Research on inflammation and its role in disease. Covers eye inflammation, personalized anti-inflammatory medicine, aging, and chronic pain links.
An international team has identified interactions between immune system pathways that could improve the treatment of diseases such as colitis. The discovery may lead to more effective treatments for millions of IBD sufferers by targeting both adaptive and innate immune systems.
Researchers found that microRNA-181b targets Card10, a protein that helps activate inflammation. In preclinical studies, the delivery of miR-181b reduced blood clot formation and prolonged time to artery blockage by up to 1.6 fold.
Researchers found that DNASE1L3 prevents lupus by breaking down DNA, which triggers immune cells to produce antibodies that cause inflammation. A new mechanism for biologic therapies has been discovered.
Researchers at Johns Hopkins Medicine found a link between rising eosinophil levels and regrowth of nasal polyps in chronic sinus disease patients. The study suggests that monitoring eosinophils could aid in detecting early growth and tracking treatment effectiveness.
Scientists from Gladstone Institutes identified salicylic acid's cancer-fighting properties by inhibiting epigenetic regulators p300 and CBP. Salicylic acid suppresses inflammation and cell growth, offering new clinical possibilities for drugs like aspirin and diflunisal.
A study found that antiretroviral therapy alone is not enough to reduce HIV-associated arterial inflammation, which increases the risk of cardiovascular disease. Additional immune-system-modulatory approaches are needed to address this issue.
Research at Osaka University reveals Lypd8's role in preventing intestinal bacteria invasion, shedding new light on ulcerative colitis pathogenesis and potential therapeutic targets. The study found that Lypd8 decreases in patients with ulcerative colitis, leading to increased susceptibility to inflammation.
Research found that high arginine levels support metabolic pathways that reduce airway inflammation in asthma. Elevated arginine metabolism in human cells and mice improved mitochondrial function to offset inflammation.
Researchers at KARBio LLC and Genentech Inc. discovered that targeting human CRTh2 (hCRTh2) depletes immune cells implicated in asthma-associated inflammation, reducing cytokine production and lung inflammation in asthmatic mice. The study's findings support further exploration of hCRTh2 as a therapeutic target for asthma treatment.
Researchers at Brigham and Women's Hospital found that dietary tryptophan can limit brain inflammation in a mouse model of multiple sclerosis. In human patients, decreased levels of these molecules were observed, hinting at a possible link between gut flora and neurodegeneration.
Research suggests that salt-inducible kinases may have therapeutic potential for autoimmune diseases. By inhibiting these enzymes, scientists were able to limit the production of inflammatory molecules by certain types of human immune cells, increasing levels of anti-inflammatory IL-10 and reducing proinflammatory cytokines.
New research suggests that even small amounts of air pollution may have long-term health effects on the developing fetus, increasing the risk of premature birth and lifelong neurological and respiratory disorders. The study found biological evidence of intrauterine inflammation in pregnant women exposed to high levels of air pollution.
Dr. Harissios Vliagoftis has been appointed as the GSK-CIHR Chair in Airway Inflammation, focusing on protease-activated receptor 2 (PAR2) research to help patients with asthma breathe easier. His work aims to develop biomarkers and treatments that can minimize discomfort and side effects.
Researchers found that SHARPIN protein inhibits caspase 1 activation, which is linked to sepsis. Treatment with a caspase 1 inhibitor reversed effects in mice and showed promise in human patients.
Losmapimod, a p38 MAPK inhibitor, failed to show cardiovascular benefits in patients hospitalized with acute MI. The trial found no reduction in recurrent major adverse cardiovascular events or all-cause mortality among patients treated with losmapimod compared to placebo.
Rice University bioengineer Jeffrey Tabor has developed next-generation sensors using bacterial two-component systems to probe the gut for early signs of inflammation. The technology aims to revolutionize diagnosis and treatment of inflammatory bowel diseases.
A recent study of nearly 3,000 patients found that elevated levels of glycoprotein acetylation (GlycA) offset the benefits of high-density lipoprotein (HDL) cholesterol in preventing heart disease. Inflammation of artery walls is a contributing factor to heart attacks and strokes.
Researchers at Joslin Diabetes Center have identified the role of natural killer cells in abdominal fat inflammation and insulin resistance. By modulating NK cell activity, they found that inflammation in abdominal fat is suppressed and insulin resistance improves.
Two unique enzymes, AIG1 and ADTRP, have been discovered that play a role in metabolism and inflammation, potentially targeting type 2 diabetes and inflammatory disorders. The enzymes are moderately inhibited by lipase inhibitors, suggesting they may be used to boost FAHFAs, which normalize glucose levels and reduce inflammation.
Researchers found a link between stress center activity in the brain and arterial inflammation, increasing cardiovascular event risk. High stress levels were associated with more inflammation and a higher risk of heart attack, stroke, and death.
Researchers discovered that prooxidants can repair a metabolic flaw in T cells that drive rheumatoid arthritis. Treating arthritic mice with ROS-inducing drugs restored the T cells' redox balance and reduced joint inflammation.
Researchers found that difficult patients distract doctors from processing clinical information correctly, leading to higher misdiagnosis rates. The study showed that even with more time spent on diagnosis, doctors were still more likely to misdiagnose difficult patients than neutral ones.
A study found that subcutaneous insulin infusion does not prevent oxidative stress and inflammation in the liver, despite reducing glycemic variability. The therapy also failed to preserve balance of anti- and pro-oxidant species.
Macrophages produce excess inflammatory cytokine IL-1beta when damaged mitochondria release signals; p62 coats damaged mitochondria, ensuring removal. This prevents chronic inflammation and potentially age-related diseases.
A recent study suggests that immunotherapy can improve cognitive ability in patients with schizophrenia by suppressing inflammation. The study found significant improvements in cognitive function after just two doses of an immune-suppressing drug, tocilizumab.
Researchers found that ceria nanoparticles can reduce inflammation in the brain following a bleeding stroke by decreasing the secretion of inflammatory chemicals. In a lab experiment, macrophages treated with ceria nanoparticles showed less damage and water accumulation at the stroke site compared to untreated cells.
Researchers found that aerobic fitness protected against metabolic dysfunction in the liver, reducing inflammation and fatty deposits. Chronic alcohol ingestion did not cause significant changes in blood insulin or glucose levels, contrary to expectations.
A study of over 287,000 patients found that African-American patients with connective tissue diseases like lupus and rheumatoid arthritis were twice as likely to develop narrowed or atherosclerotic blood vessels. Young African-Americans with CTD also had a higher risk of cardiovascular disease, including heart attacks and strokes.
Researchers at NIH/NIEHS discovered that increasing tristetraprolin (TTP) levels in mice significantly reduced or protected against inflammation. TTP may offer an effective treatment for inflammatory diseases such as rheumatoid arthritis, psoriasis, and multiple sclerosis.
A study published in Genes & Development found that inhibiting the MLL1 enzyme prevents age-related inflammation and cancer. Researchers discovered that MLL1 is critical for regulating gene expression and is commonly mutated in human cancers, leading to increased inflammation and tissue degeneration.
Dasatinib, a cancer treatment, reduces inflammation and improves lung mechanics in mice with allergic asthma. The drug targets tyrosine kinases involved in asthma's signaling pathways.
Researchers have found a link between the chickenpox and shingles vaccine and corneal inflammation in rare instances. Primary care physicians should discuss this potential side effect with susceptible patients before vaccination.
Researchers at the University of Edinburgh have identified a chemical compound that blocks KMO, fueling inflammation linked to acute pancreatitis. The approach calms inflammation in the condition and protects against organ failure, offering hope for patients with life-threatening complications.
The study found that microglia, the brain's immune system, rapidly repair damage to the blood-brain barrier after breaches. This process could be impaired by certain cardiovascular drugs intended to prevent stroke-related damage.
Scientists at Augusta University found that YAP helps control astrocyte function, regulating the protective blood-brain barrier. Without YAP, astrocytes become hyper-reactive, leading to deadly inflammation and potential hydrocephalus.
Researchers at Oxford University are exploring the link between metabolism and inflammation in metabolic diseases, including type 2 diabetes and cardiovascular disease. The projects aim to deliver effective treatments and prevention strategies, addressing a global health problem affecting over 400 million people worldwide.
A rapid molecular assay using RNA biomarkers in blood can differentiate sepsis from infection-negative systemic inflammation more accurately and quickly than traditional methods. The assay, known as SeptiCyte Lab, was validated in independent cohorts and showed high sensitivity and specificity.
A consensus report by Mayo Clinic researchers provides a standardized approach to diagnosing glomerulonephritis based on the underlying cause of the disease. This new method aims to improve personalized diagnosis and targeted treatment for patients with kidney disease.
Researchers at Boston University School of Medicine have identified Th17 cells and Th1 as key players in obesity-associated type 2 diabetes. The study reveals a biomarker that can predict the development of Type 2 diabetes in 75% of people with obesity, offering new potential targets for prevention.
Research suggests that healthy cells are optimized for a healthy ecosystem; changes in this ecosystem allow cancer-causing mutations to outcompete healthy rivals, leading to an increase in cancerous cells. Inflammation is a critical factor in this process, hurting the growth and maintenance of healthy B-cell progenitor cells.
A new study published in Biological Psychiatry found that treatment for insomnia with cognitive behavioral therapy or tai chi reduces inflammation levels in older adults. These behavioral interventions also represent a third pillar, along with diet and physical activity, to promote health and reduce age-related morbidities.
Researchers at LSU have identified a new gene regulation pathway that prevents inflammation and speeds up the skin's healing process. A nanoparticle-carried small interference RNA blocks the Nax sodium sensor, enabling faster healing.
Researchers found that male mice recruit more white blood cells to the site of inflammation than females, highlighting the importance of sex differences in inflammatory responses. This discovery has implications for how we design and interpret experiments and evaluate anti-inflammatory therapeutics.
A recent study by Temple researchers found that a protein isolated from bacterial biofilms, known as curli, can effectively relieve intestinal inflammation in animals. The results suggest that curli could be a novel immunotherapy for inflammatory bowel disease, offering a new treatment option for patients.
A new study aims to determine the mechanisms that cause some grieving survivors to suffer unanticipated and potentially fatal heart attacks. The researcher hopes to understand how stress, depression, and anxiety contribute to inflammation, a driver of cardiovascular disease.
Researchers at Jena University developed a cellular system to study inflammation processes in real time, providing a method for targeting new therapeutic approaches. The system allowed them to clarify the exact regulatory mechanism of 5-LO and FLAP interaction, enabling tests for active compounds.
Researchers found that yoga exercises improve pulmonary function and exercise capacity comparable to traditional pulmonary rehabilitation methods. Yoga-based programs may be a cost-effective alternative for COPD management.
Researchers have discovered a new molecule involved in the development of fibrosis, a condition characterized by inflammation and stiffening of skin tissue. High levels of this molecule, fibulin-5, were found to contribute to increased skin tissue inflammation and stiffening.
Researchers at Yale University have developed a synthetic process to synthesize glucosepane, a critical chemical link in both diabetes and aging. This breakthrough may lead to the development of tools to examine the role glucosepane plays in human health and potentially inhibit its formation.
Researchers from Brigham and Women's Hospital discovered specialized pro-resolving mediators (SPMs) in human breast milk that resolve inflammation, stimulate immune response, and heal wounds. These findings suggest a critical role for SPMs in infant development and immune system maturation.
Researchers at Helmholtz Centre for Environmental Research (UFZ) discovered a protein called syndecan-4 that plays a critical role in developing allergic airway inflammation. The study found that syndecan-4 helps immune cells migrate to T-cells, initiating an immune reaction and sensitization to specific allergens.
A study from the Gladstone Institutes reveals that a single drop of blood in the brain can trigger an autoimmune response akin to multiple sclerosis. Fibrinogen, a blood-clotting factor, activates microglia and recruits peripheral immune cells, causing myelin damage and inflammation.
Research found that psoriasis patients had high levels of blood vessel inflammation, even at low cardiovascular risk. The most extensive forms of psoriasis were associated with a 51% increase in blood vessel inflammation.
A Georgia State University researcher is investigating the impact of emulsifiers on gut microbiota, leading to chronic inflammatory diseases and metabolic syndrome. The study aims to determine how emulsifiers alter the intestinal tract's relationship with beneficial bacteria.
A study from the University of Eastern Finland found that infrared thermography can detect joint inflammation in ankle joints, but not knee joints. The technique also showed potential in evaluating office ergonomics and assessing musculoskeletal conditions, which could ease the workload in specialized healthcare and reduce costs.
A University of Eastern Finland study found that long sleep duration is associated with high serum copper concentrations, potentially linking it to pro-oxidative stress and chronic diseases like coronary artery disease. This association remained unchanged even when cardiovascular diseases were accounted for.
Scientists at Queen's University Belfast have developed a novel anti-inflammatory nanoparticle that shows promise in treating sepsis and Acute Respiratory Distress Syndrome (ARDS), two leading causes of death in hospitalised patients. The treatment, known as SAN101, has the potential to reduce inflammation and prevent organ failure.
Scientists have identified a gene variant that slows Alzheimer's disease progression by preventing eotaxin levels from increasing with age. The study found that individuals carrying this variant experienced a modest delay in disease onset, suggesting a potential protective mechanism against the disease.
Researchers discovered MIF, a molecule involved in EoE, which can be targeted for therapy. The study suggests a novel approach to treating this hard-to-treat food allergy, offering hope for patients with difficulty swallowing.
Researchers at the University of Zurich have discovered that an overproduction of E. coli bacteria is triggered by the availability of sialic acid, leading to intestinal inflammation. A sialidase inhibitor can prevent excessive E. coli formation and alleviate disease symptoms.