
Researchers found that post-COVID patients displayed altered autonomic nervous system functioning, with increased sympathetic activity and decreased parasympathetic activity. Obesity and physical inactivity were key factors contributing to these changes.
A new study from Karolinska Institutet and Helmholtz Center Munich found that macrophages show altered inflammatory and metabolic expression several months after mild COVID-19. Even though most individuals were symptom-free, their immune systems were more sensitive than those of healthy counterparts.
Research suggests exercise can break the vicious cycle of inflammation that leads to diabetes and depression in people with Long COVID. A 30-minute session of moderate-intensity exercise, such as walking, can be beneficial.
Researchers found that brains from patients with Alzheimer's disease had higher levels of the protein Fli-1 and fewer pericytes lining their smallest blood vessels, leading to leakage. Blocking Fli-1 improved memory in mice, suggesting a promising new approach to treating the disease.
Scientists have identified a new immune process that regulates inflammation in human fat, which may help manage obesity. The research found that specific immune cells can work together in fat tissue to cause weight gain and obesity.
A study suggests that targeting necroptosis in muscle fibers using an inhibitor can lessen myositis-induced muscle weakness and cell death, promoting muscle regeneration. This approach shows promise for treating polymyositis with potentially fewer infectious complications than current immunosuppressive therapies.
A new study found that e-cigarette vapers and hookah smokers are more likely to exhale particles through their nose compared to cigarette smokers. This unique breathing pattern may expose the nose and sinuses to higher levels of emissions, increasing the risk of upper respiratory diseases.
A new study by University of Bonn researchers found that cow's milk protein casein triggers an autoimmune response in mice, damaging neurons and myelin sheath. This cross-reactivity can occur when the immune system mistakes similar molecules for each other.
A study published at Tokyo Medical and Dental University found that Mkx regulates cellular heterogeneity and gene expression in the PDL, revealing its importance in homeostasis. The results showed that a deficiency of Mkx promotes ossification in the PDL and suggests a compensatory mechanism via Scx to maintain homeostasis.
A new study found that cashew stem bark extract inhibits abnormal gut motility associated with diarrhea, revealing a potential low-cost remedy for treating and managing the condition. The extract's mechanism of action involves blocking muscarinic acetylcholine receptors responsible for gastrointestinal motility.
A new study from Massachusetts General Hospital found that living through the COVID-19 pandemic can lead to brain inflammation and symptoms like fatigue, concentration difficulties, and depression in uninfected people. The research suggests that societal and lifestyle disruptions during the pandemic may trigger this inflammatory response.
A series of studies by NYU researchers found that e-cigarette users have a distinct oral microbiome less healthy than nonsmokers but potentially healthier than cigarette smokers. The study also reveals altered immune responses, including increased inflammation and suppression of immune reactions.
A natural product from the dried root of Sophora flavescens, combined with an enzyme inhibitor, has been found to reduce neuroinflammation in a mouse model of Parkinson's disease. The compound kurarinone may provide hope for alleviating symptoms of the incurable disorder.
Researchers at the University of Tsukuba investigated the effect of sevoflurane on sleep disturbance caused by systemic inflammation. Sevoflurane preconditioning promoted significant increases in REM sleep after LPS injection, while postconditioning had no effect.
A new study from the La Jolla Institute for Immunology reveals that two groups of regulatory CD4+ T cells develop at different times to combat acute inflammation. The early Tregs reduce autoimmune damage, while the second wave shuts down the entire immune response to signal infection clearance.
Researchers at University of Texas M. D. Anderson Cancer Center developed a novel PET imaging tool to selectively monitor inflammation and innate immune activity. The new radio-labeled molecule, [18F]4FN, is more specific and robust than existing agents, offering potential for early biomarker detection of immune-related adverse events.
Scientists have devised a method to pinpoint active ingredients from traditional Chinese medicine formulations, revealing 4 analytes with significant anti-inflammatory activity. This breakthrough could improve quality control standards and lead to better herbal remedies.
A recent review of e-cigarette research highlights the significant health risks associated with vaping, including lung inflammation and injury. The study found that e-cigarettes can cause negative effects in multiple organs, from the brain to the bladder, and may even increase the risk of lung cancer.
Researchers have identified nitric oxide as a key driver of excessive cell death and inflammation in the body. By blocking caspase-8, a protein that produces nitric oxide, unregulated cell death can be prevented, offering new treatment options for inflammatory diseases.
Researchers found that infusing bone-marrow stem cells into mice with sepsis increased their survival by 50-60% and decreased inflammation. This treatment could offer an alternative to current granulocyte transfusions, which have limited benefits.
A new study found that calorie restriction improves metabolic and immune responses, generating more T cells to fight off infections and improve energy efficiency. This could lead to a potential treatment to reduce age-related inflammation and improve metabolic health.
Prunes have been found to help prevent or delay bone loss in postmenopausal women by reducing inflammation and oxidative stress. This is due to their potential to alter the gut microbiome, which can lead to lower levels of pro-inflammatory cytokines and markers of oxidative damage.
Researchers at the University of Gothenburg mapped SARS-CoV-2 mutation patterns and found that ADAR1-induced mutations weaken the virus. These mutations are more common than other types of mutations, suggesting a protective mechanism against COVID-19.
A recent study found that protracted inflammation following COVID-19 is strongly linked to long-term changes in lung structure and function. Monitoring patients for signs of inflammation after infection may help identify those at risk of long-term lung problems.
Researchers found that prunes' phenolic compounds and dietary fiber content may alter gut microbiome, decreasing inflammatory markers and improving bone turnover. Clinical trials showed promising effects of prune consumption on bone health outcomes in postmenopausal women.
Researchers found that fuel poverty leads to higher levels of inflammation, affecting physical health, and lower life satisfaction, impacting wellbeing outcomes. The study's findings highlight the need for policies to support low-income households struggling with fuel poverty.
Researchers found that higher monocyte counts are linked to early signs of injury and scarring on lung imaging among community-dwelling adults. This suggests that hyperactive monocytes may contribute to lung injury at the early stages of interstitial lung disease.
Scientists have found evidence that carnosic acid in rosemary can block SARS-CoV-2 infection and reduce inflammation. The compound has been shown to inhibit the powerful inflammatory pathway active in severe COVID-19 and other diseases.
Scientists have identified a key receptor in the digestive tract that triggers pain and inflammation in the colon. By blocking this receptor from entering cells, researchers found significant reduction in pain and inflammation. This discovery holds promise for treating inflammatory bowel disease.
Gene-environment interactions play a crucial role in the development of autism symptoms, according to a new study by UNIGE researchers. By inhibiting Trpv4 and inducing massive inflammation, scientists observed neuronal hyperexcitability, which disrupted communication channels and led to social avoidance behaviors.
A recent study led by University at Buffalo researchers found that photobiomodulation reduces inflammation, improves blood flow and heals wounds up to 19 days faster. Light therapy accelerated skin healing from cancer radiation therapy by an average of 49-42 days.
Researchers have identified 15 biological markers that can predict severe depression in pregnant women with 83% accuracy. This finding has the potential to improve prenatal care and reduce depressive symptoms in mothers.
Researchers found a markedly increased risk of carditis associated with BNT162b2 vaccination, particularly in adolescents after the second dose. The study's findings highlight the need for refined vaccination strategies to balance risk and benefits across different sub-populations.
Researchers discovered that the IL-6 family of proteins is required for maintaining and regenerating cartilage in joints and growth plates. The study found that blocking this gene could lead to severe cartilage and skeletal changes, particularly in females.
A ketogenic diet has been shown to improve spatial memory and visual memory, lower brain inflammation indices, and cause less neuronal death in individuals with traumatic brain injuries. The diet may also slow down the rate of cellular aging, offering hope for those suffering from this condition.
The American College of Physicians (ACP) has released two new clinical guidelines for the diagnosis and management of diverticulitis. The guidelines recommend that clinicians manage most patients with uncomplicated disease in outpatient settings without antibiotics, while patients with complicated disease should be referred for colonos...
Researchers at La Jolla Institute for Immunology found that macrophages in artery walls can sense octanal, leading to inflammation and atherosclerosis. By blocking this detection, they reversed disease progression. Further research is needed to explore the role of olfactory receptors in cardiovascular diseases.
A study found that SIRT2 activation by PM2.5 exposure triggers airway inflammation, bronchial hyperresponsiveness, and organ damage in mice. Triptolide inhibition of p65 reduced PM2.5-induced effects, suggesting a novel therapeutic strategy against PM2.5 toxicity.
Researchers develop ice-inspired lubricant that enhances lubrication and reduces friction and inflammation in a rat model of osteoarthritis. The treatment, which uses microfluidic technology to create drug-loaded particles, shows promise as a potential solution for joint pain and degeneration.
Researchers found that inhibiting gasdermin D, a protein involved in septic patients' organ lesions, can prevent multiple-organ damage and improve prognosis. Disulfiram, a drug originally indicated for alcohol dependence, was shown to inhibit gasdermin D and reduce tissue injury.
A new targeted therapy inhibits specific immune cells associated with lupus nephritis, improving kidney inflammation in animal models. Elevated levels of ALCAM molecules suggest a potential new path toward personalized medicine.
A study reveals a powerful subset of vascular macrophages expressing CLEC4A2 fosters 'good' macrophage behavior, limiting plaque build-up. This discovery challenges the widely held belief that macrophages only play a harmful role in cardiovascular disease.
Research suggests early-life infection, inflammation, and metabolic changes contribute to psychiatric disorders through critical brain development periods. This may lead to new treatment approaches for depression and psychosis.
A new study by the University of North Carolina at Chapel Hill and an international team finds that triclosan triggers gut inflammation in mice. The researchers identified specific bacteria and enzymes that drive this damage, but also developed a microbiome-targeted inhibitor to block triclosan processing, preventing colitis.
Researchers at the University of Illinois Chicago have developed a new method for analyzing pyroptosis, a process of cell death previously thought to be irreversible. By using optogenetic gasdermin, they found that certain conditions can trigger pores to close within tens of seconds, suggesting the process dynamically self-regulates.
Research in mice suggests that first-responder cells launching repair after a heart attack promote more inflammation than necessary, threatening optimum healing of the heart.
Researchers have found that blocking mineralocorticoid receptors, a key factor in bone health, may help protect against bone loss and osteoporosis. This new target is thought to be more effective than previously believed logical targets, such as reducing glucocorticoid receptor activity.
A study conducted at the University of Turku found that following a healthy diet in early pregnancy can significantly reduce the risk of developing gestational diabetes. The research revealed that a diet high in saturated fats and low in essential nutrients increases inflammation and raises the risk of gestational diabetes.
Phoebe Lin's research establishes a gut-eye association in animal models, finding that certain interventions can enhance Tregs and decrease eye inflammation. Her five-year grant will investigate how intestinal microbes and the immune system can be rebalanced to treat uveitis.
Researchers at Brigham and Women's Hospital discovered a new mediator, 4S, 5S-epoxy-resolvin, that resolves acute inflammation and stimulates tissue regeneration. The study found that this mediator also controls granuloma formation in human leukocytes.
A team of researchers has fully identified the production process of thymol and carvacrol in thyme and oregano, respectively. The findings could lead to improved plant breeding and the development of new antibacterial and anti-inflammatory substances.
A new study found that children and adolescents with persistent high levels of anxiety are more likely to develop psychosis in their early 20s. Treating early anxiety by targeting stress hormones and non-resolving inflammation during childhood and teenage years could help prevent young adults from developing psychosis.
Researchers at UC Riverside have discovered that targeting the TNFR1 receptor may be a more effective approach to treating inflammatory bowel disease. By selectively blocking TNFR1, they found significant benefits in mice with Crohn's-like ileitis, suggesting this approach could offer a new opportunity for healing.