Articles tagged with Inflammatory Disorders
The study identified two genes linked to Crohn's disease: Nod2 and IL-23R. This discovery may lead to improved diagnosis and targeted drug therapies for patients with Crohn's disease.
Researchers have developed a new oral enzyme therapy that allows celiacs to safely consume low-to-moderate levels of gluten. The therapy, which involves the use of EP-B2 and PEP enzymes, has shown promise in breaking down gluten proteins and preventing inflammation.
Research suggests that pregnant women with periodontitis have higher CRP levels, which may contribute to preeclampsia and preterm delivery. The study's findings support previous research linking periodontal disease and inflammation with adverse pregnancy outcomes.
Scientists from Université Laval found that red wine polyphenols significantly modulate inflammatory components released by macrophages in response to bacterial stimuli. These anti-oxidant properties could be useful in preventing and treating inflammatory periodontal diseases as well as other disorders involving free radicals.
Researchers found that Crohn's disease patients produce lower quantities of neutrophils and inflammatory mediators in response to trauma, leading to delayed blood flow and persistence of bacteria. Treatment with Viagra corrected abnormally low blood flow, suggesting a potential role for the drug in treating the disease.
Researchers uncover first molecular insight into eosinophilic esophagitis by identifying genetic program distinguishing it from other forms of esophagitis. The study reveals eotaxin-3 as a key gene contributing to the disease, offering new potential for diagnosis and therapy.
A recent study published in American Journal of Roentgenology found that CT enteroclysis can detect complications like fistulas, abscesses, and tumors superior to conventional enteroclysis. This imaging method also detects minimal mucosal changes, a sign of early stage Crohn's disease, with no disadvantages.
Researchers at Johns Hopkins found elevated IL-6 levels correlate with tissue injury and clinical disability in Transverse Myelitis (TM) patients. Elevated IL-6 levels are necessary and sufficient to mediate neural injury, dependent on nitric oxide.
Scientists discovered that interleukin-6 increases in TM patients' cerebrospinal fluid and is linked to tissue injury. Arsenic trioxide inhibits nuclear receptor function via SEK1/JNK-mediated RXR phosphorylation. Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea.
Researchers discovered that around 3% of the bowel's surface area is covered in a glue-like substance that plugs gaps in healthy tissue. This finding may lead to new treatments for inflammatory bowel disease and explain the development of colon cancer.
A comprehensive analysis of gene expression revealed that 650 genes differ between normal individuals and patients with ulcerative colitis or Crohn disease. Down-regulation, rather than up-regulation, was the prevailing pattern found in both diseases.
A study analyzing over 180,000 breast cancer cases found that inflammatory breast carcinoma (IBC) accounts for about 2% of all breast cancers. Women diagnosed with IBC tend to be younger and have poorer survival rates compared to other types of breast cancer.
Researchers at USC College of Letters, Arts and Sciences have found a link between early exposure to inflammatory diseases like gum disease and an increased risk of Alzheimer's. The study, which analyzed data from the Swedish Twin Registry, suggests that chronic gum disease may be a preventable risk factor for Alzheimer's, adding to th...
A new study by Dr. Jane Dimmitt Champion and her team found that minority adolescent women with a history of sexual/physical abuse are at higher risk of pelvic inflammatory disease and HIV/STDs. With better screening, these health problems could be decreased.
A recent study published in PLoS Medicine found that oats can cause intolerance in some patients with celiac disease, triggering a similar molecular reaction as wheat, barley, or rye. This means that not all patients with celiac disease may be able to safely include oats in their diet.
Eosinophilic esophagitis (EE) is a rapidly rising disorder characterized by severely elevated levels of eosinophils in the esophagus, leading to vomiting and difficulty swallowing. The disease has a familial pattern suggesting genetic or environmental factors, warranting further study.
Max Planck researchers discovered that the body's own cannabinoid receptor acts as a protective system against colon inflammation. The study found that mutant mice lacking this receptor are more prone to inflammatory responses, but treatment with cannabinoids can alleviate inflammation in wild-type animals.
Researchers at PTC Therapeutics have discovered a new biochemical pathway that controls cell growth modulation. This finding has significant implications for the development of therapeutics targeting cancer cells, which rely on deregulated translation to grow uncontrollably.
The study, published in Pharmacological Reviews, reveals that activation of certain melanocortin receptors can modulate the inflammatory process, reducing major molecules involved. This discovery has implications for treating localized and systemic inflammatory disorders, including organ transplantation and chronic inflammatory diseases.
A new study by McGill University researchers has identified phospholipase A2 (cPLA2) as a key enzyme that triggers multiple sclerosis-like disease in an animal model. Treatment with a chemical inhibitor of this enzyme results in a marked reduction in the onset and severity of the disease.
Researchers investigate targeting pericytes and endothelial cells with kinase inhibitors to treat cancer and autoimmune diseases. PDX1 levels also play a crucial role in islet survival and diabetes development, while Factor H's anti-inflammatory properties are explored for hemolytic uremic syndrome treatment.
Research suggests that irritable bowel syndrome is a discrete collection of organic bowel diseases, characterized by morphological, psychological, and physiological changes. Treatment options, including cognitive behavioral therapy and tricyclic antidepressants, show promise in managing symptoms.
Researchers found strong connection between common IL-1 gene variations and elevated CRP levels, a protein marker of inflammation. The study's findings may help physicians identify patients at risk earlier and monitor disease progression.
Researchers have discovered a link between keratinocyte growth factor (KGF) concentrations and protection against bronchopulmonary dysplasia (BPD) in premature infants. Additionally, a new pH test offers a simple method to evaluate airway inflammation in diseases such as asthma and COPD.
A synthetic form of bacterial DNA has been shown to reduce the harmful effects of Inflammatory Bowel Disease (IBD) in mice while enhancing the immune system. The study's findings suggest that IBD patients may be able to take an oral form of this compound once a week to prevent flare-up periods typical of the disease.
The Emory study uses the COGNIShunt device to drain off toxins from the cerebrospinal fluid, a potential breakthrough in treating Alzheimer's disease. The 18-month trial aims to assess the effectiveness of the treatment and its impact on patients' symptoms.
The Vienna centre of excellence in biomedicine is researching into the genetic causes of chronic inflammatory diseases, such as rheumatism and arteriosclerosis. The centre brings together leading university institutes, pharmaceutical companies, and start-ups to achieve rapid transfers of research results from the laboratory to patients.
A new study found that screening all young women under 30 for Chlamydia trachomatis infection is the most efficient way to identify infected women, reducing infertility and costly medical complications. The test is cost-effective due to its high sensitivity, identifying more infections.