Articles tagged with Inflammation
Researchers at the University at Buffalo have successfully treated chronic, precancerous inflammation in the intestine using an oral biologic medication. The study found that targeting disease-promoting inflammatory cells can render them less able to cause disease, offering a promising avenue for site-specific oral therapy.
Researchers have discovered a small molecule that prevents necroptosis, a recently discovered cell death pathway linked to immune disorders. The compound 'jams the switch' on MLKL, a protein that triggers cell death, thereby preventing inflammation and promoting new treatments for inflammatory diseases.
Researchers found that excess glucose enters cells via inflammatory pathways, sparking escalating inflammation and damaging blood vessels. Lifestyle changes like exercise and weight reduction can reduce both blood sugar and inflammation.
Researchers found heme oxygenase-1 deficiency in HIV-infected brains associated with cognitive decline and increased viral load. Increasing heme oxygenase-1 expression may offer protective benefits against HIV-associated neurocognitive disorders.
Researchers at Lund University discovered inflammation and changes in the intestinal barrier function early in MS, indicating a potential link to disease progression. The study suggests that damage to the intestinal barrier may prevent the body from ending an autoimmune reaction, leading to chronic diseases like MS.
Scientists have found that punicalagin, a polyphenol in pomegranate, can inhibit neuro-inflammation in brain cells. The compound may help slow the development of diseases like Alzheimer's and Parkinson's by reducing inflammation.
The Oklahoma Medical Research Foundation has received a five-year, $14.5 million grant from the National Institutes of Health to continue its research on anthrax and its effects on humans. The project aims to identify new vaccines and drug targets by studying the human immune response to anthrax bacteria.
Researchers at UC San Diego School of Medicine found that aspirin prompts the production of 15-HETE, which converts to lipoxin to reverse inflammation. This discovery may lead to new anti-inflammatory therapies by developing drugs based on lipoxin analogues.
A new Northwestern University study finds that an intervention focused on strengthening families can reduce inflammation in children from low-income backgrounds. The training program improved parenting and communication between parents and children, leading to reduced inflammation.
A new study by Sanford-Burnham researchers identifies the NBR1 protein as a critical regulator of obesity-induced inflammation, which leads to metabolic disease. The study suggests that blocking this signal may protect against the development of metabolic disease and type 2 diabetes.
The National Psoriasis Foundation has awarded $1.05 million in research grants to 13 scientists studying new treatments and a cure for psoriasis and psoriatic arthritis. The grants will support projects focused on translating laboratory findings into improved treatments and methods for managing the diseases.
Researchers found that higher levels of C-reactive protein in maternal blood were significantly associated with an increased risk of schizophrenia in offspring. The study suggests that pregnancy-related inflammation may play a role in the development of schizophrenia, providing new insights into its biological mechanisms.
Research from UT Southwestern Medical Center found that a level of 'healthy' inflammation is necessary to prevent fatty liver and metabolic diseases. Inflammation helps remodel fat tissue, preventing the buildup of excess lipids in other tissues.
Researchers discover periodontal bacteria selectively disarm immune system, promoting dysbiosis and bone loss. The study reveals a two-pronged mechanism involving protein receptors C5aR and TLR2, which protects 'bystander' gum bacteria from clearance.
Researchers discovered that stimulating AhR in skin cells reduces inflammation in psoriasis patients, a potential new treatment approach for chronic inflammatory skin disorders. The findings suggest a novel strategy for treating psoriasis, combining immune system modulation with AhR stimulation.
A recent study published in Nutrients found that cyclists who consumed Montmorency tart cherry juice concentrate before exercise experienced less inflammation and oxidative stress. The researchers attributed the recovery benefits to the natural compounds in tart cherries, particularly anthocyanins.
Pharmacists at Jena University have developed three potential therapeutic agents that may improve the healing of inflammatory illnesses. The agents suppress a key enzyme in the body's own cascade of inflammation, specifically targeting 5-LOX, which plays a pivotal role in synthesizing leukotrienes. This breakthrough could lead to more ...
A recent study suggests that chronic disruption of circadian rhythms may contribute to inflammatory bowel disease and other harmful conditions. Consuming a high-fat, high-sugar diet can worsen the effects of circadian rhythm disruption on intestinal flora.
A University of Pennsylvania team has identified a promising new target for gum disease treatment: the complement component C3. Treating monkeys with a C3 inhibitor successfully prevented periodontitis-related inflammation and bone loss, suggesting this could be a promising drug option for humans.
A new study published in JAMA Internal Medicine found no association between resveratrol consumption and improved health outcomes. The research suggests that the supposed health benefits of resveratrol from food sources may be exaggerated or entirely unwarranted.
A study published in the Proceedings of the National Academy of Sciences found that bullied children experience chronic, systemic inflammation that persists into adulthood. In contrast, bullies may benefit from increased social status through bullying, which can protect against increases in inflammatory markers.
A study published in PLOS Pathogens found that IL-27 balances the immune response to influenza, reducing lung damage and improving recovery. The researchers discovered that well-timed IL-27 treatment can be beneficial for mice infected with a highly pathogenic influenza strain.
A low-carbohydrate diet was found to significantly reduce inflammation in patients with type 2 diabetes, whereas a traditional low-fat diet showed no similar effect. After six months, the low-carb group exhibited reduced levels of inflammatory markers and improved glucose control.
A study published in the American Journal of Respiratory Cell and Molecular Biology suggests that TNF-α, a pro-inflammatory cytokine, accelerates lung recovery and reduces scar tissue in mice with pulmonary fibrosis. The researchers found that inflammation can be beneficial during the healing process, rather than just causing scarring.
Researchers at Lomonosov Moscow State University and Pittsburgh University have identified a new biosynthetic pathway for lipid mediators, producing molecules that regulate inflammation and cell death. The study's findings could lead to the development of new anti-inflammatory drugs.
A review by Kevin J. Tracey, MD, and Clifford S. Deutschman argues that treatment for sepsis is nonspecific and limited to organ support, with no approved drugs targeting the condition. Instead, a new approach focusing on immunometabolic and neurophysiological mechanisms may be needed.
Scientists studying high-altitude trekkers found increased insulin resistance and inflammation markers after prolonged exposure to hypoxia. The study suggests possible interventions to reduce progression towards full-blown diabetes.
A traditional Chinese herbal remedy, Tripterygium wilfordii Hook F, has been shown to be as effective as methotrexate in treating rheumatoid arthritis. Combining the herbal remedy with methotrexate resulted in improved outcomes for patients, including significant reductions in disease activity and remission rates.
Silibinin from milk thistle extract reduces self-renewal of colorectal cancer stem cells, affecting cell signaling associated with inflammation. The compound also decreases levels of CSC self-renewal-promoting mRNAs.
A new study published in Blood journal found that adhering to a Mediterranean diet is associated with lower levels of platelets and white blood cells, two markers of inflammation. This eating plan is linked to reduced inflammation and heart disease risk, particularly among healthy individuals.
Researchers developed polymorphonuclear leukocyte-derived novel pro-resolving medicines (NPRMs) to deliver a lipoxin A4 analog to the site of surgery, controlling inflammation and promoting tissue and bone growth. The mini-pig model revealed significant pocket depth reductions and new bone formation in NPRM+LXA4-treated sites.
A Rutgers-led study finds acupuncture can reduce inflammation and organ injury in septic mice, with half surviving for at least a week. The treatment also triggers increased levels of dopamine, which may help alleviate other inflammatory diseases like arthritis and Crohn's disease.
Researchers have identified a rare genetic disorder that causes sporadic fevers, skin rashes, and recurring strokes in early childhood. The syndrome is caused by variants in the CECR1 gene, which impede production of a protein vital to healthy blood vessel walls.
Scientists at the University of Cambridge discovered that implant stiffness is a major cause of foreign body reactions. The team found that stiff materials trigger inflammation and cell shape changes in brain cells, leading to encapsulation with scar tissue.
A new study confirms a variant in the SERPINE1 gene is linked to cerebral palsy and death in very preterm babies. The findings add to evidence that genes may play a role in brain injury and death risk in preterm infants.
Researchers found elevated levels of translocator protein 18 kDa (TSPO) in patients with myocarditis and mice, suggesting its potential as a biomarker for heart inflammation. TSPO's role in driving disease progression and prognosis is also being explored.
Increased inflammation after infections impairs brain's ability to form spatial memories by disrupting neural circuits involved in learning and memory. The study used PET scans to measure effects of inflammation on glucose consumption in the brain, revealing a decrease in glucose metabolism in the Medial Temporal Lobe.
A study published in PLOS ONE found that DHA supplementation partially prevented metabolic damage associated with the Western diet. This led to observable changes in carbohydrate, protein, and lipid metabolism.
Researchers found that fiber activates Gpr109a receptors, which reduce inflammation in the colon and prevent cancer. Mega-doses of niacin may also help protect the colon and prevent conditions like ulcerative colitis and Crohn's disease.
Researchers developed a novel sugar-based tracer contrast agent to aid in the detection of inflamed and vulnerable artery plaques. The new tracer, fluorodeoxymannose (FDM), shows promise in targeting high-risk plaques more specifically than traditional glucose-based tracers.
Researchers at Scripps Florida Institute developed a compound that dramatically reduces joint inflammation in animal models of rheumatoid arthritis. The study showed the compound, SR2211, blocked symptoms and bone erosion in mice within eight to ten days of treatment.
Therapeutic hypothermia decreases free radical production and inflammation, improving cerebral metabolism after traumatic brain injury. However, potential negative aspects of hypothermia treatment must be further studied.
Research review highlights cranberry's unique bioactive compounds that may reduce UTI incidence, improve cardiovascular health and temper inflammation. Cranberries also show promise in supporting endothelial function and reducing arterial stiffness.
Researchers at the University of Leicester have developed a new technique to create protein-based drugs using evolutionary engineering. The method involves generating millions of variants of a protein, selecting those with improved properties, and repeating the cycle until the desired function is achieved.
Researchers at UCLA found that engineered tomatoes can reduce the negative effects of unsaturated lysophosphatidic acids (LPAs) in mice, which are linked to high cholesterol and inflammation. The tomatoes produce a peptide that mimics HDL ('good') cholesterol, stopping increases in 'bad' cholesterol and inflammation.
A new study from Hospital for Special Surgery found that achieving low disease activity within six months significantly reduces disability at two years. Patients who reached this state had better functional ability and fewer joint damages compared to those who delayed treatment.
A new study from RIKEN and Keio University reveals that Pimozide can restore steroid effects on natural helper cells in severe asthmatic patients. Researchers found that thymic stromal lymphopoietin (TSLP) induces corticosteroid resistance in these cells.
Researchers at UWM have discovered that near-infrared (NIR) and blue light can repair tissue in dramatically different ways, but both act on the same enzyme in the cell's energy supply center: the mitochondria. NIR light has been shown to improve MS symptoms in rodent models, while blue light kills bacteria that cause infection.
Researchers at Scripps Research Institute have identified key signaling proteins that contribute to the development of inflammatory diseases such as rheumatoid arthritis and psoriasis. By targeting these proteins, a new class of anti-inflammatory therapy may be developed.
A recent study found that high-dose statins significantly reduced gum inflammation in heart disease patients within four weeks. The research also showed a close link between gum inflammation and atherosclerotic disease, suggesting that improving oral hygiene may lead to improved cardiovascular health.
A clinical trial found that HydroEye(R) improved ocular irritation symptoms and halts the progression of inflammation in moderate to severe dry eye. The study showed significant benefits for post-menopausal women, providing a safer alternative to existing dry eye treatments.
A new study published in the American Journal of Pathology found that resveratrol actually worsened MS-like neuropathology and inflammation in mice. Resveratrol did not show anti-inflammatory or neuroprotective effects, contradicting previous claims about its benefits.
Researchers at Uppsala University found that combining two test methods can provide better asthma diagnosis. The combination of exhaled nitric oxide and blood eosinophil counts increases the likelihood of individuals reporting asthma symptoms or attacks.
Researchers will study TSPO's role in microglia and astrocytes to understand its function in brain injury and inflammation. The goal is to discover new therapeutic targets for treating inflammation and brain injury.
Researchers found that atorvastatin treatment decreased levels of inflammatory markers, thrombogenesis, and hyperlipidemia, suggesting its anti-inflammatory and anti-thrombotic effects. This study expanded the use of atorvastatin for acute ischemic stroke treatment by measuring multiple biomarkers.
New research finds that a subpopulation of immune cells, known as T lymphocytes, have platelets bound to their surface, reducing activation and proliferation. This discovery opens the door to potential treatments targeting platelet binding to lymphocytes.
A study by UNH researchers found no significant benefit of post-exercise ice baths in reducing muscle soreness or improving strength after intense exercise. Despite initial skepticism, lead researcher Naomi Crystal notes that moderate use of cryotherapy may still be beneficial for elite athletes.
Researchers at National University of Mexico found that prolactin can prevent chondrocyte death and associated cartilage degradation in rheumatoid arthritis models. Prolactin treatment reduced inflammation, bone erosion, joint swelling, and pain in rat models.
A study by Michigan Medicine researchers has identified five genes that play a major role in the development of Takayasu arteritis, a debilitating disease causing inflammation and damage to major blood vessels. The findings may lead to new therapeutic targets for this under-studied condition.
A multicenter clinical trial found daily omega fatty acid supplementation to be effective in improving ocular irritation symptoms and halting inflammation progression in moderate to severe dry eye patients. HydroEye clearly had a positive impact on these patients, providing safe and cost-effective relief.